3w3g - Revision history

OCA at 05:21, 3 August 2022

OCA — Wed, 03 Aug 2022 05:21:14 GMT

←Older revision		Revision as of 05:21, 3 August 2022
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	==Crystal structure of human TLR8 (unliganded form)==		==Crystal structure of human TLR8 (unliganded form)==
-	<StructureSection load='3w3g' size='340' side='right' caption='[[3w3g]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3w3g' size='340' side='right'caption='[[3w3g]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3w3g]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W3G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3W3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3w3g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W3G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TLR8, UNQ249/PRO286 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TLR8, UNQ249/PRO286 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3w3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w3g OCA], [~~http~~://pdbe.org/3w3g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3w3g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3w3g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3w3g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w3g OCA], [https://pdbe.org/3w3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w3g RCSB], [https://www.ebi.ac.uk/pdbsum/3w3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w3g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>	+	[[https://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Toll-like ~~Receptors~~\|Toll-like ~~Receptors~~]]	+	*[[Toll-like Receptor 3D structures\|Toll-like Receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ohto, U]]		[[Category: Ohto, U]]
	[[Category: Shimizu, T]]		[[Category: Shimizu, T]]

OCA at 13:38, 5 August 2016

OCA — Fri, 05 Aug 2016 13:38:41 GMT

←Older revision		Revision as of 13:38, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human TLR8 (unliganded form)==		==Crystal structure of human TLR8 (unliganded form)==
	<StructureSection load='3w3g' size='340' side='right' caption='[[3w3g]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3w3g' size='340' side='right' caption='[[3w3g]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3w3g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3w3g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W3G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TLR8, UNQ249/PRO286 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TLR8, UNQ249/PRO286 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w3g RCSB], [http://www.ebi.ac.uk/pdbsum/3w3g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w3g OCA], [http://pdbe.org/3w3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3w3g RCSB], [http://www.ebi.ac.uk/pdbsum/3w3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3w3g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3w3g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ohto, U]]		[[Category: Ohto, U]]
	[[Category: Shimizu, T]]		[[Category: Shimizu, T]]

OCA at 19:15, 25 December 2014

OCA — Thu, 25 Dec 2014 19:15:45 GMT

←Older revision		Revision as of 19:15, 25 December 2014
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-	~~{{STRUCTURE_3w3g\| PDB=3w3g \| SCENE= }}~~	+	==Crystal structure of human TLR8 (unliganded form)==
-	===Crystal structure of human TLR8 (unliganded form)===	+	<StructureSection load='3w3g' size='340' side='right' caption='[[3w3g]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23520111}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3w3g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W3G FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TLR8, UNQ249/PRO286 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w3g RCSB], [http://www.ebi.ac.uk/pdbsum/3w3g PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>		[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Toll-like receptor 7 (TLR7) and TLR8 recognize single-stranded RNA and initiate innate immune responses. Several synthetic agonists of TLR7-TLR8 display novel therapeutic potential; however, the molecular basis for ligand recognition and activation of signaling by TLR7 or TLR8 is largely unknown. In this study, the crystal structures of unliganded and ligand-induced activated human TLR8 dimers were elucidated. Ligand recognition was mediated by a dimerization interface formed by two protomers. Upon ligand stimulation, the TLR8 dimer was reorganized such that the two C termini were brought into proximity. The loop between leucine-rich repeat 14 (LRR14) and LRR15 was cleaved; however, the N- and C-terminal halves remained associated and contributed to ligand recognition and dimerization. Thus, ligand binding induces reorganization of the TLR8 dimer, which enables downstream signaling processes.
		+
		+	Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands.,Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T Science. 2013 Mar 22;339(6126):1426-9. doi: 10.1126/science.1229159. PMID:23520111<ref>PMID:23520111</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3w3g]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3W3G OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	<references ~~group="xtra"~~/><~~references~~/>	+	*[[Toll-like Receptors\|Toll-like Receptors]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ohto, U.]]	+	[[Category: Ohto, U]]
-	[[Category: Shimizu, T.]]	+	[[Category: Shimizu, T]]
-	[[Category: Tanji, H.]]	+	[[Category: Tanji, H]]
	[[Category: Glycosylation]]		[[Category: Glycosylation]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 01:28, 4 April 2013

OCA — Thu, 04 Apr 2013 01:28:31 GMT

←Older revision		Revision as of 01:28, 4 April 2013
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_3w3g\| PDB=3w3g \| SCENE= }}
		+	===Crystal structure of human TLR8 (unliganded form)===
		+	{{ABSTRACT_PUBMED_23520111}}

-	~~The entry 3w3g is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>

-	~~Authors~~: ~~Tanji, H~~.~~, Ohto, U~~.~~, Shimizu, T~~.	+	==About this Structure==
		+	[[3w3g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W3G OCA].

-	~~Description~~: ~~Crystal structure of human TLR8 (unliganded form)~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Ohto, U.]]
		+	[[Category: Shimizu, T.]]
		+	[[Category: Tanji, H.]]
		+	[[Category: Glycosylation]]
		+	[[Category: Immune system]]
		+	[[Category: Innate immunity]]
		+	[[Category: Leucine rich repeat]]
		+	[[Category: Receptor]]
		+	[[Category: Rna]]
		+	[[Category: Rna binding]]
		+	[[Category: Rna receptor]]
		+	[[Category: Rna recognition]]
		+	[[Category: Seceted]]
		+	[[Category: Secreted]]
		+	[[Category: Ssrna]]

OCA at 11:46, 30 January 2013

OCA — Wed, 30 Jan 2013 11:46:35 GMT

←Older revision		Revision as of 11:46, 30 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3w3g is ON HOLD	+	The entry 3w3g is ON HOLD until Paper Publication

	Authors: Tanji, H., Ohto, U., Shimizu, T.		Authors: Tanji, H., Ohto, U., Shimizu, T.

	Description: Crystal structure of human TLR8 (unliganded form)		Description: Crystal structure of human TLR8 (unliganded form)

OCA: Protected "3w3g" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 08:36:45 GMT

Protected "3w3g" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:36, 2 January 2013

OCA: New page: '''Unreleased structure''' The entry 3w3g is ON HOLD Authors: Tanji, H., Ohto, U., Shimizu, T. Description: Crystal structure of human TLR8 (unliganded form)

OCA — Wed, 02 Jan 2013 08:36:44 GMT

New page: '''Unreleased structure''' The entry 3w3g is ON HOLD Authors: Tanji, H., Ohto, U., Shimizu, T. Description: Crystal structure of human TLR8 (unliganded form)

New page

'''Unreleased structure'''

The entry 3w3g is ON HOLD

Authors: Tanji, H., Ohto, U., Shimizu, T.

Description: Crystal structure of human TLR8 (unliganded form)