3zen - Revision history

OCA: Redirecting to 4v8l

OCA — Wed, 10 Dec 2014 15:38:12 GMT

Redirecting to 4v8l

←Older revision		Revision as of 15:38, 10 December 2014
Line 1:		Line 1:
-	~~==Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase==~~	+	#REDIRECT [[4v8l]] This PDB entry is obsolete and replaced by 4v8l
-	~~<StructureSection load='3zen' size='340' side='right' caption='~~[[~~3zen]], [[Resolution\|resolution]] 7.50Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[3zen~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZEN FirstGlance]. <br>	+
-	~~</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>~~	+
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>~~	+
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b3y\|4b3y]]</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zen RCSB], [http://www.ebi.ac.uk/pdbsum/3zen PDBsum]</span></td></tr>	+
-	~~</table>~~	+
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The mycobacterial fatty acid synthase (FAS) complex is a giant 2.0-MDa alpha(6) homohexameric multifunctional enzyme that catalyzes synthesis of fatty acid precursors of mycolic acids, which are major components of the cell wall in Mycobacteria and play an important role in pathogenicity. Here, we present a three-dimensional reconstruction of the Mycobacterium smegmatis FAS complex at 7.5A, highly homologous to the Mycobacterium tuberculosis multienzyme, by cryo-electron microscopy. Based on the obtained structural data, which allowed us to identify secondary-structure elements, and sequence homology with the fungal FAS, we generated an accurate architectural model of the complex. The FAS system from Mycobacteria resembles a minimized version of the fungal FAS with much larger openings in the reaction chambers. These architectural features of the mycobacterial FAS may be important for the interaction with mycolic acid processing and condensing enzymes that further modify the precursors produced by FAS and for autoactivation of the FAS complex.	+
-		+
-	7.5-A Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase.,Boehringer D, Ban N, Leibundgut M J Mol Biol. 2013 Jan 3. pii: S0022-2836(12)00969-2. doi:, 10.1016/j.jmb.2012.12.021. PMID:23291528<ref>PMID:23291528</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-		+
-	~~==See Also==~~	+
-	*[[Fatty acid synthase\|Fatty acid synthase]]	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Mycobacterium smegmatis]]~~	+
-	~~[[Category: Ban, N]]~~	+
-	~~[[Category: Boehringer, D]]~~	+
-	~~[[Category: Leibundgut, M]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Mycolic acid biosynthesis]]~~	+
-	~~[[Category: Substrate channeling]]~~	+
-	~~[[Category: Transferase]]~~	+

OCA at 16:51, 9 December 2014

OCA — Tue, 09 Dec 2014 16:51:14 GMT

←Older revision		Revision as of 16:51, 9 December 2014
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-	[[~~Image:~~3zen.~~png~~\|~~left~~\|~~200px~~]]	+	==Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase==
		+	<StructureSection load='3zen' size='340' side='right' caption='[[3zen]], [[Resolution\|resolution]] 7.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zen]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZEN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b3y\|4b3y]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zen RCSB], [http://www.ebi.ac.uk/pdbsum/3zen PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mycobacterial fatty acid synthase (FAS) complex is a giant 2.0-MDa alpha(6) homohexameric multifunctional enzyme that catalyzes synthesis of fatty acid precursors of mycolic acids, which are major components of the cell wall in Mycobacteria and play an important role in pathogenicity. Here, we present a three-dimensional reconstruction of the Mycobacterium smegmatis FAS complex at 7.5A, highly homologous to the Mycobacterium tuberculosis multienzyme, by cryo-electron microscopy. Based on the obtained structural data, which allowed us to identify secondary-structure elements, and sequence homology with the fungal FAS, we generated an accurate architectural model of the complex. The FAS system from Mycobacteria resembles a minimized version of the fungal FAS with much larger openings in the reaction chambers. These architectural features of the mycobacterial FAS may be important for the interaction with mycolic acid processing and condensing enzymes that further modify the precursors produced by FAS and for autoactivation of the FAS complex.

-	~~{{STRUCTURE_3zen\| PDB=3zen \| SCENE= }}~~	+	7.5-A Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase.,Boehringer D, Ban N, Leibundgut M J Mol Biol. 2013 Jan 3. pii: S0022-2836(12)00969-2. doi:, 10.1016/j.jmb.2012.12.021. PMID:23291528<ref>PMID:23291528</ref>

-	~~===Cryo-EM Structure~~ of the ~~Mycobacterial Fatty Acid Synthase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23291528}}~~	+	==See Also==
-		+	*[[Fatty acid synthase\|Fatty acid synthase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3zen~~]] ~~is a 3 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZEN OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]
-	[[Category: Ban, N.]]	+	[[Category: Ban, N]]
-	[[Category: Boehringer, D.]]	+	[[Category: Boehringer, D]]
-	[[Category: Leibundgut, M.]]	+	[[Category: Leibundgut, M]]
	[[Category: Multifunctional enzyme]]		[[Category: Multifunctional enzyme]]
	[[Category: Mycolic acid biosynthesis]]		[[Category: Mycolic acid biosynthesis]]
	[[Category: Substrate channeling]]		[[Category: Substrate channeling]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 12:25, 30 January 2013

OCA — Wed, 30 Jan 2013 12:25:59 GMT

←Older revision		Revision as of 12:25, 30 January 2013
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-	[[Image:3zen.~~jpg~~\|left\|200px]]	+	[[Image:3zen.png\|left\|200px]]

	{{STRUCTURE_3zen\| PDB=3zen \| SCENE= }}		{{STRUCTURE_3zen\| PDB=3zen \| SCENE= }}
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	===Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase===		===Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase===

		+	{{ABSTRACT_PUBMED_23291528}}

	==About this Structure==		==About this Structure==

OCA at 09:05, 16 January 2013

OCA — Wed, 16 Jan 2013 09:05:48 GMT

←Older revision		Revision as of 09:05, 16 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zen.jpg\|left\|200px]]

-	~~The entry~~ 3zen ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3zen\| PDB=3zen \| SCENE= }}

-	~~Authors: Boehringer, D., Ban, N., Leibundgut, M.~~	+	===Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase===

-	~~Description~~: ~~Cryo~~-~~EM Structure of the Mycobacterial Fatty Acid Synthase~~	+
		+	==About this Structure==
		+	[[3zen]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZEN OCA].
		+	[[Category: Mycobacterium smegmatis]]
		+	[[Category: Ban, N.]]
		+	[[Category: Boehringer, D.]]
		+	[[Category: Leibundgut, M.]]
		+	[[Category: Multifunctional enzyme]]
		+	[[Category: Mycolic acid biosynthesis]]
		+	[[Category: Substrate channeling]]
		+	[[Category: Transferase]]

OCA at 08:37, 2 January 2013

OCA — Wed, 02 Jan 2013 08:37:57 GMT

←Older revision		Revision as of 08:37, 2 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zen is ON HOLD	+	The entry 3zen is ON HOLD until Paper Publication

	Authors: Boehringer, D., Ban, N., Leibundgut, M.		Authors: Boehringer, D., Ban, N., Leibundgut, M.

	Description: Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase		Description: Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase

OCA: Protected "3zen" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2012 10:48:52 GMT

Protected "3zen" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:48, 19 December 2012

OCA: New page: '''Unreleased structure''' The entry 3zen is ON HOLD Authors: Boehringer, D., Ban, N., Leibundgut, M. Description: Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase

OCA — Wed, 19 Dec 2012 10:48:51 GMT

New page: '''Unreleased structure''' The entry 3zen is ON HOLD Authors: Boehringer, D., Ban, N., Leibundgut, M. Description: Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase

New page

'''Unreleased structure'''

The entry 3zen is ON HOLD

Authors: Boehringer, D., Ban, N., Leibundgut, M.

Description: Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase