3up0 - Revision history

OCA at 10:25, 1 March 2024

OCA — Fri, 01 Mar 2024 10:25:39 GMT

←Older revision		Revision as of 10:25, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3up0' size='340' side='right'caption='[[3up0]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3up0' size='340' side='right'caption='[[3up0]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3up0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UP0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3up0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UP0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=D7S:(5BETA~~,~~14BETA,17ALPHA,25S)-3-OXOCHOLEST-7-EN-26-OIC+ACID'>D7S</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3up3\|3up3]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D7S:(5BETA,14BETA,17ALPHA,25S)-3-OXOCHOLEST-7-EN-26-OIC+ACID'>D7S</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">daf-12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53326 Ancylostoma ceylanicum])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3up0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3up0 OCA], [https://pdbe.org/3up0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3up0 RCSB], [https://www.ebi.ac.uk/pdbsum/3up0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3up0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3up0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3up0 OCA], [https://pdbe.org/3up0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3up0 RCSB], [https://www.ebi.ac.uk/pdbsum/3up0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3up0 ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~NCOA2_HUMAN NCOA2_HUMAN~~]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>	+	[https://www.uniprot.org/uniprot/H0USY8_9BILA H0USY8_9BILA]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Bile acid-like molecules named dafachronic acids (DAs) control the dauer formation program in C. elegans through the nuclear receptor DAF-12. This mechanism is conserved in parasitic nematodes to regulate their dauer-like infective larvae stage and as such the DAF-12 ligand binding domain (LBD) has been identified as an important therapeutic target in human parasitic hookworm species that infect more than 600 million people worldwide. Here, we report two X-ray crystal structures of the hookworm Ancylostoma ceylanicum DAF-12 LBD in complex with DA and cholestenoic acid (a bile acid-like metabolite), respectively. Structure analysis and functional studies reveal key residues responsible for species-specific ligand responses of DAF-12. Furthermore, DA binds to DAF-12 mechanistically and structurally similar to bile acids binding to the mammalian bile acid receptor FXR. Activation of DAF-12 by cholestenoic acid and the cholestenoic acid complex structure suggest that bile acid-like signaling pathways have been conserved in nematodes and mammals. Together, these results reveal the molecular mechanism for the interplay between parasite and host, provide a structural framework for DAF-12 as a promising target in treating nematode parasitism, and provide insight into the evolution of gut parasite hormone signaling pathways.	+
-		+
-	Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes.,Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, Xu HE J Biol Chem. 2011 Dec 21. PMID:22170062<ref>PMID:22170062</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3up0" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Ancylostoma ceylanicum]]		[[Category: Ancylostoma ceylanicum]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gelmedin, V]]	+	[[Category: Gelmedin V]]
-	[[Category: Hawdon, J]]	+	[[Category: Hawdon J]]
-	[[Category: Kliewer~~, S A~~]]	+	[[Category: Kliewer SA]]
-	[[Category: Mangelsdorf~~, D J~~]]	+	[[Category: Mangelsdorf DJ]]
-	[[Category: Melcher, K]]	+	[[Category: Melcher K]]
-	[[Category: Motola~~, D L~~]]	+	[[Category: Motola DL]]
-	[[Category: Xu~~, H E~~]]	+	[[Category: Xu HE]]
-	[[Category: Zhi, X]]	+	[[Category: Zhi X]]
-	[[Category: Zhou~~, X E]]~~	+	[[Category: Zhou XE]]
-	~~[[Category: Nematode]]~~	+
-	~~[[Category: Steroid binding protein-transcription complex~~]]	+

OCA at 07:54, 20 July 2022

OCA — Wed, 20 Jul 2022 07:54:29 GMT

←Older revision		Revision as of 07:54, 20 July 2022
Line 1:		Line 1:

	==Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid==		==Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid==
-	<StructureSection load='3up0' size='340' side='right' caption='[[3up0]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3up0' size='340' side='right'caption='[[3up0]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3up0]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UP0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UP0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3up0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UP0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D7S:(5BETA,14BETA,17ALPHA,25S)-3-OXOCHOLEST-7-EN-26-OIC+ACID'>D7S</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D7S:(5BETA,14BETA,17ALPHA,25S)-3-OXOCHOLEST-7-EN-26-OIC+ACID'>D7S</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3up3\|3up3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3up3\|3up3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">daf-12 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53326 Ancylostoma ceylanicum])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">daf-12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53326 Ancylostoma ceylanicum])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3up0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3up0 OCA], [~~http~~://pdbe.org/3up0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3up0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3up0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3up0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3up0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3up0 OCA], [https://pdbe.org/3up0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3up0 RCSB], [https://www.ebi.ac.uk/pdbsum/3up0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3up0 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.	+	[[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>	+	[[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Ancylostoma ceylanicum]]		[[Category: Ancylostoma ceylanicum]]
		+	[[Category: Large Structures]]
	[[Category: Gelmedin, V]]		[[Category: Gelmedin, V]]
	[[Category: Hawdon, J]]		[[Category: Hawdon, J]]

OCA at 08:53, 4 August 2016

OCA — Thu, 04 Aug 2016 08:53:02 GMT

←Older revision		Revision as of 08:53, 4 August 2016
Line 1:		Line 1:
		+
	==Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid==		==Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid==
	<StructureSection load='3up0' size='340' side='right' caption='[[3up0]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3up0' size='340' side='right' caption='[[3up0]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3up3\|3up3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3up3\|3up3]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">daf-12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53326 Ancylostoma ceylanicum])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">daf-12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53326 Ancylostoma ceylanicum])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3up0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3up0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3up0 RCSB], [http://www.ebi.ac.uk/pdbsum/3up0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3up0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3up0 OCA], [http://pdbe.org/3up0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3up0 RCSB], [http://www.ebi.ac.uk/pdbsum/3up0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3up0 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3up0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:58, 21 December 2014

OCA — Sun, 21 Dec 2014 06:58:45 GMT

←Older revision		Revision as of 06:58, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3up0\| PDB=3up0 \| SCENE= }}~~	+	==Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid==
-	===Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid===	+	<StructureSection load='3up0' size='340' side='right' caption='[[3up0]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22170062}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3up0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UP0 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D7S:(5BETA,14BETA,17ALPHA,25S)-3-OXOCHOLEST-7-EN-26-OIC+ACID'>D7S</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3up3\|3up3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">daf-12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53326 Ancylostoma ceylanicum])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3up0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3up0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3up0 RCSB], [http://www.ebi.ac.uk/pdbsum/3up0 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.		[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bile acid-like molecules named dafachronic acids (DAs) control the dauer formation program in C. elegans through the nuclear receptor DAF-12. This mechanism is conserved in parasitic nematodes to regulate their dauer-like infective larvae stage and as such the DAF-12 ligand binding domain (LBD) has been identified as an important therapeutic target in human parasitic hookworm species that infect more than 600 million people worldwide. Here, we report two X-ray crystal structures of the hookworm Ancylostoma ceylanicum DAF-12 LBD in complex with DA and cholestenoic acid (a bile acid-like metabolite), respectively. Structure analysis and functional studies reveal key residues responsible for species-specific ligand responses of DAF-12. Furthermore, DA binds to DAF-12 mechanistically and structurally similar to bile acids binding to the mammalian bile acid receptor FXR. Activation of DAF-12 by cholestenoic acid and the cholestenoic acid complex structure suggest that bile acid-like signaling pathways have been conserved in nematodes and mammals. Together, these results reveal the molecular mechanism for the interplay between parasite and host, provide a structural framework for DAF-12 as a promising target in treating nematode parasitism, and provide insight into the evolution of gut parasite hormone signaling pathways.

-	~~==Function==~~	+	Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes.,Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, Xu HE J Biol Chem. 2011 Dec 21. PMID:22170062<ref>PMID:22170062</ref>
-	~~[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator~~ of ~~the steroid~~ binding ~~domain (AF~~-~~2) but not of the modulating N-terminal domain (AF-1)~~. ~~Required with NCOA1 to control energy balance between white and brown adipose tissues~~.<ref>PMID:~~9430642~~</ref>	+
-		+
-	~~==About this Structure==~~	+
-	[[3up0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UP0 OCA].	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:022170062</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Ancylostoma ceylanicum]]		[[Category: Ancylostoma ceylanicum]]
-	[[Category: Gelmedin, V.]]	+	[[Category: Gelmedin, V]]
-	[[Category: Hawdon, J.]]	+	[[Category: Hawdon, J]]
-	[[Category: Kliewer, S A.]]	+	[[Category: Kliewer, S A]]
-	[[Category: Mangelsdorf, D J.]]	+	[[Category: Mangelsdorf, D J]]
-	[[Category: Melcher, K.]]	+	[[Category: Melcher, K]]
-	[[Category: Motola, D L.]]	+	[[Category: Motola, D L]]
-	[[Category: Xu, H E.]]	+	[[Category: Xu, H E]]
-	[[Category: Zhi, X.]]	+	[[Category: Zhi, X]]
-	[[Category: Zhou, X E.]]	+	[[Category: Zhou, X E]]
	[[Category: Nematode]]		[[Category: Nematode]]
	[[Category: Steroid binding protein-transcription complex]]		[[Category: Steroid binding protein-transcription complex]]

OCA at 11:03, 24 March 2013

OCA — Sun, 24 Mar 2013 11:03:38 GMT

←Older revision		Revision as of 11:03, 24 March 2013
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	{{STRUCTURE_3up0\| PDB=3up0 \| SCENE= }}		{{STRUCTURE_3up0\| PDB=3up0 \| SCENE= }}
-
	===Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid===		===Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid===
		+	{{ABSTRACT_PUBMED_22170062}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22170062}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 22170062 is~~ the ~~PubMed ID number.~~	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_22170062}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022170062</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022170062</ref><references group="xtra"/><references/>
	[[Category: Ancylostoma ceylanicum]]		[[Category: Ancylostoma ceylanicum]]
	[[Category: Gelmedin, V.]]		[[Category: Gelmedin, V.]]

OCA at 05:38, 11 January 2012

OCA — Wed, 11 Jan 2012 05:38:38 GMT

←Older revision		Revision as of 05:38, 11 January 2012
Line 1:		Line 1:
-	[[Image:3up0.~~jpg~~\|left\|200px]]	+	[[Image:3up0.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid===		===Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22170062}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22170062 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22170062}}

	==About this Structure==		==About this Structure==
	[[3up0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UP0 OCA].		[[3up0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UP0 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022170062</ref><references group="xtra"/>
	[[Category: Ancylostoma ceylanicum]]		[[Category: Ancylostoma ceylanicum]]
	[[Category: Gelmedin, V.]]		[[Category: Gelmedin, V.]]

OCA at 11:55, 14 December 2011

OCA — Wed, 14 Dec 2011 11:55:51 GMT

←Older revision		Revision as of 11:55, 14 December 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3up0.jpg\|left\|200px]]

-	The ~~entry 3up0~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3up0", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3up0\| PDB=3up0 \| SCENE= }}

-	~~Authors: Zhi, X., Zhou, X.E., Melcher, K., Motola, D.L., Gelmedin, V., Hawdon, J., Kliewer, S.A., Mangelsdorf, D.J., Xu, H.E.~~	+	===Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid===

-	~~Description~~: ~~Nuclear receptor DAF-12~~ from ~~hookworm~~ Ancylostoma ceylanicum ~~in complex with (25S)~~-~~delta7-dafachronic acid~~	+
		+	==About this Structure==
		+	[[3up0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UP0 OCA].
		+	[[Category: Ancylostoma ceylanicum]]
		+	[[Category: Gelmedin, V.]]
		+	[[Category: Hawdon, J.]]
		+	[[Category: Kliewer, S A.]]
		+	[[Category: Mangelsdorf, D J.]]
		+	[[Category: Melcher, K.]]
		+	[[Category: Motola, D L.]]
		+	[[Category: Xu, H E.]]
		+	[[Category: Zhi, X.]]
		+	[[Category: Zhou, X E.]]
		+	[[Category: Nematode]]
		+	[[Category: Steroid binding protein-transcription complex]]

OCA: Protected "3up0" [edit=sysop:move=sysop]

OCA — Wed, 23 Nov 2011 18:42:10 GMT

Protected "3up0" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:42, 23 November 2011

OCA: New page: '''Unreleased structure''' The entry 3up0 is ON HOLD Authors: Zhi, X., Zhou, X.E., Melcher, K., Motola, D.L., Gelmedin, V., Hawdon, J., Kliewer, S.A., Mangelsdorf, D.J., Xu, H.E. Descr...

OCA — Wed, 23 Nov 2011 18:42:08 GMT

New page: '''Unreleased structure''' The entry 3up0 is ON HOLD Authors: Zhi, X., Zhou, X.E., Melcher, K., Motola, D.L., Gelmedin, V., Hawdon, J., Kliewer, S.A., Mangelsdorf, D.J., Xu, H.E. Descr...

New page

'''Unreleased structure'''

The entry 3up0 is ON HOLD

Authors: Zhi, X., Zhou, X.E., Melcher, K., Motola, D.L., Gelmedin, V., Hawdon, J., Kliewer, S.A., Mangelsdorf, D.J., Xu, H.E.

Description: Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid