3x14 - Revision history

OCA at 05:38, 10 August 2022

OCA — Wed, 10 Aug 2022 05:38:19 GMT

←Older revision		Revision as of 05:38, 10 August 2022
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	==Crystal structure of HLA-B*0801.N80I.R82L.G83R==		==Crystal structure of HLA-B*0801.N80I.R82L.G83R==
-	<StructureSection load='3x14' size='340' side='right' caption='[[3x14]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3x14' size='340' side='right'caption='[[3x14]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3x14]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X14 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3X14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3x14]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X14 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m05\|1m05]], [[3x11\|3x11]], [[3x12\|3x12]], [[3x13\|3x13]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m05\|1m05]], [[3x11\|3x11]], [[3x12\|3x12]], [[3x13\|3x13]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-B, HLAB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-B, HLAB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x14 OCA], [~~http~~://pdbe.org/3x14 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3x14 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3x14 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3x14 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x14 OCA], [https://pdbe.org/3x14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x14 RCSB], [https://www.ebi.ac.uk/pdbsum/3x14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x14 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[~~http~~://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>	+	[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/1B08_HUMAN 1B08_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[~~http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[[https://www.uniprot.org/uniprot/1B08_HUMAN 1B08_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]
	[[Category: Vivian, J P]]		[[Category: Vivian, J P]]

OCA at 16:37, 27 February 2019

OCA — Wed, 27 Feb 2019 16:37:49 GMT

←Older revision		Revision as of 16:37, 27 February 2019
Line 3:		Line 3:
	<StructureSection load='3x14' size='340' side='right' caption='[[3x14]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3x14' size='340' side='right' caption='[[3x14]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3x14]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3x14]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X14 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m05\|1m05]], [[3x11\|3x11]], [[3x12\|3x12]], [[3x13\|3x13]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m05\|1m05]], [[3x11\|3x11]], [[3x12\|3x12]], [[3x13\|3x13]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-B, HLAB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x14 OCA], [http://pdbe.org/3x14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3x14 RCSB], [http://www.ebi.ac.uk/pdbsum/3x14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3x14 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x14 OCA], [http://pdbe.org/3x14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3x14 RCSB], [http://www.ebi.ac.uk/pdbsum/3x14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3x14 ProSAT]</span></td></tr>
	</table>		</table>
Line 27:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]
	[[Category: Vivian, J P]]		[[Category: Vivian, J P]]

OCA at 17:31, 18 January 2017

OCA — Wed, 18 Jan 2017 17:31:41 GMT

←Older revision		Revision as of 17:31, 18 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of HLA-B*0801.N80I.R82L.G83R==		==Crystal structure of HLA-B*0801.N80I.R82L.G83R==
	<StructureSection load='3x14' size='340' side='right' caption='[[3x14]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3x14' size='340' side='right' caption='[[3x14]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3x14]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X14 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3x14]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X14 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m05\|1m05]], [[3x11\|3x11]], [[3x12\|3x12]], [[3x13\|3x13]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m05\|1m05]], [[3x11\|3x11]], [[3x12\|3x12]], [[3x13\|3x13]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3x14 RCSB], [http://www.ebi.ac.uk/pdbsum/3x14 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x14 OCA], [http://pdbe.org/3x14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3x14 RCSB], [http://www.ebi.ac.uk/pdbsum/3x14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3x14 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3x14" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 05:36, 8 April 2015

OCA — Wed, 08 Apr 2015 05:36:04 GMT

←Older revision		Revision as of 05:36, 8 April 2015
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:56, 24 December 2014

OCA — Wed, 24 Dec 2014 10:56:51 GMT

←Older revision		Revision as of 10:56, 24 December 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of HLA-B*0801.N80I.R82L.G83R==
		+	<StructureSection load='3x14' size='340' side='right' caption='[[3x14]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3x14]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X14 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m05\|1m05]], [[3x11\|3x11]], [[3x12\|3x12]], [[3x13\|3x13]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3x14 RCSB], [http://www.ebi.ac.uk/pdbsum/3x14 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1B08_HUMAN 1B08_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The killer cell Ig-like receptor 3DL1 (KIR3DL1) inhibits activation of NK cells upon interaction with HLA class I molecules such as HLA-B57:01, which contains the Bw4 epitope spanning residues 77-83 (e.g., NLRIALR), and not with HLA allomorphs that possess the Bw6 motif (e.g., HLA-B08:01), which differ at residues 77, 80, 81, 82, and 83. Although Bw4 residues Ile80 and Arg83 directly interact with KIR3DL1001, their precise role in determining KIR3DL1-HLA-Bw4 specificity remains unclear. Recognition of HLA-B57:01 by either KIR3DL1+ NK cells or the NK cell line YTS transfected with KIR3DL1001 was impaired by mutation of residues 80 and 83 of HLA-B57:01 to the corresponding amino acids within the Bw6 motif. Conversely, the simultaneous introduction of three Bw4 residues at positions 80, 82, and 83 into HLA-B08:01 conferred an interaction with KIR3DL1001. Structural analysis of HLA-B57:01, HLA-B08:01, and mutants of each bearing substitutions at positions 80 and 83 revealed that Ile80 and Arg83 within the Bw4 motif constrain the conformation of Glu76, primarily through a salt bridge between Arg83 and Glu76. This salt bridge was absent in HLA-Bw6 molecules as well as position 83 mutants of HLA-B*57:01. Mutation of the Bw4 residue Ile80 also disrupted this salt bridge, providing further insight into the role that position 80 plays in mediating KIR3DL1 recognition. Thus, the strict conformation of HLA-Bw4 allotypes, held in place by the Glu76-Arg83 interaction, facilitates KIR3DL1 binding, whereas Bw6 allotypes present a platform on the alpha1 helix that is less permissive for KIR3DL1 binding.

-	The ~~entry 3x14 is ON HOLD until Paper Publication~~	+	The Interaction of KIR3DL1*001 with HLA Class I Molecules Is Dependent upon Molecular Microarchitecture within the Bw4 Epitope.,Saunders PM, Vivian JP, Baschuk N, Beddoe T, Widjaja J, O'Connor GM, Hitchen C, Pymm P, Andrews DM, Gras S, McVicar DW, Rossjohn J, Brooks AG J Immunol. 2014 Dec 5. pii: 1402542. PMID:25480565<ref>PMID:25480565</ref>

-	~~Authors: Vivian~~, J.P., Rossjohn, J.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of HLA-B*0801.N80I.R82L.G83R~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Rossjohn, J]]
		+	[[Category: Vivian, J P]]
		+	[[Category: Antigen presentation]]
		+	[[Category: Immune receptor]]
		+	[[Category: Immune system]]
		+	[[Category: Immunity]]
		+	[[Category: Immunoglobulin fold]]
		+	[[Category: Kir]]
		+	[[Category: Lilr]]
		+	[[Category: Plasma membrane]]
		+	[[Category: Tcr]]

OCA at 06:23, 26 November 2014

OCA — Wed, 26 Nov 2014 06:23:43 GMT

←Older revision		Revision as of 06:23, 26 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3x14 is ON HOLD	+	The entry 3x14 is ON HOLD until Paper Publication

	Authors: Vivian, J.P., Rossjohn, J.		Authors: Vivian, J.P., Rossjohn, J.

	Description: Crystal structure of HLA-B*0801.N80I.R82L.G83R		Description: Crystal structure of HLA-B*0801.N80I.R82L.G83R

OCA: Protected "3x14" [edit=sysop:move=sysop]

OCA — Wed, 05 Nov 2014 07:16:48 GMT

Protected "3x14" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:16, 5 November 2014

OCA: New page: '''Unreleased structure''' The entry 3x14 is ON HOLD Authors: Vivian, J.P., Rossjohn, J. Description: Crystal structure of HLA-B*0801.N80I.R82L.G83R

OCA — Wed, 05 Nov 2014 07:16:46 GMT

New page: '''Unreleased structure''' The entry 3x14 is ON HOLD Authors: Vivian, J.P., Rossjohn, J. Description: Crystal structure of HLA-B*0801.N80I.R82L.G83R

New page

'''Unreleased structure'''

The entry 3x14 is ON HOLD

Authors: Vivian, J.P., Rossjohn, J.

Description: Crystal structure of HLA-B*0801.N80I.R82L.G83R