3w96 - Revision history

OCA at 12:59, 8 November 2023

OCA — Wed, 08 Nov 2023 12:59:12 GMT

←Older revision		Revision as of 12:59, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3w96' size='340' side='right'caption='[[3w96]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3w96' size='340' side='right'caption='[[3w96]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3w96]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3w96]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W96 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3w97\|3w97]], [[3w98\|3w98]], [[3w99\|3w99]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST1H3G, H3FH, HIST1H3H, H3FK, HIST1H3I, H3FF, HIST1H3J, H3FJ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2AB, H2AFM, HIST1H2AE, H2AFA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2BJ, H2BFR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w96 OCA], [https://pdbe.org/3w96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w96 RCSB], [https://www.ebi.ac.uk/pdbsum/3w96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w96 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w96 OCA], [https://pdbe.org/3w96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w96 RCSB], [https://www.ebi.ac.uk/pdbsum/3w96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w96 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~H2B1J_HUMAN H2B1J_HUMAN~~]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>	+	[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Horikoshi, N]]	+	[[Category: Horikoshi N]]
-	[[Category: Iwasaki, W]]	+	[[Category: Iwasaki W]]
-	[[Category: Kagawa, W]]	+	[[Category: Kagawa W]]
-	[[Category: Kurumizaka, H]]	+	[[Category: Kurumizaka H]]
-	[[Category: Miya, Y]]	+	[[Category: Miya Y]]
-	[[Category: Osakabe, A]]	+	[[Category: Osakabe A]]
-	[[Category: Shibata, T]]	+	[[Category: Shibata T]]
-	[[Category: Tachiwana, H]]	+	[[Category: Tachiwana H]]
-	~~[[Category: Histone-fold]]~~	+
-	~~[[Category: Nucleosome]]~~	+
-	~~[[Category: Protein-dna complex]]~~	+
-	~~[[Category: Structural protein-dna complex~~]]	+

OCA at 05:27, 3 August 2022

OCA — Wed, 03 Aug 2022 05:27:59 GMT

←Older revision		Revision as of 05:27, 3 August 2022
Line 1:		Line 1:

	==Crystal Structure of Human Nucleosome Core Particle lacking H2A N-terminal region==		==Crystal Structure of Human Nucleosome Core Particle lacking H2A N-terminal region==
-	<StructureSection load='3w96' size='340' side='right' caption='[[3w96]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='3w96' size='340' side='right'caption='[[3w96]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3w96]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W96 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3W96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3w96]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W96 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3w97\|3w97]], [[3w98\|3w98]], [[3w99\|3w99]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3w97\|3w97]], [[3w98\|3w98]], [[3w99\|3w99]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST1H3G, H3FH, HIST1H3H, H3FK, HIST1H3I, H3FF, HIST1H3J, H3FJ ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2AB, H2AFM, HIST1H2AE, H2AFA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2BJ, H2BFR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST1H3G, H3FH, HIST1H3H, H3FK, HIST1H3I, H3FF, HIST1H3J, H3FJ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2AB, H2AFM, HIST1H2AE, H2AFA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2BJ, H2BFR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w96 OCA], [~~http~~://pdbe.org/3w96 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3w96 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3w96 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3w96 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w96 OCA], [https://pdbe.org/3w96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w96 RCSB], [https://www.ebi.ac.uk/pdbsum/3w96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w96 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>	+	[[https://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Histone\|Histone]]	+	*[[Histone 3D structures\|Histone 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Horikoshi, N]]		[[Category: Horikoshi, N]]
	[[Category: Iwasaki, W]]		[[Category: Iwasaki, W]]

OCA at 07:21, 4 August 2016

OCA — Thu, 04 Aug 2016 07:21:27 GMT

←Older revision		Revision as of 07:21, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Human Nucleosome Core Particle lacking H2A N-terminal region==		==Crystal Structure of Human Nucleosome Core Particle lacking H2A N-terminal region==
	<StructureSection load='3w96' size='340' side='right' caption='[[3w96]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3w96' size='340' side='right' caption='[[3w96]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3w97\|3w97]], [[3w98\|3w98]], [[3w99\|3w99]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3w97\|3w97]], [[3w98\|3w98]], [[3w99\|3w99]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST1H3G, H3FH, HIST1H3H, H3FK, HIST1H3I, H3FF, HIST1H3J, H3FJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2AB, H2AFM, HIST1H2AE, H2AFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2BJ, H2BFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST1H3G, H3FH, HIST1H3H, H3FK, HIST1H3I, H3FF, HIST1H3J, H3FJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2AB, H2AFM, HIST1H2AE, H2AFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2BJ, H2BFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w96 RCSB], [http://www.ebi.ac.uk/pdbsum/3w96 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w96 OCA], [http://pdbe.org/3w96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3w96 RCSB], [http://www.ebi.ac.uk/pdbsum/3w96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3w96 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3w96" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:46, 24 December 2014

OCA — Wed, 24 Dec 2014 06:46:44 GMT

←Older revision		Revision as of 06:46, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w96 RCSB], [http://www.ebi.ac.uk/pdbsum/3w96 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w96 RCSB], [http://www.ebi.ac.uk/pdbsum/3w96 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:19, 21 December 2014

OCA — Sun, 21 Dec 2014 16:19:15 GMT

←Older revision		Revision as of 16:19, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3w96\| PDB=3w96 \| SCENE= }}~~	+	==Crystal Structure of Human Nucleosome Core Particle lacking H2A N-terminal region==
-	===Crystal Structure of Human Nucleosome Core Particle lacking H2A N-terminal region===	+	<StructureSection load='3w96' size='340' side='right' caption='[[3w96]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24251097}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3w96]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W96 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3w97\|3w97]], [[3w98\|3w98]], [[3w99\|3w99]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST1H3G, H3FH, HIST1H3H, H3FK, HIST1H3I, H3FF, HIST1H3J, H3FJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2AB, H2AFM, HIST1H2AE, H2AFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2BJ, H2BFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w96 RCSB], [http://www.ebi.ac.uk/pdbsum/3w96 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Histones are the protein components of the nucleosome, which forms the basic architecture of eukaryotic chromatin. Histones H2A, H2B, H3, and H4 are composed of two common regions, the "histone fold" and the "histone tail". Many efforts have been focused on the mechanisms by which the post-translational modifications of histone tails regulate the higher-order chromatin architecture. On the other hand, previous biochemical studies have suggested that histone tails also affect the structure and stability of the nucleosome core particle itself. However, the precise contributions of each histone tail are unclear. In the present study, we determined the crystal structures of four mutant nucleosomes, in which one of the four histones, H2A, H2B, H3, or H4, lacked the N-terminal tail. We found that the deletion of the H2B or H3 N-terminal tail affected histone-DNA interactions and substantially decreased nucleosome stability. These findings provide important information for understanding the complex roles of histone tails in regulating chromatin structure.

-	~~==Function==~~	+	Contribution of histone N-terminal tails to the structure and stability of nucleosomes.,Iwasaki W, Miya Y, Horikoshi N, Osakabe A, Taguchi H, Tachiwana H, Shibata T, Kagawa W, Kurumizaka H FEBS Open Bio. 2013 Aug 22;3:363-9. doi: 10.1016/j.fob.2013.08.007. PMID:24251097<ref>PMID:24251097</ref>
-	~~[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component~~ of ~~nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility~~ to the ~~cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication~~ and ~~chromosomal~~ stability. ~~DNA accessibility is regulated via a complex set of post-translational modifications of histones~~, ~~also called histone code~~, ~~and nucleosome remodeling~~.~~<ref>PMID~~:~~11859126</ref> <ref>PMID~~:~~12860195<~~/~~ref> <ref>PMID:15019208</ref> Has broad antibacterial activity~~. ~~May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid~~.~~<ref>~~PMID:~~11859126</ref> <ref>PMID:12860195</ref>~~ <ref>PMID:~~15019208~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3w96]] is~~ a ~~10 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3W96 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024251097</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Histone\|Histone]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Horikoshi, N.]]	+	[[Category: Horikoshi, N]]
-	[[Category: Iwasaki, W.]]	+	[[Category: Iwasaki, W]]
-	[[Category: Kagawa, W.]]	+	[[Category: Kagawa, W]]
-	[[Category: Kurumizaka, H.]]	+	[[Category: Kurumizaka, H]]
-	[[Category: Miya, Y.]]	+	[[Category: Miya, Y]]
-	[[Category: Osakabe, A.]]	+	[[Category: Osakabe, A]]
-	[[Category: Shibata, T.]]	+	[[Category: Shibata, T]]
-	[[Category: Tachiwana, H.]]	+	[[Category: Tachiwana, H]]
	[[Category: Histone-fold]]		[[Category: Histone-fold]]
	[[Category: Nucleosome]]		[[Category: Nucleosome]]
	[[Category: Protein-dna complex]]		[[Category: Protein-dna complex]]
	[[Category: Structural protein-dna complex]]		[[Category: Structural protein-dna complex]]

OCA at 07:46, 18 December 2013

OCA — Wed, 18 Dec 2013 07:46:05 GMT

←Older revision		Revision as of 07:46, 18 December 2013
Line 1:		Line 1:
	{{STRUCTURE_3w96\| PDB=3w96 \| SCENE= }}		{{STRUCTURE_3w96\| PDB=3w96 \| SCENE= }}
	===Crystal Structure of Human Nucleosome Core Particle lacking H2A N-terminal region===		===Crystal Structure of Human Nucleosome Core Particle lacking H2A N-terminal region===
		+	{{ABSTRACT_PUBMED_24251097}}

	==Function==		==Function==
Line 6:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3w96]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bionectria_wenpingii Bionectria wenpingii] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W96 OCA].	+	[[3w96]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W96 OCA].

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024251097</ref><references group="xtra"/><references/>
-	[[Category: ~~Bionectria wenpingii]]~~	+	[[Category: Human]]
-	~~[[Category: Homo sapiens~~]]	+
	[[Category: Horikoshi, N.]]		[[Category: Horikoshi, N.]]
	[[Category: Iwasaki, W.]]		[[Category: Iwasaki, W.]]

OCA at 02:48, 20 September 2013

OCA — Fri, 20 Sep 2013 02:48:35 GMT

←Older revision		Revision as of 02:48, 20 September 2013
Line 6:		Line 6:

	==About this Structure==		==About this Structure==
-	[[3w96]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W96 OCA].	+	[[3w96]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Bionectria_wenpingii Bionectria wenpingii] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W96 OCA].

	==Reference==		==Reference==
	<references group="xtra"/><references/>		<references group="xtra"/><references/>
		+	[[Category: Bionectria wenpingii]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Horikoshi, N.]]		[[Category: Horikoshi, N.]]

OCA at 07:35, 28 August 2013

OCA — Wed, 28 Aug 2013 07:35:02 GMT

←Older revision		Revision as of 07:35, 28 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3w96\| PDB=3w96 \| SCENE= }}
		+	===Crystal Structure of Human Nucleosome Core Particle lacking H2A N-terminal region===

-	~~The entry 3w96~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>

-	~~Authors~~: ~~Iwasaki, W~~.~~, Miya, Y~~.~~, Horikoshi, N~~.~~, Osakabe, A., Tachiwana, H~~.~~, Shibata, T~~.~~, Kagawa, W~~.~~, Kurumizaka, H~~.	+	==About this Structure==
		+	[[3w96]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W96 OCA].

-	~~Description~~:	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Horikoshi, N.]]
		+	[[Category: Iwasaki, W.]]
		+	[[Category: Kagawa, W.]]
		+	[[Category: Kurumizaka, H.]]
		+	[[Category: Miya, Y.]]
		+	[[Category: Osakabe, A.]]
		+	[[Category: Shibata, T.]]
		+	[[Category: Tachiwana, H.]]
		+	[[Category: Histone-fold]]
		+	[[Category: Nucleosome]]
		+	[[Category: Protein-dna complex]]
		+	[[Category: Structural protein-dna complex]]

OCA at 10:40, 24 April 2013

OCA — Wed, 24 Apr 2013 10:40:45 GMT

←Older revision		Revision as of 10:40, 24 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3w96 is ON HOLD	+	The entry 3w96 is ON HOLD until Paper Publication

	Authors: Iwasaki, W., Miya, Y., Horikoshi, N., Osakabe, A., Tachiwana, H., Shibata, T., Kagawa, W., Kurumizaka, H.		Authors: Iwasaki, W., Miya, Y., Horikoshi, N., Osakabe, A., Tachiwana, H., Shibata, T., Kagawa, W., Kurumizaka, H.

-	Description: ~~Crystal Structure of Human Nucleosome Core Particle lacking H2A N-terminal region~~	+	Description:

OCA: Protected "3w96" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 19:38:20 GMT

Protected "3w96" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:38, 17 April 2013