3v6z - Revision history

OCA at 10:00, 21 December 2022

OCA — Wed, 21 Dec 2022 10:00:59 GMT

←Older revision		Revision as of 10:00, 21 December 2022
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	<StructureSection load='3v6z' size='340' side='right'caption='[[3v6z]], [[Resolution\|resolution]] 3.34Å' scene=''>		<StructureSection load='3v6z' size='340' side='right'caption='[[3v6z]], [[Resolution\|resolution]] 3.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v6z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hbv Hbv~~] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v6z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus Hepatitis B virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6Z FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v6f\|3v6f]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6z OCA], [https://pdbe.org/3v6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6z RCSB], [https://www.ebi.ac.uk/pdbsum/3v6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6z ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">preC/C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10407 HBV])</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6z OCA], [https://pdbe.org/3v6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6z RCSB], [https://www.ebi.ac.uk/pdbsum/3v6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6z ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9QMH8_HBV Q9QMH8_HBV]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hbv~~]]	+	[[Category: Hepatitis B virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Dimattia~~, M A~~]]	+	[[Category: Dimattia MA]]
-	[[Category: Grimes~~, J M~~]]	+	[[Category: Grimes JM]]
-	[[Category: Stahl~~, S J~~]]	+	[[Category: Stahl SJ]]
-	[[Category: Steven~~, A C~~]]	+	[[Category: Steven AC]]
-	[[Category: Stuart~~, D I~~]]	+	[[Category: Stuart DI]]
-	[[Category: Watts~~, N R~~]]	+	[[Category: Watts NR]]
-	[[Category: Wingfield~~, P T]]~~	+	[[Category: Wingfield PT]]
-	~~[[Category: Dimer inversion]]~~	+
-	~~[[Category: Four-helix bundle]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 08:36, 20 July 2022

OCA — Wed, 20 Jul 2022 08:36:28 GMT

←Older revision		Revision as of 08:36, 20 July 2022
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	==Crystal Structure of Hepatitis B Virus e-antigen==		==Crystal Structure of Hepatitis B Virus e-antigen==
-	<StructureSection load='3v6z' size='340' side='right' caption='[[3v6z]], [[Resolution\|resolution]] 3.34Å' scene=''>	+	<StructureSection load='3v6z' size='340' side='right'caption='[[3v6z]], [[Resolution\|resolution]] 3.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v6z]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hbv Hbv] and [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3V6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v6z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hbv Hbv] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6Z FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6f\|3v6f]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v6f\|3v6f]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">preC/C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10407 HBV])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">preC/C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10407 HBV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6z OCA], [~~http~~://pdbe.org/3v6z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3v6z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3v6z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6z OCA], [https://pdbe.org/3v6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6z RCSB], [https://www.ebi.ac.uk/pdbsum/3v6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6z ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Hbv]]		[[Category: Hbv]]
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Dimattia, M A]]		[[Category: Dimattia, M A]]

OCA at 19:05, 10 December 2016

OCA — Sat, 10 Dec 2016 19:05:05 GMT

←Older revision		Revision as of 19:05, 10 December 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Hepatitis B Virus e-antigen==		==Crystal Structure of Hepatitis B Virus e-antigen==
	<StructureSection load='3v6z' size='340' side='right' caption='[[3v6z]], [[Resolution\|resolution]] 3.34Å' scene=''>		<StructureSection load='3v6z' size='340' side='right' caption='[[3v6z]], [[Resolution\|resolution]] 3.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v6z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Hepatitis_b_virus Hepatitis b virus~~] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v6z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hbv Hbv] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6Z FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6f\|3v6f]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6f\|3v6f]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">preC/C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10407 ~~Hepatitis B virus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">preC/C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10407 HBV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v6z RCSB], [http://www.ebi.ac.uk/pdbsum/3v6z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6z OCA], [http://pdbe.org/3v6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v6z RCSB], [http://www.ebi.ac.uk/pdbsum/3v6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6z ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3v6z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hepatitis b virus~~]]	+	[[Category: Hbv]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Dimattia, M A]]		[[Category: Dimattia, M A]]

OCA at 16:44, 9 December 2014

OCA — Tue, 09 Dec 2014 16:44:29 GMT

←Older revision		Revision as of 16:44, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3v6z.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of Hepatitis B Virus e-antigen==
		+	<StructureSection load='3v6z' size='340' side='right' caption='[[3v6z]], [[Resolution\|resolution]] 3.34Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3v6z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_b_virus Hepatitis b virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6Z FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6f\|3v6f]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">preC/C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10407 Hepatitis B virus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v6z RCSB], [http://www.ebi.ac.uk/pdbsum/3v6z PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chronic hepatitis B virus (HBV) infection afflicts millions worldwide with cirrhosis and liver cancer. HBV e-antigen (HBeAg), a clinical marker for disease severity, is a nonparticulate variant of the protein (core antigen, HBcAg) that forms the building-blocks of capsids. HBeAg is not required for virion production, but is implicated in establishing immune tolerance and chronic infection. Here, we report the crystal structure of HBeAg, which clarifies how the short N-terminal propeptide of HBeAg induces a radically altered mode of dimerization relative to HBcAg ( approximately 140 degrees rotation), locked into place through formation of intramolecular disulfide bridges. This structural switch precludes capsid assembly and engenders a distinct antigenic repertoire, explaining why the two antigens are cross-reactive at the T cell level (through sequence identity) but not at the B cell level (through conformation). The structure offers insight into how HBeAg may establish immune tolerance for HBcAg while evading its robust immunogenicity.

-	~~{{STRUCTURE_3v6z\| PDB=3v6z \| SCENE= }}~~	+	Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.,Dimattia MA, Watts NR, Stahl SJ, Grimes JM, Steven AC, Stuart DI, Wingfield PT Structure. 2013 Jan 8;21(1):133-42. doi: 10.1016/j.str.2012.10.017. Epub 2012 Dec, 6. PMID:23219881<ref>PMID:23219881</ref>

-	~~===Crystal Structure~~ of ~~Hepatitis B Virus e-antigen===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23219881}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[3v6z]] is a 6 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Hepatitis_b_virus Hepatitis b virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6Z OCA].	+	</StructureSection>
	[[Category: Hepatitis b virus]]		[[Category: Hepatitis b virus]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Dimattia, M A.]]	+	[[Category: Dimattia, M A]]
-	[[Category: Grimes, J M.]]	+	[[Category: Grimes, J M]]
-	[[Category: Stahl, S J.]]	+	[[Category: Stahl, S J]]
-	[[Category: Steven, A C.]]	+	[[Category: Steven, A C]]
-	[[Category: Stuart, D I.]]	+	[[Category: Stuart, D I]]
-	[[Category: Watts, N R.]]	+	[[Category: Watts, N R]]
-	[[Category: Wingfield, P T.]]	+	[[Category: Wingfield, P T]]
	[[Category: Dimer inversion]]		[[Category: Dimer inversion]]
	[[Category: Four-helix bundle]]		[[Category: Four-helix bundle]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 12:50, 6 February 2013

OCA — Wed, 06 Feb 2013 12:50:06 GMT

←Older revision		Revision as of 12:50, 6 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3v6z.jpg\|left\|200px]]

-	~~The entry~~ 3v6z ~~is ON HOLD~~	+	{{STRUCTURE_3v6z\| PDB=3v6z \| SCENE= }}

-	~~Authors: Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.~~	+	===Crystal Structure of Hepatitis B Virus e-antigen===

-	~~Description: Crystal~~ Structure of Hepatitis ~~B Virus e~~-~~antigen~~	+	{{ABSTRACT_PUBMED_23219881}}
		+
		+	==About this Structure==
		+	[[3v6z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_b_virus Hepatitis b virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6Z OCA].
		+	[[Category: Hepatitis b virus]]
		+	[[Category: Mus musculus]]
		+	[[Category: Dimattia, M A.]]
		+	[[Category: Grimes, J M.]]
		+	[[Category: Stahl, S J.]]
		+	[[Category: Steven, A C.]]
		+	[[Category: Stuart, D I.]]
		+	[[Category: Watts, N R.]]
		+	[[Category: Wingfield, P T.]]
		+	[[Category: Dimer inversion]]
		+	[[Category: Four-helix bundle]]
		+	[[Category: Immune system]]

OCA at 06:51, 1 February 2012

OCA — Wed, 01 Feb 2012 06:51:21 GMT

←Older revision		Revision as of 06:51, 1 February 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3v6z is ON HOLD ~~until sometime in the future~~	+	The entry 3v6z is ON HOLD

-	Authors: ~~DiMattia~~, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.	+	Authors: Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.

	Description: Crystal Structure of Hepatitis B Virus e-antigen		Description: Crystal Structure of Hepatitis B Virus e-antigen

OCA at 10:18, 18 January 2012

OCA — Wed, 18 Jan 2012 10:18:10 GMT

←Older revision		Revision as of 10:18, 18 January 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3v6z is ON HOLD	+	The entry 3v6z is ON HOLD until sometime in the future

	Authors: DiMattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.		Authors: DiMattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.

	Description: Crystal Structure of Hepatitis B Virus e-antigen		Description: Crystal Structure of Hepatitis B Virus e-antigen

OCA: Protected "3v6z" [edit=sysop:move=sysop]

OCA — Wed, 28 Dec 2011 06:53:03 GMT

Protected "3v6z" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:53, 28 December 2011

OCA: New page: '''Unreleased structure''' The entry 3v6z is ON HOLD Authors: DiMattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T. Description: Crystal S...

OCA — Wed, 28 Dec 2011 06:53:02 GMT

New page: '''Unreleased structure''' The entry 3v6z is ON HOLD Authors: DiMattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T. Description: Crystal S...

New page

'''Unreleased structure'''

The entry 3v6z is ON HOLD

Authors: DiMattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.

Description: Crystal Structure of Hepatitis B Virus e-antigen