3wg1 - Revision history

OCA at 13:08, 8 November 2023

OCA — Wed, 08 Nov 2023 13:08:48 GMT

←Older revision		Revision as of 13:08, 8 November 2023
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	<StructureSection load='3wg1' size='340' side='right'caption='[[3wg1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3wg1' size='340' side='right'caption='[[3wg1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wg1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Agrae Agrae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WG1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wg1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyclocybe_aegerita Cyclocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WG1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BGC:BETA~~-~~D-GLUCOSE'>BGC</scene>~~, ~~<scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height~~: ~~3em;~~'>~~[[3wg2\|3wg2]]~~, ~~[[3wg3\|3wg3]], [[3wg4\|3wg4]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg1 OCA], [https://pdbe.org/3wg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wg1 RCSB], [https://www.ebi.ac.uk/pdbsum/3wg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg1 OCA], [https://pdbe.org/3wg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wg1 RCSB], [https://www.ebi.ac.uk/pdbsum/3wg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ATLE_CYCAE ATLE_CYCAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells. Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose) (PubMed:16051274).<ref>PMID:12757412</ref> <ref>PMID:16051274</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 3wg1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3wg1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Agrae~~]]	+	[[Category: Cyclocybe aegerita]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hirabayashi, J]]	+	[[Category: Hirabayashi J]]
-	[[Category: Hu, D]]	+	[[Category: Hu D]]
-	[[Category: Kato, R]]	+	[[Category: Kato R]]
-	[[Category: Kuwabara, N]]	+	[[Category: Kuwabara N]]
-	[[Category: Makio, H]]	+	[[Category: Makio H]]
-	[[Category: Tateno, H]]	+	[[Category: Tateno H]]
-	~~[[Category: Galectin]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 05:35, 3 August 2022

OCA — Wed, 03 Aug 2022 05:35:12 GMT

←Older revision		Revision as of 05:35, 3 August 2022
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	<StructureSection load='3wg1' size='340' side='right'caption='[[3wg1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3wg1' size='340' side='right'caption='[[3wg1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wg1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Agrae Agrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WG1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wg1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrae Agrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WG1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~LAT~~:BETA-~~LACTOSE~~'>~~LAT~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wg2\|3wg2]], [[3wg3\|3wg3]], [[3wg4\|3wg4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wg2\|3wg2]], [[3wg3\|3wg3]], [[3wg4\|3wg4]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3wg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg1 OCA], [~~http~~://pdbe.org/3wg1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3wg1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3wg1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg1 OCA], [https://pdbe.org/3wg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wg1 RCSB], [https://www.ebi.ac.uk/pdbsum/3wg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:21, 28 August 2019

OCA — Wed, 28 Aug 2019 16:21:39 GMT

←Older revision		Revision as of 16:21, 28 August 2019
Line 1:		Line 1:

	==Crystal structure of Agrocybe cylindracea galectin with lactose==		==Crystal structure of Agrocybe cylindracea galectin with lactose==
-	<StructureSection load='3wg1' size='340' side='right' caption='[[3wg1]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3wg1' size='340' side='right'caption='[[3wg1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3wg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrae Agrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WG1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3wg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrae Agrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WG1 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Agrae]]		[[Category: Agrae]]
		+	[[Category: Large Structures]]
	[[Category: Hirabayashi, J]]		[[Category: Hirabayashi, J]]
	[[Category: Hu, D]]		[[Category: Hu, D]]

OCA at 10:43, 5 August 2016

OCA — Fri, 05 Aug 2016 10:43:00 GMT

←Older revision		Revision as of 10:43, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Agrocybe cylindracea galectin with lactose==		==Crystal structure of Agrocybe cylindracea galectin with lactose==
	<StructureSection load='3wg1' size='340' side='right' caption='[[3wg1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3wg1' size='340' side='right' caption='[[3wg1]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAT:BETA-LACTOSE'>LAT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAT:BETA-LACTOSE'>LAT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wg2\|3wg2]], [[3wg3\|3wg3]], [[3wg4\|3wg4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wg2\|3wg2]], [[3wg3\|3wg3]], [[3wg4\|3wg4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wg1 RCSB], [http://www.ebi.ac.uk/pdbsum/3wg1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg1 OCA], [http://pdbe.org/3wg1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wg1 RCSB], [http://www.ebi.ac.uk/pdbsum/3wg1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3wg1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:25, 21 December 2014

OCA — Sun, 21 Dec 2014 16:25:17 GMT

←Older revision		Revision as of 16:25, 21 December 2014
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-	~~{{STRUCTURE_3wg1\| PDB=3wg1 \| SCENE= }}~~	+	==Crystal structure of Agrocybe cylindracea galectin with lactose==
-	===Crystal structure of Agrocybe cylindracea galectin with lactose===	+	<StructureSection load='3wg1' size='340' side='right' caption='[[3wg1]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24036446}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3wg1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrae Agrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WG1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAT:BETA-LACTOSE'>LAT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wg2\|3wg2]], [[3wg3\|3wg3]], [[3wg4\|3wg4]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wg1 RCSB], [http://www.ebi.ac.uk/pdbsum/3wg1 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A fungal galectin from Agrocybe cylindracea (ACG) exhibits broad binding specificity for beta-galactose-containing glycans. We determined the crystal structures of wild-type ACG and the N46A mutant, with and without glycan ligands. From these structures and a saccharide-binding analysis of the N46A mutant, we revealed that a conformational change of a unique insertion sequence containing Asn46 provides two binding modes for ACG, and thereby confers broad binding specificity. We propose that the unique sequence provides these two distinct glycan-binding modes by an induced-fit mechanism.

-	~~==About this Structure==~~	+	Conformational change of a unique sequence in a fungal galectin from Agrocybe cylindracea controls glycan ligand-binding specificity.,Kuwabara N, Hu D, Tateno H, Makyio H, Hirabayashi J, Kato R FEBS Lett. 2013 Nov 15;587(22):3620-5. doi: 10.1016/j.febslet.2013.08.046. Epub, 2013 Sep 10. PMID:24036446<ref>PMID:24036446</ref>
-	~~[[3wg1]] is~~ a ~~2 chain structure. Full crystallographic information is available~~ from ~~[http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=3WG1 OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024036446</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Hirabayashi, J.]]	+	== References ==
-	[[Category: Hu, D.]]	+	<references/>
-	[[Category: Kato, R.]]	+	__TOC__
-	[[Category: Kuwabara, N.]]	+	</StructureSection>
-	[[Category: Makio, H.]]	+	[[Category: Agrae]]
-	[[Category: Tateno, H.]]	+	[[Category: Hirabayashi, J]]
		+	[[Category: Hu, D]]
		+	[[Category: Kato, R]]
		+	[[Category: Kuwabara, N]]
		+	[[Category: Makio, H]]
		+	[[Category: Tateno, H]]
	[[Category: Galectin]]		[[Category: Galectin]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 10:23, 27 November 2013

OCA — Wed, 27 Nov 2013 10:23:43 GMT

←Older revision		Revision as of 10:23, 27 November 2013
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_3wg1\| PDB=3wg1 \| SCENE= }}
		+	===Crystal structure of Agrocybe cylindracea galectin with lactose===
		+	{{ABSTRACT_PUBMED_24036446}}

-	~~The entry~~ 3wg1 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[3wg1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG1 OCA].

-	~~Authors~~: ~~Kuwabara~~, N., Hu, D., ~~Tateno, H~~., Makio, H., ~~Hirabayashi, J., Kato, R~~.	+	==Reference==
-		+	<ref group="xtra">PMID:024036446</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of Agrocybe cylindracea galectin with lactose~~	+	[[Category: Hirabayashi, J.]]
		+	[[Category: Hu, D.]]
		+	[[Category: Kato, R.]]
		+	[[Category: Kuwabara, N.]]
		+	[[Category: Makio, H.]]
		+	[[Category: Tateno, H.]]
		+	[[Category: Galectin]]
		+	[[Category: Sugar binding protein]]

OCA at 09:24, 4 September 2013

OCA — Wed, 04 Sep 2013 09:24:40 GMT

←Older revision		Revision as of 09:24, 4 September 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3wg1 is ON HOLD	+	The entry 3wg1 is ON HOLD until Paper Publication

	Authors: Kuwabara, N., Hu, D., Tateno, H., Makio, H., Hirabayashi, J., Kato, R.		Authors: Kuwabara, N., Hu, D., Tateno, H., Makio, H., Hirabayashi, J., Kato, R.

	Description: Crystal structure of Agrocybe cylindracea galectin with lactose		Description: Crystal structure of Agrocybe cylindracea galectin with lactose

OCA: Protected "3wg1" [edit=sysop:move=sysop]

OCA — Thu, 01 Aug 2013 03:56:16 GMT

Protected "3wg1" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:56, 1 August 2013

OCA: New page: '''Unreleased structure''' The entry 3wg1 is ON HOLD Authors: Kuwabara, N., Hu, D., Tateno, H., Makio, H., Hirabayashi, J., Kato, R. Description: Crystal structure of Agrocybe cylindra...

OCA — Thu, 01 Aug 2013 03:56:15 GMT

New page: '''Unreleased structure''' The entry 3wg1 is ON HOLD Authors: Kuwabara, N., Hu, D., Tateno, H., Makio, H., Hirabayashi, J., Kato, R. Description: Crystal structure of Agrocybe cylindra...

New page

'''Unreleased structure'''

The entry 3wg1 is ON HOLD

Authors: Kuwabara, N., Hu, D., Tateno, H., Makio, H., Hirabayashi, J., Kato, R.

Description: Crystal structure of Agrocybe cylindracea galectin with lactose