3x1z - Revision history

OCA at 08:48, 20 March 2024

OCA — Wed, 20 Mar 2024 08:48:15 GMT

←Older revision		Revision as of 08:48, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3x1z' size='340' side='right'caption='[[3x1z]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='3x1z' size='340' side='right'caption='[[3x1z]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3x1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X1Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3x1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X1Z FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID~~-~~GUANYLATE+ESTER'>GNP</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.25Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3w1y\|3w1y]], [[3w1x\|3w1x]], [[3w1w\|3w1w]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Rap1b ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x1z OCA], [https://pdbe.org/3x1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x1z RCSB], [https://www.ebi.ac.uk/pdbsum/3x1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x1z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x1z OCA], [https://pdbe.org/3x1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x1z RCSB], [https://www.ebi.ac.uk/pdbsum/3x1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x1z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RAP1B_RAT RAP1B_RAT]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).	+	[https://www.uniprot.org/uniprot/RAP1B_RAT RAP1B_RAT] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Rap1B is a small GTPase involved in the regulation of numerous cellular processes including synaptic plasticity, one of the bases of memory. Like other members of the Ras family, the active GTP-bound form of Rap1B can bind to a large number of effector proteins and so transmit signals to downstream components of the signaling pathways. The structure of Rap1B bound only to a nucleotide has yet to be solved, but might help reveal an inactive conformation that can be stabilized by a small molecule drug. Unlike other Ras family proteins such as H-Ras and Rap2A, Rap1B crystallizes in an intermediate state when bound to a non-hydrolyzable GTP analog. Comparison with H-Ras and Rap2A reveals conservative mutations relative to Rap1B, distant from the bound nucleotide, which control how readily the protein may adopt the fully activated form in the presence of GTP. High resolution crystallographic structures of mutant proteins show how these changes may influence the hydrogen bonding patterns of the key switch residues.	+
-		+
-	The structure and conformational switching of Rap1B.,Noguchi H, Ikegami T, Nagadoi A, Kamatari YO, Park SY, Tame JR, Unzai S Biochem Biophys Res Commun. 2015 Jun 19;462(1):46-51. doi:, 10.1016/j.bbrc.2015.04.103. Epub 2015 Apr 29. PMID:25935485<ref>PMID:25935485</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3x1z" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]		*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ikegami, T]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Noguchi, H]]	+	[[Category: Ikegami T]]
-	[[Category: Park~~, S Y~~]]	+	[[Category: Noguchi H]]
-	[[Category: Tame~~, J R.H~~]]	+	[[Category: Park SY]]
-	[[Category: Unzai, S]]	+	[[Category: Tame JRH]]
-	~~[[Category: Signal transduction]]~~	+	[[Category: Unzai S]]
-	~~[[Category: Signaling protein~~]]	+

OCA at 05:38, 10 August 2022

OCA — Wed, 10 Aug 2022 05:38:57 GMT

←Older revision		Revision as of 05:38, 10 August 2022
Line 1:		Line 1:

	==Ras-related protein Rap1B(T65A) with GppNHp==		==Ras-related protein Rap1B(T65A) with GppNHp==
-	<StructureSection load='3x1z' size='340' side='right' caption='[[3x1z]], [[Resolution\|resolution]] 1.25Å' scene=''>	+	<StructureSection load='3x1z' size='340' side='right'caption='[[3x1z]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3x1z]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X1Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3X1Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3x1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X1Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3w1y\|3w1y]], [[3w1x\|3w1x]], [[3w1w\|3w1w]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3w1y\|3w1y]], [[3w1x\|3w1x]], [[3w1w\|3w1w]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rap1b ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rap1b ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3x1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x1z OCA], [~~http~~://pdbe.org/3x1z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3x1z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3x1z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3x1z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x1z OCA], [https://pdbe.org/3x1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x1z RCSB], [https://www.ebi.ac.uk/pdbsum/3x1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x1z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RAP1B_RAT RAP1B_RAT]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).	+	[[https://www.uniprot.org/uniprot/RAP1B_RAT RAP1B_RAT]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[GTP-binding protein\|GTP-binding protein]]	+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Ikegami, T]]		[[Category: Ikegami, T]]
	[[Category: Noguchi, H]]		[[Category: Noguchi, H]]

OCA at 16:58, 27 February 2019

OCA — Wed, 27 Feb 2019 16:58:17 GMT

←Older revision		Revision as of 16:58, 27 February 2019
Line 3:		Line 3:
	<StructureSection load='3x1z' size='340' side='right' caption='[[3x1z]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='3x1z' size='340' side='right' caption='[[3x1z]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3x1z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X1Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3x1z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X1Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3w1y\|3w1y]], [[3w1x\|3w1x]], [[3w1w\|3w1w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3w1y\|3w1y]], [[3w1x\|3w1x]], [[3w1w\|3w1w]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rap1b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x1z OCA], [http://pdbe.org/3x1z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3x1z RCSB], [http://www.ebi.ac.uk/pdbsum/3x1z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3x1z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x1z OCA], [http://pdbe.org/3x1z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3x1z RCSB], [http://www.ebi.ac.uk/pdbsum/3x1z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3x1z ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3x1z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3x1z" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[GTP-binding protein\|GTP-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Ikegami, T]]		[[Category: Ikegami, T]]
	[[Category: Noguchi, H]]		[[Category: Noguchi, H]]

OCA at 17:29, 9 March 2017

OCA — Thu, 09 Mar 2017 17:29:14 GMT

←Older revision		Revision as of 17:29, 9 March 2017
Line 1:		Line 1:
		+
	==Ras-related protein Rap1B(T65A) with GppNHp==		==Ras-related protein Rap1B(T65A) with GppNHp==
	<StructureSection load='3x1z' size='340' side='right' caption='[[3x1z]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='3x1z' size='340' side='right' caption='[[3x1z]], [[Resolution\|resolution]] 1.25Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3w1y\|3w1y]], [[3w1x\|3w1x]], [[3w1w\|3w1w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3w1y\|3w1y]], [[3w1x\|3w1x]], [[3w1w\|3w1w]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x1z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3x1z RCSB], [http://www.ebi.ac.uk/pdbsum/3x1z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x1z OCA], [http://pdbe.org/3x1z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3x1z RCSB], [http://www.ebi.ac.uk/pdbsum/3x1z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3x1z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3x1z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:31, 3 June 2015

OCA — Wed, 03 Jun 2015 12:31:34 GMT

←Older revision		Revision as of 12:31, 3 June 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Ras-related protein Rap1B(T65A) with GppNHp==
		+	<StructureSection load='3x1z' size='340' side='right' caption='[[3x1z]], [[Resolution\|resolution]] 1.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3x1z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X1Z FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3w1y\|3w1y]], [[3w1x\|3w1x]], [[3w1w\|3w1w]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x1z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3x1z RCSB], [http://www.ebi.ac.uk/pdbsum/3x1z PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RAP1B_RAT RAP1B_RAT]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rap1B is a small GTPase involved in the regulation of numerous cellular processes including synaptic plasticity, one of the bases of memory. Like other members of the Ras family, the active GTP-bound form of Rap1B can bind to a large number of effector proteins and so transmit signals to downstream components of the signaling pathways. The structure of Rap1B bound only to a nucleotide has yet to be solved, but might help reveal an inactive conformation that can be stabilized by a small molecule drug. Unlike other Ras family proteins such as H-Ras and Rap2A, Rap1B crystallizes in an intermediate state when bound to a non-hydrolyzable GTP analog. Comparison with H-Ras and Rap2A reveals conservative mutations relative to Rap1B, distant from the bound nucleotide, which control how readily the protein may adopt the fully activated form in the presence of GTP. High resolution crystallographic structures of mutant proteins show how these changes may influence the hydrogen bonding patterns of the key switch residues.

-	The ~~entry 3x1z is ON HOLD until Paper Publication~~	+	The structure and conformational switching of Rap1B.,Noguchi H, Ikegami T, Nagadoi A, Kamatari YO, Park SY, Tame JR, Unzai S Biochem Biophys Res Commun. 2015 Jun 19;462(1):46-51. doi:, 10.1016/j.bbrc.2015.04.103. Epub 2015 Apr 29. PMID:25935485<ref>PMID:25935485</ref>

-	~~Authors: Noguchi~~, H.~~, Ikegami, T., Park,~~ S.~~Y., Tame, J.R.H., Unzai, S~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Ras-related protein Rap1B(T65A) with GppNHp~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ikegami, T]]
	[[Category: Noguchi, H]]		[[Category: Noguchi, H]]
-	~~[[Category: Ikegami, T]]~~	+	[[Category: Park, S Y]]
-	[[Category: Park, S.Y]]	+	[[Category: Tame, J R.H]]
-	[[Category: Tame, J.R.H]]	+
	[[Category: Unzai, S]]		[[Category: Unzai, S]]
		+	[[Category: Signal transduction]]
		+	[[Category: Signaling protein]]

OCA at 07:05, 12 February 2015

OCA — Thu, 12 Feb 2015 07:05:33 GMT

←Older revision		Revision as of 07:05, 12 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3x1z is ON HOLD	+	The entry 3x1z is ON HOLD until Paper Publication

	Authors: Noguchi, H., Ikegami, T., Park, S.Y., Tame, J.R.H., Unzai, S.		Authors: Noguchi, H., Ikegami, T., Park, S.Y., Tame, J.R.H., Unzai, S.

OCA at 13:15, 24 December 2014

OCA — Wed, 24 Dec 2014 13:15:50 GMT

←Older revision		Revision as of 13:15, 24 December 2014
Line 6:		Line 6:

	Description: Ras-related protein Rap1B(T65A) with GppNHp		Description: Ras-related protein Rap1B(T65A) with GppNHp
		+	[[Category: Unreleased Structures]]
		+	[[Category: Noguchi, H]]
		+	[[Category: Ikegami, T]]
		+	[[Category: Park, S.Y]]
		+	[[Category: Tame, J.R.H]]
		+	[[Category: Unzai, S]]

OCA: Protected "3x1z" [edit=sysop:move=sysop]

OCA — Wed, 10 Dec 2014 12:52:25 GMT

Protected "3x1z" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:52, 10 December 2014

OCA: New page: '''Unreleased structure''' The entry 3x1z is ON HOLD Authors: Noguchi, H., Ikegami, T., Park, S.Y., Tame, J.R.H., Unzai, S. Description: Ras-related protein Rap1B(T65A) with GppNHp

OCA — Wed, 10 Dec 2014 12:52:23 GMT

New page: '''Unreleased structure''' The entry 3x1z is ON HOLD Authors: Noguchi, H., Ikegami, T., Park, S.Y., Tame, J.R.H., Unzai, S. Description: Ras-related protein Rap1B(T65A) with GppNHp

New page

'''Unreleased structure'''

The entry 3x1z is ON HOLD

Authors: Noguchi, H., Ikegami, T., Park, S.Y., Tame, J.R.H., Unzai, S.

Description: Ras-related protein Rap1B(T65A) with GppNHp