3woo - Revision history

OCA at 13:19, 8 November 2023

OCA — Wed, 08 Nov 2023 13:19:10 GMT

←Older revision		Revision as of 13:19, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3woo' size='340' side='right'caption='[[3woo]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3woo' size='340' side='right'caption='[[3woo]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3woo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_700993 Atcc 700993~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WOO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3woo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pseudoxanthomonas_mexicana Pseudoxanthomonas mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WOO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3woi\|3woi]]~~, ~~[[3woj\|3woj]], [[3wok\|3wok]], [[3wol\|3wol]], [[3wom\|3wom]], [[3won\|3won]], [[3wop\|3wop]], [[3woq\|3woq]], [[3wor\|3wor]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3woo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woo OCA], [https://pdbe.org/3woo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3woo RCSB], [https://www.ebi.ac.uk/pdbsum/3woo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3woo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3woo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woo OCA], [https://pdbe.org/3woo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3woo RCSB], [https://www.ebi.ac.uk/pdbsum/3woo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3woo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DAPB2_PSEMX DAPB2_PSEMX] Exopeptidase that catalyzes the removal of dipeptide units (NH2-P2-P1-) from the free amino termini of oligopeptides and small proteins (PubMed:24598890, PubMed:8892831, PubMed:24827749). Peptide digestion is sequential and substrate recognition is non-specific, with the exception that Pro is not suitable as a P1 residue (PubMed:24827749). Removes many residues of bioactive oligopeptides such as angiotensin I and neuromedin N and cleaves also oxidized insulin B chain. Able to hydrolyze an X-Pro bond, an imido bond. No endopeptidase activity (PubMed:8892831). May play a physiological role in feeding (PubMed:24598890).<ref>PMID:24598890</ref> <ref>PMID:24827749</ref> <ref>PMID:8892831</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 700993~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fujimoto, M]]	+	[[Category: Pseudoxanthomonas mexicana]]
-	[[Category: Iizuka, I]]	+	[[Category: Fujimoto M]]
-	[[Category: Nonaka, T]]	+	[[Category: Iizuka I]]
-	[[Category: Ogasawara, W]]	+	[[Category: Nonaka T]]
-	[[Category: Roppongi, S]]	+	[[Category: Ogasawara W]]
-	[[Category: Sakamoto, Y]]	+	[[Category: Roppongi S]]
-	[[Category: Suzuki, Y]]	+	[[Category: Sakamoto Y]]
-	[[Category: Tanaka, N]]	+	[[Category: Suzuki Y]]
-	[[Category: Tateoka, C]]	+	[[Category: Tanaka N]]
-	~~[[Category: Chymotrypsin fold]]~~	+	[[Category: Tateoka C]]
-	~~[[Category: Hydrolase-hormone complex]]~~	+
-	~~[[Category: S46 peptidase~~]]	+

OCA at 05:44, 3 August 2022

OCA — Wed, 03 Aug 2022 05:44:27 GMT

←Older revision		Revision as of 05:44, 3 August 2022
Line 1:		Line 1:

	==Crystal structure of the DAP BII hexapeptide complex I==		==Crystal structure of the DAP BII hexapeptide complex I==
-	<StructureSection load='3woo' size='340' side='right' caption='[[3woo]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3woo' size='340' side='right'caption='[[3woo]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3woo]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_700993 Atcc 700993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WOO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WOO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3woo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_700993 Atcc 700993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WOO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3woi\|3woi]], [[3woj\|3woj]], [[3wok\|3wok]], [[3wol\|3wol]], [[3wom\|3wom]], [[3won\|3won]], [[3wop\|3wop]], [[3woq\|3woq]], [[3wor\|3wor]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3woi\|3woi]], [[3woj\|3woj]], [[3wok\|3wok]], [[3wol\|3wol]], [[3wom\|3wom]], [[3won\|3won]], [[3wop\|3wop]], [[3woq\|3woq]], [[3wor\|3wor]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3woo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woo OCA], [~~http~~://pdbe.org/3woo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3woo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3woo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3woo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3woo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woo OCA], [https://pdbe.org/3woo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3woo RCSB], [https://www.ebi.ac.uk/pdbsum/3woo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3woo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 700993]]		[[Category: Atcc 700993]]
		+	[[Category: Large Structures]]
	[[Category: Fujimoto, M]]		[[Category: Fujimoto, M]]
	[[Category: Iizuka, I]]		[[Category: Iizuka, I]]

OCA at 09:16, 21 February 2019

OCA — Thu, 21 Feb 2019 09:16:35 GMT

←Older revision		Revision as of 09:16, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='3woo' size='340' side='right' caption='[[3woo]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3woo' size='340' side='right' caption='[[3woo]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3woo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WOO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3woo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_700993 Atcc 700993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WOO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3woi\|3woi]], [[3woj\|3woj]], [[3wok\|3wok]], [[3wol\|3wol]], [[3wom\|3wom]], [[3won\|3won]], [[3wop\|3wop]], [[3woq\|3woq]], [[3wor\|3wor]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3woi\|3woi]], [[3woj\|3woj]], [[3wok\|3wok]], [[3wol\|3wol]], [[3wom\|3wom]], [[3won\|3won]], [[3wop\|3wop]], [[3woq\|3woq]], [[3wor\|3wor]]</td></tr>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 700993]]
	[[Category: Fujimoto, M]]		[[Category: Fujimoto, M]]
	[[Category: Iizuka, I]]		[[Category: Iizuka, I]]

OCA at 16:12, 11 August 2016

OCA — Thu, 11 Aug 2016 16:12:15 GMT

←Older revision		Revision as of 16:12, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the DAP BII hexapeptide complex I==		==Crystal structure of the DAP BII hexapeptide complex I==
	<StructureSection load='3woo' size='340' side='right' caption='[[3woo]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3woo' size='340' side='right' caption='[[3woo]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3woi\|3woi]], [[3woj\|3woj]], [[3wok\|3wok]], [[3wol\|3wol]], [[3wom\|3wom]], [[3won\|3won]], [[3wop\|3wop]], [[3woq\|3woq]], [[3wor\|3wor]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3woi\|3woi]], [[3woj\|3woj]], [[3wok\|3wok]], [[3wol\|3wol]], [[3wom\|3wom]], [[3won\|3won]], [[3wop\|3wop]], [[3woq\|3woq]], [[3wor\|3wor]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3woo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3woo RCSB], [http://www.ebi.ac.uk/pdbsum/3woo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3woo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woo OCA], [http://pdbe.org/3woo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3woo RCSB], [http://www.ebi.ac.uk/pdbsum/3woo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3woo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3woo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:32, 5 January 2015

OCA — Mon, 05 Jan 2015 14:32:15 GMT

←Older revision		Revision as of 14:32, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3woo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WOO FirstGlance]. <br>		<table><tr><td colspan='2'>[[3woo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WOO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3woi\|3woi]], [[3woj\|3woj]], [[3wok\|3wok]], [[3wol\|3wol]], [[3wom\|3wom]], [[3won\|3won]], [[3wop\|3wop]], [[3woq\|3woq]], [[3wor\|3wor]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3woi\|3woi]], [[3woj\|3woj]], [[3wok\|3wok]], [[3wol\|3wol]], [[3wom\|3wom]], [[3won\|3won]], [[3wop\|3wop]], [[3woq\|3woq]], [[3wor\|3wor]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3woo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3woo RCSB], [http://www.ebi.ac.uk/pdbsum/3woo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3woo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3woo RCSB], [http://www.ebi.ac.uk/pdbsum/3woo PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fujimoto, M.]]	+	[[Category: Fujimoto, M]]
-	[[Category: Iizuka, I.]]	+	[[Category: Iizuka, I]]
-	[[Category: Nonaka, T.]]	+	[[Category: Nonaka, T]]
-	[[Category: Ogasawara, W.]]	+	[[Category: Ogasawara, W]]
-	[[Category: Roppongi, S.]]	+	[[Category: Roppongi, S]]
-	[[Category: Sakamoto, Y.]]	+	[[Category: Sakamoto, Y]]
-	[[Category: Suzuki, Y.]]	+	[[Category: Suzuki, Y]]
-	[[Category: Tanaka, N.]]	+	[[Category: Tanaka, N]]
-	[[Category: Tateoka, C.]]	+	[[Category: Tateoka, C]]
	[[Category: Chymotrypsin fold]]		[[Category: Chymotrypsin fold]]
	[[Category: Hydrolase-hormone complex]]		[[Category: Hydrolase-hormone complex]]
	[[Category: S46 peptidase]]		[[Category: S46 peptidase]]

OCA at 05:51, 4 September 2014

OCA — Thu, 04 Sep 2014 05:51:38 GMT

←Older revision		Revision as of 05:51, 4 September 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of the DAP BII hexapeptide complex I==
		+	<StructureSection load='3woo' size='340' side='right' caption='[[3woo]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3woo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WOO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3woi\|3woi]], [[3woj\|3woj]], [[3wok\|3wok]], [[3wol\|3wol]], [[3wom\|3wom]], [[3won\|3won]], [[3wop\|3wop]], [[3woq\|3woq]], [[3wor\|3wor]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3woo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3woo RCSB], [http://www.ebi.ac.uk/pdbsum/3woo PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The dipeptidyl aminopeptidase BII (DAP BII) belongs to a serine peptidase family, S46. The amino acid sequence of the catalytic unit of DAP BII exhibits significant similarity to those of clan PA endopeptidases, such as chymotrypsin. However, the molecular mechanism of the exopeptidase activity of family S46 peptidase is unknown. Here, we report crystal structures of DAP BII. DAP BII contains a peptidase domain including a typical double beta-barrel fold and previously unreported alpha-helical domain. The structures of peptide complexes revealed that the alpha-helical domain covers the active-site cleft and the side chain of Asn330 in the domain forms hydrogen bonds with the N-terminus of the bound peptide. These observations indicate that the alpha-helical domain regulates the exopeptidase activity of DAP BII. Because S46 peptidases are not found in mammals, we expect that our study will be useful for the design of specific inhibitors of S46 peptidases from pathogens.

-	~~The entry 3woo is ON HOLD until Paper Publication~~	+	S46 peptidases are the first exopeptidases to be members of clan PA.,Sakamoto Y, Suzuki Y, Iizuka I, Tateoka C, Roppongi S, Fujimoto M, Inaka K, Tanaka H, Masaki M, Ohta K, Okada H, Nonaka T, Morikawa Y, Nakamura KT, Ogasawara W, Tanaka N Sci Rep. 2014 May 15;4:4977. doi: 10.1038/srep04977. PMID:24827749<ref>PMID:24827749</ref>

-	~~Authors: Sakamoto~~, Y.~~, Suzuki, Y~~., Iizuka, I., ~~Tateoka, C~~., Roppongi, S., ~~Fujimoto, M~~., ~~Nonaka, T~~.~~, Ogasawara, W.,~~ Tanaka, N.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of the DAP BII hexapeptide~~ complex I	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fujimoto, M.]]
		+	[[Category: Iizuka, I.]]
		+	[[Category: Nonaka, T.]]
		+	[[Category: Ogasawara, W.]]
		+	[[Category: Roppongi, S.]]
		+	[[Category: Sakamoto, Y.]]
		+	[[Category: Suzuki, Y.]]
		+	[[Category: Tanaka, N.]]
		+	[[Category: Tateoka, C.]]
		+	[[Category: Chymotrypsin fold]]
		+	[[Category: Hydrolase-hormone complex]]
		+	[[Category: S46 peptidase]]

OCA at 07:26, 28 May 2014

OCA — Wed, 28 May 2014 07:26:37 GMT

←Older revision		Revision as of 07:26, 28 May 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3woo is ON HOLD	+	The entry 3woo is ON HOLD until Paper Publication

	Authors: Sakamoto, Y., Suzuki, Y., Iizuka, I., Tateoka, C., Roppongi, S., Fujimoto, M., Nonaka, T., Ogasawara, W., Tanaka, N.		Authors: Sakamoto, Y., Suzuki, Y., Iizuka, I., Tateoka, C., Roppongi, S., Fujimoto, M., Nonaka, T., Ogasawara, W., Tanaka, N.

	Description: Crystal structure of the DAP BII hexapeptide complex I		Description: Crystal structure of the DAP BII hexapeptide complex I

OCA at 06:38, 29 January 2014

OCA — Wed, 29 Jan 2014 06:38:41 GMT

←Older revision		Revision as of 06:38, 29 January 2014
Line 5:		Line 5:
	Authors: Sakamoto, Y., Suzuki, Y., Iizuka, I., Tateoka, C., Roppongi, S., Fujimoto, M., Nonaka, T., Ogasawara, W., Tanaka, N.		Authors: Sakamoto, Y., Suzuki, Y., Iizuka, I., Tateoka, C., Roppongi, S., Fujimoto, M., Nonaka, T., Ogasawara, W., Tanaka, N.

-	Description: Crystal structure of the DAP BII hexapeptide complex I.	+	Description: Crystal structure of the DAP BII hexapeptide complex I

OCA: Protected "3woo" [edit=sysop:move=sysop]

OCA — Wed, 08 Jan 2014 08:42:00 GMT

Protected "3woo" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:42, 8 January 2014

OCA: New page: '''Unreleased structure''' The entry 3woo is ON HOLD Authors: Sakamoto, Y., Suzuki, Y., Iizuka, I., Tateoka, C., Roppongi, S., Fujimoto, M., Nonaka, T., Ogasawara, W., Tanaka, N. Descr...

OCA — Wed, 08 Jan 2014 08:41:59 GMT

New page: '''Unreleased structure''' The entry 3woo is ON HOLD Authors: Sakamoto, Y., Suzuki, Y., Iizuka, I., Tateoka, C., Roppongi, S., Fujimoto, M., Nonaka, T., Ogasawara, W., Tanaka, N. Descr...

New page

'''Unreleased structure'''

The entry 3woo is ON HOLD

Authors: Sakamoto, Y., Suzuki, Y., Iizuka, I., Tateoka, C., Roppongi, S., Fujimoto, M., Nonaka, T., Ogasawara, W., Tanaka, N.

Description: Crystal structure of the DAP BII hexapeptide complex I.