3u46 - Revision history

OCA at 05:56, 13 July 2022

OCA — Wed, 13 Jul 2022 05:56:57 GMT

←Older revision		Revision as of 05:56, 13 July 2022
Line 1:		Line 1:

	==CH04H/CH02L P212121==		==CH04H/CH02L P212121==
-	<StructureSection load='3u46' size='340' side='right' caption='[[3u46]], [[Resolution\|resolution]] 2.91Å' scene=''>	+	<StructureSection load='3u46' size='340' side='right'caption='[[3u46]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u46]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U46 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3U46 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u46]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U46 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tcl\|3tcl]], [[3u4b\|3u4b]], [[3u4e\|3u4e]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tcl\|3tcl]], [[3u4b\|3u4b]], [[3u4e\|3u4e]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3u46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u46 OCA], [~~http~~://pdbe.org/3u46 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3u46 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3u46 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3u46 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u46 OCA], [https://pdbe.org/3u46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u46 RCSB], [https://www.ebi.ac.uk/pdbsum/3u46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u46 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kwong, P D]]		[[Category: Kwong, P D]]
	[[Category: Louder, R]]		[[Category: Louder, R]]

OCA at 11:02, 11 August 2016

OCA — Thu, 11 Aug 2016 11:02:46 GMT

←Older revision		Revision as of 11:02, 11 August 2016
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		+
	==CH04H/CH02L P212121==		==CH04H/CH02L P212121==
	<StructureSection load='3u46' size='340' side='right' caption='[[3u46]], [[Resolution\|resolution]] 2.91Å' scene=''>		<StructureSection load='3u46' size='340' side='right' caption='[[3u46]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u46]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U46 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u46]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U46 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tcl\|3tcl]], [[3u4b\|3u4b]], [[3u4e\|3u4e]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tcl\|3tcl]], [[3u4b\|3u4b]], [[3u4e\|3u4e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u46 RCSB], [http://www.ebi.ac.uk/pdbsum/3u46 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u46 OCA], [http://pdbe.org/3u46 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u46 RCSB], [http://www.ebi.ac.uk/pdbsum/3u46 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u46 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3u46" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Kwong, P D]]		[[Category: Kwong, P D]]
	[[Category: Louder, R]]		[[Category: Louder, R]]

OCA at 09:36, 4 January 2015

OCA — Sun, 04 Jan 2015 09:36:44 GMT

←Older revision		Revision as of 09:36, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3u46]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U46 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3u46]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U46 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tcl\|3tcl]], [[3u4b\|3u4b]], [[3u4e\|3u4e]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tcl\|3tcl]], [[3u4b\|3u4b]], [[3u4e\|3u4e]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u46 RCSB], [http://www.ebi.ac.uk/pdbsum/3u46 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u46 RCSB], [http://www.ebi.ac.uk/pdbsum/3u46 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 12:		Line 12:
	Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.,McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-Ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Do Kwon Y, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD Nature. 2011 Nov 23. doi: 10.1038/nature10696. PMID:22113616<ref>PMID:22113616</ref>		Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.,McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-Ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Do Kwon Y, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD Nature. 2011 Nov 23. doi: 10.1038/nature10696. PMID:22113616<ref>PMID:22113616</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Kwong, P D.]]	+	[[Category: Kwong, P D]]
-	[[Category: Louder, R.]]	+	[[Category: Louder, R]]
-	[[Category: McLellan, J S.]]	+	[[Category: McLellan, J S]]
-	[[Category: Pancera, M.]]	+	[[Category: Pancera, M]]
	[[Category: Hiv-1 antibody]]		[[Category: Hiv-1 antibody]]
	[[Category: Igg]]		[[Category: Igg]]

OCA at 06:11, 5 June 2014

OCA — Thu, 05 Jun 2014 06:11:41 GMT

←Older revision		Revision as of 06:11, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3u46.~~png~~\|~~left~~\|~~200px~~]]	+	==CH04H/CH02L P212121==
		+	<StructureSection load='3u46' size='340' side='right' caption='[[3u46]], [[Resolution\|resolution]] 2.91Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3u46]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U46 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tcl\|3tcl]], [[3u4b\|3u4b]], [[3u4e\|3u4e]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u46 RCSB], [http://www.ebi.ac.uk/pdbsum/3u46 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are themselves protected by extraordinary sequence diversity and N-linked glycosylation. Human antibodies such as PG9 nonetheless engage V1/V2 and neutralize 80% of HIV-1 isolates. Here we report the structure of V1/V2 in complex with PG9. V1/V2 forms a four-stranded beta-sheet domain, in which sequence diversity and glycosylation are largely segregated to strand-connecting loops. PG9 recognition involves electrostatic, sequence-independent and glycan interactions: the latter account for over half the interactive surface but are of sufficiently weak affinity to avoid autoreactivity. The structures of V1/V2-directed antibodies CH04 and PGT145 indicate that they share a common mode of glycan penetration by extended anionic loops. In addition to structurally defining V1/V2, the results thus identify a paradigm of antibody recognition for highly glycosylated antigens, which-with PG9-involves a site of vulnerability comprising just two glycans and a strand.

-	<!--	+	Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.,McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-Ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Do Kwon Y, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD Nature. 2011 Nov 23. doi: 10.1038/nature10696. PMID:22113616<ref>PMID:22113616</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3u46"~~, ~~creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3u46\| PDB=3u46 \| SCENE= }}~~	+

-	~~===CH04H~~/~~CH02L P212121===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22113616}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22113616 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22113616}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3u46]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U46 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022113616<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kwong, P D.]]		[[Category: Kwong, P D.]]

OCA at 06:21, 28 December 2011

OCA — Wed, 28 Dec 2011 06:21:19 GMT

←Older revision		Revision as of 06:21, 28 December 2011
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	===CH04H/CH02L P212121===		===CH04H/CH02L P212121===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22113616}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22113616 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22113616}}

	==About this Structure==		==About this Structure==
	[[3u46]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U46 OCA].		[[3u46]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U46 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022113616</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kwong, P D.]]		[[Category: Kwong, P D.]]

OCA at 08:11, 7 December 2011

OCA — Wed, 07 Dec 2011 08:11:25 GMT

←Older revision		Revision as of 08:11, 7 December 2011
Line 1:		Line 1:
-	[[Image:3u46.~~jpg~~\|left\|200px]]	+	[[Image:3u46.png\|left\|200px]]

	<!--		<!--

OCA at 06:29, 30 November 2011

OCA — Wed, 30 Nov 2011 06:29:39 GMT

←Older revision		Revision as of 06:29, 30 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3u46.jpg\|left\|200px]]

-	The ~~entry 3u46~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3u46", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3u46\| PDB=3u46 \| SCENE= }}

-	~~Authors: Louder, R., Pancera, M., McLellan, J.S., Kwong, P.D.~~	+	===CH04H/CH02L P212121===

-	~~Description~~: ~~CH04H~~/~~CH02L P212121~~	+
		+	==About this Structure==
		+	[[3u46]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U46 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Kwong, P D.]]
		+	[[Category: Louder, R.]]
		+	[[Category: McLellan, J S.]]
		+	[[Category: Pancera, M.]]
		+	[[Category: Hiv-1 antibody]]
		+	[[Category: Igg]]
		+	[[Category: Immune system]]
		+	[[Category: Immunogloblulin]]
		+	[[Category: V1v2-directed]]

OCA: Protected "3u46" [edit=sysop:move=sysop]

OCA — Sun, 30 Oct 2011 08:50:26 GMT

Protected "3u46" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:50, 30 October 2011

OCA: New page: '''Unreleased structure''' The entry 3u46 is ON HOLD Authors: Louder, R., Pancera, M., McLellan, J.S., Kwong, P.D. Description: CH04H/CH02L P212121

OCA — Sun, 30 Oct 2011 08:50:25 GMT

New page: '''Unreleased structure''' The entry 3u46 is ON HOLD Authors: Louder, R., Pancera, M., McLellan, J.S., Kwong, P.D. Description: CH04H/CH02L P212121

New page

'''Unreleased structure'''

The entry 3u46 is ON HOLD

Authors: Louder, R., Pancera, M., McLellan, J.S., Kwong, P.D.

Description: CH04H/CH02L P212121