3tjv - Revision history

OCA at 17:32, 1 November 2023

OCA — Wed, 01 Nov 2023 17:32:59 GMT

←Older revision		Revision as of 17:32, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3tjv' size='340' side='right'caption='[[3tjv]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3tjv' size='340' side='right'caption='[[3tjv]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tjv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TJV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tjv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TJV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3tju\|3tju]], [[3tk9\|3tk9]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">GZMH, CGL2, CTSGL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjv OCA], [https://pdbe.org/3tjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tjv RCSB], [https://www.ebi.ac.uk/pdbsum/3tjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjv OCA], [https://pdbe.org/3tjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tjv RCSB], [https://www.ebi.ac.uk/pdbsum/3tjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GRAH_HUMAN GRAH_HUMAN]] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>PMID:22156497</ref> <ref>PMID:23269243</ref>	+	[https://www.uniprot.org/uniprot/GRAH_HUMAN GRAH_HUMAN] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>PMID:22156497</ref> <ref>PMID:23269243</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fan, Z]]	+	[[Category: Fan Z]]
-	[[Category: Sun, F]]	+	[[Category: Sun F]]
-	[[Category: Tong, L]]	+	[[Category: Tong L]]
-	[[Category: Wang, L]]	+	[[Category: Wang L]]
-	[[Category: Wu, L]]	+	[[Category: Wu L]]
-	[[Category: Zhang, K]]	+	[[Category: Zhang K]]
-	~~[[Category: Cytolysis]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase substrate]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 17:01, 6 July 2022

OCA — Wed, 06 Jul 2022 17:01:24 GMT

←Older revision		Revision as of 17:01, 6 July 2022
Line 1:		Line 1:

	==Crystal structure of human granzyme H with a peptidyl substrate==		==Crystal structure of human granzyme H with a peptidyl substrate==
-	<StructureSection load='3tjv' size='340' side='right' caption='[[3tjv]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3tjv' size='340' side='right'caption='[[3tjv]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tjv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TJV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tjv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TJV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tju\|3tju]], [[3tk9\|3tk9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tju\|3tju]], [[3tk9\|3tk9]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMH, CGL2, CTSGL2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMH, CGL2, CTSGL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjv OCA], [~~http~~://pdbe.org/3tjv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tjv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tjv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjv OCA], [https://pdbe.org/3tjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tjv RCSB], [https://www.ebi.ac.uk/pdbsum/3tjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRAH_HUMAN GRAH_HUMAN]] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>PMID:22156497</ref> <ref>PMID:23269243</ref>	+	[[https://www.uniprot.org/uniprot/GRAH_HUMAN GRAH_HUMAN]] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>PMID:22156497</ref> <ref>PMID:23269243</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fan, Z]]		[[Category: Fan, Z]]
	[[Category: Sun, F]]		[[Category: Sun, F]]

OCA at 21:11, 5 August 2016

OCA — Fri, 05 Aug 2016 21:11:27 GMT

←Older revision		Revision as of 21:11, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human granzyme H with a peptidyl substrate==		==Crystal structure of human granzyme H with a peptidyl substrate==
	<StructureSection load='3tjv' size='340' side='right' caption='[[3tjv]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3tjv' size='340' side='right' caption='[[3tjv]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tjv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TJV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tjv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TJV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tju\|3tju]], [[3tk9\|3tk9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tju\|3tju]], [[3tk9\|3tk9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMH, CGL2, CTSGL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMH, CGL2, CTSGL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tjv RCSB], [http://www.ebi.ac.uk/pdbsum/3tjv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjv OCA], [http://pdbe.org/3tjv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tjv RCSB], [http://www.ebi.ac.uk/pdbsum/3tjv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tjv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Fan, Z]]		[[Category: Fan, Z]]
	[[Category: Sun, F]]		[[Category: Sun, F]]

OCA at 21:55, 25 December 2014

OCA — Thu, 25 Dec 2014 21:55:55 GMT

←Older revision		Revision as of 21:55, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tjv RCSB], [http://www.ebi.ac.uk/pdbsum/3tjv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tjv RCSB], [http://www.ebi.ac.uk/pdbsum/3tjv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRAH_HUMAN GRAH_HUMAN]] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>PMID:22156497</ref> <ref>PMID:23269243</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:43, 21 December 2014

OCA — Sun, 21 Dec 2014 06:43:16 GMT

←Older revision		Revision as of 06:43, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3tjv\| PDB=3tjv \| SCENE= }}~~	+	==Crystal structure of human granzyme H with a peptidyl substrate==
-	===Crystal structure of human granzyme H with a peptidyl substrate===	+	<StructureSection load='3tjv' size='340' side='right' caption='[[3tjv]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22156497}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tjv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TJV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tju\|3tju]], [[3tk9\|3tk9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMH, CGL2, CTSGL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tjv RCSB], [http://www.ebi.ac.uk/pdbsum/3tjv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human granzyme H (GzmH) is constitutively expressed in human NK cells that have important roles in innate immune responses against tumors and viruses. GzmH is a chymotrypsin-like serine protease. Its substrate preference and its mechanism of substrate recognition are poorly understood. To provide structural insights into the substrate recognition mechanisms for GzmH, we solved the crystal structures of a D102N-GzmH mutant alone and in complex with a decapeptide substrate and an inhibitor to 2.2 A, 2.4 A, and 2.7 A, respectively. The Thr(189), Gly(216), and Gly(226) specificity triad in the S1 pocket of GzmH defines its preference for bulky, aromatic residues (Tyr and Phe) at the P1 position. Notably, we discovered that an unusual RKR motif (Arg(39)-Lys(40)-Arg(41)), conserved only in GzmH, helps define the S3' and S4' binding regions, indicating the preference for acidic residues at the P3' and P4' sites. Disruption of the RKR motif or the acidic P3' and P4' residues in the substrate abolished the proteolytic activity of GzmH. We designed a tetrapeptide chloromethylketone inhibitor, Ac-PTSY-chloromethylketone, which can selectively and efficiently block the enzymatic and cytotoxic activity of GzmH, providing a useful tool for further studies on the function of GzmH.

-	~~==Function==~~	+	Structural Insights into the Substrate Specificity of Human Granzyme H: The Functional Roles of a Novel RKR Motif.,Wang L, Zhang K, Wu L, Liu S, Zhang H, Zhou Q, Tong L, Sun F, Fan Z J Immunol. 2011 Dec 9. PMID:22156497<ref>PMID:22156497</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/GRAH_HUMAN GRAH_HUMAN]] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites~~. ~~Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>~~PMID:22156497~~</ref>~~ <ref>PMID:~~23269243~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3tjv]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3TJV OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Granzyme\|Granzyme]]		*[[Granzyme\|Granzyme]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022156497</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Fan, Z.]]	+	[[Category: Fan, Z]]
-	[[Category: Sun, F.]]	+	[[Category: Sun, F]]
-	[[Category: Tong, L.]]	+	[[Category: Tong, L]]
-	[[Category: Wang, L.]]	+	[[Category: Wang, L]]
-	[[Category: Wu, L.]]	+	[[Category: Wu, L]]
-	[[Category: Zhang, K.]]	+	[[Category: Zhang, K]]
	[[Category: Cytolysis]]		[[Category: Cytolysis]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase substrate]]		[[Category: Hydrolase substrate]]
	[[Category: Serine protease]]		[[Category: Serine protease]]

OCA at 11:06, 3 July 2013

OCA — Wed, 03 Jul 2013 11:06:32 GMT

←Older revision		Revision as of 11:06, 3 July 2013
Line 2:		Line 2:
	===Crystal structure of human granzyme H with a peptidyl substrate===		===Crystal structure of human granzyme H with a peptidyl substrate===
	{{ABSTRACT_PUBMED_22156497}}		{{ABSTRACT_PUBMED_22156497}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/GRAH_HUMAN GRAH_HUMAN]] Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.<ref>PMID:22156497</ref> <ref>PMID:23269243</ref>

	==About this Structure==		==About this Structure==
Line 10:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022156497</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022156497</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fan, Z.]]		[[Category: Fan, Z.]]

OCA at 10:17, 11 March 2013

OCA — Mon, 11 Mar 2013 10:17:40 GMT

←Older revision		Revision as of 10:17, 11 March 2013
Line 1:		Line 1:
-	[[Image:3tjv.jpg\|left\|200px]]
-
-	<!--
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-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3tjv\| PDB=3tjv \| SCENE= }}		{{STRUCTURE_3tjv\| PDB=3tjv \| SCENE= }}
-
	===Crystal structure of human granzyme H with a peptidyl substrate===		===Crystal structure of human granzyme H with a peptidyl substrate===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22156497}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22156497 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22156497}}		{{ABSTRACT_PUBMED_22156497}}

	==About this Structure==		==About this Structure==
	[[3tjv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJV OCA].		[[3tjv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJV OCA].
		+
		+	==See Also==
		+	*[[Granzyme\|Granzyme]]

	==Reference==		==Reference==

OCA at 07:26, 28 December 2011

OCA — Wed, 28 Dec 2011 07:26:33 GMT

←Older revision		Revision as of 07:26, 28 December 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3tjv.jpg\|left\|200px]]

-	The ~~entry 3tjv~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3tjv", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3tjv\| PDB=3tjv \| SCENE= }}

-	~~Authors: Wang, L., Zhang, K., Wu, L., Tong, L., Sun, F., Fan, Z.~~	+	===Crystal structure of human granzyme H with a peptidyl substrate===

-	~~Description~~: ~~Crystal~~ structure ~~of human granzyme H~~ with ~~a peptidyl~~ substrate	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22156497}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22156497 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22156497}}
		+
		+	==About this Structure==
		+	[[3tjv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022156497</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Fan, Z.]]
		+	[[Category: Sun, F.]]
		+	[[Category: Tong, L.]]
		+	[[Category: Wang, L.]]
		+	[[Category: Wu, L.]]
		+	[[Category: Zhang, K.]]
		+	[[Category: Cytolysis]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase substrate]]
		+	[[Category: Serine protease]]

OCA at 05:30, 21 September 2011

OCA — Wed, 21 Sep 2011 05:30:40 GMT

←Older revision		Revision as of 05:30, 21 September 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3tjv is ON HOLD	+	The entry 3tjv is ON HOLD until Paper Publication

	Authors: Wang, L., Zhang, K., Wu, L., Tong, L., Sun, F., Fan, Z.		Authors: Wang, L., Zhang, K., Wu, L., Tong, L., Sun, F., Fan, Z.

	Description: Crystal structure of human granzyme H with a peptidyl substrate		Description: Crystal structure of human granzyme H with a peptidyl substrate

OCA at 06:04, 14 September 2011

OCA — Wed, 14 Sep 2011 06:04:36 GMT

←Older revision		Revision as of 06:04, 14 September 2011
Line 3:		Line 3:
	The entry 3tjv is ON HOLD		The entry 3tjv is ON HOLD

-	Authors: Li Wang, ~~Kai~~ Zhang, ~~Lianfeng~~ Wu, ~~Liang~~ Tong, ~~Fei~~ Sun, ~~Zusen~~ Fan	+	Authors: Wang, L., Zhang, K., Wu, L., Tong, L., Sun, F., Fan, Z.

	Description: Crystal structure of human granzyme H with a peptidyl substrate		Description: Crystal structure of human granzyme H with a peptidyl substrate