3wtq - Revision history

OCA at 08:47, 20 March 2024

OCA — Wed, 20 Mar 2024 08:47:17 GMT

←Older revision		Revision as of 08:47, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3wtq' size='340' side='right'caption='[[3wtq]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3wtq' size='340' side='right'caption='[[3wtq]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wtq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WTQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wtq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WTQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YS9:(1R,3R,7E,17BETA)-17-[(2R,3S)-3-BUTYL-6-HYDROXY-6-METHYLHEPTAN-2-YL]-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YS9</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Vdr, Nr1i1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YS9:(1R,3R,7E,17BETA)-17-[(2R,3S)-3-BUTYL-6-HYDROXY-6-METHYLHEPTAN-2-YL]-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YS9</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wtq OCA], [https://pdbe.org/3wtq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wtq RCSB], [https://www.ebi.ac.uk/pdbsum/3wtq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wtq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wtq OCA], [https://pdbe.org/3wtq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wtq RCSB], [https://www.ebi.ac.uk/pdbsum/3wtq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wtq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref> [[https://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref>	+	[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Anami, Y]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Ikura, T]]	+	[[Category: Anami Y]]
-	[[Category: Inaba, Y]]	+	[[Category: Ikura T]]
-	[[Category: Ito, N]]	+	[[Category: Inaba Y]]
-	[[Category: Itoh, T]]	+	[[Category: Ito N]]
-	[[Category: Nakabayashi, M]]	+	[[Category: Itoh T]]
-	[[Category: Yamamoto, K]]	+	[[Category: Nakabayashi M]]
-	~~[[Category: Co-factor]]~~	+	[[Category: Yamamoto K]]
-	~~[[Category: Rxr]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Vdre]]~~	+
-	~~[[Category: Vitamin d3~~]]	+

OCA at 05:31, 10 August 2022

OCA — Wed, 10 Aug 2022 05:31:06 GMT

←Older revision		Revision as of 05:31, 10 August 2022
Line 1:		Line 1:

	==Crystal structure of VDR-LBD complexed with 22S-butyl-2-methylidene-19-nor-1a,25-dihydroxyvitamin D3==		==Crystal structure of VDR-LBD complexed with 22S-butyl-2-methylidene-19-nor-1a,25-dihydroxyvitamin D3==
-	<StructureSection load='3wtq' size='340' side='right' caption='[[3wtq]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3wtq' size='340' side='right'caption='[[3wtq]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wtq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WTQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WTQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wtq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WTQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YS9:(1R,3R,7E,17BETA)-17-[(2R,3S)-3-BUTYL-6-HYDROXY-6-METHYLHEPTAN-2-YL]-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YS9</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YS9:(1R,3R,7E,17BETA)-17-[(2R,3S)-3-BUTYL-6-HYDROXY-6-METHYLHEPTAN-2-YL]-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YS9</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Vdr, Nr1i1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Vdr, Nr1i1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3wtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wtq OCA], [~~http~~://pdbe.org/3wtq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3wtq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3wtq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3wtq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wtq OCA], [https://pdbe.org/3wtq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wtq RCSB], [https://www.ebi.ac.uk/pdbsum/3wtq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wtq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref> [[~~http~~://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref>	+	[[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref> [[https://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref>
		+
		+	==See Also==
		+	*[[Vitamin D receptor 3D structures\|Vitamin D receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Anami, Y]]		[[Category: Anami, Y]]
	[[Category: Ikura, T]]		[[Category: Ikura, T]]

OCA at 08:09, 22 November 2017

OCA — Wed, 22 Nov 2017 08:09:58 GMT

←Older revision		Revision as of 08:09, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='3wtq' size='340' side='right' caption='[[3wtq]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3wtq' size='340' side='right' caption='[[3wtq]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wtq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WTQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wtq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WTQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YS9:(1R,3R,7E,17BETA)-17-[(2R,3S)-3-BUTYL-6-HYDROXY-6-METHYLHEPTAN-2-YL]-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YS9</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YS9:(1R,3R,7E,17BETA)-17-[(2R,3S)-3-BUTYL-6-HYDROXY-6-METHYLHEPTAN-2-YL]-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YS9</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Vdr, Nr1i1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wtq OCA], [http://pdbe.org/3wtq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wtq RCSB], [http://www.ebi.ac.uk/pdbsum/3wtq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wtq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wtq OCA], [http://pdbe.org/3wtq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wtq RCSB], [http://www.ebi.ac.uk/pdbsum/3wtq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wtq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref> [[http://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref>		[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref> [[http://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref>
-
-	==See Also==
-	*[[Vitamin D receptor\|Vitamin D receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Anami, Y]]		[[Category: Anami, Y]]
	[[Category: Ikura, T]]		[[Category: Ikura, T]]

OCA at 13:18, 10 May 2017

OCA — Wed, 10 May 2017 13:18:44 GMT

←Older revision		Revision as of 13:18, 10 May 2017
Line 1:		Line 1:
		+
	==Crystal structure of VDR-LBD complexed with 22S-butyl-2-methylidene-19-nor-1a,25-dihydroxyvitamin D3==		==Crystal structure of VDR-LBD complexed with 22S-butyl-2-methylidene-19-nor-1a,25-dihydroxyvitamin D3==
	<StructureSection load='3wtq' size='340' side='right' caption='[[3wtq]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3wtq' size='340' side='right' caption='[[3wtq]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3wtq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WTQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3wtq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WTQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YS9:(1R,3R,7E,17BETA)-17-[(2R,3S)-3-BUTYL-6-HYDROXY-6-METHYLHEPTAN-2-YL]-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YS9</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YS9:(1R,3R,7E,17BETA)-17-[(2R,3S)-3-BUTYL-6-HYDROXY-6-METHYLHEPTAN-2-YL]-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YS9</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wtq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wtq RCSB], [http://www.ebi.ac.uk/pdbsum/3wtq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wtq OCA], [http://pdbe.org/3wtq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wtq RCSB], [http://www.ebi.ac.uk/pdbsum/3wtq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wtq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 13:26, 5 August 2015

OCA — Wed, 05 Aug 2015 13:26:46 GMT

←Older revision		Revision as of 13:26, 5 August 2015
Line 1:		Line 1:
-	==Crystal structure of VDR-LBD complexed with 22S-~~Butyl~~-2-methylidene-19-nor-1r,25-dihydroxyvitamin D3==	+	==Crystal structure of VDR-LBD complexed with 22S-butyl-2-methylidene-19-nor-1a,25-dihydroxyvitamin D3==
	<StructureSection load='3wtq' size='340' side='right' caption='[[3wtq]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3wtq' size='340' side='right' caption='[[3wtq]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 8:		Line 8:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref> [[http://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref>		[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref> [[http://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref>
		+
		+	==See Also==
		+	*[[Vitamin D receptor\|Vitamin D receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 18:
	[[Category: Ikura, T]]		[[Category: Ikura, T]]
	[[Category: Inaba, Y]]		[[Category: Inaba, Y]]
-	[[Category: ~~Itoh~~, N]]	+	[[Category: Ito, N]]
	[[Category: Itoh, T]]		[[Category: Itoh, T]]
	[[Category: Nakabayashi, M]]		[[Category: Nakabayashi, M]]

OCA at 12:56, 15 April 2015

OCA — Wed, 15 Apr 2015 12:56:31 GMT

←Older revision		Revision as of 12:56, 15 April 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of VDR-LBD complexed with 22S-Butyl-2-methylidene-19-nor-1r,25-dihydroxyvitamin D3==
-		+	<StructureSection load='3wtq' size='340' side='right' caption='[[3wtq]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~The entry~~ 3wtq is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3wtq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WTQ FirstGlance]. <br>
-	~~Authors~~: ~~Nakabayashi, M~~.~~, Inaba, Y~~.~~, Itoh, T~~.~~, Anami, Y~~.~~, Ikura, T~~.~~, Itoh, N~~.~~, Yamamoto, K~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YS9:(1R,3R,7E,17BETA)-17-[(2R,3S)-3-BUTYL-6-HYDROXY-6-METHYLHEPTAN-2-YL]-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YS9</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wtq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wtq RCSB], [http://www.ebi.ac.uk/pdbsum/3wtq PDBsum]</span></td></tr>
-	~~Description~~: ~~Crystal structure of VDR~~-~~LBD complexed with 22S~~-~~Butyl~~-2-~~methylidene~~-19-~~nor~~-1r,25-~~dihydroxyvitamin D3~~	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	== Function ==
-	[[~~Category~~: ~~Yamamoto~~, K]]	+	[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref> [[http://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Anami, Y]]		[[Category: Anami, Y]]
-	[[Category: ~~Nakabayashi~~, M]]	+	[[Category: Ikura, T]]
		+	[[Category: Inaba, Y]]
	[[Category: Itoh, N]]		[[Category: Itoh, N]]
	[[Category: Itoh, T]]		[[Category: Itoh, T]]
-	[[Category: ~~Inaba~~, Y]]	+	[[Category: Nakabayashi, M]]
-	[[Category: ~~Ikura~~, T]]	+	[[Category: Yamamoto, K]]
		+	[[Category: Co-factor]]
		+	[[Category: Rxr]]
		+	[[Category: Transcription]]
		+	[[Category: Vdre]]
		+	[[Category: Vitamin d3]]

OCA at 12:58, 24 December 2014

OCA — Wed, 24 Dec 2014 12:58:29 GMT

←Older revision		Revision as of 12:58, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of VDR-LBD complexed with 22S-Butyl-2-methylidene-19-nor-1r,25-dihydroxyvitamin D3		Description: Crystal structure of VDR-LBD complexed with 22S-Butyl-2-methylidene-19-nor-1r,25-dihydroxyvitamin D3
		+	[[Category: Unreleased Structures]]
		+	[[Category: Yamamoto, K]]
		+	[[Category: Anami, Y]]
		+	[[Category: Nakabayashi, M]]
		+	[[Category: Itoh, N]]
		+	[[Category: Itoh, T]]
		+	[[Category: Inaba, Y]]
		+	[[Category: Ikura, T]]

OCA at 07:34, 24 September 2014

OCA — Wed, 24 Sep 2014 07:34:38 GMT

←Older revision		Revision as of 07:34, 24 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3wtq is ON HOLD	+	The entry 3wtq is ON HOLD until Paper Publication

	Authors: Nakabayashi, M., Inaba, Y., Itoh, T., Anami, Y., Ikura, T., Itoh, N., Yamamoto, K.		Authors: Nakabayashi, M., Inaba, Y., Itoh, T., Anami, Y., Ikura, T., Itoh, N., Yamamoto, K.

	Description: Crystal structure of VDR-LBD complexed with 22S-Butyl-2-methylidene-19-nor-1r,25-dihydroxyvitamin D3		Description: Crystal structure of VDR-LBD complexed with 22S-Butyl-2-methylidene-19-nor-1r,25-dihydroxyvitamin D3

OCA: Protected "3wtq" [edit=sysop:move=sysop]

OCA — Wed, 23 Apr 2014 07:01:56 GMT

Protected "3wtq" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:01, 23 April 2014

OCA: New page: '''Unreleased structure''' The entry 3wtq is ON HOLD Authors: Nakabayashi, M., Inaba, Y., Itoh, T., Anami, Y., Ikura, T., Itoh, N., Yamamoto, K. Description: Crystal structure of VDR-L...

OCA — Wed, 23 Apr 2014 07:01:55 GMT

New page: '''Unreleased structure''' The entry 3wtq is ON HOLD Authors: Nakabayashi, M., Inaba, Y., Itoh, T., Anami, Y., Ikura, T., Itoh, N., Yamamoto, K. Description: Crystal structure of VDR-L...

New page

'''Unreleased structure'''

The entry 3wtq is ON HOLD

Authors: Nakabayashi, M., Inaba, Y., Itoh, T., Anami, Y., Ikura, T., Itoh, N., Yamamoto, K.

Description: Crystal structure of VDR-LBD complexed with 22S-Butyl-2-methylidene-19-nor-1r,25-dihydroxyvitamin D3