3vqf - Revision history

OCA at 12:33, 8 November 2023

OCA — Wed, 08 Nov 2023 12:33:00 GMT

←Older revision		Revision as of 12:33, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3vqf' size='340' side='right'caption='[[3vqf]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3vqf' size='340' side='right'caption='[[3vqf]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VQF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VQF FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Lnx1 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.199Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqf OCA], [https://pdbe.org/3vqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vqf RCSB], [https://www.ebi.ac.uk/pdbsum/3vqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqf OCA], [https://pdbe.org/3vqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vqf RCSB], [https://www.ebi.ac.uk/pdbsum/3vqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LNX1_MOUSE LNX1_MOUSE]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.	+	[https://www.uniprot.org/uniprot/LNX1_MOUSE LNX1_MOUSE] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.

	==See Also==		==See Also==
Line 15:		Line 15:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Akiyoshi, Y]]	+	[[Category: Akiyoshi Y]]
-	[[Category: Furuse, M]]	+	[[Category: Furuse M]]
-	[[Category: Goda, N]]	+	[[Category: Goda N]]
-	[[Category: Hamada, D]]	+	[[Category: Hamada D]]
-	[[Category: Hiroaki, H]]	+	[[Category: Hiroaki H]]
-	[[Category: Nakagawa, A]]	+	[[Category: Nakagawa A]]
-	[[Category: Narita, H]]	+	[[Category: Narita H]]
-	[[Category: Suzuki, M]]	+	[[Category: Suzuki M]]
-	[[Category: Tenno, T]]	+	[[Category: Tenno T]]
-	~~[[Category: Claudin c-terminus]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Peptide binding protein~~]]	+

OCA at 18:58, 27 July 2022

OCA — Wed, 27 Jul 2022 18:58:26 GMT

←Older revision		Revision as of 18:58, 27 July 2022
Line 1:		Line 1:

	==Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein==		==Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein==
-	<StructureSection load='3vqf' size='340' side='right' caption='[[3vqf]], [[Resolution\|resolution]] 1.20Å' scene=''>	+	<StructureSection load='3vqf' size='340' side='right'caption='[[3vqf]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vqf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3VQF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VQF FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Lnx1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Lnx1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqf OCA], [~~http~~://pdbe.org/3vqf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3vqf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3vqf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqf OCA], [https://pdbe.org/3vqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vqf RCSB], [https://www.ebi.ac.uk/pdbsum/3vqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LNX1_MOUSE LNX1_MOUSE]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.	+	[[https://www.uniprot.org/uniprot/LNX1_MOUSE LNX1_MOUSE]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.

	==See Also==		==See Also==
-	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]	+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Akiyoshi, Y]]		[[Category: Akiyoshi, Y]]

OCA at 13:11, 4 August 2016

OCA — Thu, 04 Aug 2016 13:11:20 GMT

←Older revision		Revision as of 13:11, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein==		==Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein==
	<StructureSection load='3vqf' size='340' side='right' caption='[[3vqf]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3vqf' size='340' side='right' caption='[[3vqf]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VQF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VQF FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Lnx1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Lnx1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vqf RCSB], [http://www.ebi.ac.uk/pdbsum/3vqf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqf OCA], [http://pdbe.org/3vqf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vqf RCSB], [http://www.ebi.ac.uk/pdbsum/3vqf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LNX1_MOUSE LNX1_MOUSE]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.

	==See Also==		==See Also==
Line 11:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Akiyoshi, Y]]		[[Category: Akiyoshi, Y]]
	[[Category: Furuse, M]]		[[Category: Furuse, M]]

OCA at 07:32, 21 December 2014

OCA — Sun, 21 Dec 2014 07:32:59 GMT

←Older revision		Revision as of 07:32, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3vqf\| PDB=3vqf \| SCENE= }}~~	+	==Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein==
-	===Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein===	+	<StructureSection load='3vqf' size='340' side='right' caption='[[3vqf]], [[Resolution\|resolution]] 1.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3vqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VQF FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Lnx1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vqf RCSB], [http://www.ebi.ac.uk/pdbsum/3vqf PDBsum]</span></td></tr>
		+	</table>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~3vqf~~]] ~~is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA].~~	+	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Akiyoshi, Y.]]	+	[[Category: Akiyoshi, Y]]
-	[[Category: Furuse, M.]]	+	[[Category: Furuse, M]]
-	[[Category: Goda, N.]]	+	[[Category: Goda, N]]
-	[[Category: Hamada, D.]]	+	[[Category: Hamada, D]]
-	[[Category: Hiroaki, H.]]	+	[[Category: Hiroaki, H]]
-	[[Category: Nakagawa, A.]]	+	[[Category: Nakagawa, A]]
-	[[Category: Narita, H.]]	+	[[Category: Narita, H]]
-	[[Category: Suzuki, M.]]	+	[[Category: Suzuki, M]]
-	[[Category: Tenno, T.]]	+	[[Category: Tenno, T]]
	[[Category: Claudin c-terminus]]		[[Category: Claudin c-terminus]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]
	[[Category: Peptide binding protein]]		[[Category: Peptide binding protein]]

OCA at 08:52, 27 March 2013

OCA — Wed, 27 Mar 2013 08:52:56 GMT

←Older revision		Revision as of 08:52, 27 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3vqf\| PDB=3vqf \| SCENE= }}
		+	===Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein===

-	~~The entry~~ 3vqf is ~~ON HOLD until Mar 22 2014~~	+	==About this Structure==
-		+	[[3vqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA].
-	~~Authors~~: Akiyoshi, Y., ~~Hamada, D~~., Goda, N., ~~Tenno, T~~.~~, Narita~~, H., Nakagawa, A., ~~Furuse, M~~., Suzuki, M., ~~Hiroaki, H~~.	+	[[Category: Mus musculus]]
-		+	[[Category: Akiyoshi, Y.]]
-	~~Description~~: ~~Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein~~	+	[[Category: Furuse, M.]]
		+	[[Category: Goda, N.]]
		+	[[Category: Hamada, D.]]
		+	[[Category: Hiroaki, H.]]
		+	[[Category: Nakagawa, A.]]
		+	[[Category: Narita, H.]]
		+	[[Category: Suzuki, M.]]
		+	[[Category: Tenno, T.]]
		+	[[Category: Claudin c-terminus]]
		+	[[Category: Pdz domain]]
		+	[[Category: Peptide binding protein]]

OCA at 05:11, 27 June 2012

OCA — Wed, 27 Jun 2012 05:11:59 GMT

←Older revision		Revision as of 05:11, 27 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3vqf is ON HOLD	+	The entry 3vqf is ON HOLD until Mar 22 2014

	Authors: Akiyoshi, Y., Hamada, D., Goda, N., Tenno, T., Narita, H., Nakagawa, A., Furuse, M., Suzuki, M., Hiroaki, H.		Authors: Akiyoshi, Y., Hamada, D., Goda, N., Tenno, T., Narita, H., Nakagawa, A., Furuse, M., Suzuki, M., Hiroaki, H.

	Description: Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein		Description: Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein

OCA: Protected "3vqf" [edit=sysop:move=sysop]

OCA — Wed, 28 Mar 2012 07:15:07 GMT

Protected "3vqf" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:15, 28 March 2012

OCA: New page: '''Unreleased structure''' The entry 3vqf is ON HOLD Authors: Akiyoshi, Y., Hamada, D., Goda, N., Tenno, T., Narita, H., Nakagawa, A., Furuse, M., Suzuki, M., Hiroaki, H. Description: ...

OCA — Wed, 28 Mar 2012 07:15:06 GMT

New page: '''Unreleased structure''' The entry 3vqf is ON HOLD Authors: Akiyoshi, Y., Hamada, D., Goda, N., Tenno, T., Narita, H., Nakagawa, A., Furuse, M., Suzuki, M., Hiroaki, H. Description: ...

New page

'''Unreleased structure'''

The entry 3vqf is ON HOLD

Authors: Akiyoshi, Y., Hamada, D., Goda, N., Tenno, T., Narita, H., Nakagawa, A., Furuse, M., Suzuki, M., Hiroaki, H.

Description: Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein