3zcd - Revision history

OCA at 10:58, 20 December 2023

OCA — Wed, 20 Dec 2023 10:58:44 GMT

←Older revision		Revision as of 10:58, 20 December 2023
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	<StructureSection load='3zcd' size='340' side='right'caption='[[3zcd]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3zcd' size='340' side='right'caption='[[3zcd]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zcd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZCD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zcd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZCD FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[https://en.wikipedia.org/wiki/(2E,6E)~~-~~farnesyl_diphosphate_synthase (2E~~,~~6E)-farnesyl diphosphate synthase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.~~1.~~10 2.5.1.10] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcd OCA], [https://pdbe.org/3zcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zcd RCSB], [https://www.ebi.ac.uk/pdbsum/3zcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zcd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcd OCA], [https://pdbe.org/3zcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zcd RCSB], [https://www.ebi.ac.uk/pdbsum/3zcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zcd ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9HWY4_PSEAE Q9HWY4_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Schmidberger~~, J W~~]]	+	[[Category: Schmidberger JW]]
-	[[Category: Schneider, G]]	+	[[Category: Schneider G]]
-	[[Category: Schnell, R]]	+	[[Category: Schnell R]]
-	~~[[Category: Fpp]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 05:41, 10 August 2022

OCA — Wed, 10 Aug 2022 05:41:43 GMT

←Older revision		Revision as of 05:41, 10 August 2022
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	==Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01.==		==Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01.==
-	<StructureSection load='3zcd' size='340' side='right' caption='[[3zcd]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='3zcd' size='340' side='right'caption='[[3zcd]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zcd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZCD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zcd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZCD FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcd OCA], [~~http~~://pdbe.org/3zcd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zcd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zcd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zcd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcd OCA], [https://pdbe.org/3zcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zcd RCSB], [https://www.ebi.ac.uk/pdbsum/3zcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zcd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pseae]]		[[Category: Pseae]]
	[[Category: Schmidberger, J W]]		[[Category: Schmidberger, J W]]

OCA at 16:59, 2 January 2017

OCA — Mon, 02 Jan 2017 16:59:34 GMT

←Older revision		Revision as of 16:59, 2 January 2017
Line 1:		Line 1:
		+
	==Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01.==		==Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01.==
	<StructureSection load='3zcd' size='340' side='right' caption='[[3zcd]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3zcd' size='340' side='right' caption='[[3zcd]], [[Resolution\|resolution]] 1.55Å' scene=''>
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	<table><tr><td colspan='2'>[[3zcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZCD FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zcd RCSB], [http://www.ebi.ac.uk/pdbsum/3zcd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcd OCA], [http://pdbe.org/3zcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zcd RCSB], [http://www.ebi.ac.uk/pdbsum/3zcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zcd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zcd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:29, 1 April 2015

OCA — Wed, 01 Apr 2015 07:29:14 GMT

←Older revision		Revision as of 07:29, 1 April 2015
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zcd RCSB], [http://www.ebi.ac.uk/pdbsum/3zcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zcd RCSB], [http://www.ebi.ac.uk/pdbsum/3zcd PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Locus PA4043 in the genome of Pseudomonas aeruginosa PAO1 has been annotated as coding for a farnesyl pyrophosphate synthase (FPPS). This open reading frame was cloned and expressed recombinantly in Escherichia coli. The dimeric enzyme shows farnesyl pyrophosphate synthase activity and is strongly inhibited by ibandronate and zoledronate, drugs that are presently in clinical use. The structures of the unliganded enzyme and complexes with the substrate geranyl diphosphate (GPP), the inhibitor ibandronate and two compounds obtained from a differential scanning fluorimetry-based screen of a fragment library were determined by X-ray crystallography to resolutions of better than 2.0 A. The enzyme shows the typical alpha-helical fold of farnesyl pyrophosphate synthases. The substrate GPP binds in the S1 substrate site in an open conformation of the enzyme. In the enzyme-ibandronate complex three inhibitor molecules are bound in the active site of the enzyme. One inhibitor molecule occupies the allylic substrate site (S1) of each subunit, as observed in complexes of nitrogen-containing bisphosphonate inhibitors of farnesyl synthases from other species. Two (in subunit A) and one (in subunit B) additional ibandronate molecules are bound in the active site. The structures of the fragment complexes show two molecules bound in a hydrophobic pocket adjacent to the active site. This allosteric pocket, which has previously only been described for FPPS from eukaryotic organisms, is thus also present in enzymes from pathogenic prokaryotes and might be utilized for the design of inhibitors of bacterial FPPS with a different chemical scaffold to the highly charged bisphosphonates, which are less likely to pass bacterial membranes.
		+
		+	Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.,Schmidberger JW, Schnell R, Schneider G Acta Crystallogr D Biol Crystallogr. 2015 Mar 1;71(Pt 3):721-31. doi:, 10.1107/S1399004715001121. Epub 2015 Feb 26. PMID:25760619<ref>PMID:25760619</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:39, 21 December 2014

OCA — Sun, 21 Dec 2014 18:39:58 GMT

←Older revision		Revision as of 18:39, 21 December 2014
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-	~~{{STRUCTURE_3zcd\| PDB=3zcd \| SCENE= }}~~	+	==Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01.==
-	===Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01.===	+	<StructureSection load='3zcd' size='340' side='right' caption='[[3zcd]], [[Resolution\|resolution]] 1.55Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[3zcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZCD FirstGlance]. <br>
-	[[3zcd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCD OCA].	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>
-	[[Category: Schmidberger, J W.]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zcd RCSB], [http://www.ebi.ac.uk/pdbsum/3zcd PDBsum]</span></td></tr>
-	[[Category: Schneider, G.]]	+	</table>
-	[[Category: Schnell, R.]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Pseae]]
		+	[[Category: Schmidberger, J W]]
		+	[[Category: Schneider, G]]
		+	[[Category: Schnell, R]]
	[[Category: Fpp]]		[[Category: Fpp]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:28, 4 December 2013

OCA — Wed, 04 Dec 2013 07:28:16 GMT

←Older revision		Revision as of 07:28, 4 December 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_3zcd\| PDB=3zcd \| SCENE= }}
		+	===Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01.===

-	~~The entry~~ 3zcd is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[3zcd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCD OCA].
-	~~Authors~~: Schmidberger, J.W., Schnell, R.~~, Schneider, G.~~	+	[[Category: Schmidberger, J W.]]
-		+	[[Category: Schneider, G.]]
-	~~Description~~: ~~Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01.~~	+	[[Category: Schnell, R.]]
		+	[[Category: Fpp]]
		+	[[Category: Transferase]]

OCA: Protected "3zcd" [edit=sysop:move=sysop]

OCA — Wed, 28 Nov 2012 13:51:38 GMT

Protected "3zcd" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:51, 28 November 2012

OCA: New page: '''Unreleased structure''' The entry 3zcd is ON HOLD until Paper Publication Authors: Schmidberger, J.W., Schnell, R., Schneider, G. Description: Native structure of Farnesyl Pyrophosp...

OCA — Wed, 28 Nov 2012 13:51:37 GMT

New page: '''Unreleased structure''' The entry 3zcd is ON HOLD until Paper Publication Authors: Schmidberger, J.W., Schnell, R., Schneider, G. Description: Native structure of Farnesyl Pyrophosp...

New page

'''Unreleased structure'''

The entry 3zcd is ON HOLD until Paper Publication

Authors: Schmidberger, J.W., Schnell, R., Schneider, G.

Description: Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01.