3udc - Revision history

OCA at 17:35, 1 November 2023

OCA — Wed, 01 Nov 2023 17:35:41 GMT

←Older revision		Revision as of 17:35, 1 November 2023
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	<StructureSection load='3udc' size='340' side='right'caption='[[3udc]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='3udc' size='340' side='right'caption='[[3udc]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3udc]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UDC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3udc]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis_MB4 Caldanaerobacter subterraneus subsp. tengcongensis MB4] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UDC FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3t9n\|3t9n]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.355Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">MscS ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=83333 ECOLI])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3udc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3udc OCA], [https://pdbe.org/3udc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3udc RCSB], [https://www.ebi.ac.uk/pdbsum/3udc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3udc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3udc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3udc OCA], [https://pdbe.org/3udc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3udc RCSB], [https://www.ebi.ac.uk/pdbsum/3udc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3udc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MSCS_CALS4 MSCS_CALS4] Mechanosensitive ion channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Has high selectivity for anions, and may contribute to resistance to hypoosmotic shock.<ref>PMID:23074248</ref> [https://www.uniprot.org/uniprot/MSCS_ECOLI MSCS_ECOLI] Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds. The channel pore is formed by TM3 and the loop between TM2 and TM3. After a sharp turn at Gly-113, an alpha-helix (residues 114-127) is oriented nearly parallel to the plane of the putative lipid bilayer. On the intracellular side of the channel, the permeation pathway of MscS does not connect directly to the cytoplasm but instead opens to a large chamber that is connected to the cytoplasm. This chamber resembles a molecular filter that could serve to prescreen large molecules before they are allowed passage to the transmembrane pore. The TM1 and TM2 helices appear to be likely candidates for mediating the tension and voltage sensitivities of MscS. Gating requires large rearrangements of at least the C-terminus.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Caldanaerobacter subterraneus subsp. tengcongensis MB4]]
		+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ge, J]]	+	[[Category: Ge J]]
-	[[Category: Li, W]]	+	[[Category: Li W]]
-	[[Category: Yang, M]]	+	[[Category: Yang M]]
-	~~[[Category: Channel]]~~	+
-	~~[[Category: Mechanosensitive]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 06:08, 13 July 2022

OCA — Wed, 13 Jul 2022 06:08:37 GMT

←Older revision		Revision as of 06:08, 13 July 2022
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	==Crystal structure of a membrane protein==		==Crystal structure of a membrane protein==
-	<StructureSection load='3udc' size='340' side='right' caption='[[3udc]], [[Resolution\|resolution]] 3.35Å' scene=''>	+	<StructureSection load='3udc' size='340' side='right'caption='[[3udc]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3udc]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UDC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3udc]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UDC FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t9n\|3t9n]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3t9n\|3t9n]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MscS ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MscS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3udc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3udc OCA], [~~http~~://pdbe.org/3udc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3udc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3udc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3udc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3udc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3udc OCA], [https://pdbe.org/3udc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3udc RCSB], [https://www.ebi.ac.uk/pdbsum/3udc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3udc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 3udc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3udc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Ge, J]]		[[Category: Ge, J]]
	[[Category: Li, W]]		[[Category: Li, W]]

OCA at 00:49, 16 November 2017

OCA — Thu, 16 Nov 2017 00:49:46 GMT

←Older revision		Revision as of 00:49, 16 November 2017
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	</div>		</div>
	<div class="pdbe-citations 3udc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3udc" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ion channels\|Ion channels]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:36, 11 August 2016

OCA — Thu, 11 Aug 2016 14:36:44 GMT

←Older revision		Revision as of 14:36, 11 August 2016
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		+
	==Crystal structure of a membrane protein==		==Crystal structure of a membrane protein==
	<StructureSection load='3udc' size='340' side='right' caption='[[3udc]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='3udc' size='340' side='right' caption='[[3udc]], [[Resolution\|resolution]] 3.35Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t9n\|3t9n]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t9n\|3t9n]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MscS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MscS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3udc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3udc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3udc RCSB], [http://www.ebi.ac.uk/pdbsum/3udc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3udc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3udc OCA], [http://pdbe.org/3udc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3udc RCSB], [http://www.ebi.ac.uk/pdbsum/3udc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3udc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3udc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels\|Ion channels]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:14, 20 January 2015

OCA — Tue, 20 Jan 2015 08:14:42 GMT

←Older revision

Revision as of 08:14, 20 January 2015

OCA at 07:51, 19 June 2013

OCA — Wed, 19 Jun 2013 07:51:04 GMT

←Older revision		Revision as of 07:51, 19 June 2013
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-	[[Image:3udc.jpg\|left\|200px]]
-
	{{STRUCTURE_3udc\| PDB=3udc \| SCENE= }}		{{STRUCTURE_3udc\| PDB=3udc \| SCENE= }}
-
	===Crystal structure of a membrane protein===		===Crystal structure of a membrane protein===
-
	{{ABSTRACT_PUBMED_23074248}}		{{ABSTRACT_PUBMED_23074248}}

	==About this Structure==		==About this Structure==
	[[3udc]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDC OCA].		[[3udc]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023074248</ref><references group="xtra"/><references/>
	[[Category: Ge, J.]]		[[Category: Ge, J.]]
	[[Category: Li, W.]]		[[Category: Li, W.]]

OCA at 08:58, 31 October 2012

OCA — Wed, 31 Oct 2012 08:58:59 GMT

←Older revision		Revision as of 08:58, 31 October 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:3udc.jpg\|left\|200px]]

-	~~The entry~~ 3udc ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3udc\| PDB=3udc \| SCENE= }}

-	~~Authors: Li, W., Ge, J., Yang, M.~~	+	===Crystal structure of a membrane protein===

-	~~Description: Crystal structure of~~ a ~~membrane~~ protein	+	{{ABSTRACT_PUBMED_23074248}}
		+
		+	==About this Structure==
		+	[[3udc]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDC OCA].
		+	[[Category: Ge, J.]]
		+	[[Category: Li, W.]]
		+	[[Category: Yang, M.]]
		+	[[Category: Channel]]
		+	[[Category: Mechanosensitive]]
		+	[[Category: Membrane protein]]

OCA at 05:50, 30 November 2011

OCA — Wed, 30 Nov 2011 05:50:58 GMT

←Older revision		Revision as of 05:50, 30 November 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3udc is ON HOLD	+	The entry 3udc is ON HOLD until Paper Publication

	Authors: Li, W., Ge, J., Yang, M.		Authors: Li, W., Ge, J., Yang, M.

	Description: Crystal structure of a membrane protein		Description: Crystal structure of a membrane protein

OCA at 11:52, 16 November 2011

OCA — Wed, 16 Nov 2011 11:52:19 GMT

←Older revision		Revision as of 11:52, 16 November 2011
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	The entry 3udc is ON HOLD		The entry 3udc is ON HOLD

-	Authors: Li, ~~Wenfei~~, Ge, ~~Jingpeng~~, Yang, ~~Maojun~~	+	Authors: Li, W., Ge, J., Yang, M.

-	Description: ~~crystal~~ structure of a membrane protein	+	Description: Crystal structure of a membrane protein

OCA: Protected "3udc" [edit=sysop:move=sysop]

OCA — Wed, 09 Nov 2011 11:16:04 GMT

Protected "3udc" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:16, 9 November 2011