3tpl - Revision history

OCA at 17:33, 1 November 2023

OCA — Wed, 01 Nov 2023 17:33:36 GMT

←Older revision		Revision as of 17:33, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3tpl' size='340' side='right'caption='[[3tpl]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3tpl' size='340' side='right'caption='[[3tpl]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tpl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TPL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tpl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TPL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3tpj\|3tpj]], [[3tpp\|3tpp]], [[3tpr\|3tpr]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>BACE, BACE1, KIAA1149 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tpl OCA], [https://pdbe.org/3tpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tpl RCSB], [https://www.ebi.ac.uk/pdbsum/3tpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tpl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tpl OCA], [https://pdbe.org/3tpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tpl RCSB], [https://www.ebi.ac.uk/pdbsum/3tpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tpl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Memapsin 2]]~~	+	[[Category: Chen TT]]
-	[[Category: Chen~~, T T~~]]	+	[[Category: Greenblatt H]]
-	[[Category: Greenblatt, H]]	+	[[Category: Li MJ]]
-	[[Category: Li~~, M J~~]]	+	[[Category: Silman I]]
-	[[Category: Silman, I]]	+	[[Category: Sussman JL]]
-	[[Category: Sussman~~, J L~~]]	+	[[Category: Xu YC]]
-	[[Category: Xu~~, Y C]]~~	+
-	~~[[Category: Beta-secretase 1]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Protease~~]]	+

OCA at 17:07, 6 July 2022

OCA — Wed, 06 Jul 2022 17:07:49 GMT

←Older revision		Revision as of 17:07, 6 July 2022
Line 1:		Line 1:

	==APO Structure of BACE1==		==APO Structure of BACE1==
-	<StructureSection load='3tpl' size='340' side='right' caption='[[3tpl]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3tpl' size='340' side='right'caption='[[3tpl]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tpl]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TPL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TPL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tpl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TPL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tpj\|3tpj]], [[3tpp\|3tpp]], [[3tpr\|3tpr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tpj\|3tpj]], [[3tpp\|3tpp]], [[3tpr\|3tpr]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tpl OCA], [~~http~~://pdbe.org/3tpl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tpl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tpl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tpl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tpl OCA], [https://pdbe.org/3tpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tpl RCSB], [https://www.ebi.ac.uk/pdbsum/3tpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tpl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[~~Journal:Acta Cryst D:1~~\|~~Journal:Acta Cryst D:1~~]]	+	*[[Beta secretase\|Beta secretase]]
		+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Chen, T T]]		[[Category: Chen, T T]]

OCA at 09:54, 8 November 2017

OCA — Wed, 08 Nov 2017 09:54:10 GMT

←Older revision		Revision as of 09:54, 8 November 2017
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]
	*[[Journal:Acta Cryst D:1\|Journal:Acta Cryst D:1]]		*[[Journal:Acta Cryst D:1\|Journal:Acta Cryst D:1]]
	== References ==		== References ==

OCA at 16:58, 5 August 2016

OCA — Fri, 05 Aug 2016 16:58:46 GMT

←Older revision		Revision as of 16:58, 5 August 2016
Line 1:		Line 1:
		+
	==APO Structure of BACE1==		==APO Structure of BACE1==
	<StructureSection load='3tpl' size='340' side='right' caption='[[3tpl]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3tpl' size='340' side='right' caption='[[3tpl]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tpl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TPL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tpl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TPL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tpj\|3tpj]], [[3tpp\|3tpp]], [[3tpr\|3tpr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tpj\|3tpj]], [[3tpp\|3tpp]], [[3tpr\|3tpr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tpl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tpl RCSB], [http://www.ebi.ac.uk/pdbsum/3tpl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tpl OCA], [http://pdbe.org/3tpl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tpl RCSB], [http://www.ebi.ac.uk/pdbsum/3tpl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tpl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tpl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Chen, T T]]		[[Category: Chen, T T]]

OCA at 20:28, 25 December 2014

OCA — Thu, 25 Dec 2014 20:28:56 GMT

←Older revision		Revision as of 20:28, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tpl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tpl RCSB], [http://www.ebi.ac.uk/pdbsum/3tpl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tpl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tpl RCSB], [http://www.ebi.ac.uk/pdbsum/3tpl PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:21, 18 December 2014

OCA — Thu, 18 Dec 2014 08:21:14 GMT

←Older revision		Revision as of 08:21, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3tpl~~\| ~~PDB~~=3tpl \| ~~SCENE~~= }}	+	==APO Structure of BACE1==
-	===~~APO Structure of~~ BACE1===	+	<StructureSection load='3tpl' size='340' side='right' caption='[[3tpl]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22194329}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tpl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TPL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tpj\|3tpj]], [[3tpp\|3tpp]], [[3tpr\|3tpr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tpl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tpl RCSB], [http://www.ebi.ac.uk/pdbsum/3tpl PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	beta-Secretase (beta-site amyloid precursor protein-cleaving enzyme 1; BACE1) is a transmembrane aspartic protease that cleaves the beta-amyloid precursor protein en route to generation of the amyloid beta-peptide (Abeta) that is believed to be responsible for the Alzheimer's disease amyloid cascade. It is thus a prime target for the development of inhibitors which may serve as drugs in the treatment and/or prevention of Alzheimer's disease. In the following determination of the crystal structures of both apo and complexed BACE1, structural analysis of all crystal structures of BACE1 deposited in the PDB and molecular dynamics (MD) simulations of monomeric and `dimeric' BACE1 were used to study conformational changes in the active-site region of the enzyme. It was observed that a flap able to cover the active site is the most flexible region, adopting multiple conformational states in the various crystal structures. Both the presence or absence of an inhibitor within the active site and the crystal packing are shown to influence the flap's conformation. An open conformation of the flap is mostly observed in the apo structures, while direct hydrogen-bonding interaction between main-chain atoms of the flap and the inhibitor is a prerequisite for the flap to adopt a closed conformation in the crystal structures of complexes. Thus, a systematic study of the conformational flexibility of the enzyme may not only contribute to structure-based drug design of BACE1 inhibitors and of other targets with flexible conformations, but may also help to better understand the mechanistic events associated with the binding of substrates and inhibitors to the enzyme.

-	~~==About this Structure==~~	+	Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.,Xu Y, Li MJ, Greenblatt H, Chen W, Paz A, Dym O, Peleg Y, Chen T, Shen X, He J, Jiang H, Silman I, Sussman JL Acta Crystallogr D Biol Crystallogr. 2012 Jan;68(Pt 1):13-25. Epub 2011 Dec 9. PMID:22194329<ref>PMID:22194329</ref>
-	~~[[3tpl]] is a 3 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3TPL OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
	*[[Journal:Acta Cryst D:1\|Journal:Acta Cryst D:1]]		*[[Journal:Acta Cryst D:1\|Journal:Acta Cryst D:1]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022194329<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Chen, T T.]]	+	[[Category: Chen, T T]]
-	[[Category: Greenblatt, H.]]	+	[[Category: Greenblatt, H]]
-	[[Category: Li, M J.]]	+	[[Category: Li, M J]]
-	[[Category: Silman, I.]]	+	[[Category: Silman, I]]
-	[[Category: Sussman, J L.]]	+	[[Category: Sussman, J L]]
-	[[Category: Xu, Y C.]]	+	[[Category: Xu, Y C]]
	[[Category: Beta-secretase 1]]		[[Category: Beta-secretase 1]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Memapsin 2]]
	[[Category: Protease]]		[[Category: Protease]]

OCA at 10:47, 11 March 2013

OCA — Mon, 11 Mar 2013 10:47:09 GMT

←Older revision		Revision as of 10:47, 11 March 2013
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-	[[Image:3tpl.png\|left\|200px]]
-
	{{STRUCTURE_3tpl\| PDB=3tpl \| SCENE= }}		{{STRUCTURE_3tpl\| PDB=3tpl \| SCENE= }}
-
	===APO Structure of BACE1===		===APO Structure of BACE1===
-
	{{ABSTRACT_PUBMED_22194329}}		{{ABSTRACT_PUBMED_22194329}}

OCA at 21:07, 20 October 2012

OCA — Sat, 20 Oct 2012 21:07:22 GMT

←Older revision		Revision as of 21:07, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3tpl]] is a 3 chain structure ~~of [[Beta secretase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TPL OCA].	+	[[3tpl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TPL OCA].

	==See Also==		==See Also==

OCA at 08:01, 29 August 2012

OCA — Wed, 29 Aug 2012 08:01:22 GMT

←Older revision		Revision as of 08:01, 29 August 2012
Line 15:		Line 15:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022194329~~</ref><ref group="xtra">doi:10.1107/S0907444911047251~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022194329</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]

OCA at 03:59, 29 August 2012

OCA — Wed, 29 Aug 2012 03:59:01 GMT

←Older revision		Revision as of 03:59, 29 August 2012
Line 15:		Line 15:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022194329</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022194329</ref><ref group="xtra">doi:10.1107/S0907444911047251</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]