3ui7 - Revision history

OCA at 10:23, 1 March 2024

OCA — Fri, 01 Mar 2024 10:23:49 GMT

←Older revision		Revision as of 10:23, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3ui7' size='340' side='right'caption='[[3ui7]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='3ui7' size='340' side='right'caption='[[3ui7]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ui7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UI7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ui7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UI7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1L:6-METHOXY-3,8-DIMETHYL-4-(MORPHOLIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>C1L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.28Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1L:6-METHOXY-3,8-DIMETHYL-4-(MORPHOLIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>C1L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ui7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ui7 OCA], [https://pdbe.org/3ui7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ui7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ui7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ui7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ui7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ui7 OCA], [https://pdbe.org/3ui7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ui7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ui7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ui7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>	+	[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	A series of pyrazoloquinoline analogs have been synthesized and shown to bind to PDE10 with high affinity. From the SAR study and our lead optimization efforts, compounds 16 and 27 were found to possess potent oral antipsychotic activity in the MK-801 induced hyperactive rat model.	+
-		+
-	Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.,Yang SW, Smotryski J, McElroy WT, Tan Z, Ho G, Tulshian D, Greenlee WJ, Guzzi M, Zhang X, Mullins D, Xiao L, Hruza A, Chan TM, Rindgen D, Bleickardt C, Hodgson R Bioorg Med Chem Lett. 2011 Nov 16. PMID:22142545<ref>PMID:22142545</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3ui7" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 26:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Greenlee~~, W J~~]]	+	[[Category: Greenlee WJ]]
-	[[Category: Ho, G]]	+	[[Category: Ho G]]
-	[[Category: Hodgson, R]]	+	[[Category: Hodgson R]]
-	[[Category: Hruza, A]]	+	[[Category: Hruza A]]
-	[[Category: Mcelroy, W]]	+	[[Category: Mcelroy W]]
-	[[Category: Smotryski, J]]	+	[[Category: Smotryski J]]
-	[[Category: Tulshian, D]]	+	[[Category: Tulshian D]]
-	[[Category: Xiao, L]]	+	[[Category: Xiao L]]
-	[[Category: Yang, S]]	+	[[Category: Yang S]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inhibitor complex]]~~	+
-	~~[[Category: Mg binding]]~~	+
-	~~[[Category: Zn binding~~]]	+

OCA at 07:37, 20 July 2022

OCA — Wed, 20 Jul 2022 07:37:07 GMT

←Older revision		Revision as of 07:37, 20 July 2022
Line 1:		Line 1:

	==Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia==		==Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia==
-	<StructureSection load='3ui7' size='340' side='right' caption='[[3ui7]], [[Resolution\|resolution]] 2.28Å' scene=''>	+	<StructureSection load='3ui7' size='340' side='right'caption='[[3ui7]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ui7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UI7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ui7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UI7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1L:6-METHOXY-3,8-DIMETHYL-4-(MORPHOLIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>C1L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1L:6-METHOXY-3,8-DIMETHYL-4-(MORPHOLIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>C1L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ui7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ui7 OCA], [~~http~~://pdbe.org/3ui7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ui7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ui7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ui7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ui7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ui7 OCA], [https://pdbe.org/3ui7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ui7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ui7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ui7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>	+	[[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]	+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Greenlee, W J]]		[[Category: Greenlee, W J]]
	[[Category: Ho, G]]		[[Category: Ho, G]]

OCA at 22:03, 4 August 2016

OCA — Thu, 04 Aug 2016 22:03:00 GMT

←Older revision		Revision as of 22:03, 4 August 2016
Line 1:		Line 1:
		+
	==Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia==		==Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia==
	<StructureSection load='3ui7' size='340' side='right' caption='[[3ui7]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='3ui7' size='340' side='right' caption='[[3ui7]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ui7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UI7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ui7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UI7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1L:6-METHOXY-3,8-DIMETHYL-4-(MORPHOLIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>C1L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1L:6-METHOXY-3,8-DIMETHYL-4-(MORPHOLIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>C1L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ui7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ui7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ui7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ui7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ui7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ui7 OCA], [http://pdbe.org/3ui7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ui7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ui7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ui7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ui7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Greenlee, W J]]		[[Category: Greenlee, W J]]
	[[Category: Ho, G]]		[[Category: Ho, G]]

OCA at 20:04, 24 December 2014

OCA — Wed, 24 Dec 2014 20:04:09 GMT

←Older revision		Revision as of 20:04, 24 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3ui7.~~png~~\|~~left~~\|~~200px~~]]	+	==Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia==
		+	<StructureSection load='3ui7' size='340' side='right' caption='[[3ui7]], [[Resolution\|resolution]] 2.28Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ui7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UI7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1L:6-METHOXY-3,8-DIMETHYL-4-(MORPHOLIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>C1L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ui7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ui7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ui7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ui7 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A series of pyrazoloquinoline analogs have been synthesized and shown to bind to PDE10 with high affinity. From the SAR study and our lead optimization efforts, compounds 16 and 27 were found to possess potent oral antipsychotic activity in the MK-801 induced hyperactive rat model.

-	~~{{STRUCTURE_3ui7\| PDB=3ui7 \| SCENE= }}~~	+	Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.,Yang SW, Smotryski J, McElroy WT, Tan Z, Ho G, Tulshian D, Greenlee WJ, Guzzi M, Zhang X, Mullins D, Xiao L, Hruza A, Chan TM, Rindgen D, Bleickardt C, Hodgson R Bioorg Med Chem Lett. 2011 Nov 16. PMID:22142545<ref>PMID:22142545</ref>

-	~~===Discovery~~ of ~~orally active pyrazoloquinoline as a potent PDE10 inhibitor for~~ the ~~management of schizophrenia===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22142545}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ui7]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA].~~	+

	==See Also==		==See Also==
	*[[Phosphodiesterase\|Phosphodiesterase]]		*[[Phosphodiesterase\|Phosphodiesterase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022142545<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Greenlee, W J.]]	+	[[Category: Greenlee, W J]]
-	[[Category: Ho, G.]]	+	[[Category: Ho, G]]
-	[[Category: Hodgson, R.]]	+	[[Category: Hodgson, R]]
-	[[Category: Hruza, A.]]	+	[[Category: Hruza, A]]
-	[[Category: Mcelroy, W.]]	+	[[Category: Mcelroy, W]]
-	[[Category: Smotryski, J.]]	+	[[Category: Smotryski, J]]
-	[[Category: Tulshian, D.]]	+	[[Category: Tulshian, D]]
-	[[Category: Xiao, L.]]	+	[[Category: Xiao, L]]
-	[[Category: Yang, S.]]	+	[[Category: Yang, S]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 08:40, 20 October 2012

OCA — Sat, 20 Oct 2012 08:40:03 GMT

←Older revision		Revision as of 08:40, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ui7]] is a 2 chain structure ~~of [[Phosphodiesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA].	+	[[3ui7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA].

	==See Also==		==See Also==

OCA at 20:22, 25 July 2012

OCA — Wed, 25 Jul 2012 20:22:15 GMT

←Older revision		Revision as of 20:22, 25 July 2012
Line 1:		Line 1:
	[[Image:3ui7.png\|left\|200px]]		[[Image:3ui7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ui7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ui7\| PDB=3ui7 \| SCENE= }}		{{STRUCTURE_3ui7\| PDB=3ui7 \| SCENE= }}

	===Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia===		===Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22142545}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22142545 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_22142545}}		{{ABSTRACT_PUBMED_22142545}}

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	==See Also==		==See Also==
-	*[[Phosphodiesterase]]	+	*[[Phosphodiesterase\|Phosphodiesterase]]

	==Reference==		==Reference==

OCA at 05:38, 11 January 2012

OCA — Wed, 11 Jan 2012 05:38:26 GMT

←Older revision		Revision as of 05:38, 11 January 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3ui7.png\|left\|200px]]

-	The ~~entry 3ui7~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ui7", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ui7\| PDB=3ui7 \| SCENE= }}

-	~~Authors: Yang, S., Smotryski, J., Mcelroy, W., Ho, G., Tulshian, D., Greenlee, W.J., Hodgson, R., Xiao, L., Hruza, A.~~	+	===Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia===

-	~~Description: Discovery of orally active pyrazoloquinoline~~ as ~~a potent PDE10 inhibitor for~~ the ~~management~~ of ~~schizophrenia~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22142545}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22142545 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22142545}}
		+
		+	==About this Structure==
		+	[[3ui7]] is a 2 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA].
		+
		+	==See Also==
		+	*[[Phosphodiesterase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022142545</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Greenlee, W J.]]
		+	[[Category: Ho, G.]]
		+	[[Category: Hodgson, R.]]
		+	[[Category: Hruza, A.]]
		+	[[Category: Mcelroy, W.]]
		+	[[Category: Smotryski, J.]]
		+	[[Category: Tulshian, D.]]
		+	[[Category: Xiao, L.]]
		+	[[Category: Yang, S.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Inhibitor complex]]
		+	[[Category: Mg binding]]
		+	[[Category: Zn binding]]

OCA at 07:35, 7 December 2011

OCA — Wed, 07 Dec 2011 07:35:21 GMT

←Older revision		Revision as of 07:35, 7 December 2011
Line 3:		Line 3:
	The entry 3ui7 is ON HOLD		The entry 3ui7 is ON HOLD

-	Authors: Yang, S., Smotryski, J., Mcelroy, W., Ho, G., Tulshian, D., Greenlee, W. J., Hodgson, R., Xiao, L., Hruza, A.	+	Authors: Yang, S., Smotryski, J., Mcelroy, W., Ho, G., Tulshian, D., Greenlee, W.J., Hodgson, R., Xiao, L., Hruza, A.

	Description: Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia		Description: Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia

OCA: Protected "3ui7" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2011 11:53:54 GMT

Protected "3ui7" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:53, 16 November 2011

OCA: New page: '''Unreleased structure''' The entry 3ui7 is ON HOLD Authors: Yang, S., Smotryski, J., Mcelroy, W., Ho, G., Tulshian, D., Greenlee, W. J., Hodgson, R., Xiao, L., Hruza, A. Description:...

OCA — Wed, 16 Nov 2011 11:53:53 GMT

New page: '''Unreleased structure''' The entry 3ui7 is ON HOLD Authors: Yang, S., Smotryski, J., Mcelroy, W., Ho, G., Tulshian, D., Greenlee, W. J., Hodgson, R., Xiao, L., Hruza, A. Description:...

New page

'''Unreleased structure'''

The entry 3ui7 is ON HOLD

Authors: Yang, S., Smotryski, J., Mcelroy, W., Ho, G., Tulshian, D., Greenlee, W. J., Hodgson, R., Xiao, L., Hruza, A.

Description: Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia