3utx - Revision history

OCA at 08:06, 20 July 2022

OCA — Wed, 20 Jul 2022 08:06:36 GMT

←Older revision		Revision as of 08:06, 20 July 2022
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	==Crystal structure of bacteriorhodopsin mutant T46A==		==Crystal structure of bacteriorhodopsin mutant T46A==
-	<StructureSection load='3utx' size='340' side='right' caption='[[3utx]], [[Resolution\|resolution]] 2.47Å' scene=''>	+	<StructureSection load='3utx' size='340' side='right'caption='[[3utx]], [[Resolution\|resolution]] 2.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3utx]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Halsa Halsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UTX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3utx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Halsa Halsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UTX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3utv\|3utv]], [[3utw\|3utw]], [[3uty\|3uty]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3utv\|3utv]], [[3utw\|3utw]], [[3uty\|3uty]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bop, VNG_1467G ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=64091 HALSA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bop, VNG_1467G ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=64091 HALSA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3utx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utx OCA], [~~http~~://pdbe.org/3utx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3utx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3utx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3utx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3utx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utx OCA], [https://pdbe.org/3utx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3utx RCSB], [https://www.ebi.ac.uk/pdbsum/3utx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3utx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BACR_HALSA BACR_HALSA]] Light-driven proton pump.	+	[[https://www.uniprot.org/uniprot/BACR_HALSA BACR_HALSA]] Light-driven proton pump.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Bacteriorhodopsin\|Bacteriorhodopsin]]	+	*[[Bacteriorhodopsin 3D structures\|Bacteriorhodopsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Halsa]]		[[Category: Halsa]]
		+	[[Category: Large Structures]]
	[[Category: Bowie, J U]]		[[Category: Bowie, J U]]
	[[Category: Cao, Z]]		[[Category: Cao, Z]]

OCA at 16:50, 4 August 2016

OCA — Thu, 04 Aug 2016 16:50:48 GMT

←Older revision		Revision as of 16:50, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of bacteriorhodopsin mutant T46A==		==Crystal structure of bacteriorhodopsin mutant T46A==
	<StructureSection load='3utx' size='340' side='right' caption='[[3utx]], [[Resolution\|resolution]] 2.47Å' scene=''>		<StructureSection load='3utx' size='340' side='right' caption='[[3utx]], [[Resolution\|resolution]] 2.47Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3utv\|3utv]], [[3utw\|3utw]], [[3uty\|3uty]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3utv\|3utv]], [[3utw\|3utw]], [[3uty\|3uty]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bop, VNG_1467G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=64091 HALSA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bop, VNG_1467G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=64091 HALSA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3utx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3utx RCSB], [http://www.ebi.ac.uk/pdbsum/3utx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3utx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utx OCA], [http://pdbe.org/3utx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3utx RCSB], [http://www.ebi.ac.uk/pdbsum/3utx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3utx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3utx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:13, 24 December 2014

OCA — Wed, 24 Dec 2014 17:13:28 GMT

←Older revision		Revision as of 17:13, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3utx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Halsa Halsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UTX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3utx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Halsa Halsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UTX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3utv\|3utv]], [[3utw\|3utw]], [[3uty\|3uty]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3utv\|3utv]], [[3utw\|3utw]], [[3uty\|3uty]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bop, VNG_1467G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=64091 HALSA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bop, VNG_1467G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=64091 HALSA])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3utx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3utx RCSB], [http://www.ebi.ac.uk/pdbsum/3utx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3utx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3utx RCSB], [http://www.ebi.ac.uk/pdbsum/3utx PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACR_HALSA BACR_HALSA]] Light-driven proton pump.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Halsa]]		[[Category: Halsa]]
-	[[Category: Bowie, J U.]]	+	[[Category: Bowie, J U]]
-	[[Category: Cao, Z.]]	+	[[Category: Cao, Z]]
	[[Category: Ion transport]]		[[Category: Ion transport]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 09:22, 16 July 2014

OCA — Wed, 16 Jul 2014 09:22:29 GMT

←Older revision		Revision as of 09:22, 16 July 2014
Line 1:		Line 1:
-	[[~~Image:~~3utx.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of bacteriorhodopsin mutant T46A==
		+	<StructureSection load='3utx' size='340' side='right' caption='[[3utx]], [[Resolution\|resolution]] 2.47Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3utx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Halsa Halsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UTX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3utv\|3utv]], [[3utw\|3utw]], [[3uty\|3uty]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bop, VNG_1467G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=64091 HALSA])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3utx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3utx RCSB], [http://www.ebi.ac.uk/pdbsum/3utx PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The intricate functions of membrane proteins would not be possible without bends or breaks that are remarkably common in transmembrane helices. The frequent helix distortions are nevertheless surprising because backbone hydrogen bonds should be strong in an apolar membrane, potentially rigidifying helices. It is therefore mysterious how distortions can be generated by the evolutionary currency of random point mutations. Here we show that we can engineer a transition between distinct distorted helix conformations in bacteriorhodopsin with a single-point mutation. Moreover, we estimate the energetic cost of the conformational transitions to be smaller than 1 kcal/mol. We propose that the low energy of distortion is explained in part by the shifting of backbone hydrogen bonding partners. Consistent with this view, extensive backbone hydrogen bond shifts occur during helix conformational changes that accompany functional cycles. Our results explain how evolution has been able to liberally exploit transmembrane helix bending for the optimization of membrane protein structure, function, and dynamics.

-	~~{{STRUCTURE_3utx\| PDB=3utx \| SCENE= }}~~	+	Shifting hydrogen bonds may produce flexible transmembrane helices.,Cao Z, Bowie JU Proc Natl Acad Sci U S A. 2012 May 22;109(21):8121-6. Epub 2012 May 7. PMID:22566663<ref>PMID:22566663</ref>

-	~~===Crystal structure~~ of ~~bacteriorhodopsin mutant T46A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[3utx]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Halobacterium_sp~~. ~~Halobacterium sp.]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3UTX OCA].~~	+

	==See Also==		==See Also==
	*[[Bacteriorhodopsin\|Bacteriorhodopsin]]		*[[Bacteriorhodopsin\|Bacteriorhodopsin]]
-	[[Category: ~~Halobacterium sp.~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Halsa]]
	[[Category: Bowie, J U.]]		[[Category: Bowie, J U.]]
	[[Category: Cao, Z.]]		[[Category: Cao, Z.]]

OCA at 07:26, 20 October 2012

OCA — Sat, 20 Oct 2012 07:26:08 GMT

←Older revision		Revision as of 07:26, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3utx]] is a 2 chain structure ~~of [[Bacteriorhodopsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Halobacterium_sp. Halobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTX OCA].	+	[[3utx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Halobacterium_sp. Halobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTX OCA].

	==See Also==		==See Also==

OCA at 16:18, 25 July 2012

OCA — Wed, 25 Jul 2012 16:18:05 GMT

←Older revision		Revision as of 16:18, 25 July 2012
Line 1:		Line 1:
-	[[Image:3utx.~~jpg~~\|left\|200px]]	+	[[Image:3utx.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3utx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3utx\| PDB=3utx \| SCENE= }}		{{STRUCTURE_3utx\| PDB=3utx \| SCENE= }}

Line 13:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3utx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Halobacterium_sp. Halobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTX OCA].	+	[[3utx]] is a 2 chain structure of [[Bacteriorhodopsin]] with sequence from [http://en.wikipedia.org/wiki/Halobacterium_sp. Halobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTX OCA].
		+
		+	==See Also==
		+	*[[Bacteriorhodopsin\|Bacteriorhodopsin]]
	[[Category: Halobacterium sp.]]		[[Category: Halobacterium sp.]]
	[[Category: Bowie, J U.]]		[[Category: Bowie, J U.]]

OCA at 09:22, 9 May 2012

OCA — Wed, 09 May 2012 09:22:22 GMT

←Older revision		Revision as of 09:22, 9 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3utx.jpg\|left\|200px]]

-	The ~~entry 3utx~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3utx", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3utx\| PDB=3utx \| SCENE= }}

-	~~Authors: Cao, Z., Bowie, J.U.~~	+	===Crystal structure of bacteriorhodopsin mutant T46A===

-	~~Description: Crystal~~ structure ~~of bacteriorhodopsin mutant T46A~~	+
		+	==About this Structure==
		+	[[3utx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Halobacterium_sp. Halobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTX OCA].
		+	[[Category: Halobacterium sp.]]
		+	[[Category: Bowie, J U.]]
		+	[[Category: Cao, Z.]]
		+	[[Category: Ion transport]]
		+	[[Category: Membrane protein]]
		+	[[Category: Photoreceptor protein]]
		+	[[Category: Proton transport]]
		+	[[Category: Retinal protein]]
		+	[[Category: Sensory transduction]]

OCA at 18:44, 2 May 2012

OCA — Wed, 02 May 2012 18:44:10 GMT

←Older revision		Revision as of 18:44, 2 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3utx is ON HOLD	+	The entry 3utx is ON HOLD until Paper Publication

	Authors: Cao, Z., Bowie, J.U.		Authors: Cao, Z., Bowie, J.U.

	Description: Crystal structure of bacteriorhodopsin mutant T46A		Description: Crystal structure of bacteriorhodopsin mutant T46A

OCA at 06:42, 28 December 2011

OCA — Wed, 28 Dec 2011 06:42:58 GMT

←Older revision		Revision as of 06:42, 28 December 2011
Line 5:		Line 5:
	Authors: Cao, Z., Bowie, J.U.		Authors: Cao, Z., Bowie, J.U.

-	Description: ~~CRYSTAL STRUCTURE OF BACTERIORHODOPSIN MUTANT~~ T46A	+	Description: Crystal structure of bacteriorhodopsin mutant T46A

OCA: Protected "3utx" [edit=sysop:move=sysop]

OCA — Wed, 07 Dec 2011 07:38:48 GMT

Protected "3utx" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:38, 7 December 2011