3vfg - Revision history

OCA at 14:27, 14 March 2024

OCA — Thu, 14 Mar 2024 14:27:14 GMT

←Older revision		Revision as of 14:27, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3vfg' size='340' side='right'caption='[[3vfg]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3vfg' size='340' side='right'caption='[[3vfg]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vfg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vfg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VFG FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1psk\|1psk]]~~, [[~~2aju~~\|~~2aju~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vfg OCA], [https://pdbe.org/3vfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vfg RCSB], [https://www.ebi.ac.uk/pdbsum/3vfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vfg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vfg OCA], [https://pdbe.org/3vfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vfg RCSB], [https://www.ebi.ac.uk/pdbsum/3vfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vfg ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Ganglioside GD2 is a cell surface glycolipid that is highly expressed on cancer cells of neuroectodermal origin, including neuroblastoma, retinoblastoma, melanoma, sarcomas, brain tumors and small cell lung cancer. Monoclonal antibodies (MoAb) that target GD2 have shown clinical efficacy in the treatment of GD2 expressing tumors, and are expected to be the new standard of care for the treatment of pediatric neuroblastoma. In this study, the crystal structure of anti-GD2 murine MoAb 3F8 was solved to 1.65 A resolution and used as a template for molecular docking simulations of its antigen, the penta-saccharide head group of GD2. Molecular docking revealed a binding motif composed of 12 key interacting amino acid side-chains, involving an extensive network of interactions involving main-chain and side-chain hydrogen bonding, two Pi - CH interactions, and an important charged interaction between Arg95 of the H3 loop with the penultimate sialic acid residue of GD2. Based on in silico scanning mutagenesis of the 12 interacting amino acids from the docked 3F8:GD2 model, a single point mutation (Heavy Chain: Gly54Ile) was engineered into a humanized 3F8 (hu3F8) MoAb and found to have a 6-9 fold enhancement in antibody-dependent cell-mediated cytotoxicity of neuroblastoma and melanoma cell lines. With enhanced tumor-killing properties, the re-engineered hu3F8 has the potential be a more effective antibody for the treatment of GD2-positive tumors.

-	In silico Driven Redesign of a Clinically Relevant Antibody for the Treatment of GD2 Positive Tumors.,Ahmed M, Goldgur Y, Hu J, Guo HF, Cheung NK PLoS One. 2013 May 16;8(5):e63359. doi: 10.1371/journal.pone.0063359. Print 2013. PMID:23696816<ref>PMID:23696816</ref>	+	==See Also==
-		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3vfg" style="background-color:#fffaf0;"></div>~~	+
-	== ~~References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Ahmed, M]]	+	[[Category: Ahmed M]]
-	[[Category: Cheung, N K]]	+	[[Category: Cheung N-K]]
-	[[Category: Goldgur, Y]]	+	[[Category: Goldgur Y]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Gd2 ganglioside]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin~~]]	+

OCA at 18:42, 27 July 2022

OCA — Wed, 27 Jul 2022 18:42:37 GMT

←Older revision		Revision as of 18:42, 27 July 2022
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	==Crystal structure of monoclonal antibody 3F8 Fab fragment that binds to GD2 ganglioside==		==Crystal structure of monoclonal antibody 3F8 Fab fragment that binds to GD2 ganglioside==
-	<StructureSection load='3vfg' size='340' side='right' caption='[[3vfg]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='3vfg' size='340' side='right'caption='[[3vfg]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vfg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3VFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vfg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VFG FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1psk\|1psk]], [[2aju\|2aju]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1psk\|1psk]], [[2aju\|2aju]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3vfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vfg OCA], [~~http~~://pdbe.org/3vfg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3vfg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3vfg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3vfg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vfg OCA], [https://pdbe.org/3vfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vfg RCSB], [https://www.ebi.ac.uk/pdbsum/3vfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vfg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Ahmed, M]]		[[Category: Ahmed, M]]

OCA at 14:23, 29 March 2017

OCA — Wed, 29 Mar 2017 14:23:26 GMT

←Older revision		Revision as of 14:23, 29 March 2017
Line 1:		Line 1:
		+
	==Crystal structure of monoclonal antibody 3F8 Fab fragment that binds to GD2 ganglioside==		==Crystal structure of monoclonal antibody 3F8 Fab fragment that binds to GD2 ganglioside==
	<StructureSection load='3vfg' size='340' side='right' caption='[[3vfg]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3vfg' size='340' side='right' caption='[[3vfg]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3vfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VFG FirstGlance]. <br>		<table><tr><td colspan='2'>[[3vfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VFG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1psk\|1psk]], [[2aju\|2aju]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1psk\|1psk]], [[2aju\|2aju]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vfg RCSB], [http://www.ebi.ac.uk/pdbsum/3vfg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vfg OCA], [http://pdbe.org/3vfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vfg RCSB], [http://www.ebi.ac.uk/pdbsum/3vfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vfg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3vfg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:48, 24 June 2015

OCA — Wed, 24 Jun 2015 06:48:39 GMT

←Older revision		Revision as of 06:48, 24 June 2015
Line 1:		Line 1:
-	==Crystal structure of monoclonal ~~anitbody~~ 3F8 Fab fragment that binds to GD2 ganglioside==	+	==Crystal structure of monoclonal antibody 3F8 Fab fragment that binds to GD2 ganglioside==
	<StructureSection load='3vfg' size='340' side='right' caption='[[3vfg]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3vfg' size='340' side='right' caption='[[3vfg]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VFG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1psk\|1psk]], [[2aju\|2aju]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1psk\|1psk]], [[2aju\|2aju]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vfg RCSB], [http://www.ebi.ac.uk/pdbsum/3vfg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vfg RCSB], [http://www.ebi.ac.uk/pdbsum/3vfg PDBsum]</span></td></tr>
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Ahmed, M]]		[[Category: Ahmed, M]]
	[[Category: Cheung, N K]]		[[Category: Cheung, N K]]

OCA at 07:27, 21 December 2014

OCA — Sun, 21 Dec 2014 07:27:25 GMT

←Older revision		Revision as of 07:27, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3vfg\| PDB=3vfg \| SCENE= }}~~	+	==Crystal structure of monoclonal anitbody 3F8 Fab fragment that binds to GD2 ganglioside==
-	===Crystal structure of monoclonal anitbody 3F8 Fab fragment that binds to GD2 ganglioside===	+	<StructureSection load='3vfg' size='340' side='right' caption='[[3vfg]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23696816}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3vfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VFG FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1psk\|1psk]], [[2aju\|2aju]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vfg RCSB], [http://www.ebi.ac.uk/pdbsum/3vfg PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ganglioside GD2 is a cell surface glycolipid that is highly expressed on cancer cells of neuroectodermal origin, including neuroblastoma, retinoblastoma, melanoma, sarcomas, brain tumors and small cell lung cancer. Monoclonal antibodies (MoAb) that target GD2 have shown clinical efficacy in the treatment of GD2 expressing tumors, and are expected to be the new standard of care for the treatment of pediatric neuroblastoma. In this study, the crystal structure of anti-GD2 murine MoAb 3F8 was solved to 1.65 A resolution and used as a template for molecular docking simulations of its antigen, the penta-saccharide head group of GD2. Molecular docking revealed a binding motif composed of 12 key interacting amino acid side-chains, involving an extensive network of interactions involving main-chain and side-chain hydrogen bonding, two Pi - CH interactions, and an important charged interaction between Arg95 of the H3 loop with the penultimate sialic acid residue of GD2. Based on in silico scanning mutagenesis of the 12 interacting amino acids from the docked 3F8:GD2 model, a single point mutation (Heavy Chain: Gly54Ile) was engineered into a humanized 3F8 (hu3F8) MoAb and found to have a 6-9 fold enhancement in antibody-dependent cell-mediated cytotoxicity of neuroblastoma and melanoma cell lines. With enhanced tumor-killing properties, the re-engineered hu3F8 has the potential be a more effective antibody for the treatment of GD2-positive tumors.

-	~~==About this Structure==~~	+	In silico Driven Redesign of a Clinically Relevant Antibody for the Treatment of GD2 Positive Tumors.,Ahmed M, Goldgur Y, Hu J, Guo HF, Cheung NK PLoS One. 2013 May 16;8(5):e63359. doi: 10.1371/journal.pone.0063359. Print 2013. PMID:23696816<ref>PMID:23696816</ref>
-	~~[[3vfg]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3VFG OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023696816</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Ahmed, M.]]	+	[[Category: Ahmed, M]]
-	[[Category: Cheung, N K.]]	+	[[Category: Cheung, N K]]
-	[[Category: Goldgur, Y.]]	+	[[Category: Goldgur, Y]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Gd2 ganglioside]]		[[Category: Gd2 ganglioside]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 07:46, 30 June 2013

OCA — Sun, 30 Jun 2013 07:46:56 GMT

←Older revision		Revision as of 07:46, 30 June 2013
Line 1:		Line 1:
	{{STRUCTURE_3vfg\| PDB=3vfg \| SCENE= }}		{{STRUCTURE_3vfg\| PDB=3vfg \| SCENE= }}
	===Crystal structure of monoclonal anitbody 3F8 Fab fragment that binds to GD2 ganglioside===		===Crystal structure of monoclonal anitbody 3F8 Fab fragment that binds to GD2 ganglioside===
		+	{{ABSTRACT_PUBMED_23696816}}

	==About this Structure==		==About this Structure==
	[[3vfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA].		[[3vfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023696816</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Ahmed, M.]]		[[Category: Ahmed, M.]]

OCA at 16:28, 19 June 2013

OCA — Wed, 19 Jun 2013 16:28:03 GMT

←Older revision		Revision as of 16:28, 19 June 2013
Line 1:		Line 1:
-	[[Image:3vfg.jpg\|left\|200px]]
-
	{{STRUCTURE_3vfg\| PDB=3vfg \| SCENE= }}		{{STRUCTURE_3vfg\| PDB=3vfg \| SCENE= }}
-
	===Crystal structure of monoclonal anitbody 3F8 Fab fragment that binds to GD2 ganglioside===		===Crystal structure of monoclonal anitbody 3F8 Fab fragment that binds to GD2 ganglioside===
-

	==About this Structure==		==About this Structure==

OCA at 13:02, 6 February 2013

OCA — Wed, 06 Feb 2013 13:02:46 GMT

←Older revision		Revision as of 13:02, 6 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3vfg.jpg\|left\|200px]]

-	~~The entry~~ 3vfg ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3vfg\| PDB=3vfg \| SCENE= }}

-	~~Authors: Ahmed, M., Goldgur, Y., Cheung, N.K.~~	+	===Crystal structure of monoclonal anitbody 3F8 Fab fragment that binds to GD2 ganglioside===

-	~~Description: Crystal~~ structure ~~of monoclonal anitbody 3F8 Fab fragment that binds to GD2~~ ganglioside	+
		+	==About this Structure==
		+	[[3vfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VFG OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Ahmed, M.]]
		+	[[Category: Cheung, N K.]]
		+	[[Category: Goldgur, Y.]]
		+	[[Category: Antibody]]
		+	[[Category: Gd2 ganglioside]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin]]

OCA at 07:05, 21 March 2012

OCA — Wed, 21 Mar 2012 07:05:41 GMT

←Older revision		Revision as of 07:05, 21 March 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3vfg is ON HOLD	+	The entry 3vfg is ON HOLD until Paper Publication

	Authors: Ahmed, M., Goldgur, Y., Cheung, N.K.		Authors: Ahmed, M., Goldgur, Y., Cheung, N.K.

	Description: Crystal structure of monoclonal anitbody 3F8 Fab fragment that binds to GD2 ganglioside		Description: Crystal structure of monoclonal anitbody 3F8 Fab fragment that binds to GD2 ganglioside

OCA: Protected "3vfg" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2012 10:21:51 GMT

Protected "3vfg" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:21, 18 January 2012