3u2o - Revision history

OCA at 13:46, 14 March 2024

OCA — Thu, 14 Mar 2024 13:46:32 GMT

←Older revision		Revision as of 13:46, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3u2o' size='340' side='right'caption='[[3u2o]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='3u2o' size='340' side='right'caption='[[3u2o]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U2O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U2O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03U:METHYL+4-{[(2Z)-2-CYANO-3-HYDROXYPENT-2-ENOYL]AMINO}-4-FLUOROBIPHENYL-2-CARBOXYLATE'>03U</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.18Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03U:METHYL+4-{[(2Z)-2-CYANO-3-HYDROXYPENT-2-ENOYL]AMINO}-4-FLUOROBIPHENYL-2-CARBOXYLATE'>03U</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2o OCA], [https://pdbe.org/3u2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u2o RCSB], [https://www.ebi.ac.uk/pdbsum/3u2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2o OCA], [https://pdbe.org/3u2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u2o RCSB], [https://www.ebi.ac.uk/pdbsum/3u2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2o ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>	+	[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.	+	[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The structure-activity relationships of a novel series of biaryl dihydroorotate dehydrogenase (DHODH) inhibitors related to teriflunomide are disclosed. These biaryl derivatives were the result of structure-based design and proved to be potent DHODH inhibitors which in addition showed good antiproliferative activities on peripheral blood mononuclear cells and good efficacies in vivo in the rat adjuvant-induced-arthritis model.	+
-		+
-	Biaryl analogues of teriflunomide as potent DHODH inhibitors.,Erra M, Moreno I, Sanahuja J, Andres M, Reinoso RF, Lozoya E, Pizcueta P, Godessart N, Castro-Palomino JC Bioorg Med Chem Lett. 2011 Dec 15;21(24):7268-72. Epub 2011 Oct 20. PMID:22078215<ref>PMID:22078215</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3u2o" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
Line 29:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blaesse, M]]	+	[[Category: Blaesse M]]
-	[[Category: Erra, M]]	+	[[Category: Erra M]]
-	[[Category: Jestel, A]]	+	[[Category: Jestel A]]
-	[[Category: Krapp, S]]	+	[[Category: Krapp S]]
-	[[Category: Lozoya, E]]	+	[[Category: Lozoya E]]
-	[[Category: Segarra, V]]	+	[[Category: Segarra V]]
-	[[Category: Wenzkowski, C]]	+	[[Category: Wenzkowski C]]
-	~~[[Category: Dehydrogenase]]~~	+
-	~~[[Category: Dhodh]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 05:55, 13 July 2022

OCA — Wed, 13 Jul 2022 05:55:07 GMT

←Older revision		Revision as of 05:55, 13 July 2022
Line 1:		Line 1:

	==Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor==		==Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor==
-	<StructureSection load='3u2o' size='340' side='right' caption='[[3u2o]], [[Resolution\|resolution]] 2.18Å' scene=''>	+	<StructureSection load='3u2o' size='340' side='right'caption='[[3u2o]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u2o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3U2O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U2O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03U:METHYL+4-{[(2Z)-2-CYANO-3-HYDROXYPENT-2-ENOYL]AMINO}-4-FLUOROBIPHENYL-2-CARBOXYLATE'>03U</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03U:METHYL+4-{[(2Z)-2-CYANO-3-HYDROXYPENT-2-ENOYL]AMINO}-4-FLUOROBIPHENYL-2-CARBOXYLATE'>03U</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3u2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2o OCA], [~~http~~://pdbe.org/3u2o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3u2o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3u2o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2o OCA], [https://pdbe.org/3u2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u2o RCSB], [https://www.ebi.ac.uk/pdbsum/3u2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2o ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[~~http~~://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>	+	[[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.	+	[[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]	+	*[[Dihydroorotate dehydrogenase 3D structures\|Dihydroorotate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Blaesse, M]]		[[Category: Blaesse, M]]
	[[Category: Erra, M]]		[[Category: Erra, M]]

OCA at 09:28, 5 August 2016

OCA — Fri, 05 Aug 2016 09:28:35 GMT

←Older revision		Revision as of 09:28, 5 August 2016
Line 1:		Line 1:
		+
	==Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor==		==Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor==
	<StructureSection load='3u2o' size='340' side='right' caption='[[3u2o]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='3u2o' size='340' side='right' caption='[[3u2o]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U2O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U2O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03U:METHYL+4-{[(2Z)-2-CYANO-3-HYDROXYPENT-2-ENOYL]AMINO}-4-FLUOROBIPHENYL-2-CARBOXYLATE'>03U</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03U:METHYL+4-{[(2Z)-2-CYANO-3-HYDROXYPENT-2-ENOYL]AMINO}-4-FLUOROBIPHENYL-2-CARBOXYLATE'>03U</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Dihydroorotate_dehydrogenase~~ Dihydroorotate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u2o RCSB], [http://www.ebi.ac.uk/pdbsum/3u2o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2o OCA], [http://pdbe.org/3u2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u2o RCSB], [http://www.ebi.ac.uk/pdbsum/3u2o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2o ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3u2o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydroorotate dehydrogenase]]~~	+	[[Category: Human]]
-	~~[[Category: Homo sapiens~~]]	+
	[[Category: Blaesse, M]]		[[Category: Blaesse, M]]
	[[Category: Erra, M]]		[[Category: Erra, M]]

OCA at 06:46, 21 December 2014

OCA — Sun, 21 Dec 2014 06:46:58 GMT

←Older revision		Revision as of 06:46, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3u2o\| PDB=3u2o \| SCENE= }}~~	+	==Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor==
-	===Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor===	+	<StructureSection load='3u2o' size='340' side='right' caption='[[3u2o]], [[Resolution\|resolution]] 2.18Å' scene=''>
-	{~~{ABSTRACT_PUBMED_22078215}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3u2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U2O FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03U:METHYL+4-{[(2Z)-2-CYANO-3-HYDROXYPENT-2-ENOYL]AMINO}-4-FLUOROBIPHENYL-2-CARBOXYLATE'>03U</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase Dihydroorotate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u2o RCSB], [http://www.ebi.ac.uk/pdbsum/3u2o PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure-activity relationships of a novel series of biaryl dihydroorotate dehydrogenase (DHODH) inhibitors related to teriflunomide are disclosed. These biaryl derivatives were the result of structure-based design and proved to be potent DHODH inhibitors which in addition showed good antiproliferative activities on peripheral blood mononuclear cells and good efficacies in vivo in the rat adjuvant-induced-arthritis model.

-	~~==Disease==~~	+	Biaryl analogues of teriflunomide as potent DHODH inhibitors.,Erra M, Moreno I, Sanahuja J, Andres M, Reinoso RF, Lozoya E, Pizcueta P, Godessart N, Castro-Palomino JC Bioorg Med Chem Lett. 2011 Dec 15;21(24):7268-72. Epub 2011 Oct 20. PMID:22078215<ref>PMID:22078215</ref>
-	~~[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause~~ of ~~postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known~~ as ~~Miller syndrome~~. ~~POADS is characterized by severe micrognathia~~, ~~cleft lip and/or palate~~, ~~hypoplasia or aplasia of the posterior elements of the limbs~~, ~~coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families~~, ~~each consisting of 2 affected siblings born to unaffected~~, ~~nonconsanguineous parents~~, ~~have been described among a total of around 30 reported cases~~.<ref>PMID:~~19915526~~</ref>	+
-		+
-	~~==Function==~~	+
-	~~[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3u2o]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	<references ~~group="xtra"~~/><~~references~~/>	+	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Dihydroorotate dehydrogenase]]		[[Category: Dihydroorotate dehydrogenase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Blaesse, M.]]	+	[[Category: Blaesse, M]]
-	[[Category: Erra, M.]]	+	[[Category: Erra, M]]
-	[[Category: Jestel, A.]]	+	[[Category: Jestel, A]]
-	[[Category: Krapp, S.]]	+	[[Category: Krapp, S]]
-	[[Category: Lozoya, E.]]	+	[[Category: Lozoya, E]]
-	[[Category: Segarra, V.]]	+	[[Category: Segarra, V]]
-	[[Category: Wenzkowski, C.]]	+	[[Category: Wenzkowski, C]]
	[[Category: Dehydrogenase]]		[[Category: Dehydrogenase]]
	[[Category: Dhodh]]		[[Category: Dhodh]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 19:31, 24 March 2013

OCA — Sun, 24 Mar 2013 19:31:38 GMT

←Older revision		Revision as of 19:31, 24 March 2013
Line 1:		Line 1:
-	[[Image:3u2o.png\|left\|200px]]
-
	{{STRUCTURE_3u2o\| PDB=3u2o \| SCENE= }}		{{STRUCTURE_3u2o\| PDB=3u2o \| SCENE= }}
-
	===Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor===		===Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor===
-
	{{ABSTRACT_PUBMED_22078215}}		{{ABSTRACT_PUBMED_22078215}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

	==About this Structure==		==About this Structure==
	[[3u2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA].		[[3u2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Dihydroorotate dehydrogenase]]		[[Category: Dihydroorotate dehydrogenase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 05:25, 5 September 2012

OCA — Wed, 05 Sep 2012 05:25:25 GMT

←Older revision		Revision as of 05:25, 5 September 2012
Line 1:		Line 1:
	[[Image:3u2o.png\|left\|200px]]		[[Image:3u2o.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3u2o", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3u2o\| PDB=3u2o \| SCENE= }}		{{STRUCTURE_3u2o\| PDB=3u2o \| SCENE= }}

	===Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor===		===Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor===

		+	{{ABSTRACT_PUBMED_22078215}}

	==About this Structure==		==About this Structure==

OCA at 05:58, 28 December 2011

OCA — Wed, 28 Dec 2011 05:58:56 GMT

←Older revision		Revision as of 05:58, 28 December 2011
Line 1:		Line 1:
-	[[Image:3u2o.~~jpg~~\|left\|200px]]	+	[[Image:3u2o.png\|left\|200px]]

	<!--		<!--

OCA at 12:32, 16 November 2011

OCA — Wed, 16 Nov 2011 12:32:38 GMT

←Older revision		Revision as of 12:32, 16 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3u2o.jpg\|left\|200px]]

-	The ~~entry 3u2o~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3u2o", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3u2o\| PDB=3u2o \| SCENE= }}

-	~~Authors: Lozoya, E., Segarra, V., Erra, M., Wenzkowski, C., Jestel, A., Krapp, S., Blaesse, M.~~	+	===Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor===

-	~~Description~~: Dihydroorotate Dehydrogenase ~~(DHODH) crystal structure in complex with small molecule~~ inhibitor	+
		+	==About this Structure==
		+	[[3u2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2O OCA].
		+	[[Category: Dihydroorotate dehydrogenase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Blaesse, M.]]
		+	[[Category: Erra, M.]]
		+	[[Category: Jestel, A.]]
		+	[[Category: Krapp, S.]]
		+	[[Category: Lozoya, E.]]
		+	[[Category: Segarra, V.]]
		+	[[Category: Wenzkowski, C.]]
		+	[[Category: Dehydrogenase]]
		+	[[Category: Dhodh]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA: Protected "3u2o" [edit=sysop:move=sysop]

OCA — Sun, 30 Oct 2011 08:48:51 GMT

Protected "3u2o" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:48, 30 October 2011

OCA: New page: '''Unreleased structure''' The entry 3u2o is ON HOLD until Paper Publication Authors: Lozoya, E., Segarra, V., Erra, M., Wenzkowski, C., Jestel, A., Krapp, S., Blaesse, M. Description:...

OCA — Sun, 30 Oct 2011 08:48:50 GMT

New page: '''Unreleased structure''' The entry 3u2o is ON HOLD until Paper Publication Authors: Lozoya, E., Segarra, V., Erra, M., Wenzkowski, C., Jestel, A., Krapp, S., Blaesse, M. Description:...

New page

'''Unreleased structure'''

The entry 3u2o is ON HOLD until Paper Publication

Authors: Lozoya, E., Segarra, V., Erra, M., Wenzkowski, C., Jestel, A., Krapp, S., Blaesse, M.

Description: Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor