3veu - Revision history

OCA at 18:41, 27 July 2022

OCA — Wed, 27 Jul 2022 18:41:43 GMT

←Older revision		Revision as of 18:41, 27 July 2022
Line 1:		Line 1:

	==Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326==		==Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326==
-	<StructureSection load='3veu' size='340' side='right' caption='[[3veu]], [[Resolution\|resolution]] 1.52Å' scene=''>	+	<StructureSection load='3veu' size='340' side='right'caption='[[3veu]], [[Resolution\|resolution]] 1.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3veu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3VEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3veu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VEU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GO:(2S)-N-[(2S,3R)-3-HYDROXY-1-PHENYL-4-{[3-(PROPAN-2-YL)BENZYL]AMINO}BUTAN-2-YL]-2-[(5S)-6-OXO-1-PROPYL-1,7-DIAZASPIRO[4.4]NON-7-YL]PROPANAMIDE'>0GO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GO:(2S)-N-[(2S,3R)-3-HYDROXY-1-PHENYL-4-{[3-(PROPAN-2-YL)BENZYL]AMINO}BUTAN-2-YL]-2-[(5S)-6-OXO-1-PROPYL-1,7-DIAZASPIRO[4.4]NON-7-YL]PROPANAMIDE'>0GO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vf3\|3vf3]], [[3vg1\|3vg1]], [[4d83\|4d83]], [[4d85\|4d85]], [[4d88\|4d88]], [[4d89\|4d89]], [[4d8c\|4d8c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vf3\|3vf3]], [[3vg1\|3vg1]], [[4d83\|4d83]], [[4d85\|4d85]], [[4d88\|4d88]], [[4d89\|4d89]], [[4d8c\|4d8c]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3veu OCA], [~~http~~://pdbe.org/3veu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3veu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3veu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3veu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3veu OCA], [https://pdbe.org/3veu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3veu RCSB], [https://www.ebi.ac.uk/pdbsum/3veu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3veu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Bourgier, E]]		[[Category: Bourgier, E]]

OCA at 13:16, 5 August 2016

OCA — Fri, 05 Aug 2016 13:16:41 GMT

←Older revision		Revision as of 13:16, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326==		==Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326==
	<StructureSection load='3veu' size='340' side='right' caption='[[3veu]], [[Resolution\|resolution]] 1.52Å' scene=''>		<StructureSection load='3veu' size='340' side='right' caption='[[3veu]], [[Resolution\|resolution]] 1.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3veu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3veu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VEU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GO:(2S)-N-[(2S,3R)-3-HYDROXY-1-PHENYL-4-{[3-(PROPAN-2-YL)BENZYL]AMINO}BUTAN-2-YL]-2-[(5S)-6-OXO-1-PROPYL-1,7-DIAZASPIRO[4.4]NON-7-YL]PROPANAMIDE'>0GO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GO:(2S)-N-[(2S,3R)-3-HYDROXY-1-PHENYL-4-{[3-(PROPAN-2-YL)BENZYL]AMINO}BUTAN-2-YL]-2-[(5S)-6-OXO-1-PROPYL-1,7-DIAZASPIRO[4.4]NON-7-YL]PROPANAMIDE'>0GO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vf3\|3vf3]], [[3vg1\|3vg1]], [[4d83\|4d83]], [[4d85\|4d85]], [[4d88\|4d88]], [[4d89\|4d89]], [[4d8c\|4d8c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vf3\|3vf3]], [[3vg1\|3vg1]], [[4d83\|4d83]], [[4d85\|4d85]], [[4d88\|4d88]], [[4d89\|4d89]], [[4d8c\|4d8c]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3veu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3veu RCSB], [http://www.ebi.ac.uk/pdbsum/3veu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3veu OCA], [http://pdbe.org/3veu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3veu RCSB], [http://www.ebi.ac.uk/pdbsum/3veu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3veu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3veu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Bourgier, E]]		[[Category: Bourgier, E]]

OCA at 19:08, 25 December 2014

OCA — Thu, 25 Dec 2014 19:08:19 GMT

←Older revision		Revision as of 19:08, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3veu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3veu RCSB], [http://www.ebi.ac.uk/pdbsum/3veu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3veu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3veu RCSB], [http://www.ebi.ac.uk/pdbsum/3veu PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:56, 9 December 2014

OCA — Tue, 09 Dec 2014 14:56:59 GMT

←Older revision		Revision as of 14:56, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3veu.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326==
		+	<StructureSection load='3veu' size='340' side='right' caption='[[3veu]], [[Resolution\|resolution]] 1.52Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3veu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VEU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GO:(2S)-N-[(2S,3R)-3-HYDROXY-1-PHENYL-4-{[3-(PROPAN-2-YL)BENZYL]AMINO}BUTAN-2-YL]-2-[(5S)-6-OXO-1-PROPYL-1,7-DIAZASPIRO[4.4]NON-7-YL]PROPANAMIDE'>0GO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vf3\|3vf3]], [[3vg1\|3vg1]], [[4d83\|4d83]], [[4d85\|4d85]], [[4d88\|4d88]], [[4d89\|4d89]], [[4d8c\|4d8c]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3veu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3veu RCSB], [http://www.ebi.ac.uk/pdbsum/3veu PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Structure-based design of a series of cyclic hydroxyethylamine BACE1 inhibitors allowed the rational incorporation of prime- and nonprime-side fragments to a central core template without any amide functionality. The core scaffold selection and the structure-activity relationship development were supported by molecular modeling studies and by X-ray analysis of BACE1 complexes with various ligands to expedite the optimization of the series. The direct extension from P1-aryl- and heteroaryl moieties into the S3 binding pocket allowed the enhancement of potency and selectivity over cathepsin D. Restraining the design and synthesis of compounds to a physicochemical property space consistent with central nervous system drugs led to inhibitors with improved blood-brain barrier permeability. Guided by structure-based optimization, we were able to obtain highly potent compounds such as 60p with enzymatic and cellular IC(50) values of 2 and 50 nM, respectively, and with >200-fold selectivity over cathepsin D. Pharmacodynamic studies in APP51/16 transgenic mice at oral doses of 180 mumol/kg demonstrated significant reduction of brain Abeta levels.

-	~~{{STRUCTURE_3veu\| PDB=3veu \| SCENE= }}~~	+	Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid beta-peptides.,Rueeger H, Lueoend R, Rogel O, Rondeau JM, Mobitz H, Machauer R, Jacobson L, Staufenbiel M, Desrayaud S, Neumann U J Med Chem. 2012 Apr 12;55(7):3364-86. Epub 2012 Mar 21. PMID:22380629<ref>PMID:22380629</ref>

-	~~===Crystal Structure~~ of ~~Human Beta Secretase in Complex with NVP-AVI326===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22380629}}~~	+	==See Also==
-		+	*[[Beta secretase\|Beta secretase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3veu~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEU OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:021388807<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Bourgier, E.]]	+	[[Category: Bourgier, E]]
-	[[Category: Rondeau, J M.]]	+	[[Category: Rondeau, J M]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Structure-based drug design]]		[[Category: Structure-based drug design]]

OCA at 09:26, 21 November 2012

OCA — Wed, 21 Nov 2012 09:26:03 GMT

←Older revision		Revision as of 09:26, 21 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3veu.jpg\|left\|200px]]

-	~~The entry~~ 3veu ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3veu\| PDB=3veu \| SCENE= }}

-	~~Authors: Rondeau, J.M., Bourgier, E.~~	+	===Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326===

-	~~Description: Crystal~~ Structure ~~of Human Beta Secretase in Complex~~ with ~~NVP~~-~~AVI326~~	+	{{ABSTRACT_PUBMED_22380629}}
		+
		+	==About this Structure==
		+	[[3veu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEU OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021388807</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Memapsin 2]]
		+	[[Category: Bourgier, E.]]
		+	[[Category: Rondeau, J M.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Structure-based drug design]]

OCA at 06:04, 25 January 2012

OCA — Wed, 25 Jan 2012 06:04:17 GMT

←Older revision		Revision as of 06:04, 25 January 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3veu is ON HOLD	+	The entry 3veu is ON HOLD until Paper Publication

	Authors: Rondeau, J.M., Bourgier, E.		Authors: Rondeau, J.M., Bourgier, E.

	Description: Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326		Description: Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326

OCA: Protected "3veu" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2012 10:21:12 GMT

Protected "3veu" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:21, 18 January 2012

OCA: New page: '''Unreleased structure''' The entry 3veu is ON HOLD Authors: Rondeau, J.M., Bourgier, E. Description: Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326

OCA — Wed, 18 Jan 2012 10:21:10 GMT

New page: '''Unreleased structure''' The entry 3veu is ON HOLD Authors: Rondeau, J.M., Bourgier, E. Description: Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326

New page

'''Unreleased structure'''

The entry 3veu is ON HOLD

Authors: Rondeau, J.M., Bourgier, E.

Description: Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326