3u2a - Revision history

OCA at 05:54, 13 July 2022

OCA — Wed, 13 Jul 2022 05:54:36 GMT

←Older revision		Revision as of 05:54, 13 July 2022
Line 1:		Line 1:

	==Adaptor dependent degradation of a cell-cycle regulator reveals diversity in substrate architectures==		==Adaptor dependent degradation of a cell-cycle regulator reveals diversity in substrate architectures==
-	<StructureSection load='3u2a' size='340' side='right' caption='[[3u2a]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3u2a' size='340' side='right'caption='[[3u2a]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u2a]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cauvi Cauvi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3U2A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cauvi Cauvi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U2A FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CC3396(PdeA), CC_3396 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=155892 CAUVI])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CC3396(PdeA), CC_3396 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=155892 CAUVI])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cyclic-guanylate-specific_phosphodiesterase Cyclic-guanylate-specific phosphodiesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.52 3.1.4.52] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cyclic-guanylate-specific_phosphodiesterase Cyclic-guanylate-specific phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.52 3.1.4.52] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3u2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2a OCA], [~~http~~://pdbe.org/3u2a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3u2a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3u2a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2a OCA], [https://pdbe.org/3u2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u2a RCSB], [https://www.ebi.ac.uk/pdbsum/3u2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2a ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	[[Category: Cauvi]]		[[Category: Cauvi]]
	[[Category: Cyclic-guanylate-specific phosphodiesterase]]		[[Category: Cyclic-guanylate-specific phosphodiesterase]]
		+	[[Category: Large Structures]]
	[[Category: Chien, P]]		[[Category: Chien, P]]
	[[Category: Clark, N E]]		[[Category: Clark, N E]]

OCA at 06:34, 4 April 2018

OCA — Wed, 04 Apr 2018 06:34:29 GMT

←Older revision		Revision as of 06:34, 4 April 2018
Line 3:		Line 3:
	<StructureSection load='3u2a' size='340' side='right' caption='[[3u2a]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3u2a' size='340' side='right' caption='[[3u2a]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cauce Cauce~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U2A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cauvi Cauvi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U2A FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CC3396(PdeA), CC_3396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=155892 ~~CAUCE~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CC3396(PdeA), CC_3396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=155892 CAUVI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic-guanylate-specific_phosphodiesterase Cyclic-guanylate-specific phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.52 3.1.4.52] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic-guanylate-specific_phosphodiesterase Cyclic-guanylate-specific phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.52 3.1.4.52] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2a OCA], [http://pdbe.org/3u2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u2a RCSB], [http://www.ebi.ac.uk/pdbsum/3u2a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2a OCA], [http://pdbe.org/3u2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u2a RCSB], [http://www.ebi.ac.uk/pdbsum/3u2a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2a ProSAT]</span></td></tr>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cauce~~]]	+	[[Category: Cauvi]]
	[[Category: Cyclic-guanylate-specific phosphodiesterase]]		[[Category: Cyclic-guanylate-specific phosphodiesterase]]
	[[Category: Chien, P]]		[[Category: Chien, P]]

OCA at 19:03, 11 August 2016

OCA — Thu, 11 Aug 2016 19:03:52 GMT

←Older revision		Revision as of 19:03, 11 August 2016
Line 1:		Line 1:
		+
	==Adaptor dependent degradation of a cell-cycle regulator reveals diversity in substrate architectures==		==Adaptor dependent degradation of a cell-cycle regulator reveals diversity in substrate architectures==
	<StructureSection load='3u2a' size='340' side='right' caption='[[3u2a]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3u2a' size='340' side='right' caption='[[3u2a]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Caulobacter_vibrioides Caulobacter vibrioides~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U2A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cauce Cauce]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U2A FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CC3396(PdeA), CC_3396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=155892 ~~Caulobacter vibrioides~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CC3396(PdeA), CC_3396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=155892 CAUCE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic-guanylate-specific_phosphodiesterase Cyclic-guanylate-specific phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.52 3.1.4.52] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic-guanylate-specific_phosphodiesterase Cyclic-guanylate-specific phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.52 3.1.4.52] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u2a RCSB], [http://www.ebi.ac.uk/pdbsum/3u2a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2a OCA], [http://pdbe.org/3u2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u2a RCSB], [http://www.ebi.ac.uk/pdbsum/3u2a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2a ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3u2a" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caulobacter vibrioides~~]]	+	[[Category: Cauce]]
	[[Category: Cyclic-guanylate-specific phosphodiesterase]]		[[Category: Cyclic-guanylate-specific phosphodiesterase]]
	[[Category: Chien, P]]		[[Category: Chien, P]]

OCA at 10:41, 4 January 2015

OCA — Sun, 04 Jan 2015 10:41:26 GMT

←Older revision		Revision as of 10:41, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3u2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U2A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3u2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U2A FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CC3396(PdeA), CC_3396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=155892 Caulobacter vibrioides])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CC3396(PdeA), CC_3396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=155892 Caulobacter vibrioides])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic-guanylate-specific_phosphodiesterase Cyclic-guanylate-specific phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.52 3.1.4.52] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic-guanylate-specific_phosphodiesterase Cyclic-guanylate-specific phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.52 3.1.4.52] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u2a RCSB], [http://www.ebi.ac.uk/pdbsum/3u2a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u2a RCSB], [http://www.ebi.ac.uk/pdbsum/3u2a PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	[[Category: Caulobacter vibrioides]]		[[Category: Caulobacter vibrioides]]
	[[Category: Cyclic-guanylate-specific phosphodiesterase]]		[[Category: Cyclic-guanylate-specific phosphodiesterase]]
-	[[Category: Chien, P.]]	+	[[Category: Chien, P]]
-	[[Category: Clark, N E.]]	+	[[Category: Clark, N E]]
-	[[Category: Garman, S C.]]	+	[[Category: Garman, S C]]
-	[[Category: Rood, K.]]	+	[[Category: Rood, K]]
	[[Category: Cell-cycle]]		[[Category: Cell-cycle]]
	[[Category: Clpxp]]		[[Category: Clpxp]]

OCA at 09:28, 11 June 2014

OCA — Wed, 11 Jun 2014 09:28:03 GMT

←Older revision		Revision as of 09:28, 11 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3u2a.~~png~~\|~~left~~\|~~200px~~]]	+	==Adaptor dependent degradation of a cell-cycle regulator reveals diversity in substrate architectures==
		+	<StructureSection load='3u2a' size='340' side='right' caption='[[3u2a]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3u2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U2A FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CC3396(PdeA), CC_3396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=155892 Caulobacter vibrioides])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic-guanylate-specific_phosphodiesterase Cyclic-guanylate-specific phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.52 3.1.4.52] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u2a RCSB], [http://www.ebi.ac.uk/pdbsum/3u2a PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In Caulobacter crescentus, the ClpXP protease degrades several crucial cell-cycle regulators, including the phosphodiesterase PdeA. Degradation of PdeA requires the response regulator CpdR and signals a morphological transition in concert with initiation of DNA replication. Here, we report the structure of a Per-Arnt-Sim (PAS) domain of PdeA and show that it is necessary for CpdR-dependent degradation in vivo and in vitro. CpdR acts as an adaptor, tethering the amino-terminal PAS domain to ClpXP and promoting recognition of the weak carboxyl-terminal degron of PdeA, a combination that ensures processive proteolysis. We identify sites on the PAS domain needed for CpdR recognition and find that one subunit of the PdeA dimer can be delivered to ClpXP by its partner. Finally, we show that improper stabilization of PdeA in vivo alters cellular behavior. These results introduce an adaptor/substrate pair for ClpXP and reveal broad diversity in adaptor-mediated proteolysis.

-	~~{{STRUCTURE_3u2a\| PDB=3u2a \| SCENE= }}~~	+	Adaptor-dependent degradation of a cell-cycle regulator uses a unique substrate architecture.,Rood KL, Clark NE, Stoddard PR, Garman SC, Chien P Structure. 2012 Jul 3;20(7):1223-32. Epub 2012 Jun 7. PMID:22682744<ref>PMID:22682744</ref>

-	~~===Adaptor dependent degradation~~ of ~~a cell-cycle regulator reveals diversity in substrate architectures===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22682744}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3u2a]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022682744<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Caulobacter vibrioides]]		[[Category: Caulobacter vibrioides]]
	[[Category: Cyclic-guanylate-specific phosphodiesterase]]		[[Category: Cyclic-guanylate-specific phosphodiesterase]]

OCA at 05:14, 29 August 2012

OCA — Wed, 29 Aug 2012 05:14:58 GMT

←Older revision		Revision as of 05:14, 29 August 2012
Line 1:		Line 1:
-	[[Image:3u2a.~~jpg~~\|left\|200px]]	+	[[Image:3u2a.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3u2a", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3u2a\| PDB=3u2a \| SCENE= }}		{{STRUCTURE_3u2a\| PDB=3u2a \| SCENE= }}

	===Adaptor dependent degradation of a cell-cycle regulator reveals diversity in substrate architectures===		===Adaptor dependent degradation of a cell-cycle regulator reveals diversity in substrate architectures===

		+	{{ABSTRACT_PUBMED_22682744}}

	==About this Structure==		==About this Structure==
	[[3u2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA].		[[3u2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022682744</ref><references group="xtra"/>
	[[Category: Caulobacter vibrioides]]		[[Category: Caulobacter vibrioides]]
	[[Category: Cyclic-guanylate-specific phosphodiesterase]]		[[Category: Cyclic-guanylate-specific phosphodiesterase]]

OCA at 06:00, 30 May 2012

OCA — Wed, 30 May 2012 06:00:37 GMT

←Older revision		Revision as of 06:00, 30 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3u2a.jpg\|left\|200px]]

-	The ~~entry 3u2a~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3u2a", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3u2a\| PDB=3u2a \| SCENE= }}

-	~~Authors: Rood, K., Clark, N.E., Garman, S.C., Chien, P.~~	+	===Adaptor dependent degradation of a cell-cycle regulator reveals diversity in substrate architectures===

-	~~Description: Adaptor dependent degradation of~~ a ~~cell~~-cycle ~~regulator reveals diversity in substrate architectures~~	+
		+	==About this Structure==
		+	[[3u2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2A OCA].
		+	[[Category: Caulobacter vibrioides]]
		+	[[Category: Cyclic-guanylate-specific phosphodiesterase]]
		+	[[Category: Chien, P.]]
		+	[[Category: Clark, N E.]]
		+	[[Category: Garman, S C.]]
		+	[[Category: Rood, K.]]
		+	[[Category: Cell-cycle]]
		+	[[Category: Clpxp]]
		+	[[Category: Cyclic di-gmp]]
		+	[[Category: Hydrolase]]
		+	[[Category: Phosphodiesterase]]
		+	[[Category: Proteolysis]]

OCA: Protected "3u2a" [edit=sysop:move=sysop]

OCA — Sun, 30 Oct 2011 08:48:28 GMT

Protected "3u2a" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:48, 30 October 2011

OCA: New page: '''Unreleased structure''' The entry 3u2a is ON HOLD until Paper Publication Authors: Rood, K., Clark, N.E., Garman, S.C., Chien, P. Description: Adaptor dependent degradation of a cel...

OCA — Sun, 30 Oct 2011 08:48:27 GMT

New page: '''Unreleased structure''' The entry 3u2a is ON HOLD until Paper Publication Authors: Rood, K., Clark, N.E., Garman, S.C., Chien, P. Description: Adaptor dependent degradation of a cel...

New page

'''Unreleased structure'''

The entry 3u2a is ON HOLD until Paper Publication

Authors: Rood, K., Clark, N.E., Garman, S.C., Chien, P.

Description: Adaptor dependent degradation of a cell-cycle regulator reveals diversity in substrate architectures