3twc - Revision history

OCA at 13:41, 14 March 2024

OCA — Thu, 14 Mar 2024 13:41:44 GMT

←Older revision		Revision as of 13:41, 14 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3twc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3twc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AML:AMYLAMINE'>AML</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AML:AMYLAMINE'>AML</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twc OCA], [https://pdbe.org/3twc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twc RCSB], [https://www.ebi.ac.uk/pdbsum/3twc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twc OCA], [https://pdbe.org/3twc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twc RCSB], [https://www.ebi.ac.uk/pdbsum/3twc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twc ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]		[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The HIV envelope (Env) protein gp120 is protected from antibody recognition by a dense glycan shield. However, several of the recently identified PGT broadly neutralizing antibodies appear to interact directly with the HIV glycan coat. Crystal structures of Fabs PGT 127 and 128 with Man(9) at 1.65 and 1.29 A resolution, respectively, and glycan binding data delineate a specific high mannose binding site. Fab PGT 128 complexed with a fully glycosylated gp120 outer domain at 3.25 A reveals that the antibody penetrates the glycan shield and recognizes two conserved glycans as well as a short beta-strand segment of the gp120 V3 loop, accounting for its high binding affinity and broad specificify. Furthermore, our data suggest that the high neutralization potency of PGT 127 and 128 IgGs may be mediated by cross-linking Env trimers on the viral surface.
-
-	A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield.,Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, Liu Y, McBride R, Ito Y, Sanders RW, Ogohara C, Paulson JC, Feizi T, Scanlan CN, Wong CH, Moore JP, Olson WC, Ward AB, Poignard P, Schief WR, Burton DR, Wilson IA Science. 2011 Oct 13. PMID:21998254<ref>PMID:21998254</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3twc" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:27, 1 February 2023

OCA — Wed, 01 Feb 2023 12:27:59 GMT

←Older revision		Revision as of 12:27, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='3twc' size='340' side='right'caption='[[3twc]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3twc' size='340' side='right'caption='[[3twc]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3twc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3twc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AML:AMYLAMINE'>AML</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AML:AMYLAMINE'>AML</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>~~</td></tr>~~	+
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tv3\|3tv3]], [[3tyg\|3tyg]]</div></td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGLC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGHG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twc OCA], [https://pdbe.org/3twc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twc RCSB], [https://www.ebi.ac.uk/pdbsum/3twc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twc OCA], [https://pdbe.org/3twc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twc RCSB], [https://www.ebi.ac.uk/pdbsum/3twc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Pejchal, R]]	+	[[Category: Pejchal R]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Gp120]]~~	+
-	~~[[Category: Hiv-1 neutralizing antibody]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 05:23, 28 April 2021

OCA — Wed, 28 Apr 2021 05:23:39 GMT

←Older revision		Revision as of 05:23, 28 April 2021
Line 3:		Line 3:
	<StructureSection load='3twc' size='340' side='right'caption='[[3twc]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3twc' size='340' side='right'caption='[[3twc]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3twc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TWC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3twc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AML:AMYLAMINE'>AML</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AML:AMYLAMINE'>AML</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tv3\|3tv3]], [[3tyg\|3tyg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tv3\|3tv3]], [[3tyg\|3tyg]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGLC2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGHG1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGLC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGHG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3twc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twc OCA], [~~http~~://pdbe.org/3twc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3twc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3twc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3twc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twc OCA], [https://pdbe.org/3twc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twc RCSB], [https://www.ebi.ac.uk/pdbsum/3twc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:53, 25 December 2019

OCA — Wed, 25 Dec 2019 09:53:38 GMT

←Older revision		Revision as of 09:53, 25 December 2019
Line 1:		Line 1:

	==Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9==		==Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9==
-	<StructureSection load='3twc' size='340' side='right' caption='[[3twc]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='3twc' size='340' side='right'caption='[[3twc]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3twc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TWC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3twc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TWC FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Pejchal, R]]		[[Category: Pejchal, R]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 15:59, 4 August 2016

OCA — Thu, 04 Aug 2016 15:59:57 GMT

←Older revision		Revision as of 15:59, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9==		==Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9==
	<StructureSection load='3twc' size='340' side='right' caption='[[3twc]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3twc' size='340' side='right' caption='[[3twc]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3twc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TWC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3twc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TWC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AML:AMYLAMINE'>AML</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AML:AMYLAMINE'>AML</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tv3\|3tv3]], [[3tyg\|3tyg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tv3\|3tv3]], [[3tyg\|3tyg]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGLC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGLC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3twc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3twc RCSB], [http://www.ebi.ac.uk/pdbsum/3twc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3twc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twc OCA], [http://pdbe.org/3twc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3twc RCSB], [http://www.ebi.ac.uk/pdbsum/3twc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3twc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3twc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Pejchal, R]]		[[Category: Pejchal, R]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 06:57, 21 December 2014

OCA — Sun, 21 Dec 2014 06:57:27 GMT

←Older revision		Revision as of 06:57, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3twc\| PDB=3twc \| SCENE= }}~~	+	==Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9==
-	===Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9===	+	<StructureSection load='3twc' size='340' side='right' caption='[[3twc]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21998254}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3twc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TWC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AML:AMYLAMINE'>AML</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tv3\|3tv3]], [[3tyg\|3tyg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGLC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3twc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3twc RCSB], [http://www.ebi.ac.uk/pdbsum/3twc PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The HIV envelope (Env) protein gp120 is protected from antibody recognition by a dense glycan shield. However, several of the recently identified PGT broadly neutralizing antibodies appear to interact directly with the HIV glycan coat. Crystal structures of Fabs PGT 127 and 128 with Man(9) at 1.65 and 1.29 A resolution, respectively, and glycan binding data delineate a specific high mannose binding site. Fab PGT 128 complexed with a fully glycosylated gp120 outer domain at 3.25 A reveals that the antibody penetrates the glycan shield and recognizes two conserved glycans as well as a short beta-strand segment of the gp120 V3 loop, accounting for its high binding affinity and broad specificify. Furthermore, our data suggest that the high neutralization potency of PGT 127 and 128 IgGs may be mediated by cross-linking Env trimers on the viral surface.

-	~~==About this Structure==~~	+	A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield.,Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, Liu Y, McBride R, Ito Y, Sanders RW, Ogohara C, Paulson JC, Feizi T, Scanlan CN, Wong CH, Moore JP, Olson WC, Ward AB, Poignard P, Schief WR, Burton DR, Wilson IA Science. 2011 Oct 13. PMID:21998254<ref>PMID:21998254</ref>
-	~~[[3twc]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:021998254</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Pejchal, R.]]	+	[[Category: Pejchal, R]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
	[[Category: Fab]]		[[Category: Fab]]
	[[Category: Gp120]]		[[Category: Gp120]]
	[[Category: Hiv-1 neutralizing antibody]]		[[Category: Hiv-1 neutralizing antibody]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 21:55, 24 March 2013

OCA — Sun, 24 Mar 2013 21:55:45 GMT

←Older revision		Revision as of 21:55, 24 March 2013
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-	[[Image:3twc.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3twc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3twc\| PDB=3twc \| SCENE= }}		{{STRUCTURE_3twc\| PDB=3twc \| SCENE= }}
-
	===Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9===		===Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21998254}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21998254 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21998254}}		{{ABSTRACT_PUBMED_21998254}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:021998254</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021998254</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Pejchal, R.]]		[[Category: Pejchal, R.]]

OCA at 08:04, 30 October 2011

OCA — Sun, 30 Oct 2011 08:04:55 GMT

←Older revision		Revision as of 08:04, 30 October 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3twc.png\|left\|200px]]

-	The ~~entry 3twc~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3twc", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3twc\| PDB=3twc \| SCENE= }}

-	~~Authors: Pejchal, R., Wilson, I.A.~~	+	===Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9===

-	~~Description~~: ~~Crystal~~ structure ~~of broad and potent HIV~~-1 neutralizing antibody ~~PGT127 in complex with Man9~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21998254}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21998254 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21998254}}
		+
		+	==About this Structure==
		+	[[3twc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021998254</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Pejchal, R.]]
		+	[[Category: Wilson, I A.]]
		+	[[Category: Fab]]
		+	[[Category: Gp120]]
		+	[[Category: Hiv-1 neutralizing antibody]]
		+	[[Category: Immune system]]

OCA: Protected "3twc" [edit=sysop:move=sysop]

OCA — Wed, 28 Sep 2011 05:19:08 GMT

Protected "3twc" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:19, 28 September 2011

OCA: New page: '''Unreleased structure''' The entry 3twc is ON HOLD Authors: Pejchal, R., Wilson, I.A. Description: Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex...

OCA — Wed, 28 Sep 2011 05:19:07 GMT

New page: '''Unreleased structure''' The entry 3twc is ON HOLD Authors: Pejchal, R., Wilson, I.A. Description: Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex...

New page

'''Unreleased structure'''

The entry 3twc is ON HOLD

Authors: Pejchal, R., Wilson, I.A.

Description: Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9