3wrs - Revision history

OCA at 08:46, 20 March 2024

OCA — Wed, 20 Mar 2024 08:46:56 GMT

←Older revision		Revision as of 08:46, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3wrs' size='340' side='right'caption='[[3wrs]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='3wrs' size='340' side='right'caption='[[3wrs]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wrs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mumip Mumip~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wrs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_minute_virus_strain_MVM_prototype Murine minute virus strain MVM prototype]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WRS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.58Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[4pp4\|4pp4]], [[3wrn\|3wrn]], [[3wro\|3wro]], [[3wrq\|3wrq]], [[3wrr\|3wrr]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">NS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=648235 MUMIP])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wrs OCA], [https://pdbe.org/3wrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wrs RCSB], [https://www.ebi.ac.uk/pdbsum/3wrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wrs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wrs OCA], [https://pdbe.org/3wrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wrs RCSB], [https://www.ebi.ac.uk/pdbsum/3wrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wrs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NS1_MUMIP NS1_MUMIP]] Multifunctional protein that plays an essential role in viral DNA replication. Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition. These arrests may provide essential cellular factors for viral DNA replication. Interacts specifically with the viral DNA origin of replication and plays a direct role in DNA replication. Participates in the transcriptional regulation of several promoters including the viral p38 promoter that regulates the expression of VP1 and VP2 transcripts. Promotes apoptosis in host cell.<ref>PMID:11602746</ref> <ref>PMID:21295324</ref> <ref>PMID:7636987</ref> <ref>PMID:9188601</ref>	+	[https://www.uniprot.org/uniprot/NS1_MUMIP NS1_MUMIP] Multifunctional protein that plays an essential role in viral DNA replication. Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition. These arrests may provide essential cellular factors for viral DNA replication. Interacts specifically with the viral DNA origin of replication and plays a direct role in DNA replication. Participates in the transcriptional regulation of several promoters including the viral p38 promoter that regulates the expression of VP1 and VP2 transcripts. Promotes apoptosis in host cell.<ref>PMID:11602746</ref> <ref>PMID:21295324</ref> <ref>PMID:7636987</ref> <ref>PMID:9188601</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Members of the Parvoviridae family all encode a non-structural protein 1 (NS1) that directs replication of single-stranded viral DNA, packages viral DNA into capsid, and serves as a potent transcriptional activator. Here we report the X-ray structure of the minute virus of mice (MVM) NS1 N-terminal domain at 1.45A resolution, showing that sites for dsDNA binding, ssDNA binding and cleavage, nuclear localization, and other functions are integrated on a canonical fold of the histidine-hydrophobic-histidine superfamily of nucleases, including elements specific for this Protoparvovirus but distinct from its Bocaparvovirus or Dependoparvovirus orthologs. High resolution structural analysis reveals a nickase active site with an architecture that allows highly versatile metal ligand binding. The structures support a unified mechanism of replication origin recognition for homotelomeric and heterotelomeric parvoviruses, mediated by a basic-residue-rich hairpin and an adjacent helix in the initiator proteins and by tandem tetranucleotide motifs in the replication origins.	+
-		+
-	Structures of minute virus of mice replication initiator protein N-terminal domain: Insights into DNA nicking and origin binding.,Tewary SK, Liang L, Lin Z, Lynn A, Cotmore SF, Tattersall P, Zhao H, Tang L Virology. 2014 Dec 17;476C:61-71. doi: 10.1016/j.virol.2014.11.022. PMID:25528417<ref>PMID:25528417</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3wrs" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 15:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mumip~~]]	+	[[Category: Murine minute virus strain MVM prototype]]
-	[[Category: Tang, L]]	+	[[Category: Tang L]]
-	[[Category: Tewary~~, S K~~]]	+	[[Category: Tewary SK]]
-	[[Category: Zhao, H]]	+	[[Category: Zhao H]]
-	~~[[Category: Nuclease activity]]~~	+
-	~~[[Category: Replication]]~~	+
-	~~[[Category: Single and double stranded dna binding and nicking protein~~]]	+

OCA at 05:47, 3 August 2022

OCA — Wed, 03 Aug 2022 05:47:35 GMT

←Older revision		Revision as of 05:47, 3 August 2022
Line 1:		Line 1:

	==Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication==		==Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication==
-	<StructureSection load='3wrs' size='340' side='right' caption='[[3wrs]], [[Resolution\|resolution]] 1.58Å' scene=''>	+	<StructureSection load='3wrs' size='340' side='right'caption='[[3wrs]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wrs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mumip Mumip]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wrs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mumip Mumip]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WRS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pp4\|4pp4]], [[3wrn\|3wrn]], [[3wro\|3wro]], [[3wrq\|3wrq]], [[3wrr\|3wrr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4pp4\|4pp4]], [[3wrn\|3wrn]], [[3wro\|3wro]], [[3wrq\|3wrq]], [[3wrr\|3wrr]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=648235 MUMIP])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=648235 MUMIP])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wrs OCA], [~~http~~://pdbe.org/3wrs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3wrs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3wrs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3wrs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wrs OCA], [https://pdbe.org/3wrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wrs RCSB], [https://www.ebi.ac.uk/pdbsum/3wrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wrs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NS1_MUMIP NS1_MUMIP]] Multifunctional protein that plays an essential role in viral DNA replication. Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition. These arrests may provide essential cellular factors for viral DNA replication. Interacts specifically with the viral DNA origin of replication and plays a direct role in DNA replication. Participates in the transcriptional regulation of several promoters including the viral p38 promoter that regulates the expression of VP1 and VP2 transcripts. Promotes apoptosis in host cell.<ref>PMID:11602746</ref> <ref>PMID:21295324</ref> <ref>PMID:7636987</ref> <ref>PMID:9188601</ref>	+	[[https://www.uniprot.org/uniprot/NS1_MUMIP NS1_MUMIP]] Multifunctional protein that plays an essential role in viral DNA replication. Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition. These arrests may provide essential cellular factors for viral DNA replication. Interacts specifically with the viral DNA origin of replication and plays a direct role in DNA replication. Participates in the transcriptional regulation of several promoters including the viral p38 promoter that regulates the expression of VP1 and VP2 transcripts. Promotes apoptosis in host cell.<ref>PMID:11602746</ref> <ref>PMID:21295324</ref> <ref>PMID:7636987</ref> <ref>PMID:9188601</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mumip]]		[[Category: Mumip]]
	[[Category: Tang, L]]		[[Category: Tang, L]]

OCA at 09:21, 21 February 2019

OCA — Thu, 21 Feb 2019 09:21:06 GMT

←Older revision		Revision as of 09:21, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='3wrs' size='340' side='right' caption='[[3wrs]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='3wrs' size='340' side='right' caption='[[3wrs]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wrs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wrs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mumip Mumip]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WRS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pp4\|4pp4]], [[3wrn\|3wrn]], [[3wro\|3wro]], [[3wrq\|3wrq]], [[3wrr\|3wrr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pp4\|4pp4]], [[3wrn\|3wrn]], [[3wro\|3wro]], [[3wrq\|3wrq]], [[3wrr\|3wrr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=648235 MUMIP])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wrs OCA], [http://pdbe.org/3wrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wrs RCSB], [http://www.ebi.ac.uk/pdbsum/3wrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wrs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wrs OCA], [http://pdbe.org/3wrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wrs RCSB], [http://www.ebi.ac.uk/pdbsum/3wrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wrs ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Mumip]]
	[[Category: Tang, L]]		[[Category: Tang, L]]
	[[Category: Tewary, S K]]		[[Category: Tewary, S K]]

OCA at 17:10, 11 August 2016

OCA — Thu, 11 Aug 2016 17:10:47 GMT

←Older revision		Revision as of 17:10, 11 August 2016
Line 1:		Line 1:
		+
	==Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication==		==Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication==
	<StructureSection load='3wrs' size='340' side='right' caption='[[3wrs]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='3wrs' size='340' side='right' caption='[[3wrs]], [[Resolution\|resolution]] 1.58Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pp4\|4pp4]], [[3wrn\|3wrn]], [[3wro\|3wro]], [[3wrq\|3wrq]], [[3wrr\|3wrr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pp4\|4pp4]], [[3wrn\|3wrn]], [[3wro\|3wro]], [[3wrq\|3wrq]], [[3wrr\|3wrr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wrs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wrs RCSB], [http://www.ebi.ac.uk/pdbsum/3wrs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wrs OCA], [http://pdbe.org/3wrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wrs RCSB], [http://www.ebi.ac.uk/pdbsum/3wrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wrs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3wrs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:52, 21 January 2015

OCA — Wed, 21 Jan 2015 16:52:38 GMT

←Older revision		Revision as of 16:52, 21 January 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication==
		+	<StructureSection load='3wrs' size='340' side='right' caption='[[3wrs]], [[Resolution\|resolution]] 1.58Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3wrs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WRS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pp4\|4pp4]], [[3wrn\|3wrn]], [[3wro\|3wro]], [[3wrq\|3wrq]], [[3wrr\|3wrr]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wrs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wrs RCSB], [http://www.ebi.ac.uk/pdbsum/3wrs PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NS1_MUMIP NS1_MUMIP]] Multifunctional protein that plays an essential role in viral DNA replication. Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition. These arrests may provide essential cellular factors for viral DNA replication. Interacts specifically with the viral DNA origin of replication and plays a direct role in DNA replication. Participates in the transcriptional regulation of several promoters including the viral p38 promoter that regulates the expression of VP1 and VP2 transcripts. Promotes apoptosis in host cell.<ref>PMID:11602746</ref> <ref>PMID:21295324</ref> <ref>PMID:7636987</ref> <ref>PMID:9188601</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Members of the Parvoviridae family all encode a non-structural protein 1 (NS1) that directs replication of single-stranded viral DNA, packages viral DNA into capsid, and serves as a potent transcriptional activator. Here we report the X-ray structure of the minute virus of mice (MVM) NS1 N-terminal domain at 1.45A resolution, showing that sites for dsDNA binding, ssDNA binding and cleavage, nuclear localization, and other functions are integrated on a canonical fold of the histidine-hydrophobic-histidine superfamily of nucleases, including elements specific for this Protoparvovirus but distinct from its Bocaparvovirus or Dependoparvovirus orthologs. High resolution structural analysis reveals a nickase active site with an architecture that allows highly versatile metal ligand binding. The structures support a unified mechanism of replication origin recognition for homotelomeric and heterotelomeric parvoviruses, mediated by a basic-residue-rich hairpin and an adjacent helix in the initiator proteins and by tandem tetranucleotide motifs in the replication origins.

-	~~The entry 3wrs is ON HOLD until Feb 27 2016~~	+	Structures of minute virus of mice replication initiator protein N-terminal domain: Insights into DNA nicking and origin binding.,Tewary SK, Liang L, Lin Z, Lynn A, Cotmore SF, Tattersall P, Zhao H, Tang L Virology. 2014 Dec 17;476C:61-71. doi: 10.1016/j.virol.2014.11.022. PMID:25528417<ref>PMID:25528417</ref>

-	~~Authors: Tewary~~, S.K.~~, Zhao, H.,~~ Tang, L.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	Description: Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Tang, L]]
		+	[[Category: Tewary, S K]]
	[[Category: Zhao, H]]		[[Category: Zhao, H]]
-	[[Category: ~~Tang, L~~]]	+	[[Category: Nuclease activity]]
-	[[Category: ~~Tewary, S.K~~]]	+	[[Category: Replication]]
		+	[[Category: Single and double stranded dna binding and nicking protein]]

OCA at 12:51, 24 December 2014

OCA — Wed, 24 Dec 2014 12:51:20 GMT

←Older revision		Revision as of 12:51, 24 December 2014
Line 6:		Line 6:

	Description: Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication		Description: Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication
		+	[[Category: Unreleased Structures]]
		+	[[Category: Zhao, H]]
		+	[[Category: Tang, L]]
		+	[[Category: Tewary, S.K]]

OCA at 07:33, 24 September 2014

OCA — Wed, 24 Sep 2014 07:33:59 GMT

←Older revision		Revision as of 07:33, 24 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3wrs is ON HOLD	+	The entry 3wrs is ON HOLD until Feb 27 2016

	Authors: Tewary, S.K., Zhao, H., Tang, L.		Authors: Tewary, S.K., Zhao, H., Tang, L.

	Description: Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication		Description: Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication

OCA: Protected "3wrs" [edit=sysop:move=sysop]

OCA — Wed, 12 Mar 2014 11:39:38 GMT

Protected "3wrs" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:39, 12 March 2014

OCA: New page: '''Unreleased structure''' The entry 3wrs is ON HOLD Authors: Tewary, S.K., Zhao, H., Tang, L. Description: Minute virus of mice non-structural protein-1N-terminal nuclease domain reve...

OCA — Wed, 12 Mar 2014 11:39:36 GMT

New page: '''Unreleased structure''' The entry 3wrs is ON HOLD Authors: Tewary, S.K., Zhao, H., Tang, L. Description: Minute virus of mice non-structural protein-1N-terminal nuclease domain reve...

New page

'''Unreleased structure'''

The entry 3wrs is ON HOLD

Authors: Tewary, S.K., Zhao, H., Tang, L.

Description: Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication