3vco - Revision history

OCA at 14:24, 14 March 2024

OCA — Thu, 14 Mar 2024 14:24:06 GMT

←Older revision		Revision as of 14:24, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3vco' size='340' side='right'caption='[[3vco]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3vco' size='340' side='right'caption='[[3vco]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Blood_fluke Blood fluke~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VCO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VCO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.946Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>DHFR, Smp_175230 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~6183 Blood fluke])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vco OCA], [https://pdbe.org/3vco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vco RCSB], [https://www.ebi.ac.uk/pdbsum/3vco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vco ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vco OCA], [https://pdbe.org/3vco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vco RCSB], [https://www.ebi.ac.uk/pdbsum/3vco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vco ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style="background-color:#fffaf0;">~~	+	== Function ==
-	== ~~Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/DYR_SCHMA DYR_SCHMA] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.<ref>PMID:28288799</ref>
-	The parasite Schistosoma mansoni possesses all pathways for pyrimidine biosynthesis, in which dihydrofolate reductase (DHFR), thymidylate cycle participants, is essential for nucleotide metabolism to obtain energy and structural nucleic acids. ~~Thus, DHFRs have been widely suggested as therapeutic targets for the treatment of infectious diseases~~. ~~In this study, we expressed recombinant SmDHFR~~ in ~~a heterologous manner to obtain structural, biochemical and kinetic information~~. ~~X-ray diffraction of recombinant SmDHFR at 1.95A resolution showed that the structure exhibited the canonical DHFR fold. Isothermal titration calorimetry was used~~ to ~~determine~~ the kinetic constants for NADP+ and dihydrofolate. Moreover, inhibition assays were performed using the commercial folate analogs methotrexate and aminopterin; these analogs are recognized as folate competitors and are used as chemotherapeutic agents in cancer and autoimmune diseases. This study provides information that may prove useful for the future discovery of novel drugs and for understanding these metabolic steps from this pathway ~~of S~~. ~~mansoni, thus aiding in our understanding of the function of these~~ essential ~~pathways~~ for ~~parasite metabolism.~~	+
-		+
-	~~Structure~~ and ~~kinetics assays of recombinant Schistosoma mansoni dihydrofolate reductase.~~,~~Serrao VHB, Romanello L, Cassago A, de Souza JRT, Cheleski J, DeMarco R, Brandao-Neto J, Pereira HD Acta Trop~~. ~~2017 Jun;170:190-196. doi: 10.1016/j.actatropica.2017.03.007. Epub, 2017 Mar 11. PMID:28288799~~<ref>PMID:28288799</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3vco" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 25:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Blood fluke]]
-	[[Category: Dihydrofolate reductase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cassago, A]]	+	[[Category: Schistosoma mansoni]]
-	[[Category: DeMarco, R]]	+	[[Category: Cassago A]]
-	[[Category: Pereira~~, H M~~]]	+	[[Category: DeMarco R]]
-	[[Category: Romanello, L]]	+	[[Category: Pereira HM]]
-	[[Category: Serrao~~, V H.B]]~~	+	[[Category: Romanello L]]
-	~~[[Category: Oxidoreductase]]~~	+	[[Category: Serrao VHB]]
-	~~[[Category: Reductase~~]]	+

OCA at 18:38, 27 July 2022

OCA — Wed, 27 Jul 2022 18:38:36 GMT

←Older revision		Revision as of 18:38, 27 July 2022
Line 1:		Line 1:

	==Schistosoma mansoni Dihydrofolate reductase==		==Schistosoma mansoni Dihydrofolate reductase==
-	<StructureSection load='3vco' size='340' side='right' caption='[[3vco]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='3vco' size='340' side='right'caption='[[3vco]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vco]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3VCO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VCO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR, Smp_175230 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR, Smp_175230 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vco OCA], [~~http~~://pdbe.org/3vco PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3vco RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3vco PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3vco ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vco OCA], [https://pdbe.org/3vco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vco RCSB], [https://www.ebi.ac.uk/pdbsum/3vco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vco ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]	+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	[[Category: Blood fluke]]		[[Category: Blood fluke]]
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
		+	[[Category: Large Structures]]
	[[Category: Cassago, A]]		[[Category: Cassago, A]]
	[[Category: DeMarco, R]]		[[Category: DeMarco, R]]

OCA at 16:30, 27 February 2019

OCA — Wed, 27 Feb 2019 16:30:45 GMT

←Older revision		Revision as of 16:30, 27 February 2019
Line 3:		Line 3:
	<StructureSection load='3vco' size='340' side='right' caption='[[3vco]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3vco' size='340' side='right' caption='[[3vco]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vco]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VCO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VCO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR, Smp_175230 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vco OCA], [http://pdbe.org/3vco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vco RCSB], [http://www.ebi.ac.uk/pdbsum/3vco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vco ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vco OCA], [http://pdbe.org/3vco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vco RCSB], [http://www.ebi.ac.uk/pdbsum/3vco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vco ProSAT]</span></td></tr>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Blood fluke]]
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Cassago, A]]		[[Category: Cassago, A]]

OCA at 07:07, 24 May 2017

OCA — Wed, 24 May 2017 07:07:27 GMT

←Older revision		Revision as of 07:07, 24 May 2017
Line 3:		Line 3:
	<StructureSection load='3vco' size='340' side='right' caption='[[3vco]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3vco' size='340' side='right' caption='[[3vco]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vco]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VCO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vco]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VCO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR, Smp_175230 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vco OCA], [http://pdbe.org/3vco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vco RCSB], [http://www.ebi.ac.uk/pdbsum/3vco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vco ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vco OCA], [http://pdbe.org/3vco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vco RCSB], [http://www.ebi.ac.uk/pdbsum/3vco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vco ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The parasite Schistosoma mansoni possesses all pathways for pyrimidine biosynthesis, in which dihydrofolate reductase (DHFR), thymidylate cycle participants, is essential for nucleotide metabolism to obtain energy and structural nucleic acids. Thus, DHFRs have been widely suggested as therapeutic targets for the treatment of infectious diseases. In this study, we expressed recombinant SmDHFR in a heterologous manner to obtain structural, biochemical and kinetic information. X-ray diffraction of recombinant SmDHFR at 1.95A resolution showed that the structure exhibited the canonical DHFR fold. Isothermal titration calorimetry was used to determine the kinetic constants for NADP+ and dihydrofolate. Moreover, inhibition assays were performed using the commercial folate analogs methotrexate and aminopterin; these analogs are recognized as folate competitors and are used as chemotherapeutic agents in cancer and autoimmune diseases. This study provides information that may prove useful for the future discovery of novel drugs and for understanding these metabolic steps from this pathway of S. mansoni, thus aiding in our understanding of the function of these essential pathways for parasite metabolism.
		+
		+	Structure and kinetics assays of recombinant Schistosoma mansoni dihydrofolate reductase.,Serrao VHB, Romanello L, Cassago A, de Souza JRT, Cheleski J, DeMarco R, Brandao-Neto J, Pereira HD Acta Trop. 2017 Jun;170:190-196. doi: 10.1016/j.actatropica.2017.03.007. Epub, 2017 Mar 11. PMID:28288799<ref>PMID:28288799</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3vco" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Blood fluke]]
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Cassago, A]]		[[Category: Cassago, A]]

OCA at 09:11, 11 August 2016

OCA — Thu, 11 Aug 2016 09:11:51 GMT

←Older revision		Revision as of 09:11, 11 August 2016
Line 1:		Line 1:
		+
	==Schistosoma mansoni Dihydrofolate reductase==		==Schistosoma mansoni Dihydrofolate reductase==
	<StructureSection load='3vco' size='340' side='right' caption='[[3vco]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3vco' size='340' side='right' caption='[[3vco]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schistosoma_mansoni Schistosoma mansoni~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VCO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VCO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR, Smp_175230 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 ~~Schistosoma mansoni~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR, Smp_175230 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vco RCSB], [http://www.ebi.ac.uk/pdbsum/3vco PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vco OCA], [http://pdbe.org/3vco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vco RCSB], [http://www.ebi.ac.uk/pdbsum/3vco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vco ProSAT]</span></td></tr>
	</table>		</table>

Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Blood fluke]]
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
-	[[Category: Schistosoma mansoni]]
	[[Category: Cassago, A]]		[[Category: Cassago, A]]
	[[Category: DeMarco, R]]		[[Category: DeMarco, R]]

OCA at 09:27, 4 January 2015

OCA — Sun, 04 Jan 2015 09:27:15 GMT

←Older revision		Revision as of 09:27, 4 January 2015
Line 1:		Line 1:
-	[[~~Image:~~3vco.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Schistosoma mansoni Dihydrofolate reductase==
		+	<StructureSection load='3vco' size='340' side='right' caption='[[3vco]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VCO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR, Smp_175230 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Schistosoma mansoni])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vco RCSB], [http://www.ebi.ac.uk/pdbsum/3vco PDBsum]</span></td></tr>
		+	</table>

-	~~{{STRUCTURE_3vco\| PDB~~=~~3vco \| SCENE= }}~~	+	==See Also==
-		+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
-	~~===Schistosoma mansoni Dihydrofolate reductase~~===	+	__TOC__
-		+	</StructureSection>
-		+
-	~~==About this Structure==~~	+
-	[[~~3vco~~]] ~~is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA].~~	+
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Schistosoma mansoni]]		[[Category: Schistosoma mansoni]]
-	[[Category: Cassago, A.]]	+	[[Category: Cassago, A]]
-	[[Category: DeMarco, R.]]	+	[[Category: DeMarco, R]]
-	[[Category: Pereira, H M.]]	+	[[Category: Pereira, H M]]
-	[[Category: Romanello, L.]]	+	[[Category: Romanello, L]]
-	[[Category: Serrao, V H.B.]]	+	[[Category: Serrao, V H.B]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Reductase]]		[[Category: Reductase]]

OCA at 14:18, 6 March 2013

OCA — Wed, 06 Mar 2013 14:18:45 GMT

←Older revision		Revision as of 14:18, 6 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3vco.jpg\|left\|200px]]

-	~~The entry~~ 3vco ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3vco\| PDB=3vco \| SCENE= }}

-	~~Authors: Serrao, V.H.B., Romanello, L., Cassago, A., DeMarco, R., Pereira, H.M.~~	+	===Schistosoma mansoni Dihydrofolate reductase===

-	~~Description~~: Schistosoma mansoni Dihydrofolate reductase	+
		+	==About this Structure==
		+	[[3vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCO OCA].
		+	[[Category: Dihydrofolate reductase]]
		+	[[Category: Schistosoma mansoni]]
		+	[[Category: Cassago, A.]]
		+	[[Category: DeMarco, R.]]
		+	[[Category: Pereira, H M.]]
		+	[[Category: Romanello, L.]]
		+	[[Category: Serrao, V H.B.]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Reductase]]

OCA at 06:34, 25 July 2012

OCA — Wed, 25 Jul 2012 06:34:28 GMT

←Older revision		Revision as of 06:34, 25 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3vco is ON HOLD	+	The entry 3vco is ON HOLD until Paper Publication

	Authors: Serrao, V.H.B., Romanello, L., Cassago, A., DeMarco, R., Pereira, H.M.		Authors: Serrao, V.H.B., Romanello, L., Cassago, A., DeMarco, R., Pereira, H.M.

	Description: Schistosoma mansoni Dihydrofolate reductase		Description: Schistosoma mansoni Dihydrofolate reductase

OCA at 06:03, 25 January 2012

OCA — Wed, 25 Jan 2012 06:03:56 GMT

←Older revision		Revision as of 06:03, 25 January 2012
Line 3:		Line 3:
	The entry 3vco is ON HOLD		The entry 3vco is ON HOLD

-	Authors: Serrao, V.H.B., Romanello, L., Cassago. A., DeMarco, R., Pereira, H.M.	+	Authors: Serrao, V.H.B., Romanello, L., Cassago, A., DeMarco, R., Pereira, H.M.

	Description: Schistosoma mansoni Dihydrofolate reductase		Description: Schistosoma mansoni Dihydrofolate reductase

OCA: Protected "3vco" [edit=sysop:move=sysop]

OCA — Wed, 11 Jan 2012 06:01:35 GMT

Protected "3vco" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:01, 11 January 2012