3uhe - Revision history

OCA at 13:58, 14 March 2024

OCA — Thu, 14 Mar 2024 13:58:23 GMT

←Older revision		Revision as of 13:58, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3uhe' size='340' side='right'caption='[[3uhe]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3uhe' size='340' side='right'caption='[[3uhe]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uhe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Anain Anain~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UHE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uhe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anadara_inaequivalvis Anadara inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UHE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>~~, ~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3sdh\|3sdh]]~~, [[4sdh\|4sdh]], [[3ugy\|3ugy]], [[3ugz\|3ugz]], [[3uh3\|3uh3]], [[3uh5\|3uh5]], [[3uh6\|3uh6]], [[3uh7\|3uh7]], [[3uhb\|3uhb]], [[3uhc\|3uhc]], [[3uhd\|3uhd]], [[3uhg\|3uhg]], [[3uhh\|3uhh]], [[3uhi\|3uhi]], [[3uhk\|3uhk]], [[3uhn\|3uhn]], [[3uhq\|3uhq]], [[3uhr\|3uhr]], [[3uhs\|3uhs]], [[3uht\|3uht]], [[3uhu\|3uhu]], [[3uhv\|3uhv]], [[3uhw\|3uhw]], [[3uhx\|3uhx]], [[3uhy\|3uhy]], [[3uhz\|3uhz]], [[3ui0\|3ui0]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uhe OCA], [https://pdbe.org/3uhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uhe RCSB], [https://www.ebi.ac.uk/pdbsum/3uhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uhe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uhe OCA], [https://pdbe.org/3uhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uhe RCSB], [https://www.ebi.ac.uk/pdbsum/3uhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uhe ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/GLB1_ANAIN GLB1_ANAIN]
-	Here we present a meta-analysis of a large collection of static structures of a protein in the Protein Data Bank in order to extract the progression of structural events during protein function. We apply this strategy to the homodimeric hemoglobin HbI from Scapharca inaequivalvis. We derive a simple dynamic model describing how binding of the first ligand in one of the two chemically identical subunits facilitates a second binding event in the other partner subunit. The results of our ultrafast time-resolved crystallographic studies support this model. We demonstrate that HbI functions like a homodimeric mechanical device, such as pliers or scissors. Ligand-induced motion originating in one subunit is transmitted to the other via conserved pivot points, where the E and F' helices from two partner subunits are "bolted" together to form a stable dimer interface permitting slight relative rotation but preventing sliding.	+
-		+
-	~~Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures.,Ren Z, Srajer V, Knapp JE, Royer WE Jr Proc Natl Acad Sci U S A. 2011 Dec 14. PMID~~:~~22171006<ref>PMID:22171006<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3uhe" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]		*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Anain~~]]	+	[[Category: Anadara inaequivalvis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Knapp~~, J E~~]]	+	[[Category: Knapp JE]]
-	[[Category: Ren, Z]]	+	[[Category: Ren Z]]
-	[[Category: Royer~~, W E~~]]	+	[[Category: Royer Jr WE]]
-	[[Category: Srajer, V]]	+	[[Category: Srajer V]]
-	~~[[Category: Allostery]]~~	+
-	~~[[Category: Oxygen binding]]~~	+
-	~~[[Category: Oxygen storage]]~~	+
-	~~[[Category: Oxygen transport~~]]	+

OCA at 06:13, 13 July 2022

OCA — Wed, 13 Jul 2022 06:13:15 GMT

←Older revision		Revision as of 06:13, 13 July 2022
Line 3:		Line 3:
	<StructureSection load='3uhe' size='340' side='right'caption='[[3uhe]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3uhe' size='340' side='right'caption='[[3uhe]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uhe]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UHE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uhe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UHE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[4sdh\|4sdh]], [[3ugy\|3ugy]], [[3ugz\|3ugz]], [[3uh3\|3uh3]], [[3uh5\|3uh5]], [[3uh6\|3uh6]], [[3uh7\|3uh7]], [[3uhb\|3uhb]], [[3uhc\|3uhc]], [[3uhd\|3uhd]], [[3uhg\|3uhg]], [[3uhh\|3uhh]], [[3uhi\|3uhi]], [[3uhk\|3uhk]], [[3uhn\|3uhn]], [[3uhq\|3uhq]], [[3uhr\|3uhr]], [[3uhs\|3uhs]], [[3uht\|3uht]], [[3uhu\|3uhu]], [[3uhv\|3uhv]], [[3uhw\|3uhw]], [[3uhx\|3uhx]], [[3uhy\|3uhy]], [[3uhz\|3uhz]], [[3ui0\|3ui0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sdh\|3sdh]], [[4sdh\|4sdh]], [[3ugy\|3ugy]], [[3ugz\|3ugz]], [[3uh3\|3uh3]], [[3uh5\|3uh5]], [[3uh6\|3uh6]], [[3uh7\|3uh7]], [[3uhb\|3uhb]], [[3uhc\|3uhc]], [[3uhd\|3uhd]], [[3uhg\|3uhg]], [[3uhh\|3uhh]], [[3uhi\|3uhi]], [[3uhk\|3uhk]], [[3uhn\|3uhn]], [[3uhq\|3uhq]], [[3uhr\|3uhr]], [[3uhs\|3uhs]], [[3uht\|3uht]], [[3uhu\|3uhu]], [[3uhv\|3uhv]], [[3uhw\|3uhw]], [[3uhx\|3uhx]], [[3uhy\|3uhy]], [[3uhz\|3uhz]], [[3ui0\|3ui0]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3uhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uhe OCA], [~~http~~://pdbe.org/3uhe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3uhe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3uhe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3uhe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uhe OCA], [https://pdbe.org/3uhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uhe RCSB], [https://www.ebi.ac.uk/pdbsum/3uhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uhe ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:41, 14 August 2019

OCA — Wed, 14 Aug 2019 17:41:21 GMT

←Older revision		Revision as of 17:41, 14 August 2019
Line 1:		Line 1:

	==HBI (M37V,L73I) CO bound==		==HBI (M37V,L73I) CO bound==
-	<StructureSection load='3uhe' size='340' side='right' caption='[[3uhe]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3uhe' size='340' side='right'caption='[[3uhe]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3uhe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UHE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3uhe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UHE FirstGlance]. <br>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Anain]]		[[Category: Anain]]
		+	[[Category: Large Structures]]
	[[Category: Knapp, J E]]		[[Category: Knapp, J E]]
	[[Category: Ren, Z]]		[[Category: Ren, Z]]

OCA at 18:55, 10 December 2016

OCA — Sat, 10 Dec 2016 18:55:23 GMT

←Older revision		Revision as of 18:55, 10 December 2016
Line 1:		Line 1:
		+
	==HBI (M37V,L73I) CO bound==		==HBI (M37V,L73I) CO bound==
	<StructureSection load='3uhe' size='340' side='right' caption='[[3uhe]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3uhe' size='340' side='right' caption='[[3uhe]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uhe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Scapharca_inaequivalvis Scapharca inaequivalvis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UHE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uhe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UHE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[4sdh\|4sdh]], [[3ugy\|3ugy]], [[3ugz\|3ugz]], [[3uh3\|3uh3]], [[3uh5\|3uh5]], [[3uh6\|3uh6]], [[3uh7\|3uh7]], [[3uhb\|3uhb]], [[3uhc\|3uhc]], [[3uhd\|3uhd]], [[3uhg\|3uhg]], [[3uhh\|3uhh]], [[3uhi\|3uhi]], [[3uhk\|3uhk]], [[3uhn\|3uhn]], [[3uhq\|3uhq]], [[3uhr\|3uhr]], [[3uhs\|3uhs]], [[3uht\|3uht]], [[3uhu\|3uhu]], [[3uhv\|3uhv]], [[3uhw\|3uhw]], [[3uhx\|3uhx]], [[3uhy\|3uhy]], [[3uhz\|3uhz]], [[3ui0\|3ui0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[4sdh\|4sdh]], [[3ugy\|3ugy]], [[3ugz\|3ugz]], [[3uh3\|3uh3]], [[3uh5\|3uh5]], [[3uh6\|3uh6]], [[3uh7\|3uh7]], [[3uhb\|3uhb]], [[3uhc\|3uhc]], [[3uhd\|3uhd]], [[3uhg\|3uhg]], [[3uhh\|3uhh]], [[3uhi\|3uhi]], [[3uhk\|3uhk]], [[3uhn\|3uhn]], [[3uhq\|3uhq]], [[3uhr\|3uhr]], [[3uhs\|3uhs]], [[3uht\|3uht]], [[3uhu\|3uhu]], [[3uhv\|3uhv]], [[3uhw\|3uhw]], [[3uhx\|3uhx]], [[3uhy\|3uhy]], [[3uhz\|3uhz]], [[3ui0\|3ui0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uhe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uhe RCSB], [http://www.ebi.ac.uk/pdbsum/3uhe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uhe OCA], [http://pdbe.org/3uhe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uhe RCSB], [http://www.ebi.ac.uk/pdbsum/3uhe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uhe ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3uhe" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Scapharca inaequivalvis~~]]	+	[[Category: Anain]]
	[[Category: Knapp, J E]]		[[Category: Knapp, J E]]
	[[Category: Ren, Z]]		[[Category: Ren, Z]]

OCA at 16:26, 9 December 2014

OCA — Tue, 09 Dec 2014 16:26:07 GMT

←Older revision		Revision as of 16:26, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3uhe.~~png~~\|~~left~~\|~~200px~~]]	+	==HBI (M37V,L73I) CO bound==
		+	<StructureSection load='3uhe' size='340' side='right' caption='[[3uhe]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3uhe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UHE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sdh\|3sdh]], [[4sdh\|4sdh]], [[3ugy\|3ugy]], [[3ugz\|3ugz]], [[3uh3\|3uh3]], [[3uh5\|3uh5]], [[3uh6\|3uh6]], [[3uh7\|3uh7]], [[3uhb\|3uhb]], [[3uhc\|3uhc]], [[3uhd\|3uhd]], [[3uhg\|3uhg]], [[3uhh\|3uhh]], [[3uhi\|3uhi]], [[3uhk\|3uhk]], [[3uhn\|3uhn]], [[3uhq\|3uhq]], [[3uhr\|3uhr]], [[3uhs\|3uhs]], [[3uht\|3uht]], [[3uhu\|3uhu]], [[3uhv\|3uhv]], [[3uhw\|3uhw]], [[3uhx\|3uhx]], [[3uhy\|3uhy]], [[3uhz\|3uhz]], [[3ui0\|3ui0]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uhe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uhe RCSB], [http://www.ebi.ac.uk/pdbsum/3uhe PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Here we present a meta-analysis of a large collection of static structures of a protein in the Protein Data Bank in order to extract the progression of structural events during protein function. We apply this strategy to the homodimeric hemoglobin HbI from Scapharca inaequivalvis. We derive a simple dynamic model describing how binding of the first ligand in one of the two chemically identical subunits facilitates a second binding event in the other partner subunit. The results of our ultrafast time-resolved crystallographic studies support this model. We demonstrate that HbI functions like a homodimeric mechanical device, such as pliers or scissors. Ligand-induced motion originating in one subunit is transmitted to the other via conserved pivot points, where the E and F' helices from two partner subunits are "bolted" together to form a stable dimer interface permitting slight relative rotation but preventing sliding.

-	~~{{STRUCTURE_3uhe\| PDB=3uhe \| SCENE= }}~~	+	Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures.,Ren Z, Srajer V, Knapp JE, Royer WE Jr Proc Natl Acad Sci U S A. 2011 Dec 14. PMID:22171006<ref>PMID:22171006</ref>

-	~~===HBI (M37V~~,~~L73I) CO bound===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22171006}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3uhe]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA].~~	+

	==See Also==		==See Also==
-	*[[Hemoglobin\|Hemoglobin]]	+	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022171006<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Scapharca inaequivalvis]]		[[Category: Scapharca inaequivalvis]]
-	[[Category: Knapp, J E.]]	+	[[Category: Knapp, J E]]
-	[[Category: Ren, Z.]]	+	[[Category: Ren, Z]]
-	[[Category: Royer, W E.]]	+	[[Category: Royer, W E]]
-	[[Category: Srajer, V.]]	+	[[Category: Srajer, V]]
	[[Category: Allostery]]		[[Category: Allostery]]
	[[Category: Oxygen binding]]		[[Category: Oxygen binding]]
	[[Category: Oxygen storage]]		[[Category: Oxygen storage]]
	[[Category: Oxygen transport]]		[[Category: Oxygen transport]]

OCA at 22:21, 20 October 2012

OCA — Sat, 20 Oct 2012 22:21:03 GMT

←Older revision		Revision as of 22:21, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3uhe]] is a 2 chain structure ~~of [[Hemoglobin]]~~ with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA].	+	[[3uhe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA].

	==See Also==		==See Also==

OCA at 16:00, 27 July 2012

OCA — Fri, 27 Jul 2012 16:00:49 GMT

←Older revision		Revision as of 16:00, 27 July 2012
Line 1:		Line 1:
	[[Image:3uhe.png\|left\|200px]]		[[Image:3uhe.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3uhe", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3uhe\| PDB=3uhe \| SCENE= }}		{{STRUCTURE_3uhe\| PDB=3uhe \| SCENE= }}

	===HBI (M37V,L73I) CO bound===		===HBI (M37V,L73I) CO bound===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22171006}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22171006 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22171006}}		{{ABSTRACT_PUBMED_22171006}}

	==About this Structure==		==About this Structure==
-	[[3uhe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA].	+	[[3uhe]] is a 2 chain structure of [[Hemoglobin]] with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA].
		+
		+	==See Also==
		+	*[[Hemoglobin\|Hemoglobin]]

	==Reference==		==Reference==

OCA at 09:32, 18 January 2012

OCA — Wed, 18 Jan 2012 09:32:20 GMT

←Older revision		Revision as of 09:32, 18 January 2012
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-	[[Image:3uhe.~~jpg~~\|left\|200px]]	+	[[Image:3uhe.png\|left\|200px]]

	<!--		<!--

OCA at 07:16, 28 December 2011

OCA — Wed, 28 Dec 2011 07:16:40 GMT

←Older revision		Revision as of 07:16, 28 December 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3uhe.jpg\|left\|200px]]

-	The ~~entry 3uhe~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3uhe", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3uhe\| PDB=3uhe \| SCENE= }}

-	~~Authors: Ren~~, ~~Z., Srajer, V., Knapp, J.E., Royer Jr., W.E.~~	+	===HBI (M37V,L73I) CO bound===

-	~~Description: HBI (M37V~~,~~L73I~~) ~~CO bound~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22171006}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22171006 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22171006}}
		+
		+	==About this Structure==
		+	[[3uhe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022171006</ref><references group="xtra"/>
		+	[[Category: Scapharca inaequivalvis]]
		+	[[Category: Knapp, J E.]]
		+	[[Category: Ren, Z.]]
		+	[[Category: Royer, W E.]]
		+	[[Category: Srajer, V.]]
		+	[[Category: Allostery]]
		+	[[Category: Oxygen binding]]
		+	[[Category: Oxygen storage]]
		+	[[Category: Oxygen transport]]

OCA at 18:36, 23 November 2011

OCA — Wed, 23 Nov 2011 18:36:47 GMT

←Older revision		Revision as of 18:36, 23 November 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3uhe is ON HOLD	+	The entry 3uhe is ON HOLD until Paper Publication

-	Authors: ~~REN~~, Z., Srajer, V., ~~KNAPP~~, J.E., ~~ROYER JR~~., W.E.	+	Authors: Ren, Z., Srajer, V., Knapp, J.E., Royer Jr., W.E.

-	Description: HBI (M37V,L73I) CO ~~BOUND~~	+	Description: HBI (M37V,L73I) CO bound