3wa9 - Revision history

OCA at 13:01, 8 November 2023

OCA — Wed, 08 Nov 2023 13:01:04 GMT

←Older revision		Revision as of 13:01, 8 November 2023
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	<StructureSection load='3wa9' size='340' side='right'caption='[[3wa9]], [[Resolution\|resolution]] 3.07Å' scene=''>		<StructureSection load='3wa9' size='340' side='right'caption='[[3wa9]], [[Resolution\|resolution]] 3.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wa9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WA9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wa9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WA9 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3waa\|3waa]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.07Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">H3~~.~~1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&srchmode=5&id=9606 HUMAN]), H4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2A.Z.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wa9 OCA], [https://pdbe.org/3wa9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wa9 RCSB], [https://www.ebi.ac.uk/pdbsum/3wa9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wa9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wa9 OCA], [https://pdbe.org/3wa9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wa9 RCSB], [https://www.ebi.ac.uk/pdbsum/3wa9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wa9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~H2B1J_HUMAN H2B1J_HUMAN~~]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> [[https://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref>	+	[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arimura, Y]]	+	[[Category: Arimura Y]]
-	[[Category: Harata, M]]	+	[[Category: Harata M]]
-	[[Category: Horikoshi, N]]	+	[[Category: Horikoshi N]]
-	[[Category: Iwasaki, W]]	+	[[Category: Iwasaki W]]
-	[[Category: Kagawa, W]]	+	[[Category: Kagawa W]]
-	[[Category: Kimura, H]]	+	[[Category: Kimura H]]
-	[[Category: Kurumizaka, H]]	+	[[Category: Kurumizaka H]]
-	[[Category: Osakabe, A]]	+	[[Category: Osakabe A]]
-	[[Category: Sato, K]]	+	[[Category: Sato K]]
-	[[Category: Shimada, K]]	+	[[Category: Shimada K]]
-	[[Category: Tachiwana, H]]	+	[[Category: Tachiwana H]]
-	~~[[Category: Chromatin formation]]~~	+
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Histone fold]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Structural protein-dna complex~~]]	+

OCA at 05:29, 3 August 2022

OCA — Wed, 03 Aug 2022 05:29:05 GMT

←Older revision		Revision as of 05:29, 3 August 2022
Line 1:		Line 1:

	==The nucleosome containing human H2A.Z.1==		==The nucleosome containing human H2A.Z.1==
-	<StructureSection load='3wa9' size='340' side='right' caption='[[3wa9]], [[Resolution\|resolution]] 3.07Å' scene=''>	+	<StructureSection load='3wa9' size='340' side='right'caption='[[3wa9]], [[Resolution\|resolution]] 3.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wa9]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WA9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WA9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wa9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WA9 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3waa\|3waa]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3waa\|3waa]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H3.1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2A.Z.1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2B ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H3.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2A.Z.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3wa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wa9 OCA], [~~http~~://pdbe.org/3wa9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3wa9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3wa9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3wa9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wa9 OCA], [https://pdbe.org/3wa9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wa9 RCSB], [https://www.ebi.ac.uk/pdbsum/3wa9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wa9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> [[~~http~~://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref>	+	[[https://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> [[https://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Histone\|Histone]]	+	*[[Histone 3D structures\|Histone 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arimura, Y]]		[[Category: Arimura, Y]]
	[[Category: Harata, M]]		[[Category: Harata, M]]

OCA at 16:27, 5 August 2016

OCA — Fri, 05 Aug 2016 16:27:52 GMT

←Older revision		Revision as of 16:27, 5 August 2016
Line 1:		Line 1:
		+
	==The nucleosome containing human H2A.Z.1==		==The nucleosome containing human H2A.Z.1==
	<StructureSection load='3wa9' size='340' side='right' caption='[[3wa9]], [[Resolution\|resolution]] 3.07Å' scene=''>		<StructureSection load='3wa9' size='340' side='right' caption='[[3wa9]], [[Resolution\|resolution]] 3.07Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3waa\|3waa]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3waa\|3waa]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H3.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2A.Z.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H3.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2A.Z.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wa9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wa9 RCSB], [http://www.ebi.ac.uk/pdbsum/3wa9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wa9 OCA], [http://pdbe.org/3wa9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wa9 RCSB], [http://www.ebi.ac.uk/pdbsum/3wa9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wa9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3wa9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 03:59, 25 December 2014

OCA — Thu, 25 Dec 2014 03:59:40 GMT

←Older revision		Revision as of 03:59, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3wa9~~\| ~~PDB~~=3wa9 \| ~~SCENE~~= }}	+	==The nucleosome containing human H2A.Z.1==
-	===~~The nucleosome containing human~~ H2A.Z.1===	+	<StructureSection load='3wa9' size='340' side='right' caption='[[3wa9]], [[Resolution\|resolution]] 3.07Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24311584}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3wa9]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WA9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WA9 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3waa\|3waa]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H3.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2A.Z.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wa9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wa9 RCSB], [http://www.ebi.ac.uk/pdbsum/3wa9 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> [[http://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref>		[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> [[http://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The histone H2A.Z variant is widely conserved among eukaryotes. Two isoforms, H2A.Z.1 and H2A.Z.2, have been identified in vertebrates and may have distinct functions in cell growth and gene expression. However, no structural differences between H2A.Z.1 and H2A.Z.2 have been reported. In the present study, the crystal structures of nucleosomes containing human H2A.Z.1 and H2A.Z.2 were determined. The structures of the L1 loop regions were found to clearly differ between H2A.Z.1 and H2A.Z.2, although their amino-acid sequences in this region are identical. This structural polymorphism may have been induced by a substitution that evolutionally occurred at the position of amino acid 38 and by the flexible nature of the L1 loops of H2A.Z.1 and H2A.Z.2. It was also found that in living cells nucleosomal H2A.Z.1 exchanges more rapidly than H2A.Z.2. A mutational analysis revealed that the amino-acid difference at position 38 is at least partially responsible for the distinctive dynamics of H2A.Z.1 and H2A.Z.2. These findings provide important new information for understanding the differences in the regulation and functions of H2A.Z.1 and H2A.Z.2 in cells.
		+
		+	Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2.,Horikoshi N, Sato K, Shimada K, Arimura Y, Osakabe A, Tachiwana H, Hayashi-Takanaka Y, Iwasaki W, Kagawa W, Harata M, Kimura H, Kurumizaka H Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2431-9. doi:, 10.1107/S090744491302252X. Epub 2013 Nov 19. PMID:24311584<ref>PMID:24311584</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3wa9]] is~~ a ~~10 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3WA9 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024311584</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Histone\|Histone]]
-	[[Category: Arimura, Y.]]	+	== References ==
-	[[Category: Harata, M.]]	+	<references/>
-	[[Category: Horikoshi, N.]]	+	__TOC__
-	[[Category: Iwasaki, W.]]	+	</StructureSection>
-	[[Category: Kagawa, W.]]	+	[[Category: Human]]
-	[[Category: Kimura, H.]]	+	[[Category: Arimura, Y]]
-	[[Category: Kurumizaka, H.]]	+	[[Category: Harata, M]]
-	[[Category: Osakabe, A.]]	+	[[Category: Horikoshi, N]]
-	[[Category: Sato, K.]]	+	[[Category: Iwasaki, W]]
-	[[Category: Shimada, K.]]	+	[[Category: Kagawa, W]]
-	[[Category: Tachiwana, H.]]	+	[[Category: Kimura, H]]
		+	[[Category: Kurumizaka, H]]
		+	[[Category: Osakabe, A]]
		+	[[Category: Sato, K]]
		+	[[Category: Shimada, K]]
		+	[[Category: Tachiwana, H]]
	[[Category: Chromatin formation]]		[[Category: Chromatin formation]]
	[[Category: Dna binding]]		[[Category: Dna binding]]

OCA at 10:26, 18 December 2013

OCA — Wed, 18 Dec 2013 10:26:13 GMT

←Older revision		Revision as of 10:26, 18 December 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3wa9\| PDB=3wa9 \| SCENE= }}
		+	===The nucleosome containing human H2A.Z.1===
		+	{{ABSTRACT_PUBMED_24311584}}

-	~~The entry 3wa9~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> [[http://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref>

-	~~Authors~~: ~~Horikoshi, N., Sato, K., Shimada, K., Arimura, Y., Osakabe, A., Tachiwana, H., Iwasaki, W., Kagawa, W~~.~~, Harata, M~~.~~, Kimura, H~~.~~, Kurumizaka, H~~.	+	==About this Structure==
		+	[[3wa9]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WA9 OCA].

-	~~Description~~:	+	==Reference==
		+	<ref group="xtra">PMID:024311584</ref><references group="xtra"/><references/>
		+	[[Category: Arimura, Y.]]
		+	[[Category: Harata, M.]]
		+	[[Category: Horikoshi, N.]]
		+	[[Category: Iwasaki, W.]]
		+	[[Category: Kagawa, W.]]
		+	[[Category: Kimura, H.]]
		+	[[Category: Kurumizaka, H.]]
		+	[[Category: Osakabe, A.]]
		+	[[Category: Sato, K.]]
		+	[[Category: Shimada, K.]]
		+	[[Category: Tachiwana, H.]]
		+	[[Category: Chromatin formation]]
		+	[[Category: Dna binding]]
		+	[[Category: Histone fold]]
		+	[[Category: Nucleus]]
		+	[[Category: Structural protein-dna complex]]

OCA at 10:36, 19 June 2013

OCA — Wed, 19 Jun 2013 10:36:35 GMT

←Older revision		Revision as of 10:36, 19 June 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3wa9 is ON HOLD	+	The entry 3wa9 is ON HOLD until Paper Publication

	Authors: Horikoshi, N., Sato, K., Shimada, K., Arimura, Y., Osakabe, A., Tachiwana, H., Iwasaki, W., Kagawa, W., Harata, M., Kimura, H., Kurumizaka, H.		Authors: Horikoshi, N., Sato, K., Shimada, K., Arimura, Y., Osakabe, A., Tachiwana, H., Iwasaki, W., Kagawa, W., Harata, M., Kimura, H., Kurumizaka, H.

	Description:		Description:

OCA: Protected "3wa9" [edit=sysop:move=sysop]

OCA — Wed, 08 May 2013 07:02:32 GMT

Protected "3wa9" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:02, 8 May 2013

OCA: New page: '''Unreleased structure''' The entry 3wa9 is ON HOLD Authors: Horikoshi, N., Sato, K., Shimada, K., Arimura, Y., Osakabe, A., Tachiwana, H., Iwasaki, W., Kagawa, W., Harata, M., Kimura,...

OCA — Wed, 08 May 2013 07:02:31 GMT

New page: '''Unreleased structure''' The entry 3wa9 is ON HOLD Authors: Horikoshi, N., Sato, K., Shimada, K., Arimura, Y., Osakabe, A., Tachiwana, H., Iwasaki, W., Kagawa, W., Harata, M., Kimura,...

New page

'''Unreleased structure'''

The entry 3wa9 is ON HOLD

Authors: Horikoshi, N., Sato, K., Shimada, K., Arimura, Y., Osakabe, A., Tachiwana, H., Iwasaki, W., Kagawa, W., Harata, M., Kimura, H., Kurumizaka, H.

Description: