3u92 - Revision history

OCA at 13:51, 14 March 2024

OCA — Thu, 14 Mar 2024 13:51:19 GMT

←Older revision		Revision as of 13:51, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3u92' size='340' side='right'caption='[[3u92]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3u92' size='340' side='right'caption='[[3u92]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u92]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U92 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u92]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U92 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAI:3~~-~~(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3u93\|3u93]], [[3u94\|3u94]], [[3s9e\|3s9e]], [[1s50\|1s50]], [[1txf\|1txf]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">GRIK3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u92 OCA], [https://pdbe.org/3u92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u92 RCSB], [https://www.ebi.ac.uk/pdbsum/3u92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u92 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u92 OCA], [https://pdbe.org/3u92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u92 RCSB], [https://www.ebi.ac.uk/pdbsum/3u92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u92 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GRIK3_RAT GRIK3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.<ref>PMID:21907808</ref>	+	[https://www.uniprot.org/uniprot/GRIK3_RAT GRIK3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.<ref>PMID:21907808</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Kainate receptors (KARs) play a key role in the regulation of synaptic networks. Here, we show that zinc, a cation released at a subset of glutamatergic synapses, potentiates glutamate currents mediated by homomeric and heteromeric KARs containing GluK3 at 10-100 muM concentrations, whereas it inhibits other KAR subtypes. Potentiation of GluK3 currents is mainly due to reduced desensitization, as shown by kinetic analysis and desensitization mutants. Crystallographic and mutation analyses revealed that a specific zinc binding site is formed at the base of the ligand binding domain (LBD) dimer interface by a GluK3-specific aspartate (Asp759), together with two conserved residues, His762 and Asp730, the latter located on the partner subunit. In addition, we propose that tetrameric GluK2/GluK3 receptors are likely assembled as pairs of heterodimeric LBDs. Therefore, zinc binding stabilizes the labile GluK3 dimer interface, slows desensitization, and potentiates currents, providing a mechanism for KAR potentiation at glutamatergic synapses.	+
-		+
-	Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface.,Veran J, Kumar J, Pinheiro PS, Athane A, Mayer ML, Perrais D, Mulle C Neuron. 2012 Nov 8;76(3):565-78. doi: 10.1016/j.neuron.2012.08.027. PMID:23141068<ref>PMID:23141068</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3u92" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 27:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kumar, J~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Mayer, M L~~]]	+	[[Category: Kumar J]]
-	[[Category: ~~Ion channel]]~~	+	[[Category: Mayer ML]]
-	~~[[Category: Membrane protein~~]]	+

OCA at 06:03, 13 July 2022

OCA — Wed, 13 Jul 2022 06:03:15 GMT

←Older revision		Revision as of 06:03, 13 July 2022
Line 1:		Line 1:

	==Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form==		==Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form==
-	<StructureSection load='3u92' size='340' side='right' caption='[[3u92]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3u92' size='340' side='right'caption='[[3u92]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u92]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U92 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3U92 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u92]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U92 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u93\|3u93]], [[3u94\|3u94]], [[3s9e\|3s9e]], [[1s50\|1s50]], [[1txf\|1txf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u93\|3u93]], [[3u94\|3u94]], [[3s9e\|3s9e]], [[1s50\|1s50]], [[1txf\|1txf]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRIK3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRIK3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3u92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u92 OCA], [~~http~~://pdbe.org/3u92 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3u92 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3u92 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3u92 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u92 OCA], [https://pdbe.org/3u92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u92 RCSB], [https://www.ebi.ac.uk/pdbsum/3u92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u92 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRIK3_RAT GRIK3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.<ref>PMID:21907808</ref>	+	[[https://www.uniprot.org/uniprot/GRIK3_RAT GRIK3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.<ref>PMID:21907808</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[~~Ionotropic~~ Glutamate ~~Receptors~~\|~~Ionotropic~~ Glutamate ~~Receptors~~]]	+	*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Kumar, J]]		[[Category: Kumar, J]]
	[[Category: Mayer, M L]]		[[Category: Mayer, M L]]
	[[Category: Ion channel]]		[[Category: Ion channel]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 13:53, 4 August 2016

OCA — Thu, 04 Aug 2016 13:53:47 GMT

←Older revision		Revision as of 13:53, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form==		==Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form==
	<StructureSection load='3u92' size='340' side='right' caption='[[3u92]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3u92' size='340' side='right' caption='[[3u92]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u92]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U92 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u92]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U92 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u93\|3u93]], [[3u94\|3u94]], [[3s9e\|3s9e]], [[1s50\|1s50]], [[1txf\|1txf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u93\|3u93]], [[3u94\|3u94]], [[3s9e\|3s9e]], [[1s50\|1s50]], [[1txf\|1txf]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRIK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRIK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u92 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u92 RCSB], [http://www.ebi.ac.uk/pdbsum/3u92 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u92 OCA], [http://pdbe.org/3u92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u92 RCSB], [http://www.ebi.ac.uk/pdbsum/3u92 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u92 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3u92" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Kumar, J]]		[[Category: Kumar, J]]
	[[Category: Mayer, M L]]		[[Category: Mayer, M L]]
	[[Category: Ion channel]]		[[Category: Ion channel]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 15:19, 24 December 2014

OCA — Wed, 24 Dec 2014 15:19:23 GMT

←Older revision		Revision as of 15:19, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u92 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u92 RCSB], [http://www.ebi.ac.uk/pdbsum/3u92 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u92 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u92 RCSB], [http://www.ebi.ac.uk/pdbsum/3u92 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIK3_RAT GRIK3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.<ref>PMID:21907808</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:07, 9 December 2014

OCA — Tue, 09 Dec 2014 17:07:35 GMT

←Older revision		Revision as of 17:07, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3u92.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form==
		+	<StructureSection load='3u92' size='340' side='right' caption='[[3u92]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3u92]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U92 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u93\|3u93]], [[3u94\|3u94]], [[3s9e\|3s9e]], [[1s50\|1s50]], [[1txf\|1txf]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRIK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u92 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u92 RCSB], [http://www.ebi.ac.uk/pdbsum/3u92 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Kainate receptors (KARs) play a key role in the regulation of synaptic networks. Here, we show that zinc, a cation released at a subset of glutamatergic synapses, potentiates glutamate currents mediated by homomeric and heteromeric KARs containing GluK3 at 10-100 muM concentrations, whereas it inhibits other KAR subtypes. Potentiation of GluK3 currents is mainly due to reduced desensitization, as shown by kinetic analysis and desensitization mutants. Crystallographic and mutation analyses revealed that a specific zinc binding site is formed at the base of the ligand binding domain (LBD) dimer interface by a GluK3-specific aspartate (Asp759), together with two conserved residues, His762 and Asp730, the latter located on the partner subunit. In addition, we propose that tetrameric GluK2/GluK3 receptors are likely assembled as pairs of heterodimeric LBDs. Therefore, zinc binding stabilizes the labile GluK3 dimer interface, slows desensitization, and potentiates currents, providing a mechanism for KAR potentiation at glutamatergic synapses.

-	~~{{STRUCTURE_3u92\| PDB=3u92 \| SCENE= }}~~	+	Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface.,Veran J, Kumar J, Pinheiro PS, Athane A, Mayer ML, Perrais D, Mulle C Neuron. 2012 Nov 8;76(3):565-78. doi: 10.1016/j.neuron.2012.08.027. PMID:23141068<ref>PMID:23141068</ref>

-	~~===Crystal structure~~ of the ~~GluK3 ligand binding domain complex with kainate and zinc: P2221 form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23141068}}~~	+	==See Also==
-		+	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3u92~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U92 OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Kumar, J.]]	+	[[Category: Kumar, J]]
-	[[Category: Mayer, M L.]]	+	[[Category: Mayer, M L]]
	[[Category: Ion channel]]		[[Category: Ion channel]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 10:42, 19 December 2012

OCA — Wed, 19 Dec 2012 10:42:15 GMT

←Older revision		Revision as of 10:42, 19 December 2012
Line 1:		Line 1:
-	[[Image:3u92.~~jpg~~\|left\|200px]]	+	[[Image:3u92.png\|left\|200px]]

	{{STRUCTURE_3u92\| PDB=3u92 \| SCENE= }}		{{STRUCTURE_3u92\| PDB=3u92 \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form===		===Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form===

		+	{{ABSTRACT_PUBMED_23141068}}

	==About this Structure==		==About this Structure==

OCA at 20:44, 26 September 2012

OCA — Wed, 26 Sep 2012 20:44:47 GMT

←Older revision		Revision as of 20:44, 26 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3u92.jpg\|left\|200px]]

-	~~The entry~~ 3u92 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3u92\| PDB=3u92 \| SCENE= }}

-	~~Authors~~: ~~Kumar, J., Mayer, M.L.~~	+	===Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form===

-	~~Description: Crystal~~ structure ~~of the GluK3 ligand binding domain complex~~ with ~~kainate and zinc~~: ~~P2221 form~~	+
		+	==About this Structure==
		+	[[3u92]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U92 OCA].
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Kumar, J.]]
		+	[[Category: Mayer, M L.]]
		+	[[Category: Ion channel]]
		+	[[Category: Membrane protein]]

OCA at 07:58, 2 November 2011

OCA — Wed, 02 Nov 2011 07:58:46 GMT

←Older revision		Revision as of 07:58, 2 November 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3u92 is ON HOLD	+	The entry 3u92 is ON HOLD until Paper Publication

	Authors: Kumar, J., Mayer, M.L.		Authors: Kumar, J., Mayer, M.L.

	Description: Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form		Description: Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form

OCA: Protected "3u92" [edit=sysop:move=sysop]

OCA — Sun, 30 Oct 2011 08:55:33 GMT

Protected "3u92" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:55, 30 October 2011

OCA: New page: '''Unreleased structure''' The entry 3u92 is ON HOLD Authors: Kumar, J., Mayer, M.L. Description: Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2...

OCA — Sun, 30 Oct 2011 08:55:31 GMT

New page: '''Unreleased structure''' The entry 3u92 is ON HOLD Authors: Kumar, J., Mayer, M.L. Description: Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2...

New page

'''Unreleased structure'''

The entry 3u92 is ON HOLD

Authors: Kumar, J., Mayer, M.L.

Description: Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form