3v66 - Revision history

OCA at 12:16, 8 November 2023

OCA — Wed, 08 Nov 2023 12:16:36 GMT

←Older revision		Revision as of 12:16, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3v66' size='340' side='right'caption='[[3v66]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3v66' size='340' side='right'caption='[[3v66]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v66]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v66]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V66 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D3A:(1-{[(4R,6S)-8-CHLORO-6-(2,3-DIMETHOXYPHENYL)-4H,6H-PYRROLO[1,2-A][4,1]BENZOXAZEPIN-4-YL]ACETYL}PIPERIDIN-4-YL)ACETIC+ACID'>D3A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q30\|3q30]], [[3asx\|3asx]], [[3q2z\|3q2z]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D3A:(1-{[(4R,6S)-8-CHLORO-6-(2,3-DIMETHOXYPHENYL)-4H,6H-PYRROLO[1,2-A][4,1]BENZOXAZEPIN-4-YL]ACETYL}PIPERIDIN-4-YL)ACETIC+ACID'>D3A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v66 OCA], [https://pdbe.org/3v66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v66 RCSB], [https://www.ebi.ac.uk/pdbsum/3v66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v66 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v66 OCA], [https://pdbe.org/3v66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v66 RCSB], [https://www.ebi.ac.uk/pdbsum/3v66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v66 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FDFT_HUMAN FDFT_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Squalene synthase]]~~	+	[[Category: Haginoya N]]
-	[[Category: Haginoya, N]]	+	[[Category: Higashihashi N]]
-	[[Category: Higashihashi, N]]	+	[[Category: Ichikawa M]]
-	[[Category: Ichikawa, M]]	+	[[Category: Itoh M]]
-	[[Category: Itoh, M]]	+	[[Category: Ohki H]]
-	[[Category: Ohki, H]]	+	[[Category: Ohtsuka M]]
-	[[Category: Ohtsuka, M]]	+	[[Category: Sugita K]]
-	[[Category: Sugita, K]]	+	[[Category: Suzuki M]]
-	[[Category: Suzuki, M]]	+	[[Category: Usui H]]
-	[[Category: Usui, H]]	+
-	~~[[Category: Isoprene biosynthesis]]~~	+
-	~~[[Category: Lipid synthesis]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Steroid biosynthesis]]~~	+
-	~~[[Category: Sterol biosynthesis]]~~	+
-	~~[[Category: Terpenoid synthase fold]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 08:34, 20 July 2022

OCA — Wed, 20 Jul 2022 08:34:18 GMT

←Older revision		Revision as of 08:34, 20 July 2022
Line 1:		Line 1:

	==HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid==		==HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid==
-	<StructureSection load='3v66' size='340' side='right' caption='[[3v66]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3v66' size='340' side='right'caption='[[3v66]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v66]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V66 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3V66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v66]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V66 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3A:(1-{[(4R,6S)-8-CHLORO-6-(2,3-DIMETHOXYPHENYL)-4H,6H-PYRROLO[1,2-A][4,1]BENZOXAZEPIN-4-YL]ACETYL}PIPERIDIN-4-YL)ACETIC+ACID'>D3A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D3A:(1-{[(4R,6S)-8-CHLORO-6-(2,3-DIMETHOXYPHENYL)-4H,6H-PYRROLO[1,2-A][4,1]BENZOXAZEPIN-4-YL]ACETYL}PIPERIDIN-4-YL)ACETIC+ACID'>D3A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q30\|3q30]], [[3asx\|3asx]], [[3q2z\|3q2z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q30\|3q30]], [[3asx\|3asx]], [[3q2z\|3q2z]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3v66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v66 OCA], [~~http~~://pdbe.org/3v66 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3v66 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3v66 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3v66 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v66 OCA], [https://pdbe.org/3v66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v66 RCSB], [https://www.ebi.ac.uk/pdbsum/3v66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v66 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Squalene synthase]]		[[Category: Squalene synthase]]
	[[Category: Haginoya, N]]		[[Category: Haginoya, N]]

OCA at 19:12, 10 December 2016

OCA — Sat, 10 Dec 2016 19:12:22 GMT

←Older revision		Revision as of 19:12, 10 December 2016
Line 1:		Line 1:
		+
	==HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid==		==HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid==
	<StructureSection load='3v66' size='340' side='right' caption='[[3v66]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3v66' size='340' side='right' caption='[[3v66]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v66]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v66]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V66 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3A:(1-{[(4R,6S)-8-CHLORO-6-(2,3-DIMETHOXYPHENYL)-4H,6H-PYRROLO[1,2-A][4,1]BENZOXAZEPIN-4-YL]ACETYL}PIPERIDIN-4-YL)ACETIC+ACID'>D3A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3A:(1-{[(4R,6S)-8-CHLORO-6-(2,3-DIMETHOXYPHENYL)-4H,6H-PYRROLO[1,2-A][4,1]BENZOXAZEPIN-4-YL]ACETYL}PIPERIDIN-4-YL)ACETIC+ACID'>D3A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q30\|3q30]], [[3asx\|3asx]], [[3q2z\|3q2z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q30\|3q30]], [[3asx\|3asx]], [[3q2z\|3q2z]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v66 RCSB], [http://www.ebi.ac.uk/pdbsum/3v66 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v66 OCA], [http://pdbe.org/3v66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v66 RCSB], [http://www.ebi.ac.uk/pdbsum/3v66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v66 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3v66" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Squalene synthase]]		[[Category: Squalene synthase]]
	[[Category: Haginoya, N]]		[[Category: Haginoya, N]]

OCA at 17:53, 9 December 2014

OCA — Tue, 09 Dec 2014 17:53:44 GMT

←Older revision		Revision as of 17:53, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3v66.~~jpg~~\|~~left~~\|~~200px~~]]	+	==HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid==
		+	<StructureSection load='3v66' size='340' side='right' caption='[[3v66]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3v66]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V66 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D3A:(1-{[(4R,6S)-8-CHLORO-6-(2,3-DIMETHOXYPHENYL)-4H,6H-PYRROLO[1,2-A][4,1]BENZOXAZEPIN-4-YL]ACETYL}PIPERIDIN-4-YL)ACETIC+ACID'>D3A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3q30\|3q30]], [[3asx\|3asx]], [[3q2z\|3q2z]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v66 RCSB], [http://www.ebi.ac.uk/pdbsum/3v66 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the present article, we have reported the design, synthesis, and identification of highly potent benzhydrol derivatives as squalene synthase inhibitors (compound 1). Unfortunately, the in vivo efficacies of the compounds were not enough for acquiring the clinical candidate. We continued our investigation to obtain a more in vivo efficacious template than the benzhydrol template. In our effort, we focused on a benzoxazepine ring and designed a new tricyclic scaffold by the incorporation of heterocycle into it. Prepared pyrrolobenzoxazepine derivatives showed further efficient in vitro and in vivo activities.

-	~~{{STRUCTURE_3v66\| PDB=3v66 \| SCENE= }}~~	+	Discovery of novel tricyclic compounds as squalene synthase inhibitors.,Ichikawa M, Ohtsuka M, Ohki H, Haginoya N, Itoh M, Sugita K, Usui H, Suzuki M, Terayama K, Kanda A Bioorg Med Chem. 2012 May 1;20(9):3072-93. doi: 10.1016/j.bmc.2012.02.054. Epub, 2012 Mar 8. PMID:22464687<ref>PMID:22464687</ref>

-	~~===HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R~~,~~6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-~~a~~][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22464687}}~~	+	==See Also==
-		+	*[[Squalene synthase\|Squalene synthase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3v66~~]] ~~is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V66 OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Squalene synthase]]		[[Category: Squalene synthase]]
-	[[Category: Haginoya, N.]]	+	[[Category: Haginoya, N]]
-	[[Category: Higashihashi, N.]]	+	[[Category: Higashihashi, N]]
-	[[Category: Ichikawa, M.]]	+	[[Category: Ichikawa, M]]
-	[[Category: Itoh, M.]]	+	[[Category: Itoh, M]]
-	[[Category: Ohki, H.]]	+	[[Category: Ohki, H]]
-	[[Category: Ohtsuka, M.]]	+	[[Category: Ohtsuka, M]]
-	[[Category: Sugita, K.]]	+	[[Category: Sugita, K]]
-	[[Category: Suzuki, M.]]	+	[[Category: Suzuki, M]]
-	[[Category: Usui, H.]]	+	[[Category: Usui, H]]
	[[Category: Isoprene biosynthesis]]		[[Category: Isoprene biosynthesis]]
	[[Category: Lipid synthesis]]		[[Category: Lipid synthesis]]

OCA at 11:30, 19 December 2012

OCA — Wed, 19 Dec 2012 11:30:01 GMT

←Older revision		Revision as of 11:30, 19 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3v66.jpg\|left\|200px]]

-	~~The entry~~ 3v66 ~~is ON HOLD~~ ~~until Dec 18 2013~~	+	{{STRUCTURE_3v66\| PDB=3v66 \| SCENE= }}

-	~~Authors: Suzuki~~, M., ~~Ohtsuka~~, M., ~~Ohki~~, ~~H., Haginoya, N., Itoh, M., Sugita, K., Usui, H., Ichikawa, M., Higashihashi, N.~~	+	===HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid===

-	~~Description~~: ~~HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2~~-[~~(4R~~,~~6S)-8-chloro-6-(2~~,~~3-dimethoxyphenyl)-4H~~,~~6H-pyrrolo~~[1,~~2-a~~][4,1]~~benzoxazepin-4-yl~~]~~acetyl}~~-~~4-piperidinyl)acetic acid~~	+	{{ABSTRACT_PUBMED_22464687}}
		+
		+	==About this Structure==
		+	[[3v66]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V66 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Squalene synthase]]
		+	[[Category: Haginoya, N.]]
		+	[[Category: Higashihashi, N.]]
		+	[[Category: Ichikawa, M.]]
		+	[[Category: Itoh, M.]]
		+	[[Category: Ohki, H.]]
		+	[[Category: Ohtsuka, M.]]
		+	[[Category: Sugita, K.]]
		+	[[Category: Suzuki, M.]]
		+	[[Category: Usui, H.]]
		+	[[Category: Isoprene biosynthesis]]
		+	[[Category: Lipid synthesis]]
		+	[[Category: Multifunctional enzyme]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Steroid biosynthesis]]
		+	[[Category: Sterol biosynthesis]]
		+	[[Category: Terpenoid synthase fold]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 08:37, 16 May 2012

OCA — Wed, 16 May 2012 08:37:39 GMT

←Older revision		Revision as of 08:37, 16 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3v66 is ON HOLD	+	The entry 3v66 is ON HOLD until Dec 18 2013

	Authors: Suzuki, M., Ohtsuka, M., Ohki, H., Haginoya, N., Itoh, M., Sugita, K., Usui, H., Ichikawa, M., Higashihashi, N.		Authors: Suzuki, M., Ohtsuka, M., Ohki, H., Haginoya, N., Itoh, M., Sugita, K., Usui, H., Ichikawa, M., Higashihashi, N.

	Description: HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid		Description: HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid

OCA at 10:17, 18 January 2012

OCA — Wed, 18 Jan 2012 10:17:57 GMT

←Older revision		Revision as of 10:17, 18 January 2012
Line 3:		Line 3:
	The entry 3v66 is ON HOLD		The entry 3v66 is ON HOLD

-	Authors: Suzuki, M., Ohtsuka, M., Ohki, H., Haginoya, N., Itoh, M., Sugita, K., Usui, H., Ichikawa, M., Higashihashi, N	+	Authors: Suzuki, M., Ohtsuka, M., Ohki, H., Haginoya, N., Itoh, M., Sugita, K., Usui, H., Ichikawa, M., Higashihashi, N.

	Description: HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid		Description: HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid

OCA: Protected "3v66" [edit=sysop:move=sysop]

OCA — Wed, 28 Dec 2011 06:52:09 GMT

Protected "3v66" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:52, 28 December 2011

OCA: New page: '''Unreleased structure''' The entry 3v66 is ON HOLD Authors: Suzuki, M., Ohtsuka, M., Ohki, H., Haginoya, N., Itoh, M., Sugita, K., Usui, H., Ichikawa, M., Higashihashi, N Description...

OCA — Wed, 28 Dec 2011 06:52:08 GMT

New page: '''Unreleased structure''' The entry 3v66 is ON HOLD Authors: Suzuki, M., Ohtsuka, M., Ohki, H., Haginoya, N., Itoh, M., Sugita, K., Usui, H., Ichikawa, M., Higashihashi, N Description...

New page

'''Unreleased structure'''

The entry 3v66 is ON HOLD

Authors: Suzuki, M., Ohtsuka, M., Ohki, H., Haginoya, N., Itoh, M., Sugita, K., Usui, H., Ichikawa, M., Higashihashi, N

Description: HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid