3u6n - Revision history

OCA at 10:17, 1 March 2024

OCA — Fri, 01 Mar 2024 10:17:31 GMT

←Older revision		Revision as of 10:17, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3u6n' size='340' side='right'caption='[[3u6n]], [[Resolution\|resolution]] 3.61Å' scene=''>		<StructureSection load='3u6n' size='340' side='right'caption='[[3u6n]], [[Resolution\|resolution]] 3.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U6N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U6N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.61Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [https://pdbe.org/3u6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [https://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [https://pdbe.org/3u6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [https://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/B7ZC96_DANRE B7ZC96_DANRE]
-	High-conductance voltage- and Ca(2+)-activated K(+) channels function in many physiological processes that link cell membrane voltage and intracellular Ca(2+) concentration, including neuronal electrical activity, skeletal and smooth muscle contraction, and hair cell tuning. Like other voltage-dependent K(+) channels, Ca(2+)-activated K(+) channels open when the cell membrane depolarizes, but in contrast to other voltage-dependent K(+) channels, they also open when intracellular Ca(2+) concentrations rise. Channel opening by Ca(2+) is made possible by a structure called the gating ring, which is located in the cytoplasm. Recent structural studies have defined the Ca(2+)-free, closed, conformation of the gating ring, but the Ca(2+)-bound, open, conformation is not yet known. Here we present the Ca(2+)-bound conformation of the gating ring. This structure shows how one layer of the gating ring, in response to the binding of Ca(2+), opens like the petals of a flower. The degree to which it opens explains how Ca(2+) binding can open the transmembrane pore. These findings present a molecular basis for Ca(2+) activation of K(+) channels and suggest new possibilities for targeting the gating ring to treat conditions such as asthma and hypertension.	+
-		+
-	~~Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel.,Yuan P, Leonetti MD, Hsiung Y, MacKinnon R Nature. 2011 Dec 4;481(7379)~~:~~94-7. doi: 10.1038~~/~~nature10670. PMID:22139424<ref>PMID:22139424<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3u6n" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]		*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: MacKinnon, R]]	+	[[Category: MacKinnon R]]
-	[[Category: Yuan, P]]	+	[[Category: Yuan P]]
-	~~[[Category: Potassium channel]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 06:00, 13 July 2022

OCA — Wed, 13 Jul 2022 06:00:12 GMT

←Older revision		Revision as of 06:00, 13 July 2022
Line 3:		Line 3:
	<StructureSection load='3u6n' size='340' side='right'caption='[[3u6n]], [[Resolution\|resolution]] 3.61Å' scene=''>		<StructureSection load='3u6n' size='340' side='right'caption='[[3u6n]], [[Resolution\|resolution]] 3.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3U6N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U6N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [~~http~~://pdbe.org/3u6n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [https://pdbe.org/3u6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [https://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[Potassium ~~Channel~~\|Potassium ~~Channel~~]]	+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:38, 7 August 2019

OCA — Wed, 07 Aug 2019 06:38:54 GMT

←Older revision		Revision as of 06:38, 7 August 2019
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Open Structure of the BK channel Gating Ring==		==Open Structure of the BK channel Gating Ring==
-	<StructureSection load='3u6n' size='340' side='right' caption='[[3u6n]], [[Resolution\|resolution]] 3.61Å' scene=''>	+	<StructureSection load='3u6n' size='340' side='right'caption='[[3u6n]], [[Resolution\|resolution]] 3.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U6N FirstGlance]. <br>		<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U6N FirstGlance]. <br>
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [http://pdbe.org/3u6n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [http://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [http://pdbe.org/3u6n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [http://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 3u6n" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3u6n" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: MacKinnon, R]]		[[Category: MacKinnon, R]]
	[[Category: Yuan, P]]		[[Category: Yuan, P]]
	[[Category: Potassium channel]]		[[Category: Potassium channel]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 12:19, 6 November 2017

OCA — Mon, 06 Nov 2017 12:19:59 GMT

←Older revision		Revision as of 12:19, 6 November 2017
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 3u6n" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3u6n" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:17, 3 August 2017

OCA — Thu, 03 Aug 2017 10:17:58 GMT

←Older revision		Revision as of 10:17, 3 August 2017
Line 3:		Line 3:
	<StructureSection load='3u6n' size='340' side='right' caption='[[3u6n]], [[Resolution\|resolution]] 3.61Å' scene=''>		<StructureSection load='3u6n' size='340' side='right' caption='[[3u6n]], [[Resolution\|resolution]] 3.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U6N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U6N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dr.74676, KCNMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [http://pdbe.org/3u6n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [http://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [http://pdbe.org/3u6n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [http://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr>
	</table>		</table>
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Brachidanio rerio]]
	[[Category: MacKinnon, R]]		[[Category: MacKinnon, R]]
	[[Category: Yuan, P]]		[[Category: Yuan, P]]
	[[Category: Potassium channel]]		[[Category: Potassium channel]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 01:22, 5 August 2016

OCA — Fri, 05 Aug 2016 01:22:03 GMT

←Older revision		Revision as of 01:22, 5 August 2016
Line 1:		Line 1:
		+	{{Large structure}}
	==Open Structure of the BK channel Gating Ring==		==Open Structure of the BK channel Gating Ring==
	<StructureSection load='3u6n' size='340' side='right' caption='[[3u6n]], [[Resolution\|resolution]] 3.61Å' scene=''>		<StructureSection load='3u6n' size='340' side='right' caption='[[3u6n]], [[Resolution\|resolution]] 3.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Danio_rerio Danio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U6N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U6N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dr.74676, KCNMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 ~~Danio~~ rerio])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dr.74676, KCNMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [http://www.ebi.ac.uk/pdbsum/3u6n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [http://pdbe.org/3u6n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [http://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3u6n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Danio~~ rerio]]	+	[[Category: Brachidanio rerio]]
	[[Category: MacKinnon, R]]		[[Category: MacKinnon, R]]
	[[Category: Yuan, P]]		[[Category: Yuan, P]]
	[[Category: Potassium channel]]		[[Category: Potassium channel]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 08:22, 18 December 2014

OCA — Thu, 18 Dec 2014 08:22:09 GMT

←Older revision		Revision as of 08:22, 18 December 2014
Line 1:		Line 1:
-	~~{{Large structure}}~~	+	==Open Structure of the BK channel Gating Ring==
-	~~{{STRUCTURE_3u6n\| PDB=3u6n \| SCENE= }}~~	+	<StructureSection load='3u6n' size='340' side='right' caption='[[3u6n]], [[Resolution\|resolution]] 3.61Å' scene=''>
-	===Open Structure of the BK channel Gating Ring===	+	== Structural highlights ==
-	~~{{ABSTRACT_PUBMED_22139424}}~~	+	<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U6N FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dr.74676, KCNMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Danio rerio])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [http://www.ebi.ac.uk/pdbsum/3u6n PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-conductance voltage- and Ca(2+)-activated K(+) channels function in many physiological processes that link cell membrane voltage and intracellular Ca(2+) concentration, including neuronal electrical activity, skeletal and smooth muscle contraction, and hair cell tuning. Like other voltage-dependent K(+) channels, Ca(2+)-activated K(+) channels open when the cell membrane depolarizes, but in contrast to other voltage-dependent K(+) channels, they also open when intracellular Ca(2+) concentrations rise. Channel opening by Ca(2+) is made possible by a structure called the gating ring, which is located in the cytoplasm. Recent structural studies have defined the Ca(2+)-free, closed, conformation of the gating ring, but the Ca(2+)-bound, open, conformation is not yet known. Here we present the Ca(2+)-bound conformation of the gating ring. This structure shows how one layer of the gating ring, in response to the binding of Ca(2+), opens like the petals of a flower. The degree to which it opens explains how Ca(2+) binding can open the transmembrane pore. These findings present a molecular basis for Ca(2+) activation of K(+) channels and suggest new possibilities for targeting the gating ring to treat conditions such as asthma and hypertension.

-	~~==About this Structure==~~	+	Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel.,Yuan P, Leonetti MD, Hsiung Y, MacKinnon R Nature. 2011 Dec 4;481(7379):94-7. doi: 10.1038/nature10670. PMID:22139424<ref>PMID:22139424</ref>
-	~~[[3u6n]] is a 8 chain~~ structure ~~with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Danio_rerio Danio rerio]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3U6N OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Potassium Channel\|Potassium Channel]]		*[[Potassium Channel\|Potassium Channel]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022139424<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Danio rerio]]		[[Category: Danio rerio]]
-	[[Category: MacKinnon, R.]]	+	[[Category: MacKinnon, R]]
-	[[Category: Yuan, P.]]	+	[[Category: Yuan, P]]
	[[Category: Potassium channel]]		[[Category: Potassium channel]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 07:42, 11 March 2013

OCA — Mon, 11 Mar 2013 07:42:27 GMT

←Older revision		Revision as of 07:42, 11 March 2013
Line 1:		Line 1:
-	~~[[Image:3u6n.png\|left\|200px]]~~	+	{{Large structure}}
-		+
	{{STRUCTURE_3u6n\| PDB=3u6n \| SCENE= }}		{{STRUCTURE_3u6n\| PDB=3u6n \| SCENE= }}
-
	===Open Structure of the BK channel Gating Ring===		===Open Structure of the BK channel Gating Ring===
-
	{{ABSTRACT_PUBMED_22139424}}		{{ABSTRACT_PUBMED_22139424}}

OCA at 09:21, 20 October 2012

OCA — Sat, 20 Oct 2012 09:21:11 GMT

←Older revision		Revision as of 09:21, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3u6n]] is a 8 chain structure ~~of [[Potassium Channel]]~~ with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA].	+	[[3u6n]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA].

	==See Also==		==See Also==

OCA at 22:34, 25 July 2012

OCA — Wed, 25 Jul 2012 22:34:44 GMT

←Older revision		Revision as of 22:34, 25 July 2012
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	[[Image:3u6n.png\|left\|200px]]		[[Image:3u6n.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3u6n\| PDB=3u6n \| SCENE= }}		{{STRUCTURE_3u6n\| PDB=3u6n \| SCENE= }}

	===Open Structure of the BK channel Gating Ring===		===Open Structure of the BK channel Gating Ring===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22139424}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_22139424}}		{{ABSTRACT_PUBMED_22139424}}

	==About this Structure==		==About this Structure==
-	[[3u6n]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA].	+	[[3u6n]] is a 8 chain structure of [[Potassium Channel]] with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA].
		+
		+	==See Also==
		+	*[[Potassium Channel\|Potassium Channel]]

	==Reference==		==Reference==