3uot - Revision history

OCA at 07:53, 20 July 2022

OCA — Wed, 20 Jul 2022 07:53:59 GMT

←Older revision		Revision as of 07:53, 20 July 2022
Line 1:		Line 1:

	==Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus==		==Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus==
-	<StructureSection load='3uot' size='340' side='right' caption='[[3uot]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3uot' size='340' side='right'caption='[[3uot]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uot]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UOT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uot]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UOT FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3un0\|3un0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3un0\|3un0]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDC1, KIAA0170, NFBD1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDC1, KIAA0170, NFBD1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3uot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uot OCA], [~~http~~://pdbe.org/3uot PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3uot RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3uot PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3uot ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uot OCA], [https://pdbe.org/3uot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uot RCSB], [https://www.ebi.ac.uk/pdbsum/3uot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uot ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MDC1_HUMAN MDC1_HUMAN]] Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.<ref>PMID:14695167</ref> <ref>PMID:12475977</ref> <ref>PMID:12499369</ref> <ref>PMID:12551934</ref> <ref>PMID:12611903</ref> <ref>PMID:12607003</ref> <ref>PMID:12607004</ref> <ref>PMID:12607005</ref> <ref>PMID:15201865</ref> <ref>PMID:15377652</ref>	+	[[https://www.uniprot.org/uniprot/MDC1_HUMAN MDC1_HUMAN]] Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.<ref>PMID:14695167</ref> <ref>PMID:12475977</ref> <ref>PMID:12499369</ref> <ref>PMID:12551934</ref> <ref>PMID:12611903</ref> <ref>PMID:12607003</ref> <ref>PMID:12607004</ref> <ref>PMID:12607005</ref> <ref>PMID:15201865</ref> <ref>PMID:15377652</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Clapperton, J A]]		[[Category: Clapperton, J A]]
	[[Category: Haire, L F]]		[[Category: Haire, L F]]

OCA at 05:55, 5 August 2016

OCA — Fri, 05 Aug 2016 05:55:10 GMT

←Older revision		Revision as of 05:55, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus==		==Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus==
	<StructureSection load='3uot' size='340' side='right' caption='[[3uot]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3uot' size='340' side='right' caption='[[3uot]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UOT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UOT FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3un0\|3un0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3un0\|3un0]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDC1, KIAA0170, NFBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDC1, KIAA0170, NFBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uot RCSB], [http://www.ebi.ac.uk/pdbsum/3uot PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uot OCA], [http://pdbe.org/3uot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uot RCSB], [http://www.ebi.ac.uk/pdbsum/3uot PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uot ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3uot" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Clapperton, J A]]		[[Category: Clapperton, J A]]
	[[Category: Haire, L F]]		[[Category: Haire, L F]]

OCA at 23:35, 24 December 2014

OCA — Wed, 24 Dec 2014 23:35:05 GMT

←Older revision		Revision as of 23:35, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3uot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UOT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3uot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UOT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3un0\|3un0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3un0\|3un0]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDC1, KIAA0170, NFBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDC1, KIAA0170, NFBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uot RCSB], [http://www.ebi.ac.uk/pdbsum/3uot PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uot RCSB], [http://www.ebi.ac.uk/pdbsum/3uot PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MDC1_HUMAN MDC1_HUMAN]] Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.<ref>PMID:14695167</ref> <ref>PMID:12475977</ref> <ref>PMID:12499369</ref> <ref>PMID:12551934</ref> <ref>PMID:12611903</ref> <ref>PMID:12607003</ref> <ref>PMID:12607004</ref> <ref>PMID:12607005</ref> <ref>PMID:15201865</ref> <ref>PMID:15377652</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.,Jungmichel S, Clapperton JA, Lloyd J, Hari FJ, Spycher C, Pavic L, Li J, Haire LF, Bonalli M, Larsen DH, Lukas C, Lukas J, MacMillan D, Nielsen ML, Stucki M, Smerdon SJ Nucleic Acids Res. 2012 May;40(9):3913-28. Epub 2012 Jan 10. PMID:22234878<ref>PMID:22234878</ref>		The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.,Jungmichel S, Clapperton JA, Lloyd J, Hari FJ, Spycher C, Pavic L, Li J, Haire LF, Bonalli M, Larsen DH, Lukas C, Lukas J, MacMillan D, Nielsen ML, Stucki M, Smerdon SJ Nucleic Acids Res. 2012 May;40(9):3913-28. Epub 2012 Jan 10. PMID:22234878<ref>PMID:22234878</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Clapperton, J A.]]	+	[[Category: Clapperton, J A]]
-	[[Category: Haire, L F.]]	+	[[Category: Haire, L F]]
-	[[Category: Li, J.]]	+	[[Category: Li, J]]
-	[[Category: Lloyd, J.]]	+	[[Category: Lloyd, J]]
-	[[Category: Smerdon, S J.]]	+	[[Category: Smerdon, S J]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Dna-damage]]		[[Category: Dna-damage]]
	[[Category: Fha domain]]		[[Category: Fha domain]]
	[[Category: Mdc1 dimerization]]		[[Category: Mdc1 dimerization]]

OCA at 06:16, 5 June 2014

OCA — Thu, 05 Jun 2014 06:16:46 GMT

←Older revision		Revision as of 06:16, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3uot.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus==
		+	<StructureSection load='3uot' size='340' side='right' caption='[[3uot]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3uot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UOT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3un0\|3un0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDC1, KIAA0170, NFBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uot RCSB], [http://www.ebi.ac.uk/pdbsum/3uot PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mdc1 is a large modular phosphoprotein scaffold that maintains signaling and repair complexes at double-stranded DNA break sites. Mdc1 is anchored to damaged chromatin through interaction of its C-terminal BRCT-repeat domain with the tail of gammaH2AX following DNA damage, but the role of the N-terminal forkhead-associated (FHA) domain remains unclear. We show that a major binding target of the Mdc1 FHA domain is a previously unidentified DNA damage and ATM-dependent phosphorylation site near the N-terminus of Mdc1 itself. Binding to this motif stabilizes a weak self-association of the FHA domain to form a tight dimer. X-ray structures of free and complexed Mdc1 FHA domain reveal a 'head-to-tail' dimerization mechanism that is closely related to that seen in pre-activated forms of the Chk2 DNA damage kinase, and which both positively and negatively influences Mdc1 FHA domain-mediated interactions in human cells prior to and following DNA damage.

-	~~{{STRUCTURE_3uot\| PDB=3uot \| SCENE= }}~~	+	The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.,Jungmichel S, Clapperton JA, Lloyd J, Hari FJ, Spycher C, Pavic L, Li J, Haire LF, Bonalli M, Larsen DH, Lukas C, Lukas J, MacMillan D, Nielsen ML, Stucki M, Smerdon SJ Nucleic Acids Res. 2012 May;40(9):3913-28. Epub 2012 Jan 10. PMID:22234878<ref>PMID:22234878</ref>

-	~~===Crystal Structure~~ of ~~MDC1 FHA Domain in Complex with a Phosphorylated Peptide from~~ the ~~MDC1 N-terminus===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22234878}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3uot]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3UOT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022234878<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Clapperton, J A.]]		[[Category: Clapperton, J A.]]

OCA at 04:27, 18 July 2012

OCA — Wed, 18 Jul 2012 04:27:12 GMT

←Older revision		Revision as of 04:27, 18 July 2012
Line 1:		Line 1:
-	[[Image:3uot.~~jpg~~\|left\|200px]]	+	[[Image:3uot.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3uot", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3uot\| PDB=3uot \| SCENE= }}		{{STRUCTURE_3uot\| PDB=3uot \| SCENE= }}

	===Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus===		===Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus===

		+	{{ABSTRACT_PUBMED_22234878}}

	==About this Structure==		==About this Structure==
	[[3uot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOT OCA].		[[3uot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022234878</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Clapperton, J A.]]		[[Category: Clapperton, J A.]]

OCA at 07:43, 28 December 2011

OCA — Wed, 28 Dec 2011 07:43:28 GMT

←Older revision		Revision as of 07:43, 28 December 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3uot.jpg\|left\|200px]]

-	The ~~entry 3uot~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3uot", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3uot\| PDB=3uot \| SCENE= }}

-	~~Authors: Clapperton, J.A., Lloyd, J., Haire, L.F., Li, J., Smerdon, S.J.~~	+	===Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus===

-	~~Description: Crystal~~ Structure ~~of MDC1 FHA Domain in Complex with~~ a ~~Phosphorylated Peptide~~ from ~~the MDC1 N~~-~~terminus~~	+
		+	==About this Structure==
		+	[[3uot]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOT OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Clapperton, J A.]]
		+	[[Category: Haire, L F.]]
		+	[[Category: Li, J.]]
		+	[[Category: Lloyd, J.]]
		+	[[Category: Smerdon, S J.]]
		+	[[Category: Cell cycle]]
		+	[[Category: Dna-damage]]
		+	[[Category: Fha domain]]
		+	[[Category: Mdc1 dimerization]]

OCA: Protected "3uot" [edit=sysop:move=sysop]

OCA — Wed, 23 Nov 2011 18:41:54 GMT

Protected "3uot" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:41, 23 November 2011

OCA: New page: '''Unreleased structure''' The entry 3uot is ON HOLD Authors: Clapperton, J.A., Lloyd, J., Haire, L.F., Li, J., Smerdon, S.J. Description: Crystal Structure of MDC1 FHA Domain in Compl...

OCA — Wed, 23 Nov 2011 18:41:53 GMT

New page: '''Unreleased structure''' The entry 3uot is ON HOLD Authors: Clapperton, J.A., Lloyd, J., Haire, L.F., Li, J., Smerdon, S.J. Description: Crystal Structure of MDC1 FHA Domain in Compl...

New page

'''Unreleased structure'''

The entry 3uot is ON HOLD

Authors: Clapperton, J.A., Lloyd, J., Haire, L.F., Li, J., Smerdon, S.J.

Description: Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus