3vir - Revision history

OCA at 08:40, 20 March 2024

OCA — Wed, 20 Mar 2024 08:40:17 GMT

←Older revision		Revision as of 08:40, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3vir' size='340' side='right'caption='[[3vir]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3vir' size='340' side='right'caption='[[3vir]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vir]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Fission_yeast Fission yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VIR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vir]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VIR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BOG:B~~-~~OCTYLGLUCOSIDE'>BOG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3viq\|3viq]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">swi5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vir OCA], [https://pdbe.org/3vir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vir RCSB], [https://www.ebi.ac.uk/pdbsum/3vir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vir ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vir OCA], [https://pdbe.org/3vir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vir RCSB], [https://www.ebi.ac.uk/pdbsum/3vir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vir ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SWI5_SCHPO SWI5_SCHPO]] Required for normal mating-type switching. Also involved in the rhp51-dependent recombination DNA repair pathway.<ref>PMID:14663140</ref>	+	[https://www.uniprot.org/uniprot/SWI5_SCHPO SWI5_SCHPO] Required for normal mating-type switching. Also involved in the rhp51-dependent recombination DNA repair pathway.<ref>PMID:14663140</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Rad51 forms a helical filament on single-stranded DNA and promotes strand exchange between two homologous DNA molecules during homologous recombination. The Swi5-Sfr1 complex interacts directly with Rad51 and stimulates strand exchange. Here we describe structural and functional aspects of the complex. Swi5 and the C-terminal core domain of Sfr1 form an essential activator complex with a parallel coiled-coil heterodimer joined firmly together via two previously uncharacterized leucine-zipper motifs and a bundle. The resultant coiled coil is sharply kinked, generating an elongated crescent-shaped structure suitable for transient binding within the helical groove of the Rad51 filament. The N-terminal region of Sfr1, meanwhile, has an interface for binding of Rad51. Our data suggest that the snug fit resulting from the complementary geometry of the heterodimer activates the Rad51 filament and that the N-terminal domain of Sfr1 plays a role in the efficient recruitment of the Swi5-Sfr1 complex to the Rad51 filaments.	+
-		+
-	Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex.,Kuwabara N, Murayama Y, Hashimoto H, Kokabu Y, Ikeguchi M, Sato M, Mayanagi K, Tsutsui Y, Iwasaki H, Shimizu T Structure. 2012 Mar 7;20(3):440-9. PMID:22405003<ref>PMID:22405003</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3vir" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fission yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hashimoto, H]]	+	[[Category: Schizosaccharomyces pombe 972h-]]
-	[[Category: Iwasaki, H]]	+	[[Category: Hashimoto H]]
-	[[Category: Kuwabara, N]]	+	[[Category: Iwasaki H]]
-	[[Category: Sato, M]]	+	[[Category: Kuwabara N]]
-	[[Category: Shimizu, T]]	+	[[Category: Sato M]]
-	[[Category: Yamada, N]]	+	[[Category: Shimizu T]]
-	~~[[Category: Recombination activator]]~~	+	[[Category: Yamada N]]
-	~~[[Category: Sfr1~~]]	+

OCA at 18:48, 27 July 2022

OCA — Wed, 27 Jul 2022 18:48:03 GMT

←Older revision		Revision as of 18:48, 27 July 2022
Line 1:		Line 1:

	==Crystal strcture of Swi5 from fission yeast==		==Crystal strcture of Swi5 from fission yeast==
-	<StructureSection load='3vir' size='340' side='right' caption='[[3vir]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3vir' size='340' side='right'caption='[[3vir]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vir]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3VIR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vir]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VIR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3viq\|3viq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3viq\|3viq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">swi5 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">swi5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3vir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vir OCA], [~~http~~://pdbe.org/3vir PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3vir RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3vir PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3vir ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vir OCA], [https://pdbe.org/3vir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vir RCSB], [https://www.ebi.ac.uk/pdbsum/3vir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vir ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SWI5_SCHPO SWI5_SCHPO]] Required for normal mating-type switching. Also involved in the rhp51-dependent recombination DNA repair pathway.<ref>PMID:14663140</ref>	+	[[https://www.uniprot.org/uniprot/SWI5_SCHPO SWI5_SCHPO]] Required for normal mating-type switching. Also involved in the rhp51-dependent recombination DNA repair pathway.<ref>PMID:14663140</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Fission yeast]]		[[Category: Fission yeast]]
		+	[[Category: Large Structures]]
	[[Category: Hashimoto, H]]		[[Category: Hashimoto, H]]
	[[Category: Iwasaki, H]]		[[Category: Iwasaki, H]]

OCA at 07:58, 11 August 2016

OCA — Thu, 11 Aug 2016 07:58:22 GMT

←Older revision		Revision as of 07:58, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal strcture of Swi5 from fission yeast==		==Crystal strcture of Swi5 from fission yeast==
	<StructureSection load='3vir' size='340' side='right' caption='[[3vir]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3vir' size='340' side='right' caption='[[3vir]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vir]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schizosaccharomyces_pombe Schizosaccharomyces pombe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VIR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vir]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VIR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3viq\|3viq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3viq\|3viq]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">swi5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~4896 Schizosaccharomyces pombe~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">swi5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vir OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vir RCSB], [http://www.ebi.ac.uk/pdbsum/3vir PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vir OCA], [http://pdbe.org/3vir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vir RCSB], [http://www.ebi.ac.uk/pdbsum/3vir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vir ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SWI5_SCHPO SWI5_SCHPO]] Required for normal mating-type switching. Also involved in the rhp51-dependent recombination DNA repair pathway.<ref>PMID:14663140</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3vir" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Schizosaccharomyces pombe~~]]	+	[[Category: Fission yeast]]
	[[Category: Hashimoto, H]]		[[Category: Hashimoto, H]]
	[[Category: Iwasaki, H]]		[[Category: Iwasaki, H]]

OCA at 10:04, 4 January 2015

OCA — Sun, 04 Jan 2015 10:04:14 GMT

←Older revision		Revision as of 10:04, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3vir]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VIR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3vir]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VIR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3viq\|3viq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3viq\|3viq]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">swi5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">swi5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vir OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vir RCSB], [http://www.ebi.ac.uk/pdbsum/3vir PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vir OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vir RCSB], [http://www.ebi.ac.uk/pdbsum/3vir PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
-	[[Category: Hashimoto, H.]]	+	[[Category: Hashimoto, H]]
-	[[Category: Iwasaki, H.]]	+	[[Category: Iwasaki, H]]
-	[[Category: Kuwabara, N.]]	+	[[Category: Kuwabara, N]]
-	[[Category: Sato, M.]]	+	[[Category: Sato, M]]
-	[[Category: Shimizu, T.]]	+	[[Category: Shimizu, T]]
-	[[Category: Yamada, N.]]	+	[[Category: Yamada, N]]
	[[Category: Recombination activator]]		[[Category: Recombination activator]]
	[[Category: Sfr1]]		[[Category: Sfr1]]

OCA at 09:21, 11 June 2014

OCA — Wed, 11 Jun 2014 09:21:14 GMT

←Older revision		Revision as of 09:21, 11 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3vir.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal strcture of Swi5 from fission yeast==
		+	<StructureSection load='3vir' size='340' side='right' caption='[[3vir]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3vir]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VIR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3viq\|3viq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">swi5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vir OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vir RCSB], [http://www.ebi.ac.uk/pdbsum/3vir PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rad51 forms a helical filament on single-stranded DNA and promotes strand exchange between two homologous DNA molecules during homologous recombination. The Swi5-Sfr1 complex interacts directly with Rad51 and stimulates strand exchange. Here we describe structural and functional aspects of the complex. Swi5 and the C-terminal core domain of Sfr1 form an essential activator complex with a parallel coiled-coil heterodimer joined firmly together via two previously uncharacterized leucine-zipper motifs and a bundle. The resultant coiled coil is sharply kinked, generating an elongated crescent-shaped structure suitable for transient binding within the helical groove of the Rad51 filament. The N-terminal region of Sfr1, meanwhile, has an interface for binding of Rad51. Our data suggest that the snug fit resulting from the complementary geometry of the heterodimer activates the Rad51 filament and that the N-terminal domain of Sfr1 plays a role in the efficient recruitment of the Swi5-Sfr1 complex to the Rad51 filaments.

-	~~{{STRUCTURE_3vir\| PDB=3vir \| SCENE= }}~~	+	Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex.,Kuwabara N, Murayama Y, Hashimoto H, Kokabu Y, Ikeguchi M, Sato M, Mayanagi K, Tsutsui Y, Iwasaki H, Shimizu T Structure. 2012 Mar 7;20(3):440-9. PMID:22405003<ref>PMID:22405003</ref>

-	~~===Crystal strcture~~ of ~~Swi5 from fission yeast===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22405003}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3vir]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022405003<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Hashimoto, H.]]		[[Category: Hashimoto, H.]]

OCA at 05:55, 22 August 2012

OCA — Wed, 22 Aug 2012 05:55:49 GMT

←Older revision		Revision as of 05:55, 22 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3vir.jpg\|left\|200px]]

-	~~The entry~~ 3vir ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3vir\| PDB=3vir \| SCENE= }}

-	~~Authors: Kuwabara, N., Yamada, N., Hashimoto, H., Sato, M., Iwasaki, H., Shimizu, T.~~	+	===Crystal strcture of Swi5 from fission yeast===

-	~~Description~~: ~~Crystal strcture of Swi5~~ from ~~fission yeast~~	+	{{ABSTRACT_PUBMED_22405003}}
		+
		+	==About this Structure==
		+	[[3vir]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022405003</ref><references group="xtra"/>
		+	[[Category: Schizosaccharomyces pombe]]
		+	[[Category: Hashimoto, H.]]
		+	[[Category: Iwasaki, H.]]
		+	[[Category: Kuwabara, N.]]
		+	[[Category: Sato, M.]]
		+	[[Category: Shimizu, T.]]
		+	[[Category: Yamada, N.]]
		+	[[Category: Recombination activator]]
		+	[[Category: Sfr1]]

OCA at 06:55, 28 December 2011

OCA — Wed, 28 Dec 2011 06:55:16 GMT

←Older revision		Revision as of 06:55, 28 December 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3vir is ON HOLD	+	The entry 3vir is ON HOLD until Paper Publication

	Authors: Kuwabara, N., Yamada, N., Hashimoto, H., Sato, M., Iwasaki, H., Shimizu, T.		Authors: Kuwabara, N., Yamada, N., Hashimoto, H., Sato, M., Iwasaki, H., Shimizu, T.

	Description: Crystal strcture of Swi5 from fission yeast		Description: Crystal strcture of Swi5 from fission yeast

OCA: Protected "3vir" [edit=sysop:move=sysop]

OCA — Sun, 30 Oct 2011 08:58:03 GMT

Protected "3vir" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:58, 30 October 2011

OCA: New page: '''Unreleased structure''' The entry 3vir is ON HOLD Authors: Kuwabara, N., Yamada, N., Hashimoto, H., Sato, M., Iwasaki, H., Shimizu, T. Description: Crystal strcture of Swi5 from fis...

OCA — Sun, 30 Oct 2011 08:58:02 GMT

New page: '''Unreleased structure''' The entry 3vir is ON HOLD Authors: Kuwabara, N., Yamada, N., Hashimoto, H., Sato, M., Iwasaki, H., Shimizu, T. Description: Crystal strcture of Swi5 from fis...

New page

'''Unreleased structure'''

The entry 3vir is ON HOLD

Authors: Kuwabara, N., Yamada, N., Hashimoto, H., Sato, M., Iwasaki, H., Shimizu, T.

Description: Crystal strcture of Swi5 from fission yeast