3tzn - Revision history

OCA at 10:16, 1 March 2024

OCA — Fri, 01 Mar 2024 10:16:13 GMT

←Older revision		Revision as of 10:16, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3tzn' size='340' side='right'caption='[[3tzn]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='3tzn' size='340' side='right'caption='[[3tzn]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tzn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus~~ pestis~~" (lehmann and neumann 1896) migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tzn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZN FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3tyu\|3tyu]], [[3tzf\|3tzf]], [[3tyz\|3tyz]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.083Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">dhpS, folP, y0683, YPO3501, YP_0582 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzn OCA], [https://pdbe.org/3tzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tzn RCSB], [https://www.ebi.ac.uk/pdbsum/3tzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzn OCA], [https://pdbe.org/3tzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tzn RCSB], [https://www.ebi.ac.uk/pdbsum/3tzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~Q7CKJ1_YERPE Q7CKJ1_YERPE~~]~~] DHPS catalyzes~~ the ~~formation~~ of ~~the immediate precursor of folic acid.[RuleBase:RU361205]~~	+	[https://www.uniprot.org/uniprot/A0A2S9PLG4_YERPE A0A2S9PLG4_YERPE] Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.[RuleBase:RU361205]
-	~~<div style="background~~-~~color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	~~The sulfonamide antibiotics inhibit dihydropteroate synthase~~ (~~DHPS~~), a key enzyme in the folate pathway of bacteria and primitive eukaryotes. However, resistance mutations have severely compromised the usefulness of these drugs. We report structural, computational, and mutagenesis studies on the catalytic and resistance mechanisms of DHPS. By performing the enzyme-~~catalyzed reaction in crystalline DHPS, we have structurally characterized key intermediates along the reaction pathway. Results support an S~~(N)1 reaction mechanism via formation of a novel cationic pterin intermediate. We also show that two conserved loops generate a substructure during catalysis that creates a specific binding pocket for p-aminobenzoic acid, ~~one of the two DHPS substrates. This substructure, together with the pterin~~-~~binding pocket, explains the roles of the conserved active-site residues and reveals how sulfonamide resistance arises.~~	+
-		+
-	~~Catalysis and sulfa drug resistance in~~ dihydropteroate ~~synthase.,Yun MK, Wu Y, Li Z, Zhao Y, Waddell MB, Ferreira AM, Lee RE, Bashford D, White SW Science. 2012 Mar 2;335~~(~~6072~~)~~:1110-4. PMID:22383850<ref>PMID:22383850</ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®~~, ~~a database of~~ the ~~U.S. National Library~~ of ~~Medicine~~.~~<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3tzn" style="background-color~~:~~#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Dihydropteroate synthase 3D structures\|Dihydropteroate synthase 3D structures]]		*[[Dihydropteroate synthase 3D structures\|Dihydropteroate synthase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dihydropteroate synthase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Wu, Y~~]]	+	[[Category: Yersinia pestis]]
-	[[Category: ~~Tim barrel]]~~	+	[[Category: Wu Y]]
-	~~[[Category: Transferase~~]]	+

OCA at 05:51, 13 July 2022

OCA — Wed, 13 Jul 2022 05:51:45 GMT

←Older revision		Revision as of 05:51, 13 July 2022
Line 1:		Line 1:

	==Crystal Structure of the Yersinia pestis Dihydropteroate synthase.==		==Crystal Structure of the Yersinia pestis Dihydropteroate synthase.==
-	<StructureSection load='3tzn' size='340' side='right' caption='[[3tzn]], [[Resolution\|resolution]] 2.08Å' scene=''>	+	<StructureSection load='3tzn' size='340' side='right'caption='[[3tzn]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tzn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tzn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tyu\|3tyu]], [[3tzf\|3tzf]], [[3tyz\|3tyz]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tyu\|3tyu]], [[3tzf\|3tzf]], [[3tyz\|3tyz]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dhpS, folP, y0683, YPO3501, YP_0582 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dhpS, folP, y0683, YPO3501, YP_0582 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzn OCA], [~~http~~://pdbe.org/3tzn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tzn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tzn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzn OCA], [https://pdbe.org/3tzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tzn RCSB], [https://www.ebi.ac.uk/pdbsum/3tzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q7CKJ1_YERPE Q7CKJ1_YERPE]] DHPS catalyzes the formation of the immediate precursor of folic acid.[RuleBase:RU361205]	+	[[https://www.uniprot.org/uniprot/Q7CKJ1_YERPE Q7CKJ1_YERPE]] DHPS catalyzes the formation of the immediate precursor of folic acid.[RuleBase:RU361205]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Dihydropteroate synthase\|Dihydropteroate synthase]]	+	*[[Dihydropteroate synthase 3D structures\|Dihydropteroate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Dihydropteroate synthase]]		[[Category: Dihydropteroate synthase]]
		+	[[Category: Large Structures]]
	[[Category: Wu, Y]]		[[Category: Wu, Y]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 23:58, 4 August 2016

OCA — Thu, 04 Aug 2016 23:58:27 GMT

←Older revision		Revision as of 23:58, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the Yersinia pestis Dihydropteroate synthase.==		==Crystal Structure of the Yersinia pestis Dihydropteroate synthase.==
	<StructureSection load='3tzn' size='340' side='right' caption='[[3tzn]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='3tzn' size='340' side='right' caption='[[3tzn]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tzn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Yersinia_pestis Yersinia~~ pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tzn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TZN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tyu\|3tyu]], [[3tzf\|3tzf]], [[3tyz\|3tyz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tyu\|3tyu]], [[3tzf\|3tzf]], [[3tyz\|3tyz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dhpS, folP, y0683, YPO3501, YP_0582 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 ~~Yersinia~~ pestis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dhpS, folP, y0683, YPO3501, YP_0582 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tzn RCSB], [http://www.ebi.ac.uk/pdbsum/3tzn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzn OCA], [http://pdbe.org/3tzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tzn RCSB], [http://www.ebi.ac.uk/pdbsum/3tzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tzn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Dihydropteroate synthase]]		[[Category: Dihydropteroate synthase]]
-	[[Category: Yersinia pestis]]
	[[Category: Wu, Y]]		[[Category: Wu, Y]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 20:57, 24 December 2014

OCA — Wed, 24 Dec 2014 20:57:09 GMT

←Older revision		Revision as of 20:57, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tzn RCSB], [http://www.ebi.ac.uk/pdbsum/3tzn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tzn RCSB], [http://www.ebi.ac.uk/pdbsum/3tzn PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q7CKJ1_YERPE Q7CKJ1_YERPE]] DHPS catalyzes the formation of the immediate precursor of folic acid.[RuleBase:RU361205]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:25, 9 December 2014

OCA — Tue, 09 Dec 2014 14:25:09 GMT

←Older revision		Revision as of 14:25, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3tzn.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of the Yersinia pestis Dihydropteroate synthase.==
		+	<StructureSection load='3tzn' size='340' side='right' caption='[[3tzn]], [[Resolution\|resolution]] 2.08Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tzn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TZN FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tyu\|3tyu]], [[3tzf\|3tzf]], [[3tyz\|3tyz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dhpS, folP, y0683, YPO3501, YP_0582 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tzn RCSB], [http://www.ebi.ac.uk/pdbsum/3tzn PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The sulfonamide antibiotics inhibit dihydropteroate synthase (DHPS), a key enzyme in the folate pathway of bacteria and primitive eukaryotes. However, resistance mutations have severely compromised the usefulness of these drugs. We report structural, computational, and mutagenesis studies on the catalytic and resistance mechanisms of DHPS. By performing the enzyme-catalyzed reaction in crystalline DHPS, we have structurally characterized key intermediates along the reaction pathway. Results support an S(N)1 reaction mechanism via formation of a novel cationic pterin intermediate. We also show that two conserved loops generate a substructure during catalysis that creates a specific binding pocket for p-aminobenzoic acid, one of the two DHPS substrates. This substructure, together with the pterin-binding pocket, explains the roles of the conserved active-site residues and reveals how sulfonamide resistance arises.

-	~~{{STRUCTURE_3tzn\| PDB=3tzn \| SCENE= }}~~	+	Catalysis and sulfa drug resistance in dihydropteroate synthase.,Yun MK, Wu Y, Li Z, Zhao Y, Waddell MB, Ferreira AM, Lee RE, Bashford D, White SW Science. 2012 Mar 2;335(6072):1110-4. PMID:22383850<ref>PMID:22383850</ref>

-	~~===Crystal Structure~~ of the ~~Yersinia pestis Dihydropteroate synthase~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22383850}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3tzn]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA].~~	+

	==See Also==		==See Also==
	*[[Dihydropteroate synthase\|Dihydropteroate synthase]]		*[[Dihydropteroate synthase\|Dihydropteroate synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022383850<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Dihydropteroate synthase]]		[[Category: Dihydropteroate synthase]]
	[[Category: Yersinia pestis]]		[[Category: Yersinia pestis]]
-	[[Category: Wu, Y~~.]]~~	+	[[Category: Wu, Y]]
-	~~[[Category: Dihydropteroate synthase~~]]	+
	[[Category: Tim barrel]]		[[Category: Tim barrel]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:03, 20 October 2012

OCA — Sat, 20 Oct 2012 09:03:53 GMT

←Older revision		Revision as of 09:03, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3tzn]] is a 2 chain structure ~~of [[Dihydropteroate synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA].	+	[[3tzn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA].

	==See Also==		==See Also==

OCA at 21:39, 25 July 2012

OCA — Wed, 25 Jul 2012 21:39:30 GMT

←Older revision		Revision as of 21:39, 25 July 2012
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-	[[Image:3tzn.~~jpg~~\|left\|200px]]	+	[[Image:3tzn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3tzn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3tzn\| PDB=3tzn \| SCENE= }}		{{STRUCTURE_3tzn\| PDB=3tzn \| SCENE= }}

	===Crystal Structure of the Yersinia pestis Dihydropteroate synthase.===		===Crystal Structure of the Yersinia pestis Dihydropteroate synthase.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22383850}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22383850 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22383850}}		{{ABSTRACT_PUBMED_22383850}}

	==About this Structure==		==About this Structure==
-	[[3tzn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA].	+	[[3tzn]] is a 2 chain structure of [[Dihydropteroate synthase]] with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA].
		+
		+	==See Also==
		+	*[[Dihydropteroate synthase\|Dihydropteroate synthase]]

	==Reference==		==Reference==

OCA at 06:31, 14 March 2012

OCA — Wed, 14 Mar 2012 06:31:55 GMT

←Older revision		Revision as of 06:31, 14 March 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:3tzn.jpg\|left\|200px]]

-	The ~~entry 3tzn~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3tzn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3tzn\| PDB=3tzn \| SCENE= }}

-	~~Authors: Wu, Y~~.	+	===Crystal Structure of the Yersinia pestis Dihydropteroate synthase.===

-	~~Description~~: ~~Crystal Structure of~~ the Yersinia pestis Dihydropteroate synthase.	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22383850}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22383850 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22383850}}
		+
		+	==About this Structure==
		+	[[3tzn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022383850</ref><references group="xtra"/>
		+	[[Category: Dihydropteroate synthase]]
		+	[[Category: Yersinia pestis]]
		+	[[Category: Wu, Y.]]
		+	[[Category: Dihydropteroate synthase]]
		+	[[Category: Tim barrel]]
		+	[[Category: Transferase]]

OCA: Protected "3tzn" [edit=sysop:move=sysop]

OCA — Wed, 05 Oct 2011 06:14:37 GMT

Protected "3tzn" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:14, 5 October 2011

OCA: New page: '''Unreleased structure''' The entry 3tzn is ON HOLD Authors: Wu, Y. Description: Crystal Structure of the Yersinia pestis Dihydropteroate synthase.

OCA — Wed, 05 Oct 2011 06:14:36 GMT

New page: '''Unreleased structure''' The entry 3tzn is ON HOLD Authors: Wu, Y. Description: Crystal Structure of the Yersinia pestis Dihydropteroate synthase.

New page

'''Unreleased structure'''

The entry 3tzn is ON HOLD

Authors: Wu, Y.

Description: Crystal Structure of the Yersinia pestis Dihydropteroate synthase.