3x02 - Revision history

OCA at 13:36, 8 November 2023

OCA — Wed, 08 Nov 2023 13:36:28 GMT

←Older revision		Revision as of 13:36, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3x02' size='340' side='right'caption='[[3x02]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='3x02' size='340' side='right'caption='[[3x02]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3x02]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3x02]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X02 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=5GP:GUANOSINE~~-~~5-MONOPHOSPHATE'>5GP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; max-height: 3em;'>[[3wzz\|3wzz]], [[3x01\|3x01]], [[3x03\|3x03]], [[3x04\|3x04]], [[3x05\|3x05]], [[3x06\|3x06]], [[3x07\|3x07]], [[3x08\|3x08]], [[3x09\|3x09]], [[3x0a\|3x0a]], [[3x0b\|3x0b]], [[3x0c\|3x0c]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PIP4K2B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/1-phosphatidylinositol~~-5-~~phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x02 OCA], [https://pdbe.org/3x02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x02 RCSB], [https://www.ebi.ac.uk/pdbsum/3x02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x02 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x02 OCA], [https://pdbe.org/3x02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x02 RCSB], [https://www.ebi.ac.uk/pdbsum/3x02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x02 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PI42B_HUMAN PI42B_HUMAN]] Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.<ref>PMID:9038203</ref>	+	[https://www.uniprot.org/uniprot/PI42B_HUMAN PI42B_HUMAN] Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.<ref>PMID:9038203</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~1-phosphatidylinositol-5-phosphate 4-kinase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Asara~~, J A~~]]	+	[[Category: Asara JA]]
-	[[Category: Cantley~~, L C~~]]	+	[[Category: Cantley LC]]
-	[[Category: Daikoku, T]]	+	[[Category: Daikoku T]]
-	[[Category: Dimitoris, A]]	+	[[Category: Dimitoris A]]
-	[[Category: Emerling, B]]	+	[[Category: Emerling B]]
-	[[Category: Ishida, T]]	+	[[Category: Ishida T]]
-	[[Category: Kahoud~~, E R~~]]	+	[[Category: Kahoud ER]]
-	[[Category: Lo~~, Y H~~]]	+	[[Category: Lo YH]]
-	[[Category: Locasale~~, J W~~]]	+	[[Category: Locasale JW]]
-	[[Category: Sasaki~~, A T~~]]	+	[[Category: Sasaki AT]]
-	[[Category: Sasaki, M]]	+	[[Category: Sasaki M]]
-	[[Category: Senda, M]]	+	[[Category: Senda M]]
-	[[Category: Senda, T]]	+	[[Category: Senda T]]
-	[[Category: Shimada, I]]	+	[[Category: Shimada I]]
-	[[Category: Sumita, K]]	+	[[Category: Sumita K]]
-	[[Category: Takano, T]]	+	[[Category: Takano T]]
-	[[Category: Takeuchi, K]]	+	[[Category: Takeuchi K]]
-	[[Category: Terakawa, J]]	+	[[Category: Terakawa J]]
-	[[Category: Yokota, T]]	+	[[Category: Yokota T]]
-	[[Category: Yoshino, H]]	+	[[Category: Yoshino H]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Lipid kinase]]~~	+
-	~~[[Category: Phosphoinositide signaling]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 05:37, 10 August 2022

OCA — Wed, 10 Aug 2022 05:37:05 GMT

←Older revision		Revision as of 05:37, 10 August 2022
Line 1:		Line 1:

	==Crystal structure of PIP4KIIBETA complex with GMP==		==Crystal structure of PIP4KIIBETA complex with GMP==
-	<StructureSection load='3x02' size='340' side='right' caption='[[3x02]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='3x02' size='340' side='right'caption='[[3x02]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3x02]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X02 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3X02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3x02]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X02 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wzz\|3wzz]], [[3x01\|3x01]], [[3x03\|3x03]], [[3x04\|3x04]], [[3x05\|3x05]], [[3x06\|3x06]], [[3x07\|3x07]], [[3x08\|3x08]], [[3x09\|3x09]], [[3x0a\|3x0a]], [[3x0b\|3x0b]], [[3x0c\|3x0c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wzz\|3wzz]], [[3x01\|3x01]], [[3x03\|3x03]], [[3x04\|3x04]], [[3x05\|3x05]], [[3x06\|3x06]], [[3x07\|3x07]], [[3x08\|3x08]], [[3x09\|3x09]], [[3x0a\|3x0a]], [[3x0b\|3x0b]], [[3x0c\|3x0c]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIP4K2B ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIP4K2B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3x02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x02 OCA], [~~http~~://pdbe.org/3x02 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3x02 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3x02 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3x02 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x02 OCA], [https://pdbe.org/3x02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x02 RCSB], [https://www.ebi.ac.uk/pdbsum/3x02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x02 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PI42B_HUMAN PI42B_HUMAN]] Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.<ref>PMID:9038203</ref>	+	[[https://www.uniprot.org/uniprot/PI42B_HUMAN PI42B_HUMAN]] Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.<ref>PMID:9038203</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	[[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]]		[[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Asara, J A]]		[[Category: Asara, J A]]
	[[Category: Cantley, L C]]		[[Category: Cantley, L C]]

OCA at 16:16, 27 February 2019

OCA — Wed, 27 Feb 2019 16:16:44 GMT

←Older revision		Revision as of 16:16, 27 February 2019
Line 1:		Line 1:
		+
	==Crystal structure of PIP4KIIBETA complex with GMP==		==Crystal structure of PIP4KIIBETA complex with GMP==
	<StructureSection load='3x02' size='340' side='right' caption='[[3x02]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='3x02' size='340' side='right' caption='[[3x02]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3x02]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3x02]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X02 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wzz\|3wzz]], [[3x01\|3x01]], [[3x03\|3x03]], [[3x04\|3x04]], [[3x05\|3x05]], [[3x06\|3x06]], [[3x07\|3x07]], [[3x08\|3x08]], [[3x09\|3x09]], [[3x0a\|3x0a]], [[3x0b\|3x0b]], [[3x0c\|3x0c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wzz\|3wzz]], [[3x01\|3x01]], [[3x03\|3x03]], [[3x04\|3x04]], [[3x05\|3x05]], [[3x06\|3x06]], [[3x07\|3x07]], [[3x08\|3x08]], [[3x09\|3x09]], [[3x0a\|3x0a]], [[3x0b\|3x0b]], [[3x0c\|3x0c]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIP4K2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x02 OCA], [http://pdbe.org/3x02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3x02 RCSB], [http://www.ebi.ac.uk/pdbsum/3x02 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x02 OCA], [http://pdbe.org/3x02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3x02 RCSB], [http://www.ebi.ac.uk/pdbsum/3x02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3x02 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]]		[[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]]
		+	[[Category: Human]]
	[[Category: Asara, J A]]		[[Category: Asara, J A]]
	[[Category: Cantley, L C]]		[[Category: Cantley, L C]]

OCA at 07:39, 3 February 2016

OCA — Wed, 03 Feb 2016 07:39:03 GMT

←Older revision		Revision as of 07:39, 3 February 2016
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PI42B_HUMAN PI42B_HUMAN]] Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.<ref>PMID:9038203</ref>		[[http://www.uniprot.org/uniprot/PI42B_HUMAN PI42B_HUMAN]] Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.<ref>PMID:9038203</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	While cellular GTP concentration dramatically changes in response to an organism's cellular status, whether it serves as a metabolic cue for biological signaling remains elusive due to the lack of molecular identification of GTP sensors. Here we report that PI5P4Kbeta, a phosphoinositide kinase that regulates PI(5)P levels, detects GTP concentration and converts them into lipid second messenger signaling. Biochemical analyses show that PI5P4Kbeta preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation, and its activity reflects changes in direct proportion to the physiological GTP concentration. Structural and biological analyses reveal that the GTP-sensing activity of PI5P4Kbeta is critical for metabolic adaptation and tumorigenesis. These results demonstrate that PI5P4Kbeta is the missing GTP sensor and that GTP concentration functions as a metabolic cue via PI5P4Kbeta. The critical role of the GTP-sensing activity of PI5P4Kbeta in cancer signifies this lipid kinase as a cancer therapeutic target.
		+
		+	The Lipid Kinase PI5P4Kbeta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.,Sumita K, Lo YH, Takeuchi K, Senda M, Kofuji S, Ikeda Y, Terakawa J, Sasaki M, Yoshino H, Majd N, Zheng Y, Kahoud ER, Yokota T, Emerling BM, Asara JM, Ishida T, Locasale JW, Daikoku T, Anastasiou D, Senda T, Sasaki AT Mol Cell. 2016 Jan 21;61(2):187-98. doi: 10.1016/j.molcel.2015.12.011. Epub 2016 , Jan 7. PMID:26774281<ref>PMID:26774281</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3x02" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:00, 16 October 2015

OCA — Fri, 16 Oct 2015 04:00:39 GMT

←Older revision		Revision as of 04:00, 16 October 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of PIP4KIIBETA complex with GMP==
-		+	<StructureSection load='3x02' size='340' side='right' caption='[[3x02]], [[Resolution\|resolution]] 2.45Å' scene=''>
-	~~The entry~~ 3x02 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3x02]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X02 FirstGlance]. <br>
-	~~Authors~~: ~~Takeuchi~~, K., Lo, ~~Y.H.~~, ~~Sumita~~, K., ~~Senda~~, M., ~~Terakawa~~, J., ~~Dimitoris~~, A., ~~Locasale, J~~.W.~~, Sasaki, M~~.~~, Yoshino, H~~.~~, Zhang, Y~~.~~, Kahoud, E~~.R.~~, Takano, T~~.~~, Yokota, T~~.~~, Emerling, B~~.~~, Asara, J~~.A.~~, Ishida, T~~., ~~Shimada, I~~., ~~Daikoku, T~~., ~~Cantley, L~~.C.~~, Senda, T~~., ~~Sasaki, A~~.T.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wzz\|3wzz]], [[3x01\|3x01]], [[3x03\|3x03]], [[3x04\|3x04]], [[3x05\|3x05]], [[3x06\|3x06]], [[3x07\|3x07]], [[3x08\|3x08]], [[3x09\|3x09]], [[3x0a\|3x0a]], [[3x0b\|3x0b]], [[3x0c\|3x0c]]</td></tr>
-	~~Description~~: ~~Crystal structure~~ of ~~PIP4KIIBETA complex with GMP~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x02 OCA], [http://pdbe.org/3x02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3x02 RCSB], [http://www.ebi.ac.uk/pdbsum/3x02 PDBsum]</span></td></tr>
-	[[Category: ~~Yoshino~~, H]]	+	</table>
-	[[Category: ~~Sasaki~~, A.T]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PI42B_HUMAN PI42B_HUMAN]] Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.<ref>PMID:9038203</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]]
		+	[[Category: Asara, J A]]
		+	[[Category: Cantley, L C]]
		+	[[Category: Daikoku, T]]
		+	[[Category: Dimitoris, A]]
	[[Category: Emerling, B]]		[[Category: Emerling, B]]
-	[[Category: Sumita, K]]
	[[Category: Ishida, T]]		[[Category: Ishida, T]]
-	[[Category: ~~Yokota~~, ~~T]]~~	+	[[Category: Kahoud, E R]]
-	~~[[Category: Terakawa, J]]~~	+	[[Category: Lo, Y H]]
-	~~[[Category: Takano, T~~]]	+	[[Category: Locasale, J W]]
-	[[Category: Lo, Y.H]]	+	[[Category: Sasaki, A T]]
-	[[Category: ~~Kahoud~~, ~~E.R~~]]	+	[[Category: Sasaki, M]]
-	[[Category: ~~Cantley~~, ~~L.C~~]]	+
-	[[Category: ~~Shimada~~, ~~I]]~~	+
-	~~[[Category: Zhang, Y~~]]	+
	[[Category: Senda, M]]		[[Category: Senda, M]]
	[[Category: Senda, T]]		[[Category: Senda, T]]
-	[[Category: ~~Asara~~, ~~J.A~~]]	+	[[Category: Shimada, I]]
-	[[Category: ~~Locasale~~, ~~J.W~~]]	+	[[Category: Sumita, K]]
-	[[Category: ~~Daikoku~~, T]]	+	[[Category: Takano, T]]
-	~~[[Category: Sasaki, M]]~~	+
-	~~[[Category: Dimitoris, A~~]]	+
	[[Category: Takeuchi, K]]		[[Category: Takeuchi, K]]
		+	[[Category: Terakawa, J]]
		+	[[Category: Yokota, T]]
		+	[[Category: Yoshino, H]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Lipid kinase]]
		+	[[Category: Phosphoinositide signaling]]
		+	[[Category: Transferase]]

OCA at 13:10, 24 December 2014

OCA — Wed, 24 Dec 2014 13:10:40 GMT

←Older revision		Revision as of 13:10, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of PIP4KIIBETA complex with GMP		Description: Crystal structure of PIP4KIIBETA complex with GMP
		+	[[Category: Unreleased Structures]]
		+	[[Category: Yoshino, H]]
		+	[[Category: Sasaki, A.T]]
		+	[[Category: Emerling, B]]
		+	[[Category: Sumita, K]]
		+	[[Category: Ishida, T]]
		+	[[Category: Yokota, T]]
		+	[[Category: Terakawa, J]]
		+	[[Category: Takano, T]]
		+	[[Category: Lo, Y.H]]
		+	[[Category: Kahoud, E.R]]
		+	[[Category: Cantley, L.C]]
		+	[[Category: Shimada, I]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Senda, M]]
		+	[[Category: Senda, T]]
		+	[[Category: Asara, J.A]]
		+	[[Category: Locasale, J.W]]
		+	[[Category: Daikoku, T]]
		+	[[Category: Sasaki, M]]
		+	[[Category: Dimitoris, A]]
		+	[[Category: Takeuchi, K]]

OCA at 09:42, 29 October 2014

OCA — Wed, 29 Oct 2014 09:42:25 GMT

←Older revision		Revision as of 09:42, 29 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3x02 is ON HOLD	+	The entry 3x02 is ON HOLD until Paper Publication

	Authors: Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.		Authors: Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.

-	Description: ~~PIP4KIIBATE COMPLEX WITH~~ GMP	+	Description: Crystal structure of PIP4KIIBETA complex with GMP

OCA: Protected "3x02" [edit=sysop:move=sysop]

OCA — Mon, 20 Oct 2014 09:03:32 GMT

Protected "3x02" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:03, 20 October 2014

OCA: New page: '''Unreleased structure''' The entry 3x02 is ON HOLD Authors: Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang,...

OCA — Mon, 20 Oct 2014 09:03:30 GMT

New page: '''Unreleased structure''' The entry 3x02 is ON HOLD Authors: Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang,...

New page

'''Unreleased structure'''

The entry 3x02 is ON HOLD

Authors: Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.

Description: PIP4KIIBATE COMPLEX WITH GMP