3wo3 - Revision history

OCA at 13:18, 8 November 2023

OCA — Wed, 08 Nov 2023 13:18:10 GMT

←Older revision		Revision as of 13:18, 8 November 2023
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	<StructureSection load='3wo3' size='340' side='right'caption='[[3wo3]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3wo3' size='340' side='right'caption='[[3wo3]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wo3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WO3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wo3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WO3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~"><~~scene name='pdbligand=BMA:BETA-D-MANNOSE'~~>~~BMA~~</~~scene~~>, <~~scene name~~='~~pdbligand~~=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE'~~>~~NAG~~</~~scene~~>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[3wo2\|3wo2]], [[3wo4\|3wo4]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">IL18 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL18R1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo3 OCA], [https://pdbe.org/3wo3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wo3 RCSB], [https://www.ebi.ac.uk/pdbsum/3wo3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wo3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo3 OCA], [https://pdbe.org/3wo3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wo3 RCSB], [https://www.ebi.ac.uk/pdbsum/3wo3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wo3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells~~. [[https://www.uniprot.org/uniprot/IL18R_HUMAN IL18R_HUMAN]] Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B~~.	+	[https://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arita, K]]	+	[[Category: Arita K]]
-	[[Category: Ariyoshi, M]]	+	[[Category: Ariyoshi M]]
-	[[Category: Kato, Z]]	+	[[Category: Kato Z]]
-	[[Category: Kimura, T]]	+	[[Category: Kimura T]]
-	[[Category: Kondo, N]]	+	[[Category: Kondo N]]
-	[[Category: Ohnishi, H]]	+	[[Category: Ohnishi H]]
-	[[Category: Shirakawa, M]]	+	[[Category: Shirakawa M]]
-	[[Category: Tochio, H]]	+	[[Category: Tochio H]]
-	[[Category: Tsutsumi, N]]	+	[[Category: Tsutsumi N]]
-	~~[[Category: Allergy]]~~	+
-	~~[[Category: Autoimmunity]]~~	+
-	~~[[Category: Binary complex]]~~	+
-	~~[[Category: Glycosylation]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunity]]~~	+
-	~~[[Category: Inflammation]]~~	+
-	~~[[Category: Interleukin-18 receptor beta]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Serum~~]]	+

OCA at 05:43, 3 August 2022

OCA — Wed, 03 Aug 2022 05:43:52 GMT

←Older revision		Revision as of 05:43, 3 August 2022
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	==Crystal structure of IL-18 in complex with IL-18 receptor alpha==		==Crystal structure of IL-18 in complex with IL-18 receptor alpha==
-	<StructureSection load='3wo3' size='340' side='right' caption='[[3wo3]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='3wo3' size='340' side='right'caption='[[3wo3]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wo3]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WO3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WO3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wo3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WO3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~FUC~~:~~ALPHA~~-L-~~FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wo2\|3wo2]], [[3wo4\|3wo4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wo2\|3wo2]], [[3wo4\|3wo4]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL18 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL18R1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL18 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL18R1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo3 OCA], [~~http~~://pdbe.org/3wo3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3wo3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3wo3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3wo3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo3 OCA], [https://pdbe.org/3wo3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wo3 RCSB], [https://www.ebi.ac.uk/pdbsum/3wo3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wo3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. [[~~http~~://www.uniprot.org/uniprot/IL18R_HUMAN IL18R_HUMAN]] Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.	+	[[https://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. [[https://www.uniprot.org/uniprot/IL18R_HUMAN IL18R_HUMAN]] Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Interleukin\|Interleukin]]	+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
-	*[[Interleukin receptor\|Interleukin receptor]]	+	*[[Interleukin receptor 3D structures\|Interleukin receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arita, K]]		[[Category: Arita, K]]
	[[Category: Ariyoshi, M]]		[[Category: Ariyoshi, M]]

OCA at 09:06, 21 February 2019

OCA — Thu, 21 Feb 2019 09:06:27 GMT

←Older revision		Revision as of 09:06, 21 February 2019
Line 1:		Line 1:
		+
	==Crystal structure of IL-18 in complex with IL-18 receptor alpha==		==Crystal structure of IL-18 in complex with IL-18 receptor alpha==
	<StructureSection load='3wo3' size='340' side='right' caption='[[3wo3]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3wo3' size='340' side='right' caption='[[3wo3]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wo3]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WO3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WO3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wo3]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WO3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WO3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene>, <scene name='pdbligand=~~FUC~~:~~ALPHA~~-L-~~FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wo2\|3wo2]], [[3wo4\|3wo4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wo2\|3wo2]], [[3wo4\|3wo4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo3 OCA], [http://pdbe.org/3wo3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wo3 RCSB], [http://www.ebi.ac.uk/pdbsum/3wo3 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL18R1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo3 OCA], [http://pdbe.org/3wo3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wo3 RCSB], [http://www.ebi.ac.uk/pdbsum/3wo3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wo3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Arita, K]]		[[Category: Arita, K]]
	[[Category: Ariyoshi, M]]		[[Category: Ariyoshi, M]]

OCA at 09:00, 20 January 2016

OCA — Wed, 20 Jan 2016 09:00:03 GMT

←Older revision		Revision as of 09:00, 20 January 2016
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wo2\|3wo2]], [[3wo4\|3wo4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wo2\|3wo2]], [[3wo4\|3wo4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wo3 RCSB], [http://www.ebi.ac.uk/pdbsum/3wo3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo3 OCA], [http://pdbe.org/3wo3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wo3 RCSB], [http://www.ebi.ac.uk/pdbsum/3wo3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. [[http://www.uniprot.org/uniprot/IL18R_HUMAN IL18R_HUMAN]] Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.		[[http://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. [[http://www.uniprot.org/uniprot/IL18R_HUMAN IL18R_HUMAN]] Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Interleukin (IL)-18 is a proinflammatory cytokine that belongs to the IL-1 family and plays an important role in inflammation. The uncontrolled release of this cytokine is associated with severe chronic inflammatory disease. IL-18 forms a signalling complex with the IL-18 receptor alpha (Ralpha) and beta (Rbeta) chains at the plasma membrane, which induces multiple inflammatory cytokines. Here, we present a crystal structure of human IL-18 bound to the two receptor extracellular domains. Generally, the receptors' recognition mode for IL-18 is similar to IL-1beta; however, certain notable differences were observed. The architecture of the IL-18 receptor second domain (D2) is unique among the other IL-1R family members, which presumably distinguishes them from the IL-1 receptors that exhibit a more promiscuous ligand recognition mode. The structures and associated biochemical and cellular data should aid in developing novel drugs to neutralize IL-18 activity.
		+
		+	The structural basis for receptor recognition of human interleukin-18.,Tsutsumi N, Kimura T, Arita K, Ariyoshi M, Ohnishi H, Yamamoto T, Zuo X, Maenaka K, Park EY, Kondo N, Shirakawa M, Tochio H, Kato Z Nat Commun. 2014 Dec 15;5:5340. doi: 10.1038/ncomms6340. PMID:25500532<ref>PMID:25500532</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3wo3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Interleukin\|Interleukin]]
		+	*[[Interleukin receptor\|Interleukin receptor]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:21, 24 December 2014

OCA — Wed, 24 Dec 2014 17:21:19 GMT

←Older revision		Revision as of 17:21, 24 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wo3 RCSB], [http://www.ebi.ac.uk/pdbsum/3wo3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wo3 RCSB], [http://www.ebi.ac.uk/pdbsum/3wo3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. [[http://www.uniprot.org/uniprot/IL18R_HUMAN IL18R_HUMAN]] Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:51, 17 December 2014

OCA — Wed, 17 Dec 2014 12:51:57 GMT

←Older revision		Revision as of 12:51, 17 December 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of IL-18 in complex with IL-18 receptor alpha==
-		+	<StructureSection load='3wo3' size='340' side='right' caption='[[3wo3]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~The entry~~ 3wo3 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3wo3]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WO3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WO3 FirstGlance]. <br>
-	~~Authors~~: ~~Tsutsumi~~, N., ~~Kimura~~, T., Arita, K., Ariyoshi, M., ~~Ohnishi, H.~~, Kondo, N., Shirakawa, M~~., Kato, Z.,~~ Tochio, H.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wo2\|3wo2]], [[3wo4\|3wo4]]</td></tr>
-	~~Description~~: ~~Crystal structure of IL~~-~~18_2~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wo3 RCSB], [http://www.ebi.ac.uk/pdbsum/3wo3 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arita, K]]
		+	[[Category: Ariyoshi, M]]
		+	[[Category: Kato, Z]]
		+	[[Category: Kimura, T]]
		+	[[Category: Kondo, N]]
		+	[[Category: Ohnishi, H]]
		+	[[Category: Shirakawa, M]]
		+	[[Category: Tochio, H]]
		+	[[Category: Tsutsumi, N]]
		+	[[Category: Allergy]]
		+	[[Category: Autoimmunity]]
		+	[[Category: Binary complex]]
		+	[[Category: Glycosylation]]
		+	[[Category: Immune system]]
		+	[[Category: Immunity]]
		+	[[Category: Inflammation]]
		+	[[Category: Interleukin-18 receptor beta]]
		+	[[Category: Membrane]]
		+	[[Category: Serum]]

OCA at 07:23, 15 January 2014

OCA — Wed, 15 Jan 2014 07:23:07 GMT

←Older revision		Revision as of 07:23, 15 January 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3wo3 is ON HOLD	+	The entry 3wo3 is ON HOLD until Paper Publication

	Authors: Tsutsumi, N., Kimura, T., Arita, K., Ariyoshi, M., Ohnishi, H., Kondo, N., Shirakawa, M., Kato, Z., Tochio, H.		Authors: Tsutsumi, N., Kimura, T., Arita, K., Ariyoshi, M., Ohnishi, H., Kondo, N., Shirakawa, M., Kato, Z., Tochio, H.

-	Description: IL-18_2	+	Description: Crystal structure of IL-18_2

OCA: Protected "3wo3" [edit=sysop:move=sysop]

OCA — Wed, 25 Dec 2013 09:04:44 GMT

Protected "3wo3" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:04, 25 December 2013

OCA: New page: '''Unreleased structure''' The entry 3wo3 is ON HOLD Authors: Tsutsumi, N., Kimura, T., Arita, K., Ariyoshi, M., Ohnishi, H., Kondo, N., Shirakawa, M., Kato, Z., Tochio, H. Description...

OCA — Wed, 25 Dec 2013 09:04:43 GMT

New page: '''Unreleased structure''' The entry 3wo3 is ON HOLD Authors: Tsutsumi, N., Kimura, T., Arita, K., Ariyoshi, M., Ohnishi, H., Kondo, N., Shirakawa, M., Kato, Z., Tochio, H. Description...

New page

'''Unreleased structure'''

The entry 3wo3 is ON HOLD

Authors: Tsutsumi, N., Kimura, T., Arita, K., Ariyoshi, M., Ohnishi, H., Kondo, N., Shirakawa, M., Kato, Z., Tochio, H.

Description: IL-18_2