3uyi - Revision history

OCA at 12:14, 8 November 2023

OCA — Wed, 08 Nov 2023 12:14:59 GMT

←Older revision		Revision as of 12:14, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3uyi' size='340' side='right'caption='[[3uyi]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='3uyi' size='340' side='right'caption='[[3uyi]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ophioxylon_serpentinum Ophioxylon serpentinum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UYI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UYI FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MLZ:N~~-~~METHYL-LYSINE'>MLZ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.313Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PR ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Ophioxylon serpentinum])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyi OCA], [https://pdbe.org/3uyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uyi RCSB], [https://www.ebi.ac.uk/pdbsum/3uyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyi OCA], [https://pdbe.org/3uyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uyi RCSB], [https://www.ebi.ac.uk/pdbsum/3uyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PERR_RAUSE PERR_RAUSE]] Aldo-keto reductase involved in the biosynthesis of monoterpenoid indole alkaloids. Broad substrate specificity enzyme with a high selectivity in the group of alkaloids. Can use perakine, 19(S),20(R)-dihydro-peraksine-17,21-al, cinnamic aldehyde, p-coumaric aldehyde and 3-(3,4,5-trimethoxyphenyl)propanal as substrates, but not ketosteroids such as progesterone. NADPH could not be replaced by NADH.<ref>PMID:18409028</ref>	+	[https://www.uniprot.org/uniprot/PERR_RAUSE PERR_RAUSE] Aldo-keto reductase involved in the biosynthesis of monoterpenoid indole alkaloids. Broad substrate specificity enzyme with a high selectivity in the group of alkaloids. Can use perakine, 19(S),20(R)-dihydro-peraksine-17,21-al, cinnamic aldehyde, p-coumaric aldehyde and 3-(3,4,5-trimethoxyphenyl)propanal as substrates, but not ketosteroids such as progesterone. NADPH could not be replaced by NADH.<ref>PMID:18409028</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ophioxylon serpentinum~~]]	+	[[Category: Rauvolfia serpentina]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Mindnich, R]]	+	[[Category: Mindnich R]]
-	[[Category: Mueller, U]]	+	[[Category: Mueller U]]
-	[[Category: Panjikar, S]]	+	[[Category: Panjikar S]]
-	[[Category: Penning~~, T M~~]]	+	[[Category: Penning TM]]
-	[[Category: Rajendran, C]]	+	[[Category: Rajendran C]]
-	[[Category: Rosenthal, C]]	+	[[Category: Rosenthal C]]
-	[[Category: Stoeckigt, J]]	+	[[Category: Stoeckigt J]]
-	[[Category: Sun, L]]	+	[[Category: Sun L]]
-	[[Category: Wang, M]]	+	[[Category: Wang M]]
-	~~[[Category: 8/6 barrel]]~~	+
-	~~[[Category: Akr superfamily]]~~	+
-	~~[[Category: Nadph]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Perakine reductase~~]]	+

OCA at 08:16, 20 July 2022

OCA — Wed, 20 Jul 2022 08:16:31 GMT

←Older revision		Revision as of 08:16, 20 July 2022
Line 1:		Line 1:

	==Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding==		==Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding==
-	<StructureSection load='3uyi' size='340' side='right' caption='[[3uyi]], [[Resolution\|resolution]] 2.31Å' scene=''>	+	<StructureSection load='3uyi' size='340' side='right'caption='[[3uyi]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uyi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Devilpepper Devilpepper~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UYI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophioxylon_serpentinum Ophioxylon serpentinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UYI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 ~~Devilpepper~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Ophioxylon serpentinum])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyi OCA], [~~http~~://pdbe.org/3uyi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3uyi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3uyi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyi OCA], [https://pdbe.org/3uyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uyi RCSB], [https://www.ebi.ac.uk/pdbsum/3uyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PERR_RAUSE PERR_RAUSE]] Aldo-keto reductase involved in the biosynthesis of monoterpenoid indole alkaloids. Broad substrate specificity enzyme with a high selectivity in the group of alkaloids. Can use perakine, 19(S),20(R)-dihydro-peraksine-17,21-al, cinnamic aldehyde, p-coumaric aldehyde and 3-(3,4,5-trimethoxyphenyl)propanal as substrates, but not ketosteroids such as progesterone. NADPH could not be replaced by NADH.<ref>PMID:18409028</ref>	+	[[https://www.uniprot.org/uniprot/PERR_RAUSE PERR_RAUSE]] Aldo-keto reductase involved in the biosynthesis of monoterpenoid indole alkaloids. Broad substrate specificity enzyme with a high selectivity in the group of alkaloids. Can use perakine, 19(S),20(R)-dihydro-peraksine-17,21-al, cinnamic aldehyde, p-coumaric aldehyde and 3-(3,4,5-trimethoxyphenyl)propanal as substrates, but not ketosteroids such as progesterone. NADPH could not be replaced by NADH.<ref>PMID:18409028</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Devilpepper~~]]	+	[[Category: Large Structures]]
		+	[[Category: Ophioxylon serpentinum]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Mindnich, R]]		[[Category: Mindnich, R]]

OCA at 16:48, 4 August 2016

OCA — Thu, 04 Aug 2016 16:48:47 GMT

←Older revision		Revision as of 16:48, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding==		==Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding==
	<StructureSection load='3uyi' size='340' side='right' caption='[[3uyi]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='3uyi' size='340' side='right' caption='[[3uyi]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rauvolfia_serpentina Rauvolfia serpentina~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UYI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Devilpepper Devilpepper]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UYI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 ~~Rauvolfia serpentina~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyi RCSB], [http://www.ebi.ac.uk/pdbsum/3uyi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyi OCA], [http://pdbe.org/3uyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uyi RCSB], [http://www.ebi.ac.uk/pdbsum/3uyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3uyi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rauvolfia serpentina~~]]	+	[[Category: Devilpepper]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Mindnich, R]]		[[Category: Mindnich, R]]

OCA at 17:12, 24 December 2014

OCA — Wed, 24 Dec 2014 17:12:37 GMT

←Older revision		Revision as of 17:12, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyi RCSB], [http://www.ebi.ac.uk/pdbsum/3uyi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyi RCSB], [http://www.ebi.ac.uk/pdbsum/3uyi PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PERR_RAUSE PERR_RAUSE]] Aldo-keto reductase involved in the biosynthesis of monoterpenoid indole alkaloids. Broad substrate specificity enzyme with a high selectivity in the group of alkaloids. Can use perakine, 19(S),20(R)-dihydro-peraksine-17,21-al, cinnamic aldehyde, p-coumaric aldehyde and 3-(3,4,5-trimethoxyphenyl)propanal as substrates, but not ketosteroids such as progesterone. NADPH could not be replaced by NADH.<ref>PMID:18409028</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:36, 21 December 2014

OCA — Sun, 21 Dec 2014 07:36:18 GMT

←Older revision		Revision as of 07:36, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3uyi\| PDB=3uyi \| SCENE= }}~~	+	==Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding==
-	===Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding===	+	<StructureSection load='3uyi' size='340' side='right' caption='[[3uyi]], [[Resolution\|resolution]] 2.31Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22334702}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3uyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UYI FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Rauvolfia serpentina])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyi RCSB], [http://www.ebi.ac.uk/pdbsum/3uyi PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Perakine reductase (PR) catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. Sequence alignment shows that PR is the founder of the new AKR13D subfamily and is designated AKR13D1. The x-ray structure of methylated His(6)-PR was solved to 2.31 A. However, the active site of PR was blocked by the connected parts of the neighbor symmetric molecule in the crystal. To break the interactions and obtain the enzyme-ligand complexes, the A213W mutant was generated. The atomic structure of His(6)-PR-A213W complex with NADPH was determined at 1.77 A. Overall, PR folds in an unusual alpha(8)/beta(6) barrel that has not been observed in any other AKR protein to date. NADPH binds in an extended pocket, but the nicotinamide riboside moiety is disordered. Upon NADPH binding, dramatic conformational changes and movements were observed: two additional beta-strands in the C terminus become ordered to form one alpha-helix, and a movement of up to 24 A occurs. This conformational change creates a large space that allows the binding of substrates of variable size for PR and enhances the enzyme activity; as a result cooperative kinetics are observed as NADPH is varied. As the founding member of the new AKR13D subfamily, PR also provides a structural template and model of cofactor binding for the AKR13 family.

-	~~==Function==~~	+	Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.,Sun L, Chen Y, Rajendran C, Mueller U, Panjikar S, Wang M, Mindnich R, Rosenthal C, Penning TM, Stockigt J J Biol Chem. 2012 Mar 30;287(14):11213-21. Epub 2012 Feb 13. PMID:22334702<ref>PMID:22334702</ref>
-	~~[[http://www.uniprot.org/uniprot/PERR_RAUSE PERR_RAUSE]] Aldo~~-keto reductase ~~involved in the biosynthesis of monoterpenoid indole alkaloids~~. ~~Broad substrate specificity enzyme with a high selectivity in the group of alkaloids. Can use perakine~~, ~~19(~~S),~~20(~~R~~)-dihydro-peraksine-17~~,~~21-al~~, ~~cinnamic aldehyde~~, ~~p-coumaric aldehyde and 3-~~(~~3,4,5~~-~~trimethoxyphenyl)propanal as substrates, but not ketosteroids such as progesterone~~. ~~NADPH could not be replaced by NADH~~.<ref>PMID:~~18409028~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3uyi]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022334702</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rauvolfia serpentina]]		[[Category: Rauvolfia serpentina]]
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Mindnich, R.]]	+	[[Category: Mindnich, R]]
-	[[Category: Mueller, U.]]	+	[[Category: Mueller, U]]
-	[[Category: Panjikar, S.]]	+	[[Category: Panjikar, S]]
-	[[Category: Penning, T M.]]	+	[[Category: Penning, T M]]
-	[[Category: Rajendran, C.]]	+	[[Category: Rajendran, C]]
-	[[Category: Rosenthal, C.]]	+	[[Category: Rosenthal, C]]
-	[[Category: Stoeckigt, J.]]	+	[[Category: Stoeckigt, J]]
-	[[Category: Sun, L.]]	+	[[Category: Sun, L]]
-	[[Category: Wang, M.]]	+	[[Category: Wang, M]]
	[[Category: 8/6 barrel]]		[[Category: 8/6 barrel]]
	[[Category: Akr superfamily]]		[[Category: Akr superfamily]]

OCA at 04:38, 18 July 2013

OCA — Thu, 18 Jul 2013 04:38:02 GMT

←Older revision		Revision as of 04:38, 18 July 2013
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-	[[Image:3uyi.jpg\|left\|200px]]
-
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	{{STRUCTURE_3uyi\| PDB=3uyi \| SCENE= }}		{{STRUCTURE_3uyi\| PDB=3uyi \| SCENE= }}
-
	===Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding===		===Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding===
		+	{{ABSTRACT_PUBMED_22334702}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PERR_RAUSE PERR_RAUSE]] Aldo-keto reductase involved in the biosynthesis of monoterpenoid indole alkaloids. Broad substrate specificity enzyme with a high selectivity in the group of alkaloids. Can use perakine, 19(S),20(R)-dihydro-peraksine-17,21-al, cinnamic aldehyde, p-coumaric aldehyde and 3-(3,4,5-trimethoxyphenyl)propanal as substrates, but not ketosteroids such as progesterone. NADPH could not be replaced by NADH.<ref>PMID:18409028</ref>

	==About this Structure==		==About this Structure==
	[[3uyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA].		[[3uyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022334702</ref><references group="xtra"/><references/>
	[[Category: Rauvolfia serpentina]]		[[Category: Rauvolfia serpentina]]
	[[Category: Chen, Y.]]		[[Category: Chen, Y.]]

OCA at 07:59, 22 February 2012

OCA — Wed, 22 Feb 2012 07:59:03 GMT

←Older revision		Revision as of 07:59, 22 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3uyi.jpg\|left\|200px]]

-	The ~~entry 3uyi~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3uyi", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3uyi\| PDB=3uyi \| SCENE= }}

-	~~Authors: Sun~~, ~~L., Chen, Y., Rajendran, C., Panjikar, S., Mueller, U., Wang, M., Rosenthal, C., Mindnich, R., Penning, T.M., Stoeckigt, J.~~	+	===Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding===

-	~~Description: Crystal~~ Structure ~~of Perakine Reductase, Founder Member of~~ a ~~Novel AKR Subfamily~~ with ~~Unique Conformational Changes during NADPH Binding~~	+
		+	==About this Structure==
		+	[[3uyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA].
		+	[[Category: Rauvolfia serpentina]]
		+	[[Category: Chen, Y.]]
		+	[[Category: Mindnich, R.]]
		+	[[Category: Mueller, U.]]
		+	[[Category: Panjikar, S.]]
		+	[[Category: Penning, T M.]]
		+	[[Category: Rajendran, C.]]
		+	[[Category: Rosenthal, C.]]
		+	[[Category: Stoeckigt, J.]]
		+	[[Category: Sun, L.]]
		+	[[Category: Wang, M.]]
		+	[[Category: 8/6 barrel]]
		+	[[Category: Akr superfamily]]
		+	[[Category: Nadph]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Perakine reductase]]

OCA at 06:02, 8 February 2012

OCA — Wed, 08 Feb 2012 06:02:01 GMT

←Older revision		Revision as of 06:02, 8 February 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3uyi is ON HOLD	+	The entry 3uyi is ON HOLD until Paper Publication

	Authors: Sun, L., Chen, Y., Rajendran, C., Panjikar, S., Mueller, U., Wang, M., Rosenthal, C., Mindnich, R., Penning, T.M., Stoeckigt, J.		Authors: Sun, L., Chen, Y., Rajendran, C., Panjikar, S., Mueller, U., Wang, M., Rosenthal, C., Mindnich, R., Penning, T.M., Stoeckigt, J.

	Description: Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding		Description: Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding

OCA at 06:45, 28 December 2011

OCA — Wed, 28 Dec 2011 06:45:19 GMT

←Older revision		Revision as of 06:45, 28 December 2011
Line 3:		Line 3:
	The entry 3uyi is ON HOLD		The entry 3uyi is ON HOLD

-	Authors: Sun, L, Chen, Y, Rajendran, C, Panjikar, S, Mueller, U, Wang, M, Rosenthal, C, Mindnich, R, Penning, T.M., Stoeckigt, J	+	Authors: Sun, L., Chen, Y., Rajendran, C., Panjikar, S., Mueller, U., Wang, M., Rosenthal, C., Mindnich, R., Penning, T.M., Stoeckigt, J.

	Description: Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding		Description: Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding

OCA: Protected "3uyi" [edit=sysop:move=sysop]

OCA — Wed, 14 Dec 2011 11:15:25 GMT

Protected "3uyi" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:15, 14 December 2011