3wyo - Revision history

OCA at 13:34, 8 November 2023

OCA — Wed, 08 Nov 2023 13:34:13 GMT

←Older revision		Revision as of 13:34, 8 November 2023
Line 1:		Line 1:

	==Heterodimeric myoglobin formed by domain swapping==		==Heterodimeric myoglobin formed by domain swapping==
-	<StructureSection load='3wyo' size='340' side='right'caption='[[3wyo]]' scene=''>	+	<StructureSection load='3wyo' size='340' side='right'caption='[[3wyo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wyo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [https://pdbe.org/3wyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [https://www.ebi.ac.uk/pdbsum/3wyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [https://pdbe.org/3wyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [https://www.ebi.ac.uk/pdbsum/3wyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MYG_HORSE MYG_HORSE] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein design is a useful method to create novel artificial proteins. A rational approach to design a heterodimeric protein using domain swapping for horse myoglobin (Mb) was developed. As confirmed by X-ray crystallographic analysis, a heterodimeric Mb with two different active sites was produced efficiently from two surface mutants of Mb, in which the charges of two amino acids involved in the dimer salt bridges were reversed in each mutant individually, with the active site of one mutant modified. This study shows that the method of constructing heterodimeric Mb with domain swapping is useful for designing artificial multiheme proteins.
		+
		+	Rational Design of Heterodimeric Protein using Domain Swapping for Myoglobin.,Lin YW, Nagao S, Zhang M, Shomura Y, Higuchi Y, Hirota S Angew Chem Int Ed Engl. 2014 Nov 4. doi: 10.1002/anie.201409267. PMID:25370865<ref>PMID:25370865</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3wyo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Myoglobin 3D structures\|Myoglobin 3D structures]]		*[[Myoglobin 3D structures\|Myoglobin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Higuchi Y]]		[[Category: Higuchi Y]]

OCA at 10:38, 31 August 2022

OCA — Wed, 31 Aug 2022 10:38:22 GMT

←Older revision		Revision as of 10:38, 31 August 2022
Line 1:		Line 1:

	==Heterodimeric myoglobin formed by domain swapping==		==Heterodimeric myoglobin formed by domain swapping==
-	<StructureSection load='3wyo' size='340' side='right'caption='[[3wyo]]~~, [[Resolution\|resolution]] 2.00Å~~' scene=''>	+	<StructureSection load='3wyo' size='340' side='right'caption='[[3wyo]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[3wyo]] is a 4 chain structure.~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYO FirstGlance]. <br>
-	</td></tr>~~<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [https://pdbe.org/3wyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [https://www.ebi.ac.uk/pdbsum/3wyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyo ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vm9\|3vm9]]</div></td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [https://pdbe.org/3wyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [https://www.ebi.ac.uk/pdbsum/3wyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyo ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Function ==
-	[[https://www.uniprot.org/uniprot/MYG_HORSE MYG_HORSE]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Protein design is a useful method to create novel artificial proteins. A rational approach to design a heterodimeric protein using domain swapping for horse myoglobin (Mb) was developed. As confirmed by X-ray crystallographic analysis, a heterodimeric Mb with two different active sites was produced efficiently from two surface mutants of Mb, in which the charges of two amino acids involved in the dimer salt bridges were reversed in each mutant individually, with the active site of one mutant modified. This study shows that the method of constructing heterodimeric Mb with domain swapping is useful for designing artificial multiheme proteins.
-
-	Rational Design of Heterodimeric Protein using Domain Swapping for Myoglobin.,Lin YW, Nagao S, Zhang M, Shomura Y, Higuchi Y, Hirota S Angew Chem Int Ed Engl. 2014 Nov 4. doi: 10.1002/anie.201409267. PMID:25370865<ref>PMID:25370865</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3wyo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Myoglobin 3D structures\|Myoglobin 3D structures]]		*[[Myoglobin 3D structures\|Myoglobin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Higuchi, Y]]	+	[[Category: Higuchi Y]]
-	[[Category: Hirota, S]]	+	[[Category: Hirota S]]
-	[[Category: Lin~~, Y W~~]]	+	[[Category: Lin YW]]
-	[[Category: Nagao, S]]	+	[[Category: Nagao S]]
-	[[Category: Shomura, Y]]	+	[[Category: Shomura Y]]
-	[[Category: Zhang, M]]	+	[[Category: Zhang M]]
-	~~[[Category: Globin]]~~	+
-	~~[[Category: Oxygen binding~~]]	+

OCA at 05:00, 25 August 2022

OCA — Thu, 25 Aug 2022 05:00:17 GMT

←Older revision		Revision as of 05:00, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='3wyo' size='340' side='right'caption='[[3wyo]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3wyo' size='340' side='right'caption='[[3wyo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wyo]] is a 4 chain structure ~~with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wyo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vm9\|3vm9]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vm9\|3vm9]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9796 Equus caballus])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [https://pdbe.org/3wyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [https://www.ebi.ac.uk/pdbsum/3wyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [https://pdbe.org/3wyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [https://www.ebi.ac.uk/pdbsum/3wyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyo ProSAT]</span></td></tr>
	</table>		</table>
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Higuchi, Y]]		[[Category: Higuchi, Y]]

OCA at 05:35, 10 August 2022

OCA — Wed, 10 Aug 2022 05:35:51 GMT

←Older revision		Revision as of 05:35, 10 August 2022
Line 1:		Line 1:

	==Heterodimeric myoglobin formed by domain swapping==		==Heterodimeric myoglobin formed by domain swapping==
-	<StructureSection load='3wyo' size='340' side='right' caption='[[3wyo]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3wyo' size='340' side='right'caption='[[3wyo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wyo]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wyo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vm9\|3vm9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vm9\|3vm9]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9796 Equus caballus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9796 Equus caballus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [~~http~~://pdbe.org/3wyo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3wyo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [https://pdbe.org/3wyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [https://www.ebi.ac.uk/pdbsum/3wyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYG_HORSE MYG_HORSE]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	+	[[https://www.uniprot.org/uniprot/MYG_HORSE MYG_HORSE]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Myoglobin\|Myoglobin]]	+	*[[Myoglobin 3D structures\|Myoglobin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
		+	[[Category: Large Structures]]
	[[Category: Higuchi, Y]]		[[Category: Higuchi, Y]]
	[[Category: Hirota, S]]		[[Category: Hirota, S]]

OCA at 09:10, 21 February 2019

OCA — Thu, 21 Feb 2019 09:10:30 GMT

←Older revision		Revision as of 09:10, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='3wyo' size='340' side='right' caption='[[3wyo]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3wyo' size='340' side='right' caption='[[3wyo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wyo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wyo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WYO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vm9\|3vm9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vm9\|3vm9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9796 Equus caballus])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [http://pdbe.org/3wyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [http://www.ebi.ac.uk/pdbsum/3wyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [http://pdbe.org/3wyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [http://www.ebi.ac.uk/pdbsum/3wyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyo ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3wyo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3wyo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myoglobin\|Myoglobin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Equus caballus]]
	[[Category: Higuchi, Y]]		[[Category: Higuchi, Y]]
	[[Category: Hirota, S]]		[[Category: Hirota, S]]

OCA at 07:34, 4 August 2016

OCA — Thu, 04 Aug 2016 07:34:35 GMT

←Older revision		Revision as of 07:34, 4 August 2016
Line 1:		Line 1:
		+
	==Heterodimeric myoglobin formed by domain swapping==		==Heterodimeric myoglobin formed by domain swapping==
	<StructureSection load='3wyo' size='340' side='right' caption='[[3wyo]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3wyo' size='340' side='right' caption='[[3wyo]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vm9\|3vm9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vm9\|3vm9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [http://www.ebi.ac.uk/pdbsum/3wyo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [http://pdbe.org/3wyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [http://www.ebi.ac.uk/pdbsum/3wyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3wyo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:58, 25 December 2014

OCA — Thu, 25 Dec 2014 06:58:07 GMT

←Older revision		Revision as of 06:58, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [http://www.ebi.ac.uk/pdbsum/3wyo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [http://www.ebi.ac.uk/pdbsum/3wyo PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYG_HORSE MYG_HORSE]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:38, 19 November 2014

OCA — Wed, 19 Nov 2014 12:38:28 GMT

←Older revision		Revision as of 12:38, 19 November 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Heterodimeric myoglobin formed by domain swapping==
		+	<StructureSection load='3wyo' size='340' side='right' caption='[[3wyo]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3wyo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WYO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vm9\|3vm9]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyo RCSB], [http://www.ebi.ac.uk/pdbsum/3wyo PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein design is a useful method to create novel artificial proteins. A rational approach to design a heterodimeric protein using domain swapping for horse myoglobin (Mb) was developed. As confirmed by X-ray crystallographic analysis, a heterodimeric Mb with two different active sites was produced efficiently from two surface mutants of Mb, in which the charges of two amino acids involved in the dimer salt bridges were reversed in each mutant individually, with the active site of one mutant modified. This study shows that the method of constructing heterodimeric Mb with domain swapping is useful for designing artificial multiheme proteins.

-	~~The entry 3wyo is ON HOLD until Paper Publication~~	+	Rational Design of Heterodimeric Protein using Domain Swapping for Myoglobin.,Lin YW, Nagao S, Zhang M, Shomura Y, Higuchi Y, Hirota S Angew Chem Int Ed Engl. 2014 Nov 4. doi: 10.1002/anie.201409267. PMID:25370865<ref>PMID:25370865</ref>

-	~~Authors: Lin~~, Y.~~W., Nagao,~~ S.~~, Zhang, M~~.~~, Shomura~~, Y., ~~Higuchi~~, Y~~., Hirota~~, S.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Heterodimeric myoglobin formed by domain swapping~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Higuchi, Y]]
		+	[[Category: Hirota, S]]
		+	[[Category: Lin, Y W]]
		+	[[Category: Nagao, S]]
		+	[[Category: Shomura, Y]]
		+	[[Category: Zhang, M]]
		+	[[Category: Globin]]
		+	[[Category: Oxygen binding]]

OCA at 07:37, 24 September 2014

OCA — Wed, 24 Sep 2014 07:37:08 GMT

←Older revision		Revision as of 07:37, 24 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3wyo is ON HOLD	+	The entry 3wyo is ON HOLD until Paper Publication

	Authors: Lin, Y.W., Nagao, S., Zhang, M., Shomura, Y., Higuchi, Y., Hirota, S.		Authors: Lin, Y.W., Nagao, S., Zhang, M., Shomura, Y., Higuchi, Y., Hirota, S.

	Description: Heterodimeric myoglobin formed by domain swapping		Description: Heterodimeric myoglobin formed by domain swapping

OCA: Protected "3wyo" [edit=sysop:move=sysop]

OCA — Wed, 10 Sep 2014 07:48:46 GMT

Protected "3wyo" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:48, 10 September 2014