3uwt - Revision history

OCA at 11:51, 1 February 2023

OCA — Wed, 01 Feb 2023 11:51:49 GMT

←Older revision		Revision as of 11:51, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='3uwt' size='340' side='right'caption='[[3uwt]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3uwt' size='340' side='right'caption='[[3uwt]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UWT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UWT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BC008875, FIR, PUF60, ROBPI, SIAHBP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwt OCA], [https://pdbe.org/3uwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uwt RCSB], [https://www.ebi.ac.uk/pdbsum/3uwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwt OCA], [https://pdbe.org/3uwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uwt RCSB], [https://www.ebi.ac.uk/pdbsum/3uwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PUF60_HUMAN PUF60_HUMAN]] DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.<ref>PMID:10882074</ref> <ref>PMID:10606266</ref> <ref>PMID:11239393</ref> <ref>PMID:16452196</ref> <ref>PMID:16628215</ref> <ref>PMID:17579712</ref>	+	[https://www.uniprot.org/uniprot/PUF60_HUMAN PUF60_HUMAN] DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.<ref>PMID:10882074</ref> <ref>PMID:10606266</ref> <ref>PMID:11239393</ref> <ref>PMID:16452196</ref> <ref>PMID:16628215</ref> <ref>PMID:17579712</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Structural genomic]]
-	[[Category: TCELL, Partnership for T-Cell Biology]]
-	[[Category: Jcsg]]
-	[[Category: Partnership for t-cell biology]]
-	[[Category: PSI, Protein structure initiative]]
-	[[Category: Psi-biology]]
-	[[Category: Rna binding domain]]
-	[[Category: Rna binding protein]]
-	[[Category: Rna recognition motive]]
-	[[Category: Rrm]]
-	[[Category: Splicing]]
-	[[Category: Tcell]]

OCA at 08:13, 20 July 2022

OCA — Wed, 20 Jul 2022 08:13:20 GMT

←Older revision		Revision as of 08:13, 20 July 2022
Line 1:		Line 1:

	==Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 2.50 A resolution==		==Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 2.50 A resolution==
-	<StructureSection load='3uwt' size='340' side='right' caption='[[3uwt]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3uwt' size='340' side='right'caption='[[3uwt]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uwt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UWT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UWT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BC008875, FIR, PUF60, ROBPI, SIAHBP1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BC008875, FIR, PUF60, ROBPI, SIAHBP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3uwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwt OCA], [~~http~~://pdbe.org/3uwt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3uwt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3uwt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwt OCA], [https://pdbe.org/3uwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uwt RCSB], [https://www.ebi.ac.uk/pdbsum/3uwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PUF60_HUMAN PUF60_HUMAN]] DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.<ref>PMID:10882074</ref> <ref>PMID:10606266</ref> <ref>PMID:11239393</ref> <ref>PMID:16452196</ref> <ref>PMID:16628215</ref> <ref>PMID:17579712</ref>	+	[[https://www.uniprot.org/uniprot/PUF60_HUMAN PUF60_HUMAN]] DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.<ref>PMID:10882074</ref> <ref>PMID:10606266</ref> <ref>PMID:11239393</ref> <ref>PMID:16452196</ref> <ref>PMID:16628215</ref> <ref>PMID:17579712</ref>
	== References ==		== References ==
	<references/>		<references/>
Line 16:		Line 16:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: TCELL, Partnership for T-Cell Biology]]		[[Category: TCELL, Partnership for T-Cell Biology]]

OCA at 10:09, 8 November 2017

OCA — Wed, 08 Nov 2017 10:09:59 GMT

←Older revision		Revision as of 10:09, 8 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 2.50 A resolution==		==Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 2.50 A resolution==
	<StructureSection load='3uwt' size='340' side='right' caption='[[3uwt]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3uwt' size='340' side='right' caption='[[3uwt]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BC008875, FIR, PUF60, ROBPI, SIAHBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BC008875, FIR, PUF60, ROBPI, SIAHBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwt OCA], [http://pdbe.org/3uwt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uwt RCSB], [http://www.ebi.ac.uk/pdbsum/3uwt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwt OCA], [http://pdbe.org/3uwt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uwt RCSB], [http://www.ebi.ac.uk/pdbsum/3uwt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 27:
	[[Category: Rrm]]		[[Category: Rrm]]
	[[Category: Splicing]]		[[Category: Splicing]]
		+	[[Category: Tcell]]

OCA at 23:50, 21 October 2015

OCA — Wed, 21 Oct 2015 23:50:28 GMT

←Older revision		Revision as of 23:50, 21 October 2015
Line 2:		Line 2:
	<StructureSection load='3uwt' size='340' side='right' caption='[[3uwt]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3uwt' size='340' side='right' caption='[[3uwt]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UWT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UWT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BC008875, FIR, PUF60, ROBPI, SIAHBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BC008875, FIR, PUF60, ROBPI, SIAHBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uwt RCSB], [http://www.ebi.ac.uk/pdbsum/3uwt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwt OCA], [http://pdbe.org/3uwt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uwt RCSB], [http://www.ebi.ac.uk/pdbsum/3uwt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens]]~~	+	[[Category: Human]]
-	~~[[Category: Biology, Partnership for T-Cell~~]]	+
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
		+	[[Category: TCELL, Partnership for T-Cell Biology]]
	[[Category: Jcsg]]		[[Category: Jcsg]]
	[[Category: Partnership for t-cell biology]]		[[Category: Partnership for t-cell biology]]

OCA at 17:26, 25 December 2014

OCA — Thu, 25 Dec 2014 17:26:32 GMT

←Older revision		Revision as of 17:26, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3uwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3uwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UWT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BC008875, FIR, PUF60, ROBPI, SIAHBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BC008875, FIR, PUF60, ROBPI, SIAHBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uwt RCSB], [http://www.ebi.ac.uk/pdbsum/3uwt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uwt RCSB], [http://www.ebi.ac.uk/pdbsum/3uwt PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PUF60_HUMAN PUF60_HUMAN]] DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.<ref>PMID:10882074</ref> <ref>PMID:10606266</ref> <ref>PMID:11239393</ref> <ref>PMID:16452196</ref> <ref>PMID:16628215</ref> <ref>PMID:17579712</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Biology, Partnership for T-Cell.]]	+	[[Category: Biology, Partnership for T-Cell]]
-	[[Category: ~~JCSG, Joint Center for~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
	[[Category: Jcsg]]		[[Category: Jcsg]]
-	[[Category: Joint center for structural genomic]]
	[[Category: Partnership for t-cell biology]]		[[Category: Partnership for t-cell biology]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
	[[Category: Psi-biology]]		[[Category: Psi-biology]]
	[[Category: Rna binding domain]]		[[Category: Rna binding domain]]
Line 23:		Line 26:
	[[Category: Rrm]]		[[Category: Rrm]]
	[[Category: Splicing]]		[[Category: Splicing]]
-	[[Category: Structural genomic]]

OCA at 06:33, 5 June 2014

OCA — Thu, 05 Jun 2014 06:33:34 GMT

←Older revision		Revision as of 06:33, 5 June 2014
Line 1:		Line 1:
-	~~[[Image:3uwt.png\|left\|200px]]~~	+	==Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 2.50 A resolution==
-		+	<StructureSection load='3uwt' size='340' side='right' caption='[[3uwt]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~<!--~~	+	== Structural highlights ==
-	~~The line below this paragraph, containing "STRUCTURE_3uwt", creates the "Structure Box" on the page.~~	+	<table><tr><td colspan='2'>[[3uwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UWT FirstGlance]. <br>
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~or leave the SCENE parameter empty for the default display.~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BC008875, FIR, PUF60, ROBPI, SIAHBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	~~-->~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uwt RCSB], [http://www.ebi.ac.uk/pdbsum/3uwt PDBsum]</span></td></tr>
-	~~{{STRUCTURE_3uwt\| PDB=3uwt \| SCENE= }}~~	+	<table>
-		+	__TOC__
-	===Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 2.50 A resolution===	+	</StructureSection>
-		+
-		+
-	==~~About this Structure~~==	+
-	[[3uwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWT OCA].	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Biology, Partnership for T-Cell.]]		[[Category: Biology, Partnership for T-Cell.]]

OCA at 06:29, 11 January 2012

OCA — Wed, 11 Jan 2012 06:29:04 GMT

←Older revision		Revision as of 06:29, 11 January 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3uwt.png\|left\|200px]]

-	The ~~entry 3uwt~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3uwt", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3uwt\| PDB=3uwt \| SCENE= }}

-	~~Authors: Joint Center for Structural Genomics~~ (~~JCSG~~)~~, Partnership for T-Cell Biology~~	+	===Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 2.50 A resolution===

-	~~Description: Crystal structure of~~ a ~~RNA binding domain of poly-U binding splicing factor 60KDa (PUF60)~~ from Homo sapiens ~~at 2~~.~~50 A resolution~~	+
		+	==About this Structure==
		+	[[3uwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWT OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Biology, Partnership for T-Cell.]]
		+	[[Category: JCSG, Joint Center for Structural Genomics.]]
		+	[[Category: Jcsg]]
		+	[[Category: Joint center for structural genomic]]
		+	[[Category: Partnership for t-cell biology]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-biology]]
		+	[[Category: Rna binding domain]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rna recognition motive]]
		+	[[Category: Rrm]]
		+	[[Category: Splicing]]
		+	[[Category: Structural genomic]]

OCA: Protected "3uwt" [edit=sysop:move=sysop]

OCA — Wed, 14 Dec 2011 11:13:33 GMT

Protected "3uwt" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:13, 14 December 2011

OCA: New page: '''Unreleased structure''' The entry 3uwt is ON HOLD Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology Description: Crystal structure of a RNA bindin...

OCA — Wed, 14 Dec 2011 11:13:32 GMT

New page: '''Unreleased structure''' The entry 3uwt is ON HOLD Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology Description: Crystal structure of a RNA bindin...

New page

'''Unreleased structure'''

The entry 3uwt is ON HOLD

Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology

Description: Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 2.50 A resolution