3tzb - Revision history

OCA at 10:16, 1 March 2024

OCA — Fri, 01 Mar 2024 10:16:03 GMT

←Older revision		Revision as of 10:16, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3tzb' size='340' side='right'caption='[[3tzb]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='3tzb' size='340' side='right'caption='[[3tzb]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tzb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tzb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AA:9~~-~~AMINOACRIDINE'>AA</scene>~~, ~~<scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1901Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~NQO2, NMOR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])</td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AA:9-AMINOACRIDINE'>AA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzb OCA], [https://pdbe.org/3tzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tzb RCSB], [https://www.ebi.ac.uk/pdbsum/3tzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzb OCA], [https://pdbe.org/3tzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tzb RCSB], [https://www.ebi.ac.uk/pdbsum/3tzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>	+	[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The National Cancer Institute chemical database has been screened using in silico docking to identify novel nanomolar inhibitors of NRH:quinone oxidoreductase 2 (NQO2). The inhibitors identified from the screen exhibit a diverse range of scaffolds and the structure of one of the inhibitors, NSC13000 cocrystalized with NQO2, has been solved. This has been used to aid the generation of a structure-activity relationship between the computationally derived binding affinity and experimentally measured enzyme inhibitory potency. Many of the compounds are functionally active as inhibitors of NQO2 in cells at nontoxic concentrations. To show this, advantage was taken of the NQO2-mediated toxicity of the chemotherapeutic drug CB1954. The toxicity of this drug is substantially reduced when the function of NQO2 is inhibited, and many of the compounds achieve this in cells at nanomolar concentrations. The NQO2 inhibitors also attenuated TNFalpha-mediated, NF-small ka, CyrillicB-driven transcriptional activity. The link between NQO2 and the regulation of NF-small ka, CyrillicB was confirmed by using short interfering RNA to NQO2 and by the observation that NRH, the cofactor for NQO2 enzyme activity, could regulate NF-small ka, CyrillicB activity in an NQO2-dependent manner. NF-small ka, CyrillicB is a potential therapeutic target and this study reveals an underlying mechanism that may be usable for developing new anticancer drugs.	+
-		+
-	In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NF-kappaB signaling.,Nolan KA, Dunstan MS, Caraher MC, Scott KA, Leys D, Stratford IJ Mol Cancer Ther. 2012 Jan;11(1):194-203. doi: 10.1158/1535-7163.MCT-11-0543. Epub, 2011 Nov 16. PMID:22090421<ref>PMID:22090421</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3tzb" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
-	*[[Quinone reductase\|Quinone reductase]]	+	*[[Quinone reductase 3D structures\|Quinone reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dunstan~~, M S~~]]	+	[[Category: Dunstan MS]]
-	[[Category: Leys, D]]	+	[[Category: Leys D]]
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 05:51, 13 July 2022

OCA — Wed, 13 Jul 2022 05:51:28 GMT

←Older revision		Revision as of 05:51, 13 July 2022
Line 1:		Line 1:

	==Quinone Oxidoreductase (NQ02) bound to NSC13000==		==Quinone Oxidoreductase (NQ02) bound to NSC13000==
-	<StructureSection load='3tzb' size='340' side='right' caption='[[3tzb]], [[Resolution\|resolution]] 2.19Å' scene=''>	+	<StructureSection load='3tzb' size='340' side='right'caption='[[3tzb]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tzb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tzb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AA:9-AMINOACRIDINE'>AA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AA:9-AMINOACRIDINE'>AA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzb OCA], [~~http~~://pdbe.org/3tzb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tzb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tzb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzb OCA], [https://pdbe.org/3tzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tzb RCSB], [https://www.ebi.ac.uk/pdbsum/3tzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>	+	[[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dunstan, M S]]		[[Category: Dunstan, M S]]
	[[Category: Leys, D]]		[[Category: Leys, D]]
	[[Category: Fad]]		[[Category: Fad]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 04:43, 5 August 2016

OCA — Fri, 05 Aug 2016 04:43:56 GMT

←Older revision		Revision as of 04:43, 5 August 2016
Line 1:		Line 1:
		+
	==Quinone Oxidoreductase (NQ02) bound to NSC13000==		==Quinone Oxidoreductase (NQ02) bound to NSC13000==
	<StructureSection load='3tzb' size='340' side='right' caption='[[3tzb]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='3tzb' size='340' side='right' caption='[[3tzb]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TZB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AA:9-AMINOACRIDINE'>AA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AA:9-AMINOACRIDINE'>AA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tzb RCSB], [http://www.ebi.ac.uk/pdbsum/3tzb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzb OCA], [http://pdbe.org/3tzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tzb RCSB], [http://www.ebi.ac.uk/pdbsum/3tzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tzb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dunstan, M S]]		[[Category: Dunstan, M S]]
	[[Category: Leys, D]]		[[Category: Leys, D]]
	[[Category: Fad]]		[[Category: Fad]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 15:52, 25 December 2014

OCA — Thu, 25 Dec 2014 15:52:59 GMT

←Older revision		Revision as of 15:52, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tzb RCSB], [http://www.ebi.ac.uk/pdbsum/3tzb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tzb RCSB], [http://www.ebi.ac.uk/pdbsum/3tzb PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:13, 21 December 2014

OCA — Sun, 21 Dec 2014 07:13:31 GMT

←Older revision		Revision as of 07:13, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3tzb~~\| ~~PDB~~=3tzb \| ~~SCENE~~= }}	+	==Quinone Oxidoreductase (NQ02) bound to NSC13000==
-	===~~Quinone Oxidoreductase~~ (~~NQ02~~) ~~bound to NSC13000~~===	+	<StructureSection load='3tzb' size='340' side='right' caption='[[3tzb]], [[Resolution\|resolution]] 2.19Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22090421}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TZB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AA:9-AMINOACRIDINE'>AA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tzb RCSB], [http://www.ebi.ac.uk/pdbsum/3tzb PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The National Cancer Institute chemical database has been screened using in silico docking to identify novel nanomolar inhibitors of NRH:quinone oxidoreductase 2 (NQO2). The inhibitors identified from the screen exhibit a diverse range of scaffolds and the structure of one of the inhibitors, NSC13000 cocrystalized with NQO2, has been solved. This has been used to aid the generation of a structure-activity relationship between the computationally derived binding affinity and experimentally measured enzyme inhibitory potency. Many of the compounds are functionally active as inhibitors of NQO2 in cells at nontoxic concentrations. To show this, advantage was taken of the NQO2-mediated toxicity of the chemotherapeutic drug CB1954. The toxicity of this drug is substantially reduced when the function of NQO2 is inhibited, and many of the compounds achieve this in cells at nanomolar concentrations. The NQO2 inhibitors also attenuated TNFalpha-mediated, NF-small ka, CyrillicB-driven transcriptional activity. The link between NQO2 and the regulation of NF-small ka, CyrillicB was confirmed by using short interfering RNA to NQO2 and by the observation that NRH, the cofactor for NQO2 enzyme activity, could regulate NF-small ka, CyrillicB activity in an NQO2-dependent manner. NF-small ka, CyrillicB is a potential therapeutic target and this study reveals an underlying mechanism that may be usable for developing new anticancer drugs.

-	~~==Function==~~	+	In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NF-kappaB signaling.,Nolan KA, Dunstan MS, Caraher MC, Scott KA, Leys D, Stratford IJ Mol Cancer Ther. 2012 Jan;11(1):194-203. doi: 10.1158/1535-7163.MCT-11-0543. Epub, 2011 Nov 16. PMID:22090421<ref>PMID:22090421</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-~~dependent gamma~~-~~carboxylation of glutamate residues in prothrombin synthesis~~.<ref>PMID:~~18254726~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3tzb]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Quinone reductase\|Quinone reductase]]		*[[Quinone reductase\|Quinone reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022090421</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dunstan, M S.]]	+	[[Category: Dunstan, M S]]
-	[[Category: Leys, D.]]	+	[[Category: Leys, D]]
	[[Category: Fad]]		[[Category: Fad]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 05:04, 28 August 2013

OCA — Wed, 28 Aug 2013 05:04:20 GMT

←Older revision		Revision as of 05:04, 28 August 2013
Line 1:		Line 1:
-	[[Image:3tzb.png\|left\|200px]]
-
	{{STRUCTURE_3tzb\| PDB=3tzb \| SCENE= }}		{{STRUCTURE_3tzb\| PDB=3tzb \| SCENE= }}
-
	===Quinone Oxidoreductase (NQ02) bound to NSC13000===		===Quinone Oxidoreductase (NQ02) bound to NSC13000===
		+	{{ABSTRACT_PUBMED_22090421}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 11:
	==See Also==		==See Also==
	*[[Quinone reductase\|Quinone reductase]]		*[[Quinone reductase\|Quinone reductase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022090421</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dunstan, M S.]]		[[Category: Dunstan, M S.]]

OCA at 18:34, 20 October 2012

OCA — Sat, 20 Oct 2012 18:34:20 GMT

←Older revision		Revision as of 18:34, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3tzb]] is a 4 chain structure ~~of [[Quinone reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA].	+	[[3tzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA].

	==See Also==		==See Also==

OCA at 04:30, 27 July 2012

OCA — Fri, 27 Jul 2012 04:30:27 GMT

←Older revision		Revision as of 04:30, 27 July 2012
Line 1:		Line 1:
-	[[Image:3tzb.~~jpg~~\|left\|200px]]	+	[[Image:3tzb.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3tzb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3tzb\| PDB=3tzb \| SCENE= }}		{{STRUCTURE_3tzb\| PDB=3tzb \| SCENE= }}

Line 13:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3tzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA].	+	[[3tzb]] is a 4 chain structure of [[Quinone reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA].
		+
		+	==See Also==
		+	*[[Quinone reductase\|Quinone reductase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dunstan, M S.]]		[[Category: Dunstan, M S.]]

OCA at 08:39, 2 November 2011

OCA — Wed, 02 Nov 2011 08:39:54 GMT

←Older revision		Revision as of 08:39, 2 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3tzb.jpg\|left\|200px]]

-	The ~~entry 3tzb~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3tzb", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3tzb\| PDB=3tzb \| SCENE= }}

-	~~Authors: Dunstan, M.S., Leys, D.~~	+	===Quinone Oxidoreductase (NQ02) bound to NSC13000===

-	~~Description~~: ~~Quinone~~ Oxidoreductase ~~(NQ02) bound to NSC13000~~	+
		+	==About this Structure==
		+	[[3tzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZB OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Dunstan, M S.]]
		+	[[Category: Leys, D.]]
		+	[[Category: Fad]]
		+	[[Category: Oxidoreductase]]

OCA: Protected "3tzb" [edit=sysop:move=sysop]

OCA — Wed, 05 Oct 2011 06:14:18 GMT

Protected "3tzb" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:14, 5 October 2011