3u7k - Revision history

OCA at 17:35, 1 November 2023

OCA — Wed, 01 Nov 2023 17:35:11 GMT

←Older revision		Revision as of 17:35, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3u7k' size='340' side='right'caption='[[3u7k]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3u7k' size='340' side='right'caption='[[3u7k]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staac Staac~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U7K FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MDB:(S)~~-~~N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3~~,~~3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[3u7l\|3u7l]]~~, ~~[[3u7m\|3u7m]], [[3u7n\|3u7n]]</div></td></tr>~~	+
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b><~~/td><td class="sblockDat">SACOL1100 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [https://pdbe.org/3u7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [https://www.ebi.ac.uk/pdbsum/3u7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [https://pdbe.org/3u7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [https://www.ebi.ac.uk/pdbsum/3u7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]	+	[https://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Peptide deformylase~~]]	+	[[Category: Staphylococcus aureus subsp. aureus COL]]
-	[[Category: ~~Staac~~]]	+	[[Category: Kim KK]]
-	[[Category: ~~Kim, K K~~]]	+	[[Category: Lee BJ]]
-	[[Category: Lee~~, B J~~]]	+	[[Category: Lee HH]]
-	[[Category: Lee~~, H H~~]]	+	[[Category: Lee S-J]]
-	[[Category: Lee~~, S J~~]]	+	[[Category: Lee SJ]]
-	[[Category: Lee~~, S K~~]]	+	[[Category: Lee SK]]
-	[[Category: Suh~~, S W~~]]	+	[[Category: Suh SW]]
-	[[Category: Yoon, H J]]	+	[[Category: Yoon H-J]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Pdf]]~~	+
-	~~[[Category: Pdf-inhibitor~~]]	+

OCA at 06:01, 13 July 2022

OCA — Wed, 13 Jul 2022 06:01:20 GMT

←Older revision		Revision as of 06:01, 13 July 2022
Line 1:		Line 1:

	==Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors==		==Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors==
-	<StructureSection load='3u7k' size='340' side='right' caption='[[3u7k]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3u7k' size='340' side='right'caption='[[3u7k]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3U7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U7K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u7l\|3u7l]], [[3u7m\|3u7m]], [[3u7n\|3u7n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u7l\|3u7l]], [[3u7m\|3u7m]], [[3u7n\|3u7n]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL1100 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL1100 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [~~http~~://pdbe.org/3u7k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3u7k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [https://pdbe.org/3u7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [https://www.ebi.ac.uk/pdbsum/3u7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]	+	[[https://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Peptide deformylase]]		[[Category: Peptide deformylase]]
	[[Category: Staac]]		[[Category: Staac]]

OCA at 09:20, 21 February 2019

OCA — Thu, 21 Feb 2019 09:20:15 GMT

←Older revision		Revision as of 09:20, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='3u7k' size='340' side='right' caption='[[3u7k]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3u7k' size='340' side='right' caption='[[3u7k]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u7l\|3u7l]], [[3u7m\|3u7m]], [[3u7n\|3u7n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u7l\|3u7l]], [[3u7m\|3u7m]], [[3u7n\|3u7n]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [http://pdbe.org/3u7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [http://www.ebi.ac.uk/pdbsum/3u7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [http://pdbe.org/3u7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [http://www.ebi.ac.uk/pdbsum/3u7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7k ProSAT]</span></td></tr>
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Peptide deformylase]]		[[Category: Peptide deformylase]]
		+	[[Category: Staac]]
	[[Category: Kim, K K]]		[[Category: Kim, K K]]
	[[Category: Lee, B J]]		[[Category: Lee, B J]]

OCA at 07:25, 9 March 2017

OCA — Thu, 09 Mar 2017 07:25:34 GMT

←Older revision		Revision as of 07:25, 9 March 2017
Line 3:		Line 3:
	<StructureSection load='3u7k' size='340' side='right' caption='[[3u7k]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3u7k' size='340' side='right' caption='[[3u7k]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Staac Staac]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u7l\|3u7l]], [[3u7m\|3u7m]], [[3u7n\|3u7n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u7l\|3u7l]], [[3u7m\|3u7m]], [[3u7n\|3u7n]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [http://pdbe.org/3u7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [http://www.ebi.ac.uk/pdbsum/3u7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [http://pdbe.org/3u7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [http://www.ebi.ac.uk/pdbsum/3u7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7k ProSAT]</span></td></tr>
Line 13:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]		[[http://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptide deformylase (PDF) catalyzes the removal of the formyl group from the N-terminal methionine residue in newly synthesized polypeptides, which is an essential process in bacteria. Four new inhibitors of PDF that belong to two different classes, hydroxamate/pseudopeptide compounds [PMT387 (7a) and PMT497] and reverse-hydroxamate/nonpeptide compounds [PMT1039 (15e) and PMT1067], have been developed. These compounds inhibited the growth of several pathogens involved in respiratory-tract infections, such as Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae, and leading nosocomial pathogens such as Staphylococcus aureus and Klebsiella pneumoniae with a minimum inhibitory concentration (MIC) in the range 0.1-0.8 mg ml(-1). Interestingly, the reverse-hydroxamate/nonpeptide compounds showed a 250-fold higher antimicrobial activity towards S. aureus, although the four compounds showed similar K(i) values against S. aureus PDF enzymes, with K(i) values in the 11-85 nM range. To provide a structural basis for the discovery of additional PDF inhibitors, the crystal structures of S. aureus PDF in complex with the four inhibitors were determined at resolutions of 1.90-2.30 A. The inhibitor-bound structures displayed distinct deviations depending on the inhibitor class. The distance between the Zn(2+) ion and the carbonyl O atom of the hydroxamate inhibitors (or the hydroxyl O atom of the reverse-hydroxamate inhibitors) appears to be correlated to S. aureus inhibition activity. The structural information reported in this study should aid in the discovery of new PDF inhibitors that can be used as novel antibacterial drugs.
		+
		+	Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors.,Lee SJ, Lee SJ, Lee SK, Yoon HJ, Lee HH, Kim KK, Lee BJ, Lee BI, Suh SW Acta Crystallogr D Biol Crystallogr. 2012 Jul;68(Pt 7):784-93. doi:, 10.1107/S0907444912011912. Epub 2012 Jun 15. PMID:22751663<ref>PMID:22751663</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3u7k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Peptide deformylase]]		[[Category: Peptide deformylase]]
-	[[Category: Staac]]
	[[Category: Kim, K K]]		[[Category: Kim, K K]]
	[[Category: Lee, B J]]		[[Category: Lee, B J]]

OCA at 12:48, 11 August 2016

OCA — Thu, 11 Aug 2016 12:48:22 GMT

←Older revision		Revision as of 12:48, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors==		==Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors==
	<StructureSection load='3u7k' size='340' side='right' caption='[[3u7k]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3u7k' size='340' side='right' caption='[[3u7k]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus aureus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u7l\|3u7l]], [[3u7m\|3u7m]], [[3u7n\|3u7n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u7l\|3u7l]], [[3u7m\|3u7m]], [[3u7n\|3u7n]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1280 Staphylococcus aureus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [http://www.ebi.ac.uk/pdbsum/3u7k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [http://pdbe.org/3u7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [http://www.ebi.ac.uk/pdbsum/3u7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7k ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Peptide deformylase]]		[[Category: Peptide deformylase]]
-	[[Category: ~~Staphylococcus aureus~~]]	+	[[Category: Staac]]
	[[Category: Kim, K K]]		[[Category: Kim, K K]]
	[[Category: Lee, B J]]		[[Category: Lee, B J]]

OCA at 09:39, 4 January 2015

OCA — Sun, 04 Jan 2015 09:39:06 GMT

←Older revision		Revision as of 09:39, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7K FirstGlance]. <br>		<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u7l\|3u7l]], [[3u7m\|3u7m]], [[3u7n\|3u7n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u7l\|3u7l]], [[3u7m\|3u7m]], [[3u7n\|3u7n]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [http://www.ebi.ac.uk/pdbsum/3u7k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [http://www.ebi.ac.uk/pdbsum/3u7k PDBsum]</span></td></tr>
-	<table>	+	</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Peptide deformylase]]		[[Category: Peptide deformylase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Kim, K K.]]	+	[[Category: Kim, K K]]
-	[[Category: Lee, B J.]]	+	[[Category: Lee, B J]]
-	[[Category: Lee, H H.]]	+	[[Category: Lee, H H]]
-	[[Category: Lee, S J.]]	+	[[Category: Lee, S J]]
-	[[Category: Lee, S K.]]	+	[[Category: Lee, S K]]
-	[[Category: Suh, S W.]]	+	[[Category: Suh, S W]]
-	[[Category: Yoon, H J.]]	+	[[Category: Yoon, H J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Pdf]]		[[Category: Pdf]]
	[[Category: Pdf-inhibitor]]		[[Category: Pdf-inhibitor]]
-	[[Category: Peptide deformylase]]

OCA at 06:13, 5 June 2014

OCA — Thu, 05 Jun 2014 06:13:56 GMT

←Older revision		Revision as of 06:13, 5 June 2014
Line 1:		Line 1:
-	~~[[Image:3u7k.jpg\|left\|200px]]~~	+	==Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors==
-		+	<StructureSection load='3u7k' size='340' side='right' caption='[[3u7k]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{STRUCTURE_3u7k\| PDB=3u7k \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7K FirstGlance]. <br>
-	===Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u7l\|3u7l]], [[3u7m\|3u7m]], [[3u7n\|3u7n]]</td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
-	[[3u7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA].	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [http://www.ebi.ac.uk/pdbsum/3u7k PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Peptide deformylase]]		[[Category: Peptide deformylase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]

OCA at 05:53, 27 June 2012

OCA — Wed, 27 Jun 2012 05:53:49 GMT

←Older revision		Revision as of 05:53, 27 June 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3u7k.jpg\|left\|200px]]

-	~~The entry~~ 3u7k ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3u7k\| PDB=3u7k \| SCENE= }}

-	~~Authors: Lee, S.J., Lee, S.J., Lee, S.K., Yoon, H.J., Lee, H.H., Kim, K.K., Lee, B.J., Suh, S.W.~~	+	===Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors===

-	~~Description~~: ~~Crystal structures of the~~ Staphylococcus aureus ~~peptide~~ deformylase in complex ~~with two classes of new inhibitors~~	+
		+	==About this Structure==
		+	[[3u7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA].
		+	[[Category: Peptide deformylase]]
		+	[[Category: Staphylococcus aureus]]
		+	[[Category: Kim, K K.]]
		+	[[Category: Lee, B J.]]
		+	[[Category: Lee, H H.]]
		+	[[Category: Lee, S J.]]
		+	[[Category: Lee, S K.]]
		+	[[Category: Suh, S W.]]
		+	[[Category: Yoon, H J.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Pdf]]
		+	[[Category: Pdf-inhibitor]]
		+	[[Category: Peptide deformylase]]

OCA at 07:58, 2 November 2011

OCA — Wed, 02 Nov 2011 07:58:13 GMT

←Older revision		Revision as of 07:58, 2 November 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3u7k is ON HOLD	+	The entry 3u7k is ON HOLD until Paper Publication

	Authors: Lee, S.J., Lee, S.J., Lee, S.K., Yoon, H.J., Lee, H.H., Kim, K.K., Lee, B.J., Suh, S.W.		Authors: Lee, S.J., Lee, S.J., Lee, S.K., Yoon, H.J., Lee, H.H., Kim, K.K., Lee, B.J., Suh, S.W.

	Description: Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors		Description: Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors

OCA: Protected "3u7k" [edit=sysop:move=sysop]

OCA — Sun, 30 Oct 2011 08:54:00 GMT

Protected "3u7k" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:54, 30 October 2011