3wxw - Revision history

OCA: Redirecting to 6ks1

OCA — Wed, 19 Aug 2020 06:14:35 GMT

Redirecting to 6ks1

←Older revision		Revision as of 06:14, 19 August 2020
Line 1:		Line 1:
-		+	#REDIRECT [[6ks1]] This PDB entry is obsolete and replaced by 6ks1
-	~~==Crystal structure of the human adiponectin receptor 2==~~	+
-	~~<StructureSection load='3wxw' size='340' side='right' caption='~~[[~~3wxw]], [[Resolution\|resolution]] 2.40Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[3wxw~~]] is ~~a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]~~ and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WXW FirstGlance]. <br>	+
-	~~</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wxv\|3wxv]]</td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADIPOR2, PAQR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wxw OCA], [http://pdbe.org/3wxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wxw RCSB], [http://www.ebi.ac.uk/pdbsum/3wxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wxw ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Function ==~~	+
-	~~[[http://www.uniprot.org/uniprot/ADR2_HUMAN ADR2_HUMAN]] Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted~~ by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.<ref>PMID:12802337</ref>	+
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules. AdipoR1 and AdipoR2 were predicted to contain seven transmembrane helices with the opposite topology to G-protein-coupled receptors. Here we report the crystal structures of human AdipoR1 and AdipoR2 at 2.9 and 2.4 A resolution, respectively, which represent a novel class of receptor structure. The seven-transmembrane helices, conformationally distinct from those of G-protein-coupled receptors, enclose a large cavity where three conserved histidine residues coordinate a zinc ion. The zinc-binding structure may have a role in the adiponectin-stimulated AMPK phosphorylation and UCP2 upregulation. Adiponectin may broadly interact with the extracellular face, rather than the carboxy-terminal tail, of the receptors. The present information will facilitate the understanding of novel structure-function relationships and the development and optimization of AdipoR agonists for the treatment of obesity-related diseases, such as type 2 diabetes.	+
-		+
-	Crystal structures of the human adiponectin receptors.,Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Nakamura Y, Hosaka T, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hato M, Ogasawara S, Hino T, Murata T, Iwata S, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T, Yokoyama S Nature. 2015 Apr 16;520(7547):312-6. doi: 10.1038/nature14301. Epub 2015 Apr 8. PMID:25855295<ref>PMID:25855295</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3wxw" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Human]]~~	+
-	~~[[Category: Lk3 transgenic mice]]~~	+
-	~~[[Category: Fujii, Y]]~~	+
-	~~[[Category: Hosaka, T]]~~	+
-	~~[[Category: Iwabu, M]]~~	+
-	~~[[Category: Kadowaki, T]]~~	+
-	~~[[Category: Kimura-Someya, T]]~~	+
-	~~[[Category: Nakamura, Y]]~~	+
-	~~[[Category: Okada-Iwabu, M]]~~	+
-	~~[[Category: Shirouzu, M]]~~	+
-	~~[[Category: Tanabe, H]]~~	+
-	~~[[Category: Yamauchi, T]]~~	+
-	~~[[Category: Yokoyama, S]]~~	+
-	~~[[Category: Adiponectin]]~~	+
-	~~[[Category: Appl1]]~~	+
-	~~[[Category: Appl2]]~~	+
-	~~[[Category: Glucose and lipid metabolism]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein-immune system complex]]~~	+
-	~~[[Category: Osmotin]]~~	+
-	~~[[Category: Paqr family]]~~	+

OCA at 09:46, 21 February 2019

OCA — Thu, 21 Feb 2019 09:46:15 GMT

←Older revision		Revision as of 09:46, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='3wxw' size='340' side='right' caption='[[3wxw]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3wxw' size='340' side='right' caption='[[3wxw]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wxw]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wxw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WXW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wxv\|3wxv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wxv\|3wxv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADIPOR2, PAQR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wxw OCA], [http://pdbe.org/3wxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wxw RCSB], [http://www.ebi.ac.uk/pdbsum/3wxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wxw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wxw OCA], [http://pdbe.org/3wxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wxw RCSB], [http://www.ebi.ac.uk/pdbsum/3wxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wxw ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Fujii, Y]]		[[Category: Fujii, Y]]
	[[Category: Hosaka, T]]		[[Category: Hosaka, T]]

OCA at 18:51, 1 February 2017

OCA — Wed, 01 Feb 2017 18:51:53 GMT

←Older revision		Revision as of 18:51, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of the human adiponectin receptor 2==		==Crystal structure of the human adiponectin receptor 2==
	<StructureSection load='3wxw' size='340' side='right' caption='[[3wxw]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3wxw' size='340' side='right' caption='[[3wxw]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wxv\|3wxv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wxv\|3wxv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wxw RCSB], [http://www.ebi.ac.uk/pdbsum/3wxw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wxw OCA], [http://pdbe.org/3wxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wxw RCSB], [http://www.ebi.ac.uk/pdbsum/3wxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wxw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3wxw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:21, 22 April 2015

OCA — Wed, 22 Apr 2015 07:21:25 GMT

←Older revision		Revision as of 07:21, 22 April 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ADR2_HUMAN ADR2_HUMAN]] Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.<ref>PMID:12802337</ref>		[[http://www.uniprot.org/uniprot/ADR2_HUMAN ADR2_HUMAN]] Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.<ref>PMID:12802337</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules. AdipoR1 and AdipoR2 were predicted to contain seven transmembrane helices with the opposite topology to G-protein-coupled receptors. Here we report the crystal structures of human AdipoR1 and AdipoR2 at 2.9 and 2.4 A resolution, respectively, which represent a novel class of receptor structure. The seven-transmembrane helices, conformationally distinct from those of G-protein-coupled receptors, enclose a large cavity where three conserved histidine residues coordinate a zinc ion. The zinc-binding structure may have a role in the adiponectin-stimulated AMPK phosphorylation and UCP2 upregulation. Adiponectin may broadly interact with the extracellular face, rather than the carboxy-terminal tail, of the receptors. The present information will facilitate the understanding of novel structure-function relationships and the development and optimization of AdipoR agonists for the treatment of obesity-related diseases, such as type 2 diabetes.
		+
		+	Crystal structures of the human adiponectin receptors.,Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Nakamura Y, Hosaka T, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hato M, Ogasawara S, Hino T, Murata T, Iwata S, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T, Yokoyama S Nature. 2015 Apr 16;520(7547):312-6. doi: 10.1038/nature14301. Epub 2015 Apr 8. PMID:25855295<ref>PMID:25855295</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:56, 15 April 2015

OCA — Wed, 15 Apr 2015 12:56:51 GMT

←Older revision		Revision as of 12:56, 15 April 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of the human adiponectin receptor 2==
-		+	<StructureSection load='3wxw' size='340' side='right' caption='[[3wxw]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~The entry~~ 3wxw is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3wxw]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WXW FirstGlance]. <br>
-	~~Authors~~: ~~Yokoyama~~, S.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wxv\|3wxv]]</td></tr>
-	~~Description~~: ~~Structure of a membrane protein~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wxw RCSB], [http://www.ebi.ac.uk/pdbsum/3wxw PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ADR2_HUMAN ADR2_HUMAN]] Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.<ref>PMID:12802337</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fujii, Y]]
		+	[[Category: Hosaka, T]]
		+	[[Category: Iwabu, M]]
		+	[[Category: Kadowaki, T]]
		+	[[Category: Kimura-Someya, T]]
		+	[[Category: Nakamura, Y]]
		+	[[Category: Okada-Iwabu, M]]
		+	[[Category: Shirouzu, M]]
		+	[[Category: Tanabe, H]]
		+	[[Category: Yamauchi, T]]
	[[Category: Yokoyama, S]]		[[Category: Yokoyama, S]]
		+	[[Category: Adiponectin]]
		+	[[Category: Appl1]]
		+	[[Category: Appl2]]
		+	[[Category: Glucose and lipid metabolism]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein-immune system complex]]
		+	[[Category: Osmotin]]
		+	[[Category: Paqr family]]

OCA at 13:05, 24 December 2014

OCA — Wed, 24 Dec 2014 13:05:02 GMT

←Older revision		Revision as of 13:05, 24 December 2014
Line 6:		Line 6:

	Description: Structure of a membrane protein		Description: Structure of a membrane protein
		+	[[Category: Unreleased Structures]]
		+	[[Category: Yokoyama, S]]

OCA at 09:41, 29 October 2014

OCA — Wed, 29 Oct 2014 09:41:49 GMT

←Older revision		Revision as of 09:41, 29 October 2014
Line 3:		Line 3:
	The entry 3wxw is ON HOLD until Paper Publication		The entry 3wxw is ON HOLD until Paper Publication

-	Authors: ~~Tanabe, H., Fujii, Y., Nakamura, Y., Hosaka, T., Okada-Iwabu, M., Iwabu, M., Kimura-Someya, T., Shirouzu, M., Yamauchi, T., Kadowaki, T.,~~ Yokoyama, S.	+	Authors: Yokoyama, S.

	Description: Structure of a membrane protein		Description: Structure of a membrane protein

OCA at 07:47, 10 September 2014

OCA — Wed, 10 Sep 2014 07:47:55 GMT

←Older revision		Revision as of 07:47, 10 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3wxw is ON HOLD	+	The entry 3wxw is ON HOLD until Paper Publication

	Authors: Tanabe, H., Fujii, Y., Nakamura, Y., Hosaka, T., Okada-Iwabu, M., Iwabu, M., Kimura-Someya, T., Shirouzu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S.		Authors: Tanabe, H., Fujii, Y., Nakamura, Y., Hosaka, T., Okada-Iwabu, M., Iwabu, M., Kimura-Someya, T., Shirouzu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S.

	Description: Structure of a membrane protein		Description: Structure of a membrane protein

OCA at 06:12, 27 August 2014

OCA — Wed, 27 Aug 2014 06:12:52 GMT

←Older revision		Revision as of 06:12, 27 August 2014
Line 5:		Line 5:
	Authors: Tanabe, H., Fujii, Y., Nakamura, Y., Hosaka, T., Okada-Iwabu, M., Iwabu, M., Kimura-Someya, T., Shirouzu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S.		Authors: Tanabe, H., Fujii, Y., Nakamura, Y., Hosaka, T., Okada-Iwabu, M., Iwabu, M., Kimura-Someya, T., Shirouzu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S.

-	Description: ~~structure~~ of a membrane protein	+	Description: Structure of a membrane protein

OCA: Protected "3wxw" [edit=sysop:move=sysop]

OCA — Wed, 20 Aug 2014 14:00:56 GMT

Protected "3wxw" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:00, 20 August 2014