3tsj - Revision history

OCA at 06:45, 3 April 2024

OCA — Wed, 03 Apr 2024 06:45:18 GMT

←Older revision		Revision as of 06:45, 3 April 2024
Line 3:		Line 3:
	<StructureSection load='3tsj' size='340' side='right'caption='[[3tsj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3tsj' size='340' side='right'caption='[[3tsj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tsj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TSJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tsj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TSJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q3r\|3q3r]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsj OCA], [https://pdbe.org/3tsj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tsj RCSB], [https://www.ebi.ac.uk/pdbsum/3tsj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tsj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsj OCA], [https://pdbe.org/3tsj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tsj RCSB], [https://www.ebi.ac.uk/pdbsum/3tsj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tsj ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q2I6V7_PHLPR Q2I6V7_PHLPR]
-	~~BACKGROUND~~: Phl p 4 is a major pollen allergen but exhibits lower allergenicity than other major allergens. The natural protein is glycosylated and shows cross-reactivity with related and structurally unrelated allergens. OBJECTIVE: We sought to determine the high-resolution crystal structure of Phl p 4 and to evaluate the immunologic properties of the recombinant allergen in comparison with natural Phl p 4. METHODS: Different isoallergens of Phl p 4 were expressed, and the nonglycosylated mutant was crystallized. The specific role of protein and carbohydrate epitopes for allergenicity was studied by using IgE inhibition and basophil release assays. RESULTS: The 3-dimensional structure was determined by using x-ray crystallography at a resolution of 1.9 A. The allergen is a glucose dehydrogenase with a bicovalently attached flavin adenine dinucleotide. Glycosylated and nonglycosylated recombinant Phl p 4 showed identical inhibition of IgE binding, but compared with natural Phl p 4, all recombinant isoforms displayed a reduced IgE-binding inhibition. However, the recombinant protein exhibited an approximately 10-fold higher potency in basophil release assays than the natural protein. CONCLUSION: The crystal structure reveals the compact globular nature of the protein, and the observed binding pocket implies the size of the natural substrate. Plant-derived cross-reactive carbohydrate determinants (CCDs) appear to reduce the allergenicity of the natural allergen, whereas the Pichia pastoris-derived glycosylation does not. Our results imply yet undescribed mechanism of how CCDs dampen the immune response, leading to a novel understanding of the role of CCDs.	+
-		+
-	Crystal structure and immunologic characterization of the major grass pollen allergen Phl p 4.,Zafred D, Nandy A, Pump L, Kahlert H, Keller W J Allergy Clin Immunol. 2013 Sep;132(3):696-703.e10. doi:, 10.1016/~~j.jaci.2013.03.021. Epub 2013 May 14. PMID:23683465<ref>PMID:23683465<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3tsj" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Keller, W~~]]	+	[[Category: Phleum pratense]]
-	[[Category: ~~Nandy, A~~]]	+	[[Category: Keller W]]
-	[[Category: ~~Zafred, D~~]]	+	[[Category: Nandy A]]
-	[[Category: ~~Allergen]]~~	+	[[Category: Zafred D]]
-	~~[[Category: Allergy]]~~	+
-	~~[[Category: Bi-covalent flavinylation]]~~	+
-	~~[[Category: Dehydrogenase]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Glucose dehydrogenase]]~~	+
-	~~[[Category: Grass pollen]]~~	+
-	~~[[Category: N-glycosylation]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Pollen~~]]	+

OCA at 05:43, 13 July 2022

OCA — Wed, 13 Jul 2022 05:43:25 GMT

←Older revision		Revision as of 05:43, 13 July 2022
Line 3:		Line 3:
	<StructureSection load='3tsj' size='340' side='right'caption='[[3tsj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3tsj' size='340' side='right'caption='[[3tsj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tsj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TSJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tsj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TSJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q3r\|3q3r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q3r\|3q3r]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsj OCA], [~~http~~://pdbe.org/3tsj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tsj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tsj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tsj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsj OCA], [https://pdbe.org/3tsj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tsj RCSB], [https://www.ebi.ac.uk/pdbsum/3tsj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tsj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:54, 28 August 2019

OCA — Wed, 28 Aug 2019 16:54:58 GMT

←Older revision		Revision as of 16:54, 28 August 2019
Line 1:		Line 1:

	==Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity==		==Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity==
-	<StructureSection load='3tsj' size='340' side='right' caption='[[3tsj]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3tsj' size='340' side='right'caption='[[3tsj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tsj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TSJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tsj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TSJ FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Keller, W]]		[[Category: Keller, W]]
	[[Category: Nandy, A]]		[[Category: Nandy, A]]

OCA at 11:51, 3 August 2017

OCA — Thu, 03 Aug 2017 11:51:16 GMT

←Older revision		Revision as of 11:51, 3 August 2017
Line 3:		Line 3:
	<StructureSection load='3tsj' size='340' side='right' caption='[[3tsj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3tsj' size='340' side='right' caption='[[3tsj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tsj]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Common_timothy Common timothy]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TSJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tsj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TSJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q3r\|3q3r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q3r\|3q3r]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phlp4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=15957 Common timothy])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsj OCA], [http://pdbe.org/3tsj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tsj RCSB], [http://www.ebi.ac.uk/pdbsum/3tsj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tsj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsj OCA], [http://pdbe.org/3tsj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tsj RCSB], [http://www.ebi.ac.uk/pdbsum/3tsj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tsj ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Phl p 4 is a major pollen allergen but exhibits lower allergenicity than other major allergens. The natural protein is glycosylated and shows cross-reactivity with related and structurally unrelated allergens. OBJECTIVE: We sought to determine the high-resolution crystal structure of Phl p 4 and to evaluate the immunologic properties of the recombinant allergen in comparison with natural Phl p 4. METHODS: Different isoallergens of Phl p 4 were expressed, and the nonglycosylated mutant was crystallized. The specific role of protein and carbohydrate epitopes for allergenicity was studied by using IgE inhibition and basophil release assays. RESULTS: The 3-dimensional structure was determined by using x-ray crystallography at a resolution of 1.9 A. The allergen is a glucose dehydrogenase with a bicovalently attached flavin adenine dinucleotide. Glycosylated and nonglycosylated recombinant Phl p 4 showed identical inhibition of IgE binding, but compared with natural Phl p 4, all recombinant isoforms displayed a reduced IgE-binding inhibition. However, the recombinant protein exhibited an approximately 10-fold higher potency in basophil release assays than the natural protein. CONCLUSION: The crystal structure reveals the compact globular nature of the protein, and the observed binding pocket implies the size of the natural substrate. Plant-derived cross-reactive carbohydrate determinants (CCDs) appear to reduce the allergenicity of the natural allergen, whereas the Pichia pastoris-derived glycosylation does not. Our results imply yet undescribed mechanism of how CCDs dampen the immune response, leading to a novel understanding of the role of CCDs.
		+
		+	Crystal structure and immunologic characterization of the major grass pollen allergen Phl p 4.,Zafred D, Nandy A, Pump L, Kahlert H, Keller W J Allergy Clin Immunol. 2013 Sep;132(3):696-703.e10. doi:, 10.1016/j.jaci.2013.03.021. Epub 2013 May 14. PMID:23683465<ref>PMID:23683465</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3tsj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Common timothy]]
	[[Category: Keller, W]]		[[Category: Keller, W]]
	[[Category: Nandy, A]]		[[Category: Nandy, A]]

OCA at 10:36, 11 August 2016

OCA — Thu, 11 Aug 2016 10:36:54 GMT

←Older revision		Revision as of 10:36, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity==		==Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity==
	<StructureSection load='3tsj' size='340' side='right' caption='[[3tsj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3tsj' size='340' side='right' caption='[[3tsj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tsj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Phleum_pratense Phleum pratense~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TSJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tsj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Common_timothy Common timothy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TSJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q3r\|3q3r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q3r\|3q3r]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phlp4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=15957 ~~Phleum pratense~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phlp4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=15957 Common timothy])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tsj RCSB], [http://www.ebi.ac.uk/pdbsum/3tsj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsj OCA], [http://pdbe.org/3tsj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tsj RCSB], [http://www.ebi.ac.uk/pdbsum/3tsj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tsj ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Phleum pratense~~]]	+	[[Category: Common timothy]]
	[[Category: Keller, W]]		[[Category: Keller, W]]
	[[Category: Nandy, A]]		[[Category: Nandy, A]]

OCA at 11:05, 4 January 2015

OCA — Sun, 04 Jan 2015 11:05:33 GMT

←Older revision		Revision as of 11:05, 4 January 2015
Line 1:		Line 1:
-	~~[[Image:3tsj.jpg\|left\|200px]]~~	+	==Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity==
-		+	<StructureSection load='3tsj' size='340' side='right' caption='[[3tsj]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{STRUCTURE_3tsj\| PDB=3tsj \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3tsj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TSJ FirstGlance]. <br>
-	===Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q3r\|3q3r]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phlp4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=15957 Phleum pratense])</td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tsj RCSB], [http://www.ebi.ac.uk/pdbsum/3tsj PDBsum]</span></td></tr>
-	[[3tsj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA].	+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Phleum pratense]]		[[Category: Phleum pratense]]
-	[[Category: Keller, W.]]	+	[[Category: Keller, W]]
-	[[Category: Nandy, A.]]	+	[[Category: Nandy, A]]
-	[[Category: Zafred, D.]]	+	[[Category: Zafred, D]]
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Allergy]]		[[Category: Allergy]]

OCA at 07:18, 19 September 2012

OCA — Wed, 19 Sep 2012 07:18:03 GMT

←Older revision		Revision as of 07:18, 19 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3tsj.jpg\|left\|200px]]

-	~~The entry~~ 3tsj ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3tsj\| PDB=3tsj \| SCENE= }}

-	~~Authors: Zafred~~, ~~D., Nandy, A., Keller, W.~~	+	===Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity===

-	~~Description: Crystal structure of Phl p 4,~~ a ~~grass pollen allergen~~ with ~~glucose~~ dehydrogenase ~~activity~~	+
		+	==About this Structure==
		+	[[3tsj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSJ OCA].
		+	[[Category: Phleum pratense]]
		+	[[Category: Keller, W.]]
		+	[[Category: Nandy, A.]]
		+	[[Category: Zafred, D.]]
		+	[[Category: Allergen]]
		+	[[Category: Allergy]]
		+	[[Category: Bi-covalent flavinylation]]
		+	[[Category: Dehydrogenase]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Glucose dehydrogenase]]
		+	[[Category: Grass pollen]]
		+	[[Category: N-glycosylation]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Pollen]]

OCA at 08:42, 30 October 2011

OCA — Sun, 30 Oct 2011 08:42:40 GMT

←Older revision		Revision as of 08:42, 30 October 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3tsj is ON HOLD	+	The entry 3tsj is ON HOLD until Paper Publication

	Authors: Zafred, D., Nandy, A., Keller, W.		Authors: Zafred, D., Nandy, A., Keller, W.

	Description: Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity		Description: Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity

OCA: Protected "3tsj" [edit=sysop:move=sysop]

OCA — Wed, 21 Sep 2011 05:34:00 GMT

Protected "3tsj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:34, 21 September 2011

OCA: New page: '''Unreleased structure''' The entry 3tsj is ON HOLD Authors: Zafred, D., Nandy, A., Keller, W. Description: Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrog...

OCA — Wed, 21 Sep 2011 05:34:00 GMT

New page: '''Unreleased structure''' The entry 3tsj is ON HOLD Authors: Zafred, D., Nandy, A., Keller, W. Description: Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrog...

New page

'''Unreleased structure'''

The entry 3tsj is ON HOLD

Authors: Zafred, D., Nandy, A., Keller, W.

Description: Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity