3uv9 - Revision history

OCA at 14:09, 14 March 2024

OCA — Thu, 14 Mar 2024 14:09:14 GMT

←Older revision		Revision as of 14:09, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3uv9' size='340' side='right'caption='[[3uv9]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3uv9' size='340' side='right'caption='[[3uv9]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Macmu Macmu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UV9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UV9 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2lm3\|2lm3]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.549Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">TRIM5 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9544 MACMU])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv9 OCA], [https://pdbe.org/3uv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uv9 RCSB], [https://www.ebi.ac.uk/pdbsum/3uv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv9 OCA], [https://pdbe.org/3uv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uv9 RCSB], [https://www.ebi.ac.uk/pdbsum/3uv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TRIM5_MACMU TRIM5_MACMU]] Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV-agm).<ref>PMID:21734049</ref> <ref>PMID:21035162</ref> <ref>PMID:22291694</ref>	+	[https://www.uniprot.org/uniprot/TRIM5_MACMU TRIM5_MACMU] Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV-agm).<ref>PMID:21734049</ref> <ref>PMID:21035162</ref> <ref>PMID:22291694</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Tripartite motif protein TRIM5alpha blocks retroviral replication after cell entry, and species-specific differences in its activity are determined by sequence variations within the C-terminal B30.2/PRYSPRY domain. Here we report a high-resolution structure of a TRIM5alpha PRYSPRY domain, the PRYSPRY of the rhesus monkey TRIM5alpha that potently restricts HIV infection, and identify features involved in its interaction with the HIV capsid. The extensive capsid-binding interface maps on the structurally divergent face of the protein formed by hypervariable loop segments, confirming that TRIM5alpha evolution is largely determined by its binding specificity. Interactions with the capsid are mediated by flexible variable loops via a mechanism that parallels antigen recognition by IgM antibodies, a similarity that may help explain some of the unusual functional properties of TRIM5alpha. Distinctive features of this pathogen-recognition interface, such as structural plasticity conferred by the mobile v1 segment and interaction with multiple epitopes, may allow restriction of divergent retroviruses and increase resistance to capsid mutations.	+
-		+
-	Structure of the rhesus monkey TRIM5alpha PRYSPRY domain, the HIV capsid recognition module.,Biris N, Yang Y, Taylor AB, Tomashevski A, Guo M, Hart PJ, Diaz-Griffero F, Ivanov DN Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13278-83. doi:, 10.1073/pnas.1203536109. Epub 2012 Jul 30. PMID:22847415<ref>PMID:22847415</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3uv9" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 14:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Macmu~~]]	+	[[Category: Macaca mulatta]]
-	[[Category: Biris, N]]	+	[[Category: Biris N]]
-	[[Category: Diaz-Griffero, F]]	+	[[Category: Diaz-Griffero F]]
-	[[Category: Guo, M]]	+	[[Category: Guo M]]
-	[[Category: Hart~~, P J~~]]	+	[[Category: Hart PJ]]
-	[[Category: Ivanov, D]]	+	[[Category: Ivanov D]]
-	[[Category: Taylor~~, A B~~]]	+	[[Category: Taylor AB]]
-	[[Category: Tomashevskii, A]]	+	[[Category: Tomashevskii A]]
-	[[Category: Yang, Y]]	+	[[Category: Yang Y]]
-	~~[[Category: Antiretroviral]]~~	+
-	~~[[Category: Domain swap]]~~	+
-	~~[[Category: Hiv capsid]]~~	+
-	~~[[Category: Ligase~~]]	+

OCA at 08:09, 20 July 2022

OCA — Wed, 20 Jul 2022 08:09:24 GMT

←Older revision		Revision as of 08:09, 20 July 2022
Line 1:		Line 1:

	==Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain==		==Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain==
-	<StructureSection load='3uv9' size='340' side='right' caption='[[3uv9]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='3uv9' size='340' side='right'caption='[[3uv9]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uv9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UV9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UV9 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lm3\|2lm3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lm3\|2lm3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM5 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3uv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv9 OCA], [~~http~~://pdbe.org/3uv9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3uv9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3uv9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv9 OCA], [https://pdbe.org/3uv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uv9 RCSB], [https://www.ebi.ac.uk/pdbsum/3uv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TRIM5_MACMU TRIM5_MACMU]] Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV-agm).<ref>PMID:21734049</ref> <ref>PMID:21035162</ref> <ref>PMID:22291694</ref>	+	[[https://www.uniprot.org/uniprot/TRIM5_MACMU TRIM5_MACMU]] Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV-agm).<ref>PMID:21734049</ref> <ref>PMID:21035162</ref> <ref>PMID:22291694</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Macmu]]		[[Category: Macmu]]
	[[Category: Biris, N]]		[[Category: Biris, N]]

OCA at 06:44, 5 August 2016

OCA — Fri, 05 Aug 2016 06:44:54 GMT

←Older revision		Revision as of 06:44, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain==		==Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain==
	<StructureSection load='3uv9' size='340' side='right' caption='[[3uv9]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3uv9' size='340' side='right' caption='[[3uv9]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Macaca_mulatta Macaca mulatta~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UV9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UV9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lm3\|2lm3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lm3\|2lm3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 ~~Macaca mulatta~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uv9 RCSB], [http://www.ebi.ac.uk/pdbsum/3uv9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv9 OCA], [http://pdbe.org/3uv9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uv9 RCSB], [http://www.ebi.ac.uk/pdbsum/3uv9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3uv9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Macaca mulatta~~]]	+	[[Category: Macmu]]
	[[Category: Biris, N]]		[[Category: Biris, N]]
	[[Category: Diaz-Griffero, F]]		[[Category: Diaz-Griffero, F]]

OCA at 23:57, 24 December 2014

OCA — Wed, 24 Dec 2014 23:57:11 GMT

←Older revision		Revision as of 23:57, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uv9 RCSB], [http://www.ebi.ac.uk/pdbsum/3uv9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uv9 RCSB], [http://www.ebi.ac.uk/pdbsum/3uv9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRIM5_MACMU TRIM5_MACMU]] Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV-agm).<ref>PMID:21734049</ref> <ref>PMID:21035162</ref> <ref>PMID:22291694</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:39, 21 December 2014

OCA — Sun, 21 Dec 2014 06:39:35 GMT

←Older revision		Revision as of 06:39, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3uv9\| PDB=3uv9 \| SCENE= }}~~	+	==Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain==
-	===Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain===	+	<StructureSection load='3uv9' size='340' side='right' caption='[[3uv9]], [[Resolution\|resolution]] 1.55Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22847415}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3uv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UV9 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lm3\|2lm3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 Macaca mulatta])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uv9 RCSB], [http://www.ebi.ac.uk/pdbsum/3uv9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tripartite motif protein TRIM5alpha blocks retroviral replication after cell entry, and species-specific differences in its activity are determined by sequence variations within the C-terminal B30.2/PRYSPRY domain. Here we report a high-resolution structure of a TRIM5alpha PRYSPRY domain, the PRYSPRY of the rhesus monkey TRIM5alpha that potently restricts HIV infection, and identify features involved in its interaction with the HIV capsid. The extensive capsid-binding interface maps on the structurally divergent face of the protein formed by hypervariable loop segments, confirming that TRIM5alpha evolution is largely determined by its binding specificity. Interactions with the capsid are mediated by flexible variable loops via a mechanism that parallels antigen recognition by IgM antibodies, a similarity that may help explain some of the unusual functional properties of TRIM5alpha. Distinctive features of this pathogen-recognition interface, such as structural plasticity conferred by the mobile v1 segment and interaction with multiple epitopes, may allow restriction of divergent retroviruses and increase resistance to capsid mutations.

-	~~==Function==~~	+	Structure of the rhesus monkey TRIM5alpha PRYSPRY domain, the HIV capsid recognition module.,Biris N, Yang Y, Taylor AB, Tomashevski A, Guo M, Hart PJ, Diaz-Griffero F, Ivanov DN Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13278-83. doi:, 10.1073/pnas.1203536109. Epub 2012 Jul 30. PMID:22847415<ref>PMID:22847415</ref>
-	~~[[http://www.uniprot.org/uniprot/TRIM5_MACMU TRIM5_MACMU]] Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in~~ the ~~life cycle~~, ~~after viral entry but before reverse transcription. In addition to acting as a~~ capsid~~-specific restriction factor, also acts as a pattern~~ recognition ~~receptor that activates innate immune signaling in response to the retroviral capsid lattice~~. ~~Binding to the viral capsid triggers its E3 ubiquitin ligase activity~~, ~~and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains~~, ~~which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1~~, ~~TAB2~~, ~~and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF~~-~~kappa-B and MAPK-responsive inflammatory genes~~, ~~thereby leading to an innate immune response in the infected cell~~. ~~Restricts infection by human immunodeficiency virus type 1~~ (~~HIV-1~~) ~~and simian immunodeficiency virus (SIV~~-~~agm)~~.~~<ref>PMID~~:~~21734049<~~/~~ref> <ref>~~PMID:~~21035162</ref>~~ <ref>PMID:~~22291694~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3uv9]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Macaca_mulatta Macaca mulatta]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3UV9 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022847415</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Macaca mulatta]]		[[Category: Macaca mulatta]]
-	[[Category: Biris, N.]]	+	[[Category: Biris, N]]
-	[[Category: Diaz-Griffero, F.]]	+	[[Category: Diaz-Griffero, F]]
-	[[Category: Guo, M.]]	+	[[Category: Guo, M]]
-	[[Category: Hart, P J.]]	+	[[Category: Hart, P J]]
-	[[Category: Ivanov, D.]]	+	[[Category: Ivanov, D]]
-	[[Category: Taylor, A B.]]	+	[[Category: Taylor, A B]]
-	[[Category: Tomashevskii, A.]]	+	[[Category: Tomashevskii, A]]
-	[[Category: Yang, Y.]]	+	[[Category: Yang, Y]]
	[[Category: Antiretroviral]]		[[Category: Antiretroviral]]
	[[Category: Domain swap]]		[[Category: Domain swap]]
	[[Category: Hiv capsid]]		[[Category: Hiv capsid]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 15:15, 19 June 2013

OCA — Wed, 19 Jun 2013 15:15:54 GMT

←Older revision		Revision as of 15:15, 19 June 2013
Line 1:		Line 1:
-	[[Image:3uv9.jpg\|left\|200px]]
-
	{{STRUCTURE_3uv9\| PDB=3uv9 \| SCENE= }}		{{STRUCTURE_3uv9\| PDB=3uv9 \| SCENE= }}
-
	===Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain===		===Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain===
		+	{{ABSTRACT_PUBMED_22847415}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/TRIM5_MACMU TRIM5_MACMU]] Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV-agm).<ref>PMID:21734049</ref> <ref>PMID:21035162</ref> <ref>PMID:22291694</ref>

	==About this Structure==		==About this Structure==
	[[3uv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV9 OCA].		[[3uv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV9 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022847415</ref><references group="xtra"/><references/>
	[[Category: Macaca mulatta]]		[[Category: Macaca mulatta]]
	[[Category: Biris, N.]]		[[Category: Biris, N.]]

OCA at 05:29, 8 August 2012

OCA — Wed, 08 Aug 2012 05:29:43 GMT

←Older revision		Revision as of 05:29, 8 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3uv9.jpg\|left\|200px]]

-	~~The entry~~ 3uv9 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3uv9\| PDB=3uv9 \| SCENE= }}

-	~~Authors: Biris, N., Yang, Y., Taylor, A.B., Tomashevskii, A., Guo, M., Hart, P.J., Diaz-Griffero, F., Ivanov, D.~~	+	===Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain===

-	~~Description~~: ~~Primate innate immunity protein~~	+
		+	==About this Structure==
		+	[[3uv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV9 OCA].
		+	[[Category: Macaca mulatta]]
		+	[[Category: Biris, N.]]
		+	[[Category: Diaz-Griffero, F.]]
		+	[[Category: Guo, M.]]
		+	[[Category: Hart, P J.]]
		+	[[Category: Ivanov, D.]]
		+	[[Category: Taylor, A B.]]
		+	[[Category: Tomashevskii, A.]]
		+	[[Category: Yang, Y.]]
		+	[[Category: Antiretroviral]]
		+	[[Category: Domain swap]]
		+	[[Category: Hiv capsid]]
		+	[[Category: Ligase]]

OCA at 05:56, 11 January 2012

OCA — Wed, 11 Jan 2012 05:56:47 GMT

←Older revision		Revision as of 05:56, 11 January 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3uv9 is ON HOLD	+	The entry 3uv9 is ON HOLD until Paper Publication

	Authors: Biris, N., Yang, Y., Taylor, A.B., Tomashevskii, A., Guo, M., Hart, P.J., Diaz-Griffero, F., Ivanov, D.		Authors: Biris, N., Yang, Y., Taylor, A.B., Tomashevskii, A., Guo, M., Hart, P.J., Diaz-Griffero, F., Ivanov, D.

	Description: Primate innate immunity protein		Description: Primate innate immunity protein

OCA: Protected "3uv9" [edit=sysop:move=sysop]

OCA — Wed, 07 Dec 2011 07:40:16 GMT

Protected "3uv9" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:40, 7 December 2011

OCA: New page: '''Unreleased structure''' The entry 3uv9 is ON HOLD Authors: Biris, N., Yang, Y., Taylor, A.B., Tomashevskii, A., Guo, M., Hart, P.J., Diaz-Griffero, F., Ivanov, D. Description: Prima...

OCA — Wed, 07 Dec 2011 07:40:15 GMT

New page: '''Unreleased structure''' The entry 3uv9 is ON HOLD Authors: Biris, N., Yang, Y., Taylor, A.B., Tomashevskii, A., Guo, M., Hart, P.J., Diaz-Griffero, F., Ivanov, D. Description: Prima...

New page

'''Unreleased structure'''

The entry 3uv9 is ON HOLD

Authors: Biris, N., Yang, Y., Taylor, A.B., Tomashevskii, A., Guo, M., Hart, P.J., Diaz-Griffero, F., Ivanov, D.

Description: Primate innate immunity protein