3uyj - Revision history

OCA at 08:16, 20 July 2022

OCA — Wed, 20 Jul 2022 08:16:30 GMT

←Older revision		Revision as of 08:16, 20 July 2022
Line 1:		Line 1:

	==Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG==		==Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG==
-	<StructureSection load='3uyj' size='340' side='right' caption='[[3uyj]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='3uyj' size='340' side='right'caption='[[3uyj]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uyj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UYJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uyj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UYJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JMJD5, KDM8 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JMJD5, KDM8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3uyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyj OCA], [~~http~~://pdbe.org/3uyj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3uyj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3uyj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyj OCA], [https://pdbe.org/3uyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uyj RCSB], [https://www.ebi.ac.uk/pdbsum/3uyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.	+	[[https://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.

	==See Also==		==See Also==
-	*[[Jumonji domain-containing protein\|Jumonji domain-containing protein]]	+	*[[Jumonji domain-containing protein 3D structures\|Jumonji domain-containing protein 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Su, X]]		[[Category: Su, X]]

OCA at 00:56, 5 August 2016

OCA — Fri, 05 Aug 2016 00:56:21 GMT

←Older revision		Revision as of 00:56, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG==		==Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG==
	<StructureSection load='3uyj' size='340' side='right' caption='[[3uyj]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3uyj' size='340' side='right' caption='[[3uyj]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uyj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UYJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uyj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UYJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JMJD5, KDM8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JMJD5, KDM8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyj RCSB], [http://www.ebi.ac.uk/pdbsum/3uyj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyj OCA], [http://pdbe.org/3uyj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uyj RCSB], [http://www.ebi.ac.uk/pdbsum/3uyj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.		[[http://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
		+
		+	==See Also==
		+	*[[Jumonji domain-containing protein\|Jumonji domain-containing protein]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Su, X]]		[[Category: Su, X]]

OCA at 14:32, 25 December 2014

OCA — Thu, 25 Dec 2014 14:32:12 GMT

←Older revision		Revision as of 14:32, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyj RCSB], [http://www.ebi.ac.uk/pdbsum/3uyj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyj RCSB], [http://www.ebi.ac.uk/pdbsum/3uyj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:06, 9 December 2014

OCA — Tue, 09 Dec 2014 16:06:09 GMT

←Older revision		Revision as of 16:06, 9 December 2014
Line 1:		Line 1:
-	~~[[Image:3uyj.png\|left\|200px]]~~	+	==Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG==
-		+	<StructureSection load='3uyj' size='340' side='right' caption='[[3uyj]], [[Resolution\|resolution]] 2.35Å' scene=''>
-	~~{{STRUCTURE_3uyj\| PDB=3uyj \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3uyj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UYJ FirstGlance]. <br>
-	===Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JMJD5, KDM8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyj RCSB], [http://www.ebi.ac.uk/pdbsum/3uyj PDBsum]</span></td></tr>
-	[[3uyj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYJ OCA].	+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Li, H.]]	+	[[Category: Li, H]]
-	[[Category: Su, X.]]	+	[[Category: Su, X]]
	[[Category: Demethylase]]		[[Category: Demethylase]]
	[[Category: Jellyroll-like all beta fold]]		[[Category: Jellyroll-like all beta fold]]
	[[Category: Nuclear]]		[[Category: Nuclear]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:08, 2 January 2013

OCA — Wed, 02 Jan 2013 08:08:02 GMT

←Older revision		Revision as of 08:08, 2 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3uyj.png\|left\|200px]]

-	~~The entry~~ 3uyj ~~is ON HOLD~~	+	{{STRUCTURE_3uyj\| PDB=3uyj \| SCENE= }}

-	~~Authors: Su, X., Li, H.~~	+	===Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG===

-	~~Description: Crystal~~ structure ~~of JMJD5 catalytic core domain in complex~~ with ~~nickle and alpha~~-KG	+
		+	==About this Structure==
		+	[[3uyj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYJ OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Li, H.]]
		+	[[Category: Su, X.]]
		+	[[Category: Demethylase]]
		+	[[Category: Jellyroll-like all beta fold]]
		+	[[Category: Nuclear]]
		+	[[Category: Oxidoreductase]]

OCA: Protected "3uyj" [edit=sysop:move=sysop]

OCA — Wed, 14 Dec 2011 11:15:27 GMT

Protected "3uyj" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:15, 14 December 2011

OCA: New page: '''Unreleased structure''' The entry 3uyj is ON HOLD Authors: Su, X., Li, H. Description: Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG

OCA — Wed, 14 Dec 2011 11:15:26 GMT

New page: '''Unreleased structure''' The entry 3uyj is ON HOLD Authors: Su, X., Li, H. Description: Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG

New page

'''Unreleased structure'''

The entry 3uyj is ON HOLD

Authors: Su, X., Li, H.

Description: Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG