3vkg - Revision history

OCA at 08:40, 20 March 2024

OCA — Wed, 20 Mar 2024 08:40:27 GMT

←Older revision		Revision as of 08:40, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3vkg' size='340' side='right'caption='[[3vkg]], [[Resolution\|resolution]] 2.81Å' scene=''>		<StructureSection load='3vkg' size='340' side='right'caption='[[3vkg]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vkg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vkg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VKG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.81Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height~~: ~~3em;~~'>~~[[3ay1\|3ay1]]~~, ~~[[3vkh\|3vkh]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkg OCA], [https://pdbe.org/3vkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vkg RCSB], [https://www.ebi.ac.uk/pdbsum/3vkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vkg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkg OCA], [https://pdbe.org/3vkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vkg RCSB], [https://www.ebi.ac.uk/pdbsum/3vkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vkg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DYHC_DICDI DYHC_DICDI]] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.	+	[https://www.uniprot.org/uniprot/DYHC_DICDI DYHC_DICDI] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Dyneins are microtubule-based AAA(+) motor complexes that power ciliary beating, cell division, cell migration and intracellular transport. Here we report the most complete structure obtained so far, to our knowledge, of the 380-kDa motor domain of Dictyostelium discoideum cytoplasmic dynein at 2.8 A resolution; the data are reliable enough to discuss the structure and mechanism at the level of individual amino acid residues. Features that can be clearly visualized at this resolution include the coordination of ADP in each of four distinct nucleotide-binding sites in the ring-shaped AAA(+) ATPase unit, a newly identified interaction interface between the ring and mechanical linker, and junctional structures between the ring and microtubule-binding stalk, all of which should be critical for the mechanism of dynein motility. We also identify a long-range allosteric communication pathway between the primary ATPase and the microtubule-binding sites. Our work provides a framework for understanding the mechanism of dynein-based motility.	+
-		+
-	The 2.8 A crystal structure of the dynein motor domain.,Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G Nature. 2012 Mar 7;484(7394):345-50. doi: 10.1038/nature10955. PMID:22398446<ref>PMID:22398446</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3vkg" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Dynein 3D structures\|Dynein 3D structures]]		*[[Dynein 3D structures\|Dynein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dictyostelium discoideum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kon, T]]	+	[[Category: Kon T]]
-	[[Category: Kurisu, G]]	+	[[Category: Kurisu G]]
-	[[Category: Oyama, T]]	+	[[Category: Oyama T]]
-	[[Category: Shimo-Kon, R]]	+	[[Category: Shimo-Kon R]]
-	[[Category: Suto, K]]	+	[[Category: Suto K]]
-	~~[[Category: Aaa+ protein]]~~	+
-	~~[[Category: Microtuble]]~~	+
-	~~[[Category: Molecular motor]]~~	+
-	~~[[Category: Motor protein~~]]	+

OCA at 18:50, 27 July 2022

OCA — Wed, 27 Jul 2022 18:50:06 GMT

←Older revision		Revision as of 18:50, 27 July 2022
Line 3:		Line 3:
	<StructureSection load='3vkg' size='340' side='right'caption='[[3vkg]], [[Resolution\|resolution]] 2.81Å' scene=''>		<StructureSection load='3vkg' size='340' side='right'caption='[[3vkg]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vkg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3VKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vkg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VKG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ay1\|3ay1]], [[3vkh\|3vkh]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ay1\|3ay1]], [[3vkh\|3vkh]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkg OCA], [~~http~~://pdbe.org/3vkg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3vkg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3vkg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3vkg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkg OCA], [https://pdbe.org/3vkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vkg RCSB], [https://www.ebi.ac.uk/pdbsum/3vkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vkg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DYHC_DICDI DYHC_DICDI]] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.	+	[[https://www.uniprot.org/uniprot/DYHC_DICDI DYHC_DICDI]] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:34, 28 August 2019

OCA — Wed, 28 Aug 2019 16:34:29 GMT

←Older revision		Revision as of 16:34, 28 August 2019
Line 1:		Line 1:

	==X-ray structure of an MTBD truncation mutant of dynein motor domain==		==X-ray structure of an MTBD truncation mutant of dynein motor domain==
-	<StructureSection load='3vkg' size='340' side='right' caption='[[3vkg]], [[Resolution\|resolution]] 2.81Å' scene=''>	+	<StructureSection load='3vkg' size='340' side='right'caption='[[3vkg]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3vkg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VKG FirstGlance]. <br>		<table><tr><td colspan='2'>[[3vkg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VKG FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3vkg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3vkg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dynein 3D structures\|Dynein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kon, T]]		[[Category: Kon, T]]
	[[Category: Kurisu, G]]		[[Category: Kurisu, G]]

OCA at 11:11, 16 November 2017

OCA — Thu, 16 Nov 2017 11:11:31 GMT

←Older revision		Revision as of 11:11, 16 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3vkg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3vkg" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Dynein\|Dynein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:54, 3 August 2017

OCA — Thu, 03 Aug 2017 10:54:44 GMT

←Older revision		Revision as of 10:54, 3 August 2017
Line 3:		Line 3:
	<StructureSection load='3vkg' size='340' side='right' caption='[[3vkg]], [[Resolution\|resolution]] 2.81Å' scene=''>		<StructureSection load='3vkg' size='340' side='right' caption='[[3vkg]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vkg]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vkg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VKG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ay1\|3ay1]], [[3vkh\|3vkh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ay1\|3ay1]], [[3vkh\|3vkh]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDB_G0276355, dhcA, slime mold ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 ATCC 11735])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkg OCA], [http://pdbe.org/3vkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vkg RCSB], [http://www.ebi.ac.uk/pdbsum/3vkg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vkg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkg OCA], [http://pdbe.org/3vkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vkg RCSB], [http://www.ebi.ac.uk/pdbsum/3vkg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vkg ProSAT]</span></td></tr>
	</table>		</table>
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 11735]]
	[[Category: Kon, T]]		[[Category: Kon, T]]
	[[Category: Kurisu, G]]		[[Category: Kurisu, G]]

OCA at 01:49, 5 August 2016

OCA — Fri, 05 Aug 2016 01:49:41 GMT

←Older revision		Revision as of 01:49, 5 August 2016
Line 1:		Line 1:
		+
	==X-ray structure of an MTBD truncation mutant of dynein motor domain==		==X-ray structure of an MTBD truncation mutant of dynein motor domain==
	<StructureSection load='3vkg' size='340' side='right' caption='[[3vkg]], [[Resolution\|resolution]] 2.81Å' scene=''>		<StructureSection load='3vkg' size='340' side='right' caption='[[3vkg]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Synthetic_construct Synthetic construct~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VKG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ay1\|3ay1]], [[3vkh\|3vkh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ay1\|3ay1]], [[3vkh\|3vkh]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDB_G0276355, dhcA, slime mold ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~32630 synthetic construct~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDB_G0276355, dhcA, slime mold ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 ATCC 11735])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vkg RCSB], [http://www.ebi.ac.uk/pdbsum/3vkg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkg OCA], [http://pdbe.org/3vkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vkg RCSB], [http://www.ebi.ac.uk/pdbsum/3vkg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vkg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3vkg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Synthetic construct~~]]	+	[[Category: Atcc 11735]]
	[[Category: Kon, T]]		[[Category: Kon, T]]
	[[Category: Kurisu, G]]		[[Category: Kurisu, G]]

OCA at 21:44, 24 December 2014

OCA — Wed, 24 Dec 2014 21:44:54 GMT

←Older revision		Revision as of 21:44, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vkg RCSB], [http://www.ebi.ac.uk/pdbsum/3vkg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vkg RCSB], [http://www.ebi.ac.uk/pdbsum/3vkg PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DYHC_DICDI DYHC_DICDI]] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:02, 9 December 2014

OCA — Tue, 09 Dec 2014 17:02:58 GMT

←Older revision		Revision as of 17:02, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3vkg.~~png~~\|~~left~~\|~~200px~~]]	+	==X-ray structure of an MTBD truncation mutant of dynein motor domain==
		+	<StructureSection load='3vkg' size='340' side='right' caption='[[3vkg]], [[Resolution\|resolution]] 2.81Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3vkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VKG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ay1\|3ay1]], [[3vkh\|3vkh]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDB_G0276355, dhcA, slime mold ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32630 synthetic construct])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vkg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vkg RCSB], [http://www.ebi.ac.uk/pdbsum/3vkg PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dyneins are microtubule-based AAA(+) motor complexes that power ciliary beating, cell division, cell migration and intracellular transport. Here we report the most complete structure obtained so far, to our knowledge, of the 380-kDa motor domain of Dictyostelium discoideum cytoplasmic dynein at 2.8 A resolution; the data are reliable enough to discuss the structure and mechanism at the level of individual amino acid residues. Features that can be clearly visualized at this resolution include the coordination of ADP in each of four distinct nucleotide-binding sites in the ring-shaped AAA(+) ATPase unit, a newly identified interaction interface between the ring and mechanical linker, and junctional structures between the ring and microtubule-binding stalk, all of which should be critical for the mechanism of dynein motility. We also identify a long-range allosteric communication pathway between the primary ATPase and the microtubule-binding sites. Our work provides a framework for understanding the mechanism of dynein-based motility.

-	~~{{STRUCTURE_3vkg\| PDB=3vkg \| SCENE= }}~~	+	The 2.8 A crystal structure of the dynein motor domain.,Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G Nature. 2012 Mar 7;484(7394):345-50. doi: 10.1038/nature10955. PMID:22398446<ref>PMID:22398446</ref>

-	~~===X-ray structure~~ of ~~an MTBD truncation mutant of dynein motor domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22398446}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3vkg]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Synthetic_construct Synthetic construct]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA].~~	+

	==See Also==		==See Also==
	*[[Dynein\|Dynein]]		*[[Dynein\|Dynein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Synthetic construct]]		[[Category: Synthetic construct]]
-	[[Category: Kon, T.]]	+	[[Category: Kon, T]]
-	[[Category: Kurisu, G.]]	+	[[Category: Kurisu, G]]
-	[[Category: Oyama, T.]]	+	[[Category: Oyama, T]]
-	[[Category: Shimo-Kon, R.]]	+	[[Category: Shimo-Kon, R]]
-	[[Category: Suto, K.]]	+	[[Category: Suto, K]]
	[[Category: Aaa+ protein]]		[[Category: Aaa+ protein]]
	[[Category: Microtuble]]		[[Category: Microtuble]]
	[[Category: Molecular motor]]		[[Category: Molecular motor]]
	[[Category: Motor protein]]		[[Category: Motor protein]]

OCA at 09:26, 20 October 2012

OCA — Sat, 20 Oct 2012 09:26:47 GMT

←Older revision		Revision as of 09:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3vkg]] is a 2 chain structure ~~of [[Dynein]]~~ with sequence from [http://en.wikipedia.org/wiki/~~Dictyostelium_discoideum,_synthetic Dictyostelium discoideum, synthetic~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA].	+	[[3vkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKG OCA].

	==See Also==		==See Also==
	*[[Dynein\|Dynein]]		*[[Dynein\|Dynein]]
-	[[Category: ~~Dictyostelium discoideum, synthetic~~]]	+	[[Category: Synthetic construct]]
	[[Category: Kon, T.]]		[[Category: Kon, T.]]
	[[Category: Kurisu, G.]]		[[Category: Kurisu, G.]]

OCA at 20:40, 26 September 2012

OCA — Wed, 26 Sep 2012 20:40:05 GMT

←Older revision		Revision as of 20:40, 26 September 2012
Line 3:		Line 3:
	{{STRUCTURE_3vkg\| PDB=3vkg \| SCENE= }}		{{STRUCTURE_3vkg\| PDB=3vkg \| SCENE= }}

-	===~~Crystal~~ structure of an motor ~~protein~~===	+	===X-ray structure of an MTBD truncation mutant of dynein motor domain===

		+	{{ABSTRACT_PUBMED_22398446}}

	==About this Structure==		==About this Structure==