3vp6 - Revision history

OCA at 18:56, 27 July 2022

OCA — Wed, 27 Jul 2022 18:56:43 GMT

←Older revision		Revision as of 18:56, 27 July 2022
Line 1:		Line 1:

	==Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation==		==Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation==
-	<StructureSection load='3vp6' size='340' side='right' caption='[[3vp6]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3vp6' size='340' side='right'caption='[[3vp6]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vp6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VP6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3VP6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vp6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VP6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HLD:4-OXO-4H-PYRAN-2,6-DICARBOXYLIC+ACID'>HLD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HLD:4-OXO-4H-PYRAN-2,6-DICARBOXYLIC+ACID'>HLD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAD1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAD1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3vp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vp6 OCA], [~~http~~://pdbe.org/3vp6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3vp6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3vp6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3vp6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vp6 OCA], [https://pdbe.org/3vp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vp6 RCSB], [https://www.ebi.ac.uk/pdbsum/3vp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vp6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Defects in GAD1 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1) [MIM:[~~http~~://omim.org/entry/603513 603513]]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.<ref>PMID:15571623</ref>	+	[[https://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Defects in GAD1 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1) [MIM:[https://omim.org/entry/603513 603513]]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.<ref>PMID:15571623</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Catalyzes the production of GABA.	+	[[https://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Catalyzes the production of GABA.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 29:
	[[Category: Glutamate decarboxylase]]		[[Category: Glutamate decarboxylase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Buckle, A M]]		[[Category: Buckle, A M]]
	[[Category: Fenalti, G]]		[[Category: Fenalti, G]]

OCA at 23:56, 4 August 2016

OCA — Thu, 04 Aug 2016 23:56:09 GMT

←Older revision		Revision as of 23:56, 4 August 2016
Line 1:		Line 1:
		+
	==Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation==		==Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation==
	<StructureSection load='3vp6' size='340' side='right' caption='[[3vp6]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3vp6' size='340' side='right' caption='[[3vp6]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacteroides_caccae Bacteroides caccae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VP6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VP6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HLD:4-OXO-4H-PYRAN-2,6-DICARBOXYLIC+ACID'>HLD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HLD:4-OXO-4H-PYRAN-2,6-DICARBOXYLIC+ACID'>HLD</scene></td></tr>
-	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-~~LYSINE(~~3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-~~YLMETHANE)~~'>LLP</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~47678 Bacteroides caccae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3vp6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vp6 OCA], [http://pdbe.org/3vp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3vp6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vp6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3vp6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacteroides caccae]]
	[[Category: Glutamate decarboxylase]]		[[Category: Glutamate decarboxylase]]
		+	[[Category: Human]]
	[[Category: Buckle, A M]]		[[Category: Buckle, A M]]
	[[Category: Fenalti, G]]		[[Category: Fenalti, G]]

OCA at 06:31, 21 December 2014

OCA — Sun, 21 Dec 2014 06:31:26 GMT

←Older revision		Revision as of 06:31, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3vp6\| PDB=3vp6 \| SCENE= }}~~	+	==Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation==
-	===Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation===	+	<StructureSection load='3vp6' size='340' side='right' caption='[[3vp6]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23126365}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3vp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_caccae Bacteroides caccae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VP6 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HLD:4-OXO-4H-PYRAN-2,6-DICARBOXYLIC+ACID'>HLD</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=47678 Bacteroides caccae])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3vp6 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Defects in GAD1 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1) [MIM:[http://omim.org/entry/603513 603513]]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.<ref>PMID:15571623</ref>		[[http://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Defects in GAD1 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1) [MIM:[http://omim.org/entry/603513 603513]]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.<ref>PMID:15571623</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Catalyzes the production of GABA.		[[http://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Catalyzes the production of GABA.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Imbalances in GABA homeostasis underlie psychiatric and movement disorders. The ability of the 65kDa isoform of glutamic acid decarboxylase, GAD65, to control synaptic GABA levels is influenced through its capacity to auto-inactivate. In contrast, the GAD67 isoform is constitutively active. Previous structural insights suggest that flexibility in the GAD65 catalytic loop drives enzyme inactivation. To test this idea, we constructed a panel of GAD65/67 chimeras and compared the ability of these molecules to auto-inactivate. Together, our data reveal the important finding that the C-terminal domain of GAD plays a key role in controlling GAD65 auto-inactivation. In support of these findings, we determined the X-ray crystal structure of a GAD65/67 chimera that reveals the conformation of the catalytic loop is intimately linked to the C-terminal domain.

-	~~==About this Structure==~~	+	Structural characterization on the mechanism of auto-inactivation for Human Glutamic Acid Decarboxylase.,Langendorf CG, Tuck KL, Key TL, Fenalti G, Pike RN, Rosado CJ, Wong AS, Buckle AM, Law RH, Whisstock JC Biosci Rep. 2012 Nov 5. PMID:23126365<ref>PMID:23126365</ref>
-	~~[[3vp6]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacteroides_caccae Bacteroides caccae]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3VP6 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023126365</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacteroides caccae]]		[[Category: Bacteroides caccae]]
	[[Category: Glutamate decarboxylase]]		[[Category: Glutamate decarboxylase]]
-	[[Category: Buckle, A M.]]	+	[[Category: Buckle, A M]]
-	[[Category: Fenalti, G.]]	+	[[Category: Fenalti, G]]
-	[[Category: Key, T L.G.]]	+	[[Category: Key, T L.G]]
-	[[Category: Langendorf, C G.]]	+	[[Category: Langendorf, C G]]
-	[[Category: Law, R H.P.]]	+	[[Category: Law, R H.P]]
-	[[Category: Rosado, C J.]]	+	[[Category: Rosado, C J]]
-	[[Category: Tuck, K L.]]	+	[[Category: Tuck, K L]]
-	[[Category: Whisstock, J C.]]	+	[[Category: Whisstock, J C]]
-	[[Category: Wong, A S.M.]]	+	[[Category: Wong, A S.M]]
	[[Category: Catalytic loop swap]]		[[Category: Catalytic loop swap]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 06:25, 14 August 2013

OCA — Wed, 14 Aug 2013 06:25:04 GMT

←Older revision		Revision as of 06:25, 14 August 2013
Line 4:		Line 4:

	==Disease==		==Disease==
-	[[http://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Defects in GAD1 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1) [MIM:[http://omim.org/entry/603513 603513]]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.<ref>PMID:15571623</ref>	+	[[http://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Defects in GAD1 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1) [MIM:[http://omim.org/entry/603513 603513]]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.<ref>PMID:15571623</ref>

	==Function==		==Function==
Line 13:		Line 13:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023126365</ref><references group="xtra"/><references/>
	[[Category: Bacteroides caccae]]		[[Category: Bacteroides caccae]]
	[[Category: Glutamate decarboxylase]]		[[Category: Glutamate decarboxylase]]

OCA at 05:21, 25 March 2013

OCA — Mon, 25 Mar 2013 05:21:03 GMT

←Older revision		Revision as of 05:21, 25 March 2013
Line 1:		Line 1:
-	[[Image:3vp6.jpg\|left\|200px]]
-
	{{STRUCTURE_3vp6\| PDB=3vp6 \| SCENE= }}		{{STRUCTURE_3vp6\| PDB=3vp6 \| SCENE= }}
-
	===Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation===		===Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation===
-
	{{ABSTRACT_PUBMED_23126365}}		{{ABSTRACT_PUBMED_23126365}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Defects in GAD1 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1) [MIM:[http://omim.org/entry/603513 603513]]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.<ref>PMID:15571623</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/DCE1_HUMAN DCE1_HUMAN]] Catalyzes the production of GABA.

	==About this Structure==		==About this Structure==
	[[3vp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_caccae Bacteroides caccae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VP6 OCA].		[[3vp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_caccae Bacteroides caccae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VP6 OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Bacteroides caccae]]		[[Category: Bacteroides caccae]]
	[[Category: Glutamate decarboxylase]]		[[Category: Glutamate decarboxylase]]

OCA at 08:45, 16 January 2013

OCA — Wed, 16 Jan 2013 08:45:27 GMT

←Older revision		Revision as of 08:45, 16 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3vp6.jpg\|left\|200px]]

-	~~The entry~~ 3vp6 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3vp6\| PDB=3vp6 \| SCENE= }}

-	~~Authors: Langendorf, C.G., Tuck, K.L., Key, T.L.G., Rosado, C.J., Wong, A.S.M., Fenalti, G., Buckle, A.M., Law, R.H.P., Whisstock, J.C.~~	+	===Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation===

-	~~Description~~: ~~Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation~~	+	{{ABSTRACT_PUBMED_23126365}}
		+
		+	==About this Structure==
		+	[[3vp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_caccae Bacteroides caccae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VP6 OCA].
		+	[[Category: Bacteroides caccae]]
		+	[[Category: Glutamate decarboxylase]]
		+	[[Category: Buckle, A M.]]
		+	[[Category: Fenalti, G.]]
		+	[[Category: Key, T L.G.]]
		+	[[Category: Langendorf, C G.]]
		+	[[Category: Law, R H.P.]]
		+	[[Category: Rosado, C J.]]
		+	[[Category: Tuck, K L.]]
		+	[[Category: Whisstock, J C.]]
		+	[[Category: Wong, A S.M.]]
		+	[[Category: Catalytic loop swap]]
		+	[[Category: Lyase]]

OCA at 04:42, 8 August 2012

OCA — Wed, 08 Aug 2012 04:42:44 GMT

←Older revision		Revision as of 04:42, 8 August 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3vp6 is ON HOLD	+	The entry 3vp6 is ON HOLD until Paper Publication

	Authors: Langendorf, C.G., Tuck, K.L., Key, T.L.G., Rosado, C.J., Wong, A.S.M., Fenalti, G., Buckle, A.M., Law, R.H.P., Whisstock, J.C.		Authors: Langendorf, C.G., Tuck, K.L., Key, T.L.G., Rosado, C.J., Wong, A.S.M., Fenalti, G., Buckle, A.M., Law, R.H.P., Whisstock, J.C.

	Description: Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation		Description: Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation

OCA: Protected "3vp6" [edit=sysop:move=sysop]

OCA — Thu, 08 Mar 2012 05:20:13 GMT

Protected "3vp6" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:20, 8 March 2012

OCA: New page: '''Unreleased structure''' The entry 3vp6 is ON HOLD Authors: Langendorf, C.G., Tuck, K.L., Key, T.L.G., Rosado, C.J., Wong, A.S.M., Fenalti, G., Buckle, A.M., Law, R.H.P., Whisstock, J...

OCA — Thu, 08 Mar 2012 05:20:12 GMT

New page: '''Unreleased structure''' The entry 3vp6 is ON HOLD Authors: Langendorf, C.G., Tuck, K.L., Key, T.L.G., Rosado, C.J., Wong, A.S.M., Fenalti, G., Buckle, A.M., Law, R.H.P., Whisstock, J...

New page

'''Unreleased structure'''

The entry 3vp6 is ON HOLD

Authors: Langendorf, C.G., Tuck, K.L., Key, T.L.G., Rosado, C.J., Wong, A.S.M., Fenalti, G., Buckle, A.M., Law, R.H.P., Whisstock, J.C.

Description: Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation