3tt6 - Revision history

OCA at 17:33, 1 November 2023

OCA — Wed, 01 Nov 2023 17:33:49 GMT

←Older revision		Revision as of 17:33, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3tt6' size='340' side='right'caption='[[3tt6]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='3tt6' size='340' side='right'caption='[[3tt6]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tt6]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TT6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tt6]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TT6 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3tt7\|3tt7]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.592Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">clpP ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt6 OCA], [https://pdbe.org/3tt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tt6 RCSB], [https://www.ebi.ac.uk/pdbsum/3tt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tt6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt6 OCA], [https://pdbe.org/3tt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tt6 RCSB], [https://www.ebi.ac.uk/pdbsum/3tt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tt6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CLPP_BACSU CLPP_BACSU]] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). ClpXP is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor.<ref>PMID:16899079</ref>	+	[https://www.uniprot.org/uniprot/CLPP_BACSU CLPP_BACSU] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). ClpXP is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor.<ref>PMID:16899079</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835]]~~	+	[[Category: Bacillus subtilis]]
-	~~[[Category: Endopeptidase Clp~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kim~~, M K~~]]	+	[[Category: Kim MK]]
-	[[Category: Lee, B G]]	+	[[Category: Lee B-G]]
-	[[Category: Song~~, H K]]~~	+	[[Category: Song HK]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 05:44, 13 July 2022

OCA — Wed, 13 Jul 2022 05:44:04 GMT

←Older revision		Revision as of 05:44, 13 July 2022
Line 1:		Line 1:

	==Structure of ClpP from Bacillus subtilis in compressed state==		==Structure of ClpP from Bacillus subtilis in compressed state==
-	<StructureSection load='3tt6' size='340' side='right' caption='[[3tt6]], [[Resolution\|resolution]] 2.59Å' scene=''>	+	<StructureSection load='3tt6' size='340' side='right'caption='[[3tt6]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tt6]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TT6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tt6]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TT6 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tt7\|3tt7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tt7\|3tt7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">clpP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">clpP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt6 OCA], [~~http~~://pdbe.org/3tt6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tt6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tt6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tt6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt6 OCA], [https://pdbe.org/3tt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tt6 RCSB], [https://www.ebi.ac.uk/pdbsum/3tt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tt6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CLPP_BACSU CLPP_BACSU]] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). ClpXP is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor.<ref>PMID:16899079</ref>	+	[[https://www.uniprot.org/uniprot/CLPP_BACSU CLPP_BACSU]] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). ClpXP is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor.<ref>PMID:16899079</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3tt6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3tt6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Clp protease 3D structures\|Clp protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Endopeptidase Clp]]		[[Category: Endopeptidase Clp]]
		+	[[Category: Large Structures]]
	[[Category: Kim, M K]]		[[Category: Kim, M K]]
	[[Category: Lee, B G]]		[[Category: Lee, B G]]
	[[Category: Song, H K]]		[[Category: Song, H K]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 09:56, 8 November 2017

OCA — Wed, 08 Nov 2017 09:56:20 GMT

←Older revision		Revision as of 09:56, 8 November 2017
Line 3:		Line 3:
	<StructureSection load='3tt6' size='340' side='right' caption='[[3tt6]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='3tt6' size='340' side='right' caption='[[3tt6]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tt6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TT6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tt6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TT6 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tt7\|3tt7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tt7\|3tt7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">clpP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "~~Bacillus globigii~~" ~~Migula 1900~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">clpP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt6 OCA], [http://pdbe.org/3tt6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tt6 RCSB], [http://www.ebi.ac.uk/pdbsum/3tt6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tt6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt6 OCA], [http://pdbe.org/3tt6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tt6 RCSB], [http://www.ebi.ac.uk/pdbsum/3tt6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tt6 ProSAT]</span></td></tr>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3tt6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3tt6" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Clp Protease\|Clp Protease]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Endopeptidase Clp]]		[[Category: Endopeptidase Clp]]
	[[Category: Kim, M K]]		[[Category: Kim, M K]]

OCA at 20:08, 4 August 2016

OCA — Thu, 04 Aug 2016 20:08:42 GMT

←Older revision		Revision as of 20:08, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of ClpP from Bacillus subtilis in compressed state==		==Structure of ClpP from Bacillus subtilis in compressed state==
	<StructureSection load='3tt6' size='340' side='right' caption='[[3tt6]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='3tt6' size='340' side='right' caption='[[3tt6]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tt6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TT6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tt6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TT6 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tt7\|3tt7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tt7\|3tt7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">clpP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus ~~subtilis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">clpP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tt6 RCSB], [http://www.ebi.ac.uk/pdbsum/3tt6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt6 OCA], [http://pdbe.org/3tt6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tt6 RCSB], [http://www.ebi.ac.uk/pdbsum/3tt6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tt6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tt6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Endopeptidase Clp]]		[[Category: Endopeptidase Clp]]
	[[Category: Kim, M K]]		[[Category: Kim, M K]]

OCA at 12:42, 25 December 2014

OCA — Thu, 25 Dec 2014 12:42:43 GMT

←Older revision		Revision as of 12:42, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tt6 RCSB], [http://www.ebi.ac.uk/pdbsum/3tt6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tt6 RCSB], [http://www.ebi.ac.uk/pdbsum/3tt6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CLPP_BACSU CLPP_BACSU]] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). ClpXP is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor.<ref>PMID:16899079</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Clp Protease\|Clp Protease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:35, 21 December 2014

OCA — Sun, 21 Dec 2014 06:35:54 GMT

←Older revision		Revision as of 06:35, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3tt6~~\| ~~PDB~~=3tt6 \| ~~SCENE~~= }}	+	==Structure of ClpP from Bacillus subtilis in compressed state==
-	===~~Structure~~ of ClpP from Bacillus subtilis in compressed state~~===~~	+	<StructureSection load='3tt6' size='340' side='right' caption='[[3tt6]], [[Resolution\|resolution]] 2.59Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22080375}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tt6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TT6 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tt7\|3tt7]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">clpP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tt6 RCSB], [http://www.ebi.ac.uk/pdbsum/3tt6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ClpP is a cylindrical protease that is tightly regulated by Clp-ATPases. The activation mechanism of ClpP using acyldepsipeptide antibiotics as mimics of natural activators showed enlargement of the axial entrance pore for easier processing of incoming substrates. However, the elimination of degradation products from inside the ClpP chamber remains unclear since there is no exit pore for releasing these products in all determined ClpP structures. Here we report a new crystal structure of ClpP from Bacillus subtilis, which shows a significantly compressed shape along the axial direction. A portion of the handle regions comprising the heptameric ring-ring contacts shows structural transition from an ordered to a disordered state, which triggers the large conformational change from an extended to an overall compressed structure. Along with this structural change, 14 side pores are generated for product release and the catalytic triad adopts an inactive orientation. We have also determined B. subtilis ClpP inhibited by diisopropylfluoro-phosphate and analyzed the active site in detail. Structural information pertaining to several different conformational steps such as those related to extended, ADEP-activated, DFP-inhibited and compressed forms of ClpP from B. subtilis is available. Structural comparisons suggest that functionally important regions in the ClpP-family such as N-terminal segments for the axial pore, catalytic triads, and handle domains for the product releasing pore exhibit intrinsically dynamic and unique structural features. This study provides valuable insights for understanding the enigmatic cylindrical degradation machinery of ClpP as well as other related proteases such as HslV and the 20S proteasome.

-	~~==Function==~~	+	Structural insights into the conformational diversity of ClpP from Bacillus subtilis.,Lee BG, Kim MK, Song HK Mol Cells. 2011 Nov 9. PMID:22080375<ref>PMID:22080375</ref>
-	~~[[http://www.uniprot.org/uniprot/CLPP_BACSU CLPP_BACSU]] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in~~ the ~~degradation~~ of ~~misfolded proteins (By similarity)~~. ~~ClpXP is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW~~. ~~This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor~~.<ref>PMID:~~16899079~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3tt6]] is~~ a ~~7 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022080375</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Endopeptidase Clp]]		[[Category: Endopeptidase Clp]]
-	[[Category: Kim, M K.]]	+	[[Category: Kim, M K]]
-	[[Category: Lee, B G.]]	+	[[Category: Lee, B G]]
-	[[Category: Song, H K.]]	+	[[Category: Song, H K]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 07:10, 30 June 2013

OCA — Sun, 30 Jun 2013 07:10:11 GMT

←Older revision		Revision as of 07:10, 30 June 2013
Line 1:		Line 1:
-	[[Image:3tt6.png\|left\|200px]]
-
	{{STRUCTURE_3tt6\| PDB=3tt6 \| SCENE= }}		{{STRUCTURE_3tt6\| PDB=3tt6 \| SCENE= }}
-
	===Structure of ClpP from Bacillus subtilis in compressed state===		===Structure of ClpP from Bacillus subtilis in compressed state===
		+	{{ABSTRACT_PUBMED_22080375}}

-	~~{{ABSTRACT_PUBMED_22080375}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CLPP_BACSU CLPP_BACSU]] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). ClpXP is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor.<ref>PMID:16899079</ref>

	==About this Structure==		==About this Structure==
	[[3tt6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA].		[[3tt6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA].

-	==~~See Also~~==	+	==Reference==
-	*[[Clp Protease\|Clp Protease]]	+	<ref group="xtra">PMID:022080375</ref><references group="xtra"/><references/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Endopeptidase Clp]]		[[Category: Endopeptidase Clp]]

OCA at 16:48, 20 October 2012

OCA — Sat, 20 Oct 2012 16:48:15 GMT

←Older revision		Revision as of 16:48, 20 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3tt6.png\|left\|200px]]

-	~~The entry~~ 3tt6 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3tt6\| PDB=3tt6 \| SCENE= }}

-	~~Authors: Lee, B.-G., Kim, M.K., Song, H.K.~~	+	===Structure of ClpP from Bacillus subtilis in compressed state===

-	~~Description:~~ Structure ~~of ClpP~~ from Bacillus subtilis ~~in compressed state~~	+	{{ABSTRACT_PUBMED_22080375}}
		+
		+	==About this Structure==
		+	[[3tt6]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT6 OCA].
		+
		+	==See Also==
		+	*[[Clp Protease\|Clp Protease]]
		+	[[Category: Bacillus subtilis]]
		+	[[Category: Endopeptidase Clp]]
		+	[[Category: Kim, M K.]]
		+	[[Category: Lee, B G.]]
		+	[[Category: Song, H K.]]
		+	[[Category: Hydrolase]]

OCA at 08:43, 30 October 2011

OCA — Sun, 30 Oct 2011 08:43:00 GMT

←Older revision		Revision as of 08:43, 30 October 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3tt6 is ON HOLD	+	The entry 3tt6 is ON HOLD until Paper Publication

	Authors: Lee, B.-G., Kim, M.K., Song, H.K.		Authors: Lee, B.-G., Kim, M.K., Song, H.K.

	Description: Structure of ClpP from Bacillus subtilis in compressed state		Description: Structure of ClpP from Bacillus subtilis in compressed state

OCA: Protected "3tt6" [edit=sysop:move=sysop]

OCA — Wed, 21 Sep 2011 05:34:39 GMT

Protected "3tt6" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:34, 21 September 2011