3wyf - Revision history

OCA at 13:33, 8 November 2023

OCA — Wed, 08 Nov 2023 13:33:26 GMT

←Older revision		Revision as of 13:33, 8 November 2023
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	<StructureSection load='3wyf' size='340' side='right'caption='[[3wyf]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='3wyf' size='340' side='right'caption='[[3wyf]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wyf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wyf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_AWRI796 Saccharomyces cerevisiae AWRI796] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GTP:GUANOSINE~~-~~5-TRIPHOSPHATE'>GTP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.22Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3wyg\|3wyg]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">AWRI796_3356 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=764097 Baker's yeast]), AWRI796_2363, YIL063C, YRB2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), CRM1, G8514, KAP124, XPO1, YGR218W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [https://pdbe.org/3wyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [https://www.ebi.ac.uk/pdbsum/3wyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [https://pdbe.org/3wyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [https://www.ebi.ac.uk/pdbsum/3wyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	~~[[https://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES). [~~[https://www.uniprot.org/uniprot/YRB2_YEAST YRB2_YEAST]] Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1.<ref>PMID:9395535</ref>	+	[https://www.uniprot.org/uniprot/YRB2_YEAST YRB2_YEAST] Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1.<ref>PMID:9395535</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Koyama, M~~]]	+	[[Category: Saccharomyces cerevisiae AWRI796]]
-	[[Category: ~~Matsuura, Y~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Shirai, N~~]]	+	[[Category: Koyama M]]
-	[[Category: ~~Gtp-binding protein-gtp-binding protein inhibitor complex~~]]	+	[[Category: Matsuura Y]]
-	[[Category: ~~Heat repeat]]~~	+	[[Category: Shirai N]]
-	~~[[Category: Nuclear export~~]]	+

OCA at 05:35, 10 August 2022

OCA — Wed, 10 Aug 2022 05:35:40 GMT

←Older revision		Revision as of 05:35, 10 August 2022
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	==Crystal structure of Xpo1p-Yrb2p-Gsp1p-GTP complex==		==Crystal structure of Xpo1p-Yrb2p-Gsp1p-GTP complex==
-	<StructureSection load='3wyf' size='340' side='right' caption='[[3wyf]], [[Resolution\|resolution]] 2.22Å' scene=''>	+	<StructureSection load='3wyf' size='340' side='right'caption='[[3wyf]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wyf]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WYF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wyf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyg\|3wyg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wyg\|3wyg]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AWRI796_3356 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=764097 Baker's yeast]), AWRI796_2363, YIL063C, YRB2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), CRM1, G8514, KAP124, XPO1, YGR218W ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AWRI796_3356 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=764097 Baker's yeast]), AWRI796_2363, YIL063C, YRB2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), CRM1, G8514, KAP124, XPO1, YGR218W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [~~http~~://pdbe.org/3wyf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3wyf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [https://pdbe.org/3wyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [https://www.ebi.ac.uk/pdbsum/3wyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES). [[~~http~~://www.uniprot.org/uniprot/YRB2_YEAST YRB2_YEAST]] Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1.<ref>PMID:9395535</ref>	+	[[https://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES). [[https://www.uniprot.org/uniprot/YRB2_YEAST YRB2_YEAST]] Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1.<ref>PMID:9395535</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Exportin\|Exportin]]	+	*[[Exportin 3D structures\|Exportin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Koyama, M]]		[[Category: Koyama, M]]
	[[Category: Matsuura, Y]]		[[Category: Matsuura, Y]]

OCA at 09:29, 21 February 2019

OCA — Thu, 21 Feb 2019 09:29:15 GMT

←Older revision		Revision as of 09:29, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='3wyf' size='340' side='right' caption='[[3wyf]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='3wyf' size='340' side='right' caption='[[3wyf]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wyf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WYF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wyf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WYF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyg\|3wyg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyg\|3wyg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AWRI796_3356 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=764097 Baker's yeast]), AWRI796_2363, YIL063C, YRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), CRM1, G8514, KAP124, XPO1, YGR218W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [http://pdbe.org/3wyf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [http://www.ebi.ac.uk/pdbsum/3wyf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [http://pdbe.org/3wyf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [http://www.ebi.ac.uk/pdbsum/3wyf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyf ProSAT]</span></td></tr>
	</table>		</table>
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
	[[Category: Koyama, M]]		[[Category: Koyama, M]]
	[[Category: Matsuura, Y]]		[[Category: Matsuura, Y]]

OCA at 11:17, 5 August 2016

OCA — Fri, 05 Aug 2016 11:17:29 GMT

←Older revision		Revision as of 11:17, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Xpo1p-Yrb2p-Gsp1p-GTP complex==		==Crystal structure of Xpo1p-Yrb2p-Gsp1p-GTP complex==
	<StructureSection load='3wyf' size='340' side='right' caption='[[3wyf]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='3wyf' size='340' side='right' caption='[[3wyf]], [[Resolution\|resolution]] 2.22Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyg\|3wyg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyg\|3wyg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [http://www.ebi.ac.uk/pdbsum/3wyf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [http://pdbe.org/3wyf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [http://www.ebi.ac.uk/pdbsum/3wyf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3wyf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Exportin\|Exportin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:22, 25 December 2014

OCA — Thu, 25 Dec 2014 18:22:44 GMT

←Older revision		Revision as of 18:22, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [http://www.ebi.ac.uk/pdbsum/3wyf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [http://www.ebi.ac.uk/pdbsum/3wyf PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES). [[http://www.uniprot.org/uniprot/YRB2_YEAST YRB2_YEAST]] Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1.<ref>PMID:9395535</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:07, 10 December 2014

OCA — Wed, 10 Dec 2014 12:07:26 GMT

←Older revision		Revision as of 12:07, 10 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [http://www.ebi.ac.uk/pdbsum/3wyf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [http://www.ebi.ac.uk/pdbsum/3wyf PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteins and ribonucleoproteins containing a nuclear export signal (NES) assemble with the exportin Xpo1p (yeast CRM1) and Gsp1p-GTP (yeast Ran-GTP) in the nucleus and exit through the nuclear pore complex. In the cytoplasm, Yrb1p (yeast RanBP1) displaces NES from Xpo1p. Efficient export of NES-cargoes requires Yrb2p (yeast RanBP3), a primarily nuclear protein containing nucleoporin-like phenylalanine-glycine (FG) repeats and a low-affinity Gsp1p-binding domain (RanBD). Here, we show that Yrb2p strikingly accelerates the association of Gsp1p-GTP and NES to Xpo1p. We have solved the crystal structure of the Xpo1p-Yrb2p-Gsp1p-GTP complex, a key assembly intermediate that can bind cargo rapidly. Although the NES-binding cleft of Xpo1p is closed in this intermediate, our data suggest that preloading of Gsp1p-GTP onto Xpo1p by Yrb2p, conformational flexibility of Xpo1p, and the low affinity of RanBD enable active displacement of Yrb2p RanBD by NES to occur effectively. The structure also reveals the major binding sites for FG repeats on Xpo1p.
		+
		+	Structural insights into how yrb2p accelerates the assembly of the xpo1p nuclear export complex.,Koyama M, Shirai N, Matsuura Y Cell Rep. 2014 Nov 6;9(3):983-95. doi: 10.1016/j.celrep.2014.09.052. Epub 2014, Oct 30. PMID:25437554<ref>PMID:25437554</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:49, 12 November 2014

OCA — Wed, 12 Nov 2014 06:49:39 GMT

←Older revision		Revision as of 06:49, 12 November 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Xpo1p-Yrb2p-Gsp1p-GTP complex==
-		+	<StructureSection load='3wyf' size='340' side='right' caption='[[3wyf]], [[Resolution\|resolution]] 2.22Å' scene=''>
-	~~The entry~~ 3wyf is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3wyf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WYF FirstGlance]. <br>
-	~~Authors~~: ~~Koyama~~, M., ~~Shirai~~, N., Matsuura, Y.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyg\|3wyg]]</td></tr>
-	~~Description~~: ~~transport~~ complex 1	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyf RCSB], [http://www.ebi.ac.uk/pdbsum/3wyf PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Koyama, M]]
		+	[[Category: Matsuura, Y]]
		+	[[Category: Shirai, N]]
		+	[[Category: Gtp-binding protein-gtp-binding protein inhibitor complex]]
		+	[[Category: Heat repeat]]
		+	[[Category: Nuclear export]]

OCA at 07:48, 10 September 2014

OCA — Wed, 10 Sep 2014 07:48:24 GMT

←Older revision		Revision as of 07:48, 10 September 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3wyf is ON HOLD	+	The entry 3wyf is ON HOLD until Paper Publication

	Authors: Koyama, M., Shirai, N., Matsuura, Y.		Authors: Koyama, M., Shirai, N., Matsuura, Y.

	Description: transport complex 1		Description: transport complex 1

OCA: Protected "3wyf" [edit=sysop:move=sysop]

OCA — Thu, 04 Sep 2014 03:35:07 GMT

Protected "3wyf" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:35, 4 September 2014

OCA: New page: '''Unreleased structure''' The entry 3wyf is ON HOLD Authors: Koyama, M., Shirai, N., Matsuura, Y. Description: transport complex 1

OCA — Thu, 04 Sep 2014 03:35:05 GMT

New page: '''Unreleased structure''' The entry 3wyf is ON HOLD Authors: Koyama, M., Shirai, N., Matsuura, Y. Description: transport complex 1

New page

'''Unreleased structure'''

The entry 3wyf is ON HOLD

Authors: Koyama, M., Shirai, N., Matsuura, Y.

Description: transport complex 1