3vi8 - Revision history

OCA at 12:22, 8 November 2023

OCA — Wed, 08 Nov 2023 12:22:41 GMT

←Older revision		Revision as of 12:22, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3vi8' size='340' side='right'caption='[[3vi8]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3vi8' size='340' side='right'caption='[[3vi8]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vi8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VI8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vi8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VI8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=13M:(2S)~~-~~2-(4-METHOXY-3-{~~[~~(PYREN-~~1~~-YLCARBONYL)AMINO]METHYL}BENZYL)BUTANOIC+ACID'>13M</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[2znn\|2znn~~]~~]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13M:(2S)-2-(4-METHOXY-3-{[(PYREN-1-YLCARBONYL)AMINO]METHYL}BENZYL)BUTANOIC+ACID'>13M</scene></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">PPARA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vi8 OCA], [https://pdbe.org/3vi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vi8 RCSB], [https://www.ebi.ac.uk/pdbsum/3vi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vi8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vi8 OCA], [https://pdbe.org/3vi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vi8 RCSB], [https://www.ebi.ac.uk/pdbsum/3vi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vi8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN]] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>	+	[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Miyachi, H]]	+	[[Category: Miyachi H]]
-	[[Category: Morikawa, K]]	+	[[Category: Morikawa K]]
-	[[Category: Oyama, T]]	+	[[Category: Oyama T]]
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Ppar]]~~	+
-	~~[[Category: Protein-ligand complex]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 18:47, 27 July 2022

OCA — Wed, 27 Jul 2022 18:47:22 GMT

←Older revision		Revision as of 18:47, 27 July 2022
Line 1:		Line 1:

	==Human PPAR alpha ligand binding domain in complex with a synthetic agonist APHM13==		==Human PPAR alpha ligand binding domain in complex with a synthetic agonist APHM13==
-	<StructureSection load='3vi8' size='340' side='right' caption='[[3vi8]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='3vi8' size='340' side='right'caption='[[3vi8]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vi8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3VI8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vi8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VI8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13M:(2S)-2-(4-METHOXY-3-{[(PYREN-1-YLCARBONYL)AMINO]METHYL}BENZYL)BUTANOIC+ACID'>13M</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13M:(2S)-2-(4-METHOXY-3-{[(PYREN-1-YLCARBONYL)AMINO]METHYL}BENZYL)BUTANOIC+ACID'>13M</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2znn\|2znn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2znn\|2znn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3vi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vi8 OCA], [~~http~~://pdbe.org/3vi8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3vi8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3vi8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vi8 OCA], [https://pdbe.org/3vi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vi8 RCSB], [https://www.ebi.ac.uk/pdbsum/3vi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vi8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN]] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>	+	[[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN]] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Peroxisome ~~Proliferator~~-~~Activated Receptors~~\|Peroxisome ~~Proliferator~~-~~Activated Receptors~~]]	+	*[[Peroxisome proliferator-activated receptor 3D structures\|Peroxisome proliferator-activated receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Miyachi, H]]		[[Category: Miyachi, H]]
	[[Category: Morikawa, K]]		[[Category: Morikawa, K]]

OCA at 07:01, 2 March 2016

OCA — Wed, 02 Mar 2016 07:01:42 GMT

←Older revision		Revision as of 07:01, 2 March 2016
Line 1:		Line 1:
-	==Human ~~PPRR~~ alpha ligand binding domain in complex with a synthetic agonist APHM13==	+
		+	==Human PPAR alpha ligand binding domain in complex with a synthetic agonist APHM13==
	<StructureSection load='3vi8' size='340' side='right' caption='[[3vi8]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3vi8' size='340' side='right' caption='[[3vi8]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vi8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VI8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vi8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VI8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13M:(2S)-2-(4-METHOXY-3-{[(PYREN-1-YLCARBONYL)AMINO]METHYL}BENZYL)BUTANOIC+ACID'>13M</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13M:(2S)-2-(4-METHOXY-3-{[(PYREN-1-YLCARBONYL)AMINO]METHYL}BENZYL)BUTANOIC+ACID'>13M</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2znn\|2znn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2znn\|2znn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vi8 RCSB], [http://www.ebi.ac.uk/pdbsum/3vi8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vi8 OCA], [http://pdbe.org/3vi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vi8 RCSB], [http://www.ebi.ac.uk/pdbsum/3vi8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3vi8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Miyachi, H]]		[[Category: Miyachi, H]]
	[[Category: Morikawa, K]]		[[Category: Morikawa, K]]

OCA at 12:17, 25 December 2014

OCA — Thu, 25 Dec 2014 12:17:14 GMT

←Older revision		Revision as of 12:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3vi8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VI8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3vi8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VI8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13M:(2S)-2-(4-METHOXY-3-{[(PYREN-1-YLCARBONYL)AMINO]METHYL}BENZYL)BUTANOIC+ACID'>13M</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13M:(2S)-2-(4-METHOXY-3-{[(PYREN-1-YLCARBONYL)AMINO]METHYL}BENZYL)BUTANOIC+ACID'>13M</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2znn\|2znn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2znn\|2znn]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vi8 RCSB], [http://www.ebi.ac.uk/pdbsum/3vi8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vi8 RCSB], [http://www.ebi.ac.uk/pdbsum/3vi8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN]] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Miyachi, H.]]	+	[[Category: Miyachi, H]]
-	[[Category: Morikawa, K.]]	+	[[Category: Morikawa, K]]
-	[[Category: Oyama, T.]]	+	[[Category: Oyama, T]]
	[[Category: Nuclear receptor]]		[[Category: Nuclear receptor]]
	[[Category: Ppar]]		[[Category: Ppar]]
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 09:14, 11 June 2014

OCA — Wed, 11 Jun 2014 09:14:30 GMT

←Older revision		Revision as of 09:14, 11 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3vi8.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Human PPRR alpha ligand binding domain in complex with a synthetic agonist APHM13==
		+	<StructureSection load='3vi8' size='340' side='right' caption='[[3vi8]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3vi8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VI8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13M:(2S)-2-(4-METHOXY-3-{[(PYREN-1-YLCARBONYL)AMINO]METHYL}BENZYL)BUTANOIC+ACID'>13M</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2znn\|2znn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vi8 RCSB], [http://www.ebi.ac.uk/pdbsum/3vi8 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human peroxisome proliferator-activated receptors (hPPARs) are ligand-dependent transcription factors that control various biological responses, and there are three subtypes: hPPARalpha, hPPARdelta, and hPPARgamma. We report here that alpha-substituted phenylpropanoic acid-type hPPAR agonists with similar structure bind to the hPPAR ligand binding domain (LBD) in different conformations, depending on the receptor subtype. These results might indicate that hPPAR ligand binding pockets have multiple binding points that can be utilized to accommodate structurally flexible hPPAR ligands.

-	~~{{STRUCTURE_3vi8\| PDB=3vi8 \| SCENE= }}~~	+	Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.,Kuwabara N, Oyama T, Tomioka D, Ohashi M, Yanagisawa J, Shimizu T, Miyachi H J Med Chem. 2012 Jan 26;55(2):893-902. Epub 2012 Jan 10. PMID:22185225<ref>PMID:22185225</ref>

-	~~===Human PPRR alpha ligand binding domain in complex with~~ a ~~synthetic agonist APHM13===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22185225}}~~	+	==See Also==
-		+	*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3vi8~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI8 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:022185225<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Miyachi, H.]]		[[Category: Miyachi, H.]]

OCA at 05:11, 29 August 2012

OCA — Wed, 29 Aug 2012 05:11:09 GMT

←Older revision		Revision as of 05:11, 29 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3vi8.jpg\|left\|200px]]

-	~~The entry~~ 3vi8 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3vi8\| PDB=3vi8 \| SCENE= }}

-	~~Authors: Oyama, T., Miyachi, H., Morikawa, K.~~	+	===Human PPRR alpha ligand binding domain in complex with a synthetic agonist APHM13===

-	~~Description~~: ~~Human PPRR alpha~~ ligand ~~binding domain in~~ complex ~~with a synthetic agonist APHM13~~	+	{{ABSTRACT_PUBMED_22185225}}
		+
		+	==About this Structure==
		+	[[3vi8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VI8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022185225</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Miyachi, H.]]
		+	[[Category: Morikawa, K.]]
		+	[[Category: Oyama, T.]]
		+	[[Category: Nuclear receptor]]
		+	[[Category: Ppar]]
		+	[[Category: Protein-ligand complex]]
		+	[[Category: Transcription]]

OCA at 06:55, 28 December 2011

OCA — Wed, 28 Dec 2011 06:55:09 GMT

←Older revision		Revision as of 06:55, 28 December 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3vi8 is ON HOLD	+	The entry 3vi8 is ON HOLD until Paper Publication

	Authors: Oyama, T., Miyachi, H., Morikawa, K.		Authors: Oyama, T., Miyachi, H., Morikawa, K.

	Description: Human PPRR alpha ligand binding domain in complex with a synthetic agonist APHM13		Description: Human PPRR alpha ligand binding domain in complex with a synthetic agonist APHM13

OCA at 08:57, 30 October 2011

OCA — Sun, 30 Oct 2011 08:57:34 GMT

←Older revision		Revision as of 08:57, 30 October 2011
Line 5:		Line 5:
	Authors: Oyama, T., Miyachi, H., Morikawa, K.		Authors: Oyama, T., Miyachi, H., Morikawa, K.

-	Description: ~~HUMAN~~ PPRR ~~ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH A SYNTHETIC AGONIST~~ APHM13	+	Description: Human PPRR alpha ligand binding domain in complex with a synthetic agonist APHM13

OCA: Protected "3vi8" [edit=sysop:move=sysop]

OCA — Wed, 05 Oct 2011 06:17:17 GMT

Protected "3vi8" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:17, 5 October 2011

OCA: New page: '''Unreleased structure''' The entry 3vi8 is ON HOLD Authors: Oyama, T., Miyachi, H., Morikawa, K. Description: HUMAN PPRR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH A SYNTHETIC AGONI...

OCA — Wed, 05 Oct 2011 06:17:16 GMT

New page: '''Unreleased structure''' The entry 3vi8 is ON HOLD Authors: Oyama, T., Miyachi, H., Morikawa, K. Description: HUMAN PPRR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH A SYNTHETIC AGONI...

New page

'''Unreleased structure'''

The entry 3vi8 is ON HOLD

Authors: Oyama, T., Miyachi, H., Morikawa, K.

Description: HUMAN PPRR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH A SYNTHETIC AGONIST APHM13