3u0r - Revision history

OCA at 08:38, 20 March 2024

OCA — Wed, 20 Mar 2024 08:38:01 GMT

←Older revision		Revision as of 08:38, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3u0r' size='340' side='right'caption='[[3u0r]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3u0r' size='340' side='right'caption='[[3u0r]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0R FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~API5~~, ~~MIG8 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [https://pdbe.org/3u0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [https://www.ebi.ac.uk/pdbsum/3u0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [https://pdbe.org/3u0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [https://www.ebi.ac.uk/pdbsum/3u0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>	+	[https://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Apoptosis inhibitor 5 (API5) is an anti-apoptotic protein that is up-regulated in various cancer cells. Here, we present the crystal structure of human API5. API5 exhibits an elongated all alpha-helical structure. The N-terminal half of API5 is similar to the HEAT repeat and the C-terminal half is similar to the ARM (Armadillo-like) repeat. HEAT and ARM repeats have been implicated in protein-protein interactions, suggesting that the cellular roles of API5 may be to mediate protein-protein interactions. Various components of multiprotein complexes have been identified as API5-interacting protein partners, suggesting that API5 may act as a scaffold for multiprotein complexes. API5 exists as a monomer, and the functionally important heptad leucine repeat does not exhibit the predicted a dimeric leucine zipper. Additionally, Lys-251, which can be acetylated in cells, plays important roles in the inhibition of apoptosis under serum deprivation conditions. The acetylation of this lysine also affects the stability of API5 in cells.	+
-		+
-	Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules.,Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI J Biol Chem. 2012 Mar 30;287(14):10727-37. doi: 10.1074/jbc.M111.317594. Epub, 2012 Feb 12. PMID:22334682<ref>PMID:22334682</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3u0r" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cho~~, J W~~]]	+	[[Category: Cho JW]]
-	[[Category: Han~~, B G~~]]	+	[[Category: Han BG]]
-	[[Category: Jeong~~, K C~~]]	+	[[Category: Jeong KC]]
-	[[Category: Kim~~, K H~~]]	+	[[Category: Kim KH]]
-	[[Category: Kim~~, T W~~]]	+	[[Category: Kim TW]]
-	[[Category: Lee~~, B I~~]]	+	[[Category: Lee BI]]
-	[[Category: Lee~~, S H~~]]	+	[[Category: Lee SH]]
-	[[Category: Noh~~, K H~~]]	+	[[Category: Noh KH]]
-	[[Category: Suh~~, S W~~]]	+	[[Category: Suh SW]]
-	[[Category: Yoon~~, H J]]~~	+	[[Category: Yoon HJ]]
-	~~[[Category: Apoptosis inhibitor]]~~	+
-	~~[[Category: Armadillo repeat]]~~	+
-	~~[[Category: Heat repeat]]~~	+
-	~~[[Category: Lysine acetylation~~]]	+

OCA at 05:52, 13 July 2022

OCA — Wed, 13 Jul 2022 05:52:56 GMT

←Older revision		Revision as of 05:52, 13 July 2022
Line 1:		Line 1:

	==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==		==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==
-	<StructureSection load='3u0r' size='340' side='right' caption='[[3u0r]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3u0r' size='340' side='right'caption='[[3u0r]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u0r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3U0R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0R FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">API5, MIG8 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">API5, MIG8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [~~http~~://pdbe.org/3u0r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3u0r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [https://pdbe.org/3u0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [https://www.ebi.ac.uk/pdbsum/3u0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>	+	[[https://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cho, J W]]		[[Category: Cho, J W]]
	[[Category: Han, B G]]		[[Category: Han, B G]]

OCA at 22:07, 5 August 2016

OCA — Fri, 05 Aug 2016 22:07:29 GMT

←Older revision		Revision as of 22:07, 5 August 2016
Line 1:		Line 1:
		+
	==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==		==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==
	<StructureSection load='3u0r' size='340' side='right' caption='[[3u0r]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3u0r' size='340' side='right' caption='[[3u0r]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U0R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U0R FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">API5, MIG8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">API5, MIG8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [http://www.ebi.ac.uk/pdbsum/3u0r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [http://pdbe.org/3u0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [http://www.ebi.ac.uk/pdbsum/3u0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3u0r" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Cho, J W]]		[[Category: Cho, J W]]
	[[Category: Han, B G]]		[[Category: Han, B G]]

OCA at 22:19, 25 December 2014

OCA — Thu, 25 Dec 2014 22:19:29 GMT

←Older revision		Revision as of 22:19, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [http://www.ebi.ac.uk/pdbsum/3u0r PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [http://www.ebi.ac.uk/pdbsum/3u0r PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:33, 21 December 2014

OCA — Sun, 21 Dec 2014 07:33:32 GMT

←Older revision		Revision as of 07:33, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3u0r\| PDB=3u0r \| SCENE= }}~~	+	==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==
-	===Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules===	+	<StructureSection load='3u0r' size='340' side='right' caption='[[3u0r]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22334682}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3u0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U0R FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">API5, MIG8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [http://www.ebi.ac.uk/pdbsum/3u0r PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Apoptosis inhibitor 5 (API5) is an anti-apoptotic protein that is up-regulated in various cancer cells. Here, we present the crystal structure of human API5. API5 exhibits an elongated all alpha-helical structure. The N-terminal half of API5 is similar to the HEAT repeat and the C-terminal half is similar to the ARM (Armadillo-like) repeat. HEAT and ARM repeats have been implicated in protein-protein interactions, suggesting that the cellular roles of API5 may be to mediate protein-protein interactions. Various components of multiprotein complexes have been identified as API5-interacting protein partners, suggesting that API5 may act as a scaffold for multiprotein complexes. API5 exists as a monomer, and the functionally important heptad leucine repeat does not exhibit the predicted a dimeric leucine zipper. Additionally, Lys-251, which can be acetylated in cells, plays important roles in the inhibition of apoptosis under serum deprivation conditions. The acetylation of this lysine also affects the stability of API5 in cells.

-	~~==Function==~~	+	Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules.,Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI J Biol Chem. 2012 Mar 30;287(14):10727-37. doi: 10.1074/jbc.M111.317594. Epub, 2012 Feb 12. PMID:22334682<ref>PMID:22334682</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly~~. ~~Negatively regulates ACIN1~~. ~~By binding to ACIN1~~, ~~it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation~~. ~~Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>~~PMID:~~10780674</ref> <ref>PMID:17112319</ref>~~ <ref>PMID:~~19387494~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3u0r]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022334682</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Cho, J W.]]	+	[[Category: Cho, J W]]
-	[[Category: Han, B G.]]	+	[[Category: Han, B G]]
-	[[Category: Jeong, K C.]]	+	[[Category: Jeong, K C]]
-	[[Category: Kim, K H.]]	+	[[Category: Kim, K H]]
-	[[Category: Kim, T W.]]	+	[[Category: Kim, T W]]
-	[[Category: Lee, B I.]]	+	[[Category: Lee, B I]]
-	[[Category: Lee, S H.]]	+	[[Category: Lee, S H]]
-	[[Category: Noh, K H.]]	+	[[Category: Noh, K H]]
-	[[Category: Suh, S W.]]	+	[[Category: Suh, S W]]
-	[[Category: Yoon, H J.]]	+	[[Category: Yoon, H J]]
	[[Category: Apoptosis inhibitor]]		[[Category: Apoptosis inhibitor]]
	[[Category: Armadillo repeat]]		[[Category: Armadillo repeat]]
	[[Category: Heat repeat]]		[[Category: Heat repeat]]
	[[Category: Lysine acetylation]]		[[Category: Lysine acetylation]]

OCA at 14:31, 10 July 2013

OCA — Wed, 10 Jul 2013 14:31:35 GMT

←Older revision		Revision as of 14:31, 10 July 2013
Line 1:		Line 1:
-	[[Image:3u0r.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3u0r", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3u0r\| PDB=3u0r \| SCENE= }}		{{STRUCTURE_3u0r\| PDB=3u0r \| SCENE= }}
-
	===Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules===		===Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules===
		+	{{ABSTRACT_PUBMED_22334682}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>

	==About this Structure==		==About this Structure==
	[[3u0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA].		[[3u0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022334682</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cho, J W.]]		[[Category: Cho, J W.]]

OCA at 07:56, 22 February 2012

OCA — Wed, 22 Feb 2012 07:56:39 GMT

←Older revision		Revision as of 07:56, 22 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3u0r.jpg\|left\|200px]]

-	The ~~entry 3u0r~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3u0r", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3u0r\| PDB=3u0r \| SCENE= }}

-	~~Authors: Han, B.G., KIm, K.H., Jeong, K.C., Cho, J.W., Noh, K.H., Kim, T.W., Yoon, H.J., Suh, S.W., Lee, S.H., Lee, B.I.~~	+	===Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules===

-	~~Description: Helical repeat~~ structure ~~of apoptosis inhibitor 5 reveals protein~~-~~protein interaction modules~~	+
		+	==About this Structure==
		+	[[3u0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Cho, J W.]]
		+	[[Category: Han, B G.]]
		+	[[Category: Jeong, K C.]]
		+	[[Category: Kim, K H.]]
		+	[[Category: Kim, T W.]]
		+	[[Category: Lee, B I.]]
		+	[[Category: Lee, S H.]]
		+	[[Category: Noh, K H.]]
		+	[[Category: Suh, S W.]]
		+	[[Category: Yoon, H J.]]
		+	[[Category: Apoptosis inhibitor]]
		+	[[Category: Armadillo repeat]]
		+	[[Category: Heat repeat]]
		+	[[Category: Lysine acetylation]]

OCA at 07:56, 2 November 2011

OCA — Wed, 02 Nov 2011 07:56:39 GMT

←Older revision		Revision as of 07:56, 2 November 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3u0r is ON HOLD	+	The entry 3u0r is ON HOLD until Paper Publication

	Authors: Han, B.G., KIm, K.H., Jeong, K.C., Cho, J.W., Noh, K.H., Kim, T.W., Yoon, H.J., Suh, S.W., Lee, S.H., Lee, B.I.		Authors: Han, B.G., KIm, K.H., Jeong, K.C., Cho, J.W., Noh, K.H., Kim, T.W., Yoon, H.J., Suh, S.W., Lee, S.H., Lee, B.I.

	Description: Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules		Description: Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules

OCA: Protected "3u0r" [edit=sysop:move=sysop]

OCA — Wed, 05 Oct 2011 06:15:44 GMT

Protected "3u0r" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:15, 5 October 2011

OCA: New page: '''Unreleased structure''' The entry 3u0r is ON HOLD Authors: Han, B.G., KIm, K.H., Jeong, K.C., Cho, J.W., Noh, K.H., Kim, T.W., Yoon, H.J., Suh, S.W., Lee, S.H., Lee, B.I. Descriptio...

OCA — Wed, 05 Oct 2011 06:15:43 GMT

New page: '''Unreleased structure''' The entry 3u0r is ON HOLD Authors: Han, B.G., KIm, K.H., Jeong, K.C., Cho, J.W., Noh, K.H., Kim, T.W., Yoon, H.J., Suh, S.W., Lee, S.H., Lee, B.I. Descriptio...

New page

'''Unreleased structure'''

The entry 3u0r is ON HOLD

Authors: Han, B.G., KIm, K.H., Jeong, K.C., Cho, J.W., Noh, K.H., Kim, T.W., Yoon, H.J., Suh, S.W., Lee, S.H., Lee, B.I.

Description: Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules